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Editorial

HIV-1 Tropism

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Pages 473-481 | Published online: 17 Dec 2007

Bibliography

  • Olsen WC , DoshanH, ZhanCet al.: Prolonged coating of CCR5 lymphocytes by PRO 140, a humanized CCR5 monoclonal antibody for HIV-1 therapy. Presented at: 13th Conference on Retroviruses and Opportunistic Infections. Denver, CO, USA, 5–8 February 2006, Abstract 515.
  • Olsen WC , NagashimaK, RosenfieldS, MaddonP: Potent synergistic inhibition of HIV-1 by combinations of the viral entry inhibitors PRO542 and T-20. Presented at: 40th (ICAAC) Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, ON, Canada, 17–20 September 2000, Abstract 549.
  • Jacobson JM , IsraelRJ, LowyIet al.: Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO542. Antimicrob. Agents Chemother.48, 423–429 (2004).
  • Norris D , MoralesJ, GodofskyEet al.: TNX-355, in combination with optimized background regimen (OBR), achieves statistically significant viral load reduction and CD4 cell count increase when compared with OBR alone in Phase 2 study at 48 weeks. Presented at: XVI International AIDS Conference. Toronto, Canada, 13–18 August 2006, Abstract THLB0218.
  • Moyle GE , DeJesusM, BoffitoRet al.: CXCR4 antagonism: proof of activity with AMD11070. Presented at: 14th Conference on Retroviruses and Opportunistic Infections. Los Angeles, CA, USA, 25–28 February 2007, Abstract 511.
  • Saag M , RosenkranzS, BeckerSet al.: Proof of concept of antiretroviral activity of AMD11070 (an orally administered CXCR4 entry inhibitor): results of the first dosing cohort a studied in ACTG protocol A5210. Presented at: 14th Conference on Retroviruses and Opportunistic Infections. Los Angeles, CA, USA, 25–28 February 2007, Abstract 512.
  • Dorr P , WestbyM, DobbsSet al.: Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob. Agents Chemother.49(11), 4721–4732 (2005).
  • Dorr P , MacartneyM, RickettGet al.: UK-427, 857, a novel small molecule HIV entry inhibitor is a specific antagonist of the chemokine receptor CCR5. Presented at: 10th Conference on Retroviruses and Opportunistic Infections. Hynes Convention Center, Boston, MA, USA, 10–14 February 2003, Abstract 443.
  • Gulick RM , SuZ, FlexnerCet al.: Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-infected, treatment-experienced patients: AIDS clinical trials group 5211. J. Infect. Dis.196(2), 304–312 (2007).
  • Clotet B , RaffiF, CooperDet al.: Clinical management of treatment-experienced, HIV-infected patients with the fusion inhibitor enfuvirtide: consensus recommendations. AIDS18(8), 1137–1146, (2004).
  • Delmedico M , BrayB, CammackNet al.: Next generation HIV peptide fusion inhibitor candidates achieve potent, durable suppression of virus replication in vitro and improved pharmacokinetic properties. Presented at: 13th Conference on Retroviruses and Opportunistic Infections. Denver, CO, USA, 5–8 February 2006, Abstract 48.
  • Li F , Goila-GaurR, SalzwedelKet al.: PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing. Proc. Natl Acad. Sci. USA100(23), 13555–13560 (2003).
  • Feng Y , BroderC, KennedyP, BergerE: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane G protein-coupled receptor.Science272, 872–877 (1996).
  • Dragic T , LitwinV, AllawayGet al.: HIV-1 entry into CD4R cells is mediated by the chemokine receptor CC-CKR-5. Nature381, 667–673 (1996).
  • Deng H , LiuR, EllmeierWet al.: Identification of a major co-receptor for primary isolates of HIV-1. Nature381, 661–666 (1996).
  • Berger E , DomsR, FenyöEet al.: A new classification for HIV-1. Nature391, 240 (1998).
  • Tersmette M , de GoedeR, AlBIet al.: Differential syncytium-inducing capacity of HIV isolates: frequent detection of syncytium-inducing isolates in patients with AIDS and AIDS-related complex.J. Virol.62, 2026–2032 (1988).
  • Bozzette S , McCutchanJ, SpectorS, WrightB, RichmanD: A cross-sectional comparison of persons with syncytium- and non-syncytium-inducing HIV.J. Infect. Dis.168, 1374–1379 (1993).
  • Koot M , KeetI, VosA, de GoedeR, RoosM, CoutinhoR: Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4R cell depletion and progression to AIDS.Ann. Intern. Med.118, 681–688 (1993).
  • Spijderman I , de WolfF, LangendamM, SchuitemakerH, CoutinhoR: Emergence of syncytium-inducing HIV type 1 variants coincides with a progression to AIDS.J. Infect. Dis.178, 397–403 (1998).
  • Hoffman T , DomsRW: Chemokines and coreceptors in HIV/SIV host interactions.AIDS, 12(Suppl. A), S17–S26 (1998).
  • Jekle A , KepplerOT, De ClercqE, ScholsD, WeinsteinM, GoldsmithMA: In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells.J. Virol.77, 5846–5854 (2003).
  • Tersmette M , GrutersRA, de WolfFet al.: Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates.J. Virol.63, 2118–2125 (1989).
  • Tersmette M , LangeJM, de GoedeREet al.: Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality. Lancet1(8645), 983–985 (1989).
  • Zaitseva M , LeeS, RabinRet al.: CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection. J. Immunol.161, 3103–3113 (1998).
  • Correa R , Munoz-FernandezMA: Viral phenotype affects the thymic production of new T cells in HIV-1-infected children.AIDS15, 1959–1963 (2001).
  • Malkevitch N , McDermottD, YiJet al.: Coreceptor choice and T cell depletion by R5, X4, and R5X4 HIV-1 variants in CCR5-deficient (CCR5D32) and normal human lymphoid tissue. Virology281, 239–247 (2001).
  • Hazemberg M , OttoS, HamannDet al.: Depletion of naive CD4 T cells by CXCR4-using HIV-1 variants occurs mainly through increased T-cell death and activation. AIDS17, 1419–1424 (2003).
  • Nishimura Y , BrownC, MattapallilJet al.: Resting naive CD4R T cells are massively infected and eliminated by X4-tropic simian-human immunodeficiency viruses in macaques. Proc. Natl Acad. Sci. USA102, 8000–8005 (2005).
  • Moyle GJ , WildfireA, MandaliaSet al.: Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection. J. Infect. Dis.191(6), 866–872 (2005).
  • Lalezari J , GoodrichJ, DeJesusEet al.: Efficacy and safety of maraviroc plus optimised background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1: 24 week results from a Phase 2b/3 study in the US and Canada. Presented at: 14th Conference on Retroviruses and Opportunistic Infections. Los Angeles, CA, USA, 25–28 February 2007, Abstract 104bLB.
  • Nelson M , FatkenheuerG, KonourinaIet al.: Efficacy and safety of maraviroc plus optimised background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia and North America: 24 week results. Presented at: 14th Conference on Retroviruses and Opportunistic Infections. Los Angeles, CA, USA, 25–28 February 2007, Abstract 104aLB.
  • Lalezari J , MayerH: Efficacy and safety of maraviroc (MVC) in antiretroviral treatment-experienced patients infected with CCR5-tropic HIV-1: 48-week results of MOTIVATE 1. Presented at: 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL, USA, 17–20 September 2007.
  • Mayer H , van der RystE, SaagMetal.: Safety and efficacy of maraviroc (MVC), a novel CCR5 antagonist, when used in combination with optimized background therapy (OBT) for the treatment of antiretroviral-experienced subjects infected with dual/mixed-tropic HIV-1: 24 week results of a Phase 2b exploratory trial. Presented at: XVI International AIDS Conference. Toronto, Canada, 13–18 August 2006, Abstract THLB0215.
  • Schuitemaker H , KootM, KootstraNet al.: Biological phenotype of HIV type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus populations. J. Virol.66, 1354–1360 (1992).
  • Connor R , SheridanK, CeradiniD, ChoeS, LandayN: Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals.J. Exp. Med.185, 621–628 (1997).
  • Daar ES , KeslerKL, PetropoulosCJet al.: Baseline HIV type 1 coreceptor tropism predicts disease progression. 45(5), 643–649 (2007)
  • Labernardiere J , Lebel-BinayS, FaudonJL, HolguinA, SorianoV, CheretA: Tropism determination and performance of Phenoscript HIV-1 entry inhibitors assay.Antivir. Ther. (Lond.)9, S141 (2004).
  • Huang W , WrinM, YapJet al.: A rapid multi-functional HIV-1 entry assay for measuring drug susceptibility, co-receptor tropism, and antibody neutralization. Presented at: 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. McCormick Place Lakeside Center, Chicago, IL, USA, 16–19 December 2001.
  • Westby M , WhitcombJ, HuangWet al.: Reversible predominance of CXCR4 utilizing variants in a non-responsive dual tropic patient receiving the CCR5 antagonist UK-427,857. Presented at: 11th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA, USA, 8–11 February 2004, Abstract 538.
  • Kitrinos K , LaBrancheC, StanhopeM, MadsenH, DemarstJ: Clonal analysis detects pre-existing R5X4-tropic virus in a patient demonstrating populations-level tropism shift on 873140 monotherapy.Antivir. Ther. (Lond.)10(Suppl.), 68 (2005).
  • Kitrinos K , IrlbeckD, BonnyTet al.: HIV-1 co-receptor tropism in drug naive patients representing different HIV-1 subtypes tested in 2005. Presented at: 1st International Workshop on Targeting HIV Entry. Bethesda, MD, USA, 2–3 December 2005, Abstract 6.
  • Whitcomb J , HuangW, FransenSet al.: Development and characterisation of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob. Agents Chemother.51(2), 566–575 (2007).
  • Reeves JD , HanD, LiuYet al.: Enhancements to the Trofile HIV coreceptor tropism assay enable reliable detection of CXCR4-using subpopulations at less than 1%. Presented at: 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL, USA, 17–20 September 2007.
  • Stawiski E , WhitcombJ, CoakleyEet al.: Coreceptor tropism predictions based on V3 loop sequence in antiretroviral experienced patients are specific but incensitive for the detection of CXCR4-using variants. Presented at: 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL, USA, 17–20 September 2007.
  • Moncunill G , Armand-UgonM, ClotetBet al.: HIV-1 co-receptor switch induced by antagonism to CCR5. Presented at: 14th Conference on Retroviruses and Opportunistic Infections. Los Angeles, CA, USA, 25–28 February 2007, Abstract 618.
  • Delobel P , Sandres-SaunéK, CazabatMet al.: R5 to X4 switch of the predominant HIV-1 population in cellular reservoirs during effective highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr.38, 382–392 (2005).
  • Skrabal K , TrouplinV, LabrosseBet al.: Impact of antiretroviral treatment on the tropism of HIV-1 plasma virus populations. AIDS17, 809–814 (2003).
  • Galán I , JimenezJ, González-RiveraMet al.: Virological phenotype switches under salvage therapy with lopinavir-ritonavir in heavily pretreated HIV-1 vertically infected children. AIDS18, 247–255 (2004).
  • Johnston E , ZijenahL, MutetwaSet al.: High frequency of syncytium-inducing and CXCR4-tropic viruses among HIV type 1 subtype C-infected patients receiving antiretroviral treatment. J. Virol.77, 7682–7688 (2003).
  • Koot M , van LeeuwenR, de GoedeREet al.: Conversion rate towards a syncytium-inducing (SI) phenotype during different stages of human immunodeficiency virus type 1 infection and prognostic value of SI phenotype for survival after AIDS diagnosis.J. Infect. Dis.179, 254–258 (1999).
  • Furrer H , WendlandT, MinderCet al.: Association of syncytium inducing phenotype of HIV-1 with CD4 cell count, viral load and sociodemographic characteristics. AIDS12, 1341–1346 (1998).
  • Bozzette SA , McCutchanJA, SpectorSA, WrightB, RichmanDD: A cross-sectional comparison of persons with syncytium- and non-syncytium-inducing human immunodeficiency virus.J. Infect. Dis.168, 1374–1379 (1993).
  • Waters LJ , MandaliaS, WildfireAet al.: CXCR4/mixed-tropic HIV-1 is associated with more rapid CD4 cell decline compared with CCR5-tropic virus in antiretroviral-naive individuals. Presented at: 46th Annual ICAAC Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA, 27–30 September 2006.
  • Begaud E , FeindirongaiG, VersmissePet al.: Broad spectrum of coreceptor usage and rapid disease progression in HIV-1-infected individuals from Central African Republic. AIDS Res. Hum. Retroviruses19(7), 551–560 (2003).
  • Casper C , NaverL, ClevestigPet al.: Coreceptor change appears after immune deficiency is established in children infected with different HIV-1 subtypes. AIDS Res. Hum. Retroviruses18(5), 343–352 (2002).
  • Pohlmann S , KrumbiegelM, KirchhoffF: Coreceptor usage of BOB/GPR15 and Bonzo/STRL33 by primary isolates of human immunodeficiency virus type 1.J. Gen.Virol.80(Pt 5), 1241–1251 (1999).
  • Tscherning-Casper C , VodrosD, MenuEet al.: Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1. J. Acquir. Immune Defic. Syndr.24(1), 1–9 (2000).
  • Zerhouni-Layachi B , HusainM, RossMJet al.: Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. AIDS20(4), 621–624 (2006).
  • Cilliers T , WilleyS, SullivanWMet al.: Use of alternate coreceptors on primary cells by two HIV-1 isolates. Virology339(1), 136–144 (2005).
  • Tscherning C , AlaeusA, FredrikssonRet al.: Differences in chemokine coreceptor usage between genetic subtypes of HIV-1. Virology241(2), 181–188 (1998).
  • Jansson M , BackstromE, BjorndanAet al.: Co-receptor usage and RANTES sensitivity of non-syncytium-inducing HIV-1 isolates obtained from patients with AIDS. J. Hum. Virol.2, 325–338 (1999).
  • Koning F , KwaD, Boeser-NunninkBet al.: Decreasing sensitivity to RANTES (regulated on activation, normally T cell-expressed and -secreted) neutralization of CC chemokine receptor 5-using, non-syncytium-inducing virus variants in the course of HIV type 1 infection. J. Infect. Dis.188, 864–872 (2003).
  • Karlsson L , AntonssonL, ShiYet al.: Co-evolution of RANTES sensitivity and mode of CCR5 receptor use by HIV type 1 of the R5 phenotype. J. Virol.78, 11807–11815 (2004).
  • Kwa D , VingerhoedJ, BoeserB, SchuitemakerH: Increased in vitro cytopathicity of CC chemokine receptor 5-restricted HIV type 1 primary isolates correlates with a progressive clinical course of infection.J. Infect. Dis.187, 1397–1403 (2003).
  • Gray L , SterjovskiJ, ChurchillMet al.: Uncoupling coreceptor usage of HIV-1 from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with AIDS. Virology337, 384–398 (2005).
  • Murga JD , FrantiM, PevearDCet al.: Potent antiviral synergy between monoclonal antibody and small-molecule CCR5 inhibitors of human immunodeficiency virus type 1. Antimicrob. Agents Chemother.50(10), 3289–3296 (2006).
  • Tremblay CL , GiguelF, ChouTC, DongH, TakashimaK, HirschMS: TAK-652, a novel CCR5 inhibitor, has favourable drug interactions with other antiretrovirals in vitro.Antivir. Ther.10, 967–968 (2005).
  • Tremblay CL , GiguelF, GuanY, ChouTC, TakashimaK, HirschMS: TAK-220, a novel small-molecule CCR5 antagonist, has favourable anti-human immunodeficiency virus interactions with other antiretrovirals in vitro.Antimicrob. Agents Chemother.49, 3483–3485 (2005).
  • Tremblay CL , GiguelF, KollmannCet al.: Anti-human immunodeficiency virus interactions of SCH-C (SCH 351125), a CCR5 antagonist, with other antiretroviral agents in vitro. Antimicrob. Agents Chemother.46, 1336–1339 (2002).
  • Dorr P , WestbyM, DobbsSet al.: Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob. Agents Chemother.49(11), 4721–4732 (2005).
  • Nagashima K , RosenfieldS, ThompsonDet al.: Mechanisms of synergy between HIV-1 attachment, coreceptor and fusion inhibitors. Presented at: 8th Conference on Retroviruses and Opportunistic Infections. Chicago, IL, USA, 4–8 February 2001, Abstract 310.
  • Westby M , MoriJ, Smith-BurchnellCet al.: Maraviroc (UK-427,857)-resistant HIV-1 variants, selected by serial passage, are sensitive to CCR5 antagonists and T-20. Presented at: XIV International HIV Drug Resistance Workshop IC Report: Basic Principles and Clinical Implications. Québec City, Québec, Canada, 7–11 June 2005, Abstract 65 (poster).
  • Strizki JM , WojcikL, MarozsanAJet al.: Properties of in vitro generated HIV-1 variants resistant to the CCR5 antagonists SCH 351125 and SCH 417690. Presented at: XIV International HIV Drug Resistance Workshop IC Report: Basic Principles and Clinical Implications. Québec City, Québec, Canada, 7–11 June 2005, Abstract 59 (poster).
  • Ray N , HarrisonJE, BlackburnLAet al.: Clinical resistance to enfuvirtide does not affect susceptibility of human immunodeficiency virus type 1 to other classes of entry inhibitors. J. Virol.81(7), 3240–3250 (2007).
  • Delmedico M , BrayB, CammackNet al.: Next generation HIV peptide fusion inhibitor candidates achieve potent, durable suppression of virus replication in vitro and improved pharmacokinetic properties. Presented at: 13th Conference on Retroviruses and Opportunistic Infections. Denver, CO, USA, 5–8 February 2006, Abstract 48.
  • Glass WG , LimJK, CholeraR, PletnevAG, GaoJL, MurphyPM: Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection.J. Exp. Med.202(8), 1087–1098 (2005).
  • Lim JK , GlassWG, McDermottDH, MurphyPM: CCR5: no longer a ‘good for nothing‘ gene-chemokine control of West Nile virus infection.Trends Immunol.27(7), 308–312 (2006).
  • Diamond MS , KleinRS: A genetic basis for human susceptibility to West Nile virus.Trends Microbiol.14(7), 287–289 (2006).
  • Glass WG , McDermotDH, LimJKet al.: CCR5 deficiency increases risk of symptomatic West Nile virus infection. J. Exp. Med.203(1), 35–40 (2006).
  • Goulding C , McManusR, MurphyAet al.: The CCR5-D32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. Gut54(8), 1157–1161 (2005).
  • Hellier S , FrodshamA, HenningBet al.: Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hepatology38, 1468–1476 (2003).
  • Vincent T , PortalesP, BaillatVet al.: T-cell surface CCR5 density is not correlated with hepatitis severity in hepatitis C virus/HIV-coinfected individuals. J. Acquir. Immune Defic. Syndr.38, 305–309 (2005).
  • Wasmuth HE , WerthA, MuellerTet al.: CC chemokine receptor 5 D32 polymorphism in two independent cohorts of hepatitis C virus infected patients without hemophilia. J. Mol. Med.82(1), 64–69 (2004).
  • Woitas RP , AhlenstielG, IwanAet al.: Frequency of the HIV-protective CC chemokine receptor 5-D32/D32 genotype is increased in hepatitis C. Gastroenterology122(7), 1721–1728 (2002).
  • Thoelen I , VerbeeckJ, WollantsEet al.: Frequency of the CCR5D32 mutant allele is not increased in Belgian hepatitis C virus-infected patients. Viral Immunol.18(1), 232–235 (2005).
  • Tommasi AM , FabrisP, CarderiIet al.: Lack of higher frequency of the chemokine receptor 5-D32/D32 genotype in hepatitis C. J. Clin. Gastroenterol.40(5), 440–443 (2006).
  • Promrat K , McDermottDH, GonzalezCMet al.: Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology124(2), 352–360 (2003).
  • Ahlenstiel G , BergT, WoitasRPet al.: Effects of the CCR5-D32 mutation on antiviral treatment in chronic hepatitis C. J. Hepatol.39(2), 245–252 (2003).
  • Tsibris AMN , ParedesR, SuZet al.: Vicriviroc therapy and EBV plasma viral loads in HIV-1 infected treatment-experienced subjects. Presented at: 14th Conference on Retroviruses and Opportunistic Infections. Los Angeles, CA, USA, 25–28 February 2007, Poster 844.
  • Skrabal K , TrouplinV, LabrosseBet al.: Impact of antiretroviral treatment on the tropism of HIV-1 plasma virus populations. AIDS17, 809–814 (2003).
  • Kulkosky J , PomerantzRJ: Approaching eradication of highly active antiretroviral therapy-persistent human immunodeficiency virus type 1 reservoirs with immune activation therapy.Clin. Infect. Dis.35, 1520–1526 (2002).
  • Johnson WE , DesrosiersRC: Viral persistance: HIV‘s strategies of immune system evasion.Annu. Rev. Med.53, 499–518 (2002).
  • Smith KA : To cure chronic HIV infection, a new therapeutic strategy is needed.Curr. Opin. Immunol.13, 617–624 (2001).
  • Lehrman G , HogueIB, PalmerSet al.: Depletion of HIV-1 infection in vivo: a proof of concept study.Lancet366, 549–555 (2005).

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