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Biomarkers in Medicine Volume 1, 2007 - Issue 4
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Review

New Potential Uses for Cardiac Troponins

Vlad C Vasile1 Mayo Clinic & Mayo Medical School,Department of Internal Medicine,Division of Cardiovascular Diseases & Department of Laboratory Medicine & Pathology,Rochester,Minnesota,USACorrespondence[email protected]
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Allan S Jaffe1 Mayo Clinic & Mayo Medical School,Department of Internal Medicine,Division of Cardiovascular Diseases & Department of Laboratory Medicine & Pathology,Rochester,Minnesota,USA;2 Mayo Clinic,200 First St. SW,Division of Cardiovascular Diseases,Gonda 5,Rochester,Minnesota55905,USA.Correspondence[email protected]
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Pages 491-501 | Published online: 17 Dec 2007

Bibliography

  • Alpert JS , ThygesenK, AntmanEet al.: Myocardial infarction redefined – a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J. Am. Coll. Cardiol.36(3), 959–969 (2000).
  • Myocardial infarction redefined – a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur. Heart J.21(18), 1502–1513 (2000).
  • Takeda S , YamashitaA, MaedaKet al.: Structure of the core domain of human cardiac troponin in the Ca2+-saturated form. Nature424(6944), 35–41 (2003).
  • Dhoot GK , FrearsonN, PerrySV: Polymorphic forms of troponin T and troponin C and their localization in striated muscle cell types.Exp. Cell Res.122(2), 339–350 (1979).
  • Dhoot GK , PerrySV: Distribution of polymorphic forms of troponin components and tropomyosin in skeletal muscle.Nature278(5706), 714–718 (1979).
  • Dhoot GK , GellPG, PerrySV: The localization of the different forms of troponin I in skeletal and cardiac muscle cells.Exp. Cell Res.117(2), 357–370 (1978).
  • Schreier T , KedesL, GahlmannR: Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene.J. Biol. Chem.265(34), 21247–21253 (1990).
  • Cummins P , PerrySV: Troponin I from human skeletal and cardiac muscles.Biochem. J.171(1), 251–259 (1978).
  • Vallins WJ , BrandNJ, DabhadeNet al.: Molecular cloning of human cardiac troponin I using polymerase chain reaction. FEBS Lett.270(1–2), 57–61 (1990).
  • Perry SV : Troponin I: inhibitor or facilitator.Mol. Cell Biochem.190(1–2), 9–32 (1999).
  • Katrukha A : Antibody selection strategies in cardiac troponin assay. In: Cardiac Markers (2nd Edition). Wu ABH (Ed.). Humana Press Inc., Totowa, New Jersey, USA (2003).
  • Larue C , Defacque-LacquementH, CalzolariCet al.: New monoclonal antibodies as probes for human cardiac troponin I: epitopic analysis with synthetic peptides. Mol. Immunol.29(2), 271–278 (1992).
  • Perry SV : Troponin T: genetics, properties and function.J. Muscle Res. Cell Motil.19(6), 575–602 (1998).
  • Gahlmann R , TrouttAB, WadeRPet al.: Alternative splicing generates variants in important functional domains of human slow skeletal troponin T. J. Biol. Chem.262(33), 16122–16126 (1987).
  • Katus HA , LooserS, HallermayerKet al.: Development and in vitro characterization of a new immunoassay of cardiac troponin T. Clin. Chem.38(3), 386–393 (1992).
  • Ricchiuti V , VossEM, NeyAet al.: Cardiac troponin T isoforms expressed in renal diseased skeletal muscle will not cause false-positive results by the second generation cardiac troponin T assay by Boehringer Mannheim. Clin.Chem.44(9), 1919–1924 (1998).
  • Gordon AM , HomsherE, RegnierM: Regulation of contraction in striated muscle.Physiol. Rev.80(2), 853–924 (2000).
  • Metzger JM , WestfallMV: Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation.Circ. Res.94(2), 146–158 (2004).
  • Solaro RJ : The special structure and function of troponin I in regulation of cardiac contraction and relaxation.Adv. Exp. Med. Biol.538, 389–401 (2003).
  • McDonough JL , Van EykJE: Developing the next generation of cardiac markers: disease-induced modifications of troponin I.Prog. Cardiovasc.Dis.47(3), 207–216 (2004).
  • McDonough JH , BenjaminA, McMonagleJDet al.: Effects of fosphenytoin on nerve agent-induced status epilepticus.Drug Chem. Toxicol.27(1), 27–39 (2004).
  • Morel JE , PinsetHI: Ultrastructure of the contractile system of striated skeletal muscle and the processes of muscular contraction. II. Releasing system and mechanisms of muscular contraction.Biomedicine22(3), 186–194 (1975).
  • Mashima H , KabasawaK: Modeling of cardiac muscle contraction based on the cross-bridge mechanism.Adv. Exp. Med. Biol.170, 807–820 (1984).
  • McDonough JL , ArrellDK, Van EykJE: Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury.Circ. Res.84(1), 9–20 (1999).
  • Sumandea MP , BurkartEM, KobayashiTet al.: Molecular and integrated biology of thin filament protein phosphorylation in heart muscle. Ann. NY Acad. Sci.1015, 39–52 (2004).
  • Kim SJ , KudejRK, YataniAet al.: A novel mechanism for myocardial stunning involving impaired Ca2+ handling. Circ. Res.89(9), 831–837 (2001).
  • McDonough JL , LabuggerR, PickettWet al.: Cardiac troponin I is modified in the myocardium of bypass patients. Circulation103(1), 58–64 (2001).
  • Van Eyk JE , MurphyAM: The role of troponin abnormalities as a cause for stunned myocardium.Coron. Artery Dis.12(5), 343–347 (2001).
  • Murphy AM , KoglerH, GeorgakopoulosDet al.: Transgenic mouse model of stunned myocardium. Science287(5452), 488–491 (2000).
  • Narolska NA , PiroddiN, BelusAet al.: Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle. Circ. Res.99(9), 1012–1020 (2006).
  • Neagoe C , KulkeM, del MonteFet al.: Titin isoform switch in ischemic human heart disease.Circulation106(11), 1333–1341 (2002).
  • Katrukha AG , BereznikovaAV, EsakovaTVet al.: Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin. Chem.43, 1379–1385 (1997).
  • Wu AH , FengYJ, MooreRet al.: Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization. Clin. Chem.44, 1198–1208 (1998).
  • Labugger R , SimpsonJA, QuickMet al.: Strategy for analysis of cardiac troponins in biological samples with a combination of affinity chromatography and mass spectrometry. Clin.Chem.49, 873–879 (2003).
  • Atar D , MadsenLH, LabuggerRet al.: Molecular modifications of troponin I and T detected in serum from patients with acute myocardial infarction. Ugeskr.Laeg.165(2), 116–120 (2003).
  • Adams JE 3rd, SchechtmanKB, LandtYet al.: Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I.Clin. Chem.40, 1291–1295 (1994).
  • Katus HA , RemppisA, ScheffoldTet al.: Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. Am. J. Cardiol.67(16), 1360–1367 (1991).
  • Jaffe AS , LandtY, ParvinCAet al.: Comparative sensitivity of cardiac troponin I and lactate dehydrogenase isoenzymes for diagnosing acute myocardial infarction. Clin.Chem.42(11), 1770–1776 (1996).
  • Ellis K , DreisbachAW, LertoraJL: Plasma elimination of cardiac troponin I in end-stage renal disease.South Med. J.94(10), 993–996 (2001).
  • Kragten JA , HermensWT, van Dieijen-VisserMP: Cardiac troponin T release into plasma after acute myocardial infarction: only fractional recovery compared with enzymes.Ann. Clin. Biochem.33, 314–323 (1996).
  • Kragten JA , HermensWT, van Dieijen-VisserMP: Cumulative troponin T release after acute myocardial infarction. Influence of reperfusion.Eur. J. Clin. Chem. Clin.Biochem.35(6), 459–467 (1997).
  • Jugdutt BI : Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?Circulation108(11), 1395–1403 (2003).
  • Lee MS , MakkarRR: Stem-cell transplantation in myocardial infarction: a status report.Ann. Intern. Med.140(9), 729–737 (2004).
  • Ishikawa Y , SaffitzJE, MealmanTLet al.: Reversible myocardial ischemic injury is not associated with increased creatine kinase activity in plasma. Clin. Chem.43(3), 467–475 (1997).
  • Simpson JA , van EykJE, IscoeS: Hypoxemia-induced modification of troponin I and T in canine diaphragm.J. Appl. Physiol.88(2), 753–760 (2000).
  • Simpson JA , Van EykJ, IscoeS: Respiratory muscle injury, fatigue and serum skeletal troponin I in rat.J. Physiol.554, 891–903 (2004).
  • Carlson RJ , NavoneA, McConnellJPet al.: Effect of myocardial ischemia on cardiac troponin I and T. Am. J. Cardiol.89(2), 224–226 (2002).
  • Chen Y , SerfassRC, Mackey-BojackSMet al.: Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise. J. Appl. Physiol.88(5), 1749–1755 (2000).
  • Rifai N , DouglasPS, O‘TooleMet al.: Cardiac troponin T and I, echocardiographic (correction of electrocardiographic) wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon. Am. J. Cardiol.83(7), 1085–1089 (1999).
  • Neumayr G , GaenzerH, PfisterRet al.: Plasma levels of cardiac troponin I after prolonged strenuous endurance exercise. Am. J. Cardiol.87(3), 369–371 (2001).
  • Lowbeer C , SeebergerA, GustafssonSAet al.: Serum cardiac troponin T, troponin I, plasma BNP and left ventricular mass index in professional football players. J. Sci. Med. Sport10(5), 291–296 (2007).
  • Whyte GP , StephensN, SeniorRet al.: Treat the patient not the blood test: the implications of an elevation in cardiac troponin following prolonged endurance exercise. Br. J. Sports Med.200, 33–72 (2006).
  • Davila-Roman VG , GuestTM, TuteurPGet al.: Transient right but not left ventricular dysfunction after strenuous exercise at high altitude. J. Am. Coll. Cardiol.30(2), 468–473 (1997).
  • Sobel BE , LeWinterMM: Ingenuous interpretation of elevated blood levels of macromolecular markers of myocardial injury: a recipe for confusion.J. Am. Coll. Cardiol.35(5), 1355–1358 (2000).
  • Vidotto C , TschanH, AtamaniukJet al.: Responses of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) to competitive endurance exercise in recreational athletes. Int. J. Sports Med.26(8), 645–650 (2005).
  • Konig D , SchumacherYO, HeinrichLet al.: Myocardial stress after competitive exercise in professional road cyclists. Med. Sci. Sports Exerc.35(10), 1679–1683 (2003).
  • Neumayr G , PfisterR, MitterbauerGet al.: Effect of the ‘Race Across The Alps‘ in elite cyclists on plasma cardiac troponins I and T. Am. J. Cardiol.89(4), 484–486 (2002).
  • Laster SB , SheltonTJ, BarzilaiBet al.: Determinants of the recovery of right ventricular performance following experimental chronic right coronary artery occlusion. Circulation88(2), 696–708 (1993).
  • Laster SB , OhnishiY, SaffitzJEet al.: Effects of reperfusion on ischemic right ventricular dysfunction. Disparate mechanisms of benefit related to duration of ischemia. Circulation90(3), 1398–1409 (1994).
  • Goldstein JA : Pathophysiology and management of right heart ischemia.J. Am. Coll. Cardiol.40(5), 841–853 (2002).
  • Bolli R , MarbanE: Molecular and cellular mechanisms of myocardial stunning.Physiol. Rev.79(2), 609–634 (1999).
  • Stack RS , PhillipsHR 3rd, GriersonDSet al.: Functional improvement of jeopardized myocardium following intracoronary streptokinase infusion in acute myocardial infarction.J. Clin. Invest.72(1), 84–95 (1983).
  • Christian TF , BehrenbeckT, PellikkaPAet al.: Mismatch of left ventricular function and infarct size demonstrated by technetium-99m isonitrile imaging after reperfusion therapy for acute myocardial infarction: identification of myocardial stunning and hyperkinesia. J. Am. Coll. Cardiol.16(7), 1632–1638 (1990).
  • Grines CL , O‘NeillWW, AnselmoEGet al.: Comparison of left ventricular function and contractile reserve after successful recanalization by thrombolysis versus rescue percutaneous transluminal coronary angioplasty for acute myocardial infarction. Am. J. Cardiol.62(7), 352–357 (1988).
  • Topol EJ , WeissJL, BrinkerJAet al.: Regional wall motion improvement after coronary thrombolysis with recombinant tissue plasminogen activator: importance of coronary angioplasty. J. Am. Coll. Cardiol.6(2), 426–433 (1985).
  • Marban E , GaoWD: Stunned myocardium: a disease of the myofilaments?Basic Res. Cardiol.90(4), 269–272 (1995).
  • Gao WD , AtarD, BackxPHet al.: Relationship between intracellular calcium and contractile force in stunned myocardium. Direct evidence for decreased myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle. Circ. Res.76(6), 1036–1048 (1995).
  • Gao WD , LiuY, MellgrenRet al.: Intrinsic myofilament alterations underlying the decreased contractility of stunned myocardium. A consequence of Ca2+-dependent proteolysis? Circ. Res.78(3), 455–465 (1996).
  • Van Eyk JE , PowersF, LawWet al.: Breakdown and release of myofilament proteins during ischemia and ischemia/reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation. Circ. Res.82(2), 261–271 (1998).
  • Marston SB , RedwoodCS: Modulation of thin filament activation by breakdown or isoform switching of thin filament proteins: physiological and pathological implications.Circ. Res.93(12), 1170–1178 (2003).
  • Dote K , SatoH, TateishiHet al.: Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases. J. Cardiol.21(2), 203–214 (1991).
  • Tsuchihashi K , UeshimaK, UchidaTet al.: Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. Angina Pectoris-Myocardial Infarction Investigations in Japan. J. Am. Coll. Cardiol.38(1), 11–18 (2001).
  • Desmet WJ , AdriaenssensBF, DensJA: Apical ballooning of the left ventricle: first series in white patients.Heart89(9), 1027–1031 (2003).
  • Gianni M , DentaliF, GrandiAMet al.: Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur. Heart J.27(13), 1523–1529 (2006).
  • Citro R , GalderisiM, MaioneAet al.: Sequential transthoracic ultrasound assessment of coronary flow reserve in a patient with Tako-tsubo syndrome. J. Am. Soc. Echocardiogr.19(11), 1405–1408 (2006).
  • Meimoun P , MalaquinD, BenaliT, TribouilloyC: Assessment of coronary flow reserve by transthoracic Doppler echocardiography in left apical ballooning syndrome.Eur. J. Echocardiogr. (2007) (Epub ahead of print).
  • Abe Y , KondoM, MatsuokaRet al.: Assessment of clinical features in transient left ventricular apical ballooning. J. Am. Coll. Cardiol.41(5), 737–742 (2003).
  • Wittstein IS , ThiemannDR, LimaJAet al.: Neurohumoral features of myocardial stunning due to sudden emotional stress. N. Engl. J. Med.352(6), 539–548 (2005).
  • Ueyama T , KasamatsuK, HanoTet al.: Emotional stress induces transient left ventricular hypocontraction in the rat via activation of cardiac adrenoceptors: a possible animal model of ‘tako-tsubo‘ cardiomyopathy. Circ. J.66(7), 712–713 (2002).
  • Sharkey SW , LesserJR, ZenovichAGet al.: Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circulation111(4), 472–479 (2005).
  • Ibanez B , NavarroF, CordobaM et al.: Tako-tsubo transient left ventricular apical ballooning: is intravascular ultrasound the key to resolve the enigma?Heart91(1), 102–104 (2005).
  • Bybee KA , PrasadA, BarsnessGWet al.: Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am. J. Cardiol.94(3), 343–346 (2004).
  • Jaffe AS , KatusH: Acute coronary syndrome biomarkers: the need for more adequate reporting.Circulation110(2), 104–106 (2004).
  • Weaver WD , SimesRJ, BetriuAet al.: Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review. JAMA278(23), 2093–2098 (1997).
  • Kloner RA , RezkallaSH: Cardiac protection during acute myocardial infarction: where do we stand in 2004?J. Am. Coll. Cardiol.44(2), 276–286 (2004).
  • Braunwald E , KlonerRA: Myocardial reperfusion: a double-edged sword?J. Clin. Invest.76(5), 1713–1719 (1985).
  • Gao WD , AtarD, LiuYet al.: Role of troponin I proteolysis in the pathogenesis of stunned myocardium. Circ. Res.80(3), 393–399 (1997).
  • Prasan AM , McCarronHC, HamblyBDet al.: Effect of treatment on ventricular function and troponin I proteolysis in reperfused myocardium. J. Mol. Cell. Cardiol.34(4), 401–411(2002).
  • Canty JM , LeeTC: Troponin I proteolysis and myocardial stunning: now you see it-now you don‘t.J. Mol. Cell. Cardiol.34(4), 375–377 (2002).
  • Sherman AJ , KlockeFJ, DeckerRSet al.: Myofibrillar disruption in hypocontractile myocardium showing perfusion-contraction matches and mismatches. Am. J. Physiol. Heart Circ. Physiol.278(4), 1320–1334 (2000).
  • Zeitz O , MaassAE, Van NguyenPet al.: Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na+-Ca2+ exchange.Circ. Res.90(9), 988–995 (2002).
  • Li G , MartinAF, SolaroJR: Localization of regions of troponin I important in deactivation of cardiac myofilaments by acidic pH.J. Mol. Cell. Cardiol.33(7), 1309–1320 (2001).
  • Smith SC , LadensonJH, MasonJWet al.: Elevations of cardiac troponin I associated with myocarditis. Experimental and clinical correlates. Circulation95(1), 163–168 (1997).
  • Bachmaier K , MairJ, OffnerFet al.: Serum cardiac troponin T and creatine kinase-MB elevations in murine autoimmune myocarditis. Circulation92(7), 1927–1932 (1995).
  • Lauer B , NiederauC, KuhlUet al.: Cardiac troponin T in patients with clinically suspected myocarditis. J. Am. Coll. Cardiol.30(5), 1354–1359 (1997).
  • Franz WM , RemppisA, KandolfRet al.: Serum troponin T: diagnostic marker for acute myocarditis. Clin. Chem.42(2), 340–341 (1996).
  • Feldman AM , McNamaraD: Myocarditis.N. Engl. J. Med.343(19), 1388–1398 (2000).
  • Goser S , AndrassyM, BussSJet al.: Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium. Circulation114(16), 1693–1702 (2006).
  • Schulz O , Paul-WalterC, LehmannMet al.: Usefulness of detectable levels of troponin, below the 99th percentile of the normal range as a clue to the presence of underlying coronary artery disease. Am. J. Cardiol.100(5), 764–769 (2007).
  • Müller-Bardorff M , WeidtmannB, GiannitsisEet al.: Release kinetics of cardiac troponin T in survivors of confirmed severe pulmonary embolism. Clin. Chem.48(4), 673–675 (2002).
  • Collins AJ , LiS, MaJZet al.: Cardiovascular disease in end-stage renal disease patients. Am. J. Kidney Dis.38, 26–29 (2001).
  • United States Renal Data System. USRDS 1999 Annual Data Report. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease, 89–100 (1999).
  • United States Renal Data System. USRDS 1999 Annual Data Report. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease (1999).
  • Herzog CA , MaJZ, CollinsAJ: Poor long-term survival after acute myocardial infarction among patients on long-term dialysis.N. Engl. J. Med.339, 799–805 (1998).
  • Freda BJ , TangWH, VanLenteF et al.: Cardiac troponins in renal insufficiency review and clinical implications.J. Am. Coll. Cardiol.40, 2065–2071 (2002).
  • DeZoysa JR : Cardiac troponins and renal disease.Nephrology9, 83–88 (2004).
  • Apple FS , MurakamiMM, PearceLAet al.: Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease. Circulation106, 2941–2945 (2002).
  • deFilippi C , WassermanS, RosanioSet al.: Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis. JAMA290, 353–359 (2003).
  • Panteghini M , PaganiF, YeoKT et al.: Evaluation of imprecision for cardiac troponin assays at low-range concentrations.Clin. Chem.50, 327–332 (2004).
  • Apple FS : Clinical and analytical standardization issues confronting cardiac troponin I.Clin. Chem.45, 18–20 (1999).
  • Panteghini M , GerhardtW, AppleFS: Quality specifications for cardiac troponin assays.Clin. Chem. Lab. Med.39, 175–179 (2001).
  • Eriksson S , HellmanJ, PetterssonK: Autoantibodies against cardiac troponins.N. Engl. J. Med.352, 98–100 (2005).
  • Zoccali C : Biomarkers in chronic kidney disease: utility and issues towards better understanding.Curr. Opin. Nephrol. Hypertens.14, 532–537 (2005).
  • Diris J , HackengCM, KoomanJPet al.: Impaired renal clearance explains elevated troponin T fragments in hemodialysis patients. Circulation109, 23–25 ( 2004).
  • Saggin L , GorzaL, AusoniSet al.: Troponin I switching in the developing heart. J. Biol. Chem.264, 16299–16302 (1989).
  • Toyota N , ShimadaY: Differentiation of troponin in cardiac and skeletal muscles in chicken embryos as studied by immunofluorescence microscopy.J. Cell Biol.91, 497–504 (1981).
  • England PJ : Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart.Biochem. J.160, 295–304 (1976).
  • Mittmann K , JaquetK, HeilmeyerLMG: Ordered phosphorylation of a duplicated minimal recognition motif for cAMP-dependent protein kinase present in cardiac troponin I.FEBS Lett.302, 133–137 (1992).
  • Martin AF : Turnover of cardiac troponin subunits. Kinetic evidence for a precursor pool of troponin-I.J. Biol. Chem.256, 964–968 (1981).
  • Solaro RJ , MoirAJ, PerrySV: Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart.Nature262, 615–617 (1976).
  • Ababou A , DesjarlaisJR: Solvation energetics and conformational change in EF-hand proteins.Protein Sci.10, 301–312 (2001).
  • Finley N , AbbottMB, AbusamhadnehEet al.: NMR analysis of cardiac troponin C-troponin I complexes: effects of phosphorylation. FEBS Lett.453, 107–112 (1999).
  • Sakthivel S , FinleyNL, RosevearPRet al.: In vivo and in vitro analysis of cardiac troponin I phosphorylation. J. Biol. Chem.280, 703–714 (2005).
  • Schmidtmann A , LohmannK, JaquetK: The interaction of the bisphosphorylated N-terminal arm of cardiac troponin I-A 31P-NMR study.FEBS Lett.513, 289–293 (2002).
  • Ward DG , BrewerSM, GallonCEet al.: NMR and mutagenesis studies on the phosphorylation region of human cardiac troponin I. Biochemistry43, 5772–5781 (2004).
  • Keane NE , QuirkPG, GaoYet al.: The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase – structural consequences and functional implications. Eur. J. Biochem.248, 329–337 (1997).
  • Buscemi N , FosterDB, NeverovaIet al.: p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I. Circ. Res.91, 509–516 (2002).
  • Fahie-Wilson MN , CarmichaelDJ, DelaneyMPet al.: Cardiac troponin T circulates in the free, intact form in patients with kidney failure,Clin. Chem.52, 414–420 (2006).
  • Bunk DM , WelchMJ: Characterization of a new certified reference material for human cardiac troponin I.Clin. Chem.52, 212–219 (2006).
  • Christenson RH , DuhSH, AppleFSet al.: Toward standardization of cardiac troponin I measurements part II: assessing commutability of candidate reference materials and harmonization of cardiac troponin I assays. Clin. Chem.52, 1685–1692 (2006).

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