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Review

Biomarkers in the Development of Novel Disease-Modifying Therapies for Osteoarthritis

, , &
Pages 587-602 | Published online: 12 Dec 2008

Bibliography

  • Lawrence RC , FelsonDT, HelmickCGet al. : Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.Arthritis Rheum.58, 26–35(2008).
  • Brandt KD , MazzucaSA: Lessons learned from nine clinical trials of disease-modifying osteoarthritis drugs.Arthritis Rheum.52, 3349–3359(2005).
  • Rousseau JC , DelmasPD: Biological markers in osteoarthritis.Nat. Clin. Pract. Rheumatol.3, 346–356(2007).
  • Bauer DC , HunterDJ, AbramsonSBet al. : Classification of osteoarthritis biomarkers: a proposed approach.Osteoarthr. Cartil.14, 723–727(2006).
  • King KB , LindseyCT, DunnTC, RiesMD, SteinbachLS, MajumdarS: A study of the relationship between molecular biomarkers of joint degeneration and the magnetic resonance-measured characteristics of cartilage in 16 symptomatic knees.Osteoarthr. Cartil.22, 1117–1123(2004).
  • Kong SY , StablerTV, CriscioneLG, ElliottAL, JordanJM, KrausVB: Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis.Arthritis Rheum.54, 2496–2504(2006).
  • Conrozier T , PooleAR, FerrandFet al. : Serum concentrations of type II collagen biomarkers (C2C, C1, 2C and CPII) suggest different pathophysiologies in patients with hip osteoarthritis.Clin. Exp. Rheumatol.26, 430–435(2008).
  • Mazzuca SA , PooleAR, BrandtKD, KatzBP, LaneKA, LobanokT: Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis.J. Rheumatol.33, 1147–1151(2006).
  • Hunter DJ , LiJ, LaValleyMet al. : Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study.Arthritis Res. Ther.9, R108 (2007).
  • Pickering E , Szekely-KlepserG, NemirovskiyOet al. : Urinary type II collagen neoepitope (uTIINE): a marker of osteoarthritis activity.Osteoarthr. Cartil.12, S93 (2004).
  • Hellio Le Graverand MP , BrandtKD, MazzucaSAet al. : Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritis.Osteoarthr. Cartil.14, 1189–1195(2006).
  • Otterness IG , BrandtKD, Le Graverand MP, Mazzuca SA: Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing. Arthritis Rheum.56, 3644–3649(2007).
  • Deberg M , DubucJE, LabasseAet al. : One-year follow-up of Coll2–1, Coll2–1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement.Ann. Rheum. Dis.67, 168–174(2008).
  • Deberg M , LabasseA, ChristgauSet al. : New serum biochemical markers (Coll 2–1 and Coll 2–1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis.Osteoarthr. Cartil.13, 258–265(2005).
  • Henrotin Y , DebergM, DubucJE, QuettierE, ChristgauS, ReginsterJY: Type II collagen peptides for measuring cartilage degradation.Biorheology41, 543–547(2004).
  • Deberg MA , LabasseAH, ColletteJ, SeidelL, ReginsterJY, HenrotinYE: One-year increase of Coll 2–1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression.Osteoarthr. Cartil.13, 1059–1065(2005).
  • Charni N , JuilletF, GarneroP: Urinary type II collagen helical peptide (HELIX-II) as a new biochemical marker of cartilage degradation in patients with osteoarthritis and rheumatoid arthritis.Arthritis Rheum.52, 1081–1090(2005).
  • Garnero P , CharniN, JuilletF, ConrozierT, VignonE: Increased urinary type II collagen helical and C telopeptide levels are independently associated with a rapidly destructive hip osteoarthritis.Ann. Rheum. Dis.65, 1639–1644(2006).
  • Quintana DJ , GarneroP, HuebnerJL, Charni-Ben Tabassi N, Kraus VB: PIIANP and HELIXII diurnal variation. Osteoarthr. Cartil.16(10), 1192–1195(2008).
  • Aurich M , PooleAR, ReinerAet al. : Matrix homeostasis in aging normal human ankle cartilage.Arthritis Rheum.46, 2903–2910(2002).
  • Hollander AP , PidouxI, ReinerA, RorabeckC, BourneRA, PooleR: Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.J. Clin. Invest.96, 2859–2869(1995).
  • Garnero P , PipernoM, GineytsE, ChristgauS, DelmasPD, VignonE: Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage.Ann. Rheum. Dis.60, 619–626(2001).
  • Garnero P , ConrozierT, ChristgauS, MathieuP, DelmasPD, VignonE: Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis.Ann. Rheum. Dis.62, 939–943(2003).
  • Reijman M , HazesJM, Bierma-ZeinstraSMet al. : A new marker for osteoarthritis: cross-sectional and longitudinal approach.Arthritis Rheum.50, 2471–2478(2004).
  • Jordan KM , SyddallHE, GarneroPet al. : Urinary CTX-II and glucosyl–galactosyl–pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men.Ann. Rheum. Dis.65, 871–877(2006).
  • Dam EB , ByrjalsenI, KarsdalMA, QvistP, ChristiansenC: Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI.Osteoarthr. Cartil. (2008) (Epub ahead of print).
  • Garnero P , MazieresB, GueguenAet al. : Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological joint damage in patients with hip osteoarthritis: the ECHODIAH cohort.J. Rheumatol.32, 697–703(2005).
  • Mazieres B , HucherM, ZaimM, GarneroP: Effect of chondroitin sulphate in symptomatic knee osteoarthritis: a multicentre, randomised, double-blind, placebo-controlled study.Ann. Rheum. Dis.66, 639–645(2007).
  • Bruyere O , ColletteJ, KothariMet al. : Osteoarthritis, magnetic resonance imaging, and biochemical markers: a one year prospective study.Ann. Rheum. Dis.65, 1050–1054(2006).
  • Sharif M , KirwanJ, CharniN, SandellLJ, WhittlesC, GarneroP: A 5-year longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis: association with disease progression.Rheumatology (Oxford)46, 938–943(2007).
  • Garnero P , AronsteinWS, CohenSBet al. : Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the Knee Osteoarthritis Structural Arthritis randomized clinical trial.Osteoarthr. Cartil.16, 660–666(2008).
  • Mazzuca SA , BrandtKD, EyreDR, KatzBP, AskewJ, LaneKA: Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritis.Ann. Rheum. Dis.65, 1055–1059(2006).
  • Henrotin Y , AddisonS, KrausV, DebergM: Type II collagen markers in osteoarthritis: what do they indicate?Curr. Opin. Rheumatol.19, 444–450(2007).
  • van der Rest M , GarroneR: Collagen family of proteins.FASEB J.5, 2814–2823(1991).
  • Garnero P , AyralX, RousseauJCet al. : Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis.Arthritis Rheum.46, 2613–2624(2002).
  • Rousseau JC , ZhuY, MiossecPet al. : Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis.Osteoarthr. Cartil.12, 440–447(2004).
  • Rousseau JC , SandellLJ, DelmasPD, GarneroP: Development and clinical application in arthritis of a new immunoassay for serum type IIA procollagen NH2 propeptide.Methods Mol. Med.101, 25–37(2004).
  • Chen HC , ShahS, StablerTV, LiYJ, KrausVB: Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study.Osteoarthr. Cartil.16(9), 1054–1059(2008).
  • Lohmander LS , YoshiharaY, RoosH, KobayashiT, YamadaH, ShinmeiM: Procollagen II C-propeptide in joint fluid: changes in concentration with age, time after knee injury, and osteoarthritis.J. Rheumatol.23, 1765–1769(1996).
  • Kobayashi T , YoshiharaY, SamuraAet al. : Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis.Ann. Rheum. Dis.56, 500–503(1997).
  • Sugiyama S , ItokazuM, SuzukiY, ShimizuK: Procollagen II C propeptide level in the synovial fluid as a predictor of radiographic progression in early knee osteoarthritis.Ann. Rheum. Dis.62, 27–32(2003).
  • Elsaid KA , ChichesterCO: Review: collagen markers in early arthritic diseases.Clin. Chim. Acta365, 68–77(2006).
  • Carter QL , DotzlafJ, SwearingenCet al. : Development and characterization of a novel ELISA based assay for the quantitation of sub-nanomolar levels of neoepitope exposed NITEGE-containing aggrecan fragments.J. Immunol. Methods328, 162–168(2007).
  • Glasson SS , AskewR, SheppardBet al. : Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.Nature434, 644–648(2005).
  • Stanton H , RogersonFM, EastCJet al. : ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.Nature434, 648–652(2005).
  • Fosang AJ , RogersonFM, EastCJ, StantonH: ADAMTS-5: the story so far.Eur. Cell. Mater.15, 11–26(2008).
  • Lark MW , BayneEK, FlanaganJet al. : Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.J. Clin. Invest.100, 93–106(1997).
  • Struglics A , LarssonS, PrattaMA, KumarS, LarkMW, LohmanderLS: Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.Osteoarthr. Cartil.14, 101–113(2006).
  • Malfait AM , LiuRQ, IjiriK, KomiyaS, TortorellaMD: Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.J. Biol. Chem.277, 22201–22208(2002).
  • Sandy JD , FlanneryCR, NeamePJ, LohmanderLS: The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373–Ala 374 bond of the interglobular domain.J. Clin. Invest.89, 1512–1516(1992).
  • Pratta MA , SuJL, LeesnitzerMAet al. : Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments.Osteoarthr. Cartil.14, 702–713(2006).
  • Rizkalla G , ReinerA, BogochE, PooleAR: Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease.J. Clin. Invest.90, 2268–2277(1992).
  • Poole AR , IonescuM, SwanA, DieppePA: Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis.J. Clin. Invest.94, 25–33(1994).
  • Lohmander LS , IonescuM, JugessurH, PooleAR: Changes in joint cartilage aggrecan after knee injury and in osteoarthritis.Arthritis Rheum.42, 534–544(1999).
  • Aurich M , SquiresGR, ReinerAet al. : Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints.Arthritis Rheum.52, 112–119(2005).
  • Ishiguro N , ItoT, ItoHet al. : Relationship of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover: analyses of synovial fluid from patients with osteoarthritis.Arthritis Rheum.42, 129–136(1999).
  • Pothacharoen P , TeekachunhateanS, LouthrenooWet al. : Raised chondroitin sulfate epitopes and hyaluronan in serum from rheumatoid arthritis and osteoarthritis patients.Osteoarthr. Cartil.14, 299–301(2006).
  • Fawthrop F , YaqubR, BelcherC, BaylissM, LedinghamJ, DohertyM: Chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in progressive versus non-progressive osteoarthritis.Ann. Rheum. Dis.56, 119–122(1997).
  • Vilim V , OlejarovaM, MachacekS, GatterovaJ, KrausVB, PavelkaK: Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis.Osteoarthr. Cartil.10, 707–713(2002).
  • Sharif M , SaxneT, ShepstoneLet al. : Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint.Br. J. Rheumatol.34, 306–310(1995).
  • Clark AG , JordanJM, VilimVet al. : Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project.Arthritis Rheum.42, 2356–2364(1999).
  • Senolt L , BraunM, OlejarovaM, ForejtovaS, GatterovaJ, PavelkaK: Increased pentosidine, an advanced glycation end product, in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric matrix protein.Ann. Rheum. Dis.64, 886–890(2005).
  • Chaganti RK , KelmanA, LuiLet al. : Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis.Osteoarthr. Cartil.16(5), 566–571(2007).
  • Kelman A , LuiL, YaoW, KrummeA, NevittM, LaneNE: Association of higher levels of serum cartilage oligomeric matrix protein and N-telopeptide crosslinks with the development of radiographic hip osteoarthritis in elderly women.Arthritis Rheum.54, 236–243(2006).
  • Fernandes FA , PucinelliML, da Silva NP, Feldman D: Serum cartilage oligomeric matrix protein (COMP) levels in knee osteoarthritis in a Brazilian population: clinical and radiological correlation. Scand. J. Rheumatol.36, 211–215(2007).
  • Petersson IF , BoegardT, SvenssonB, HeinegardD, SaxneT: Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint.Br. J. Rheumatol.37, 46–50(1998).
  • Jung YO , DoJH, KangHJet al. : Correlation of sonographic severity with biochemical markers of synovium and cartilage in knee osteoarthritis patients.Clin. Exp. Rheumatol.24, 253–259(2006).
  • Meulenbelt I , KloppenburgM, KroonHMet al. : Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study.Osteoarthr. Cartil.15, 379–385(2007).
  • Recklies AD , BaillargeonL, WhiteC: Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes.Arthritis Rheum.41, 997–1006(1998).
  • Vilim V , VytasekR, OlejarovaMet al. : Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis.Osteoarthr. Cartil.9, 612–618(2001).
  • Pullig O , WeselohG, RonnebergerD, KakonenS, SwobodaB: Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone.Calcif. Tissue Int.67, 230–240(2000).
  • Jiang LS , ZhangZM, JiangSD, ChenWH, DaiLY: Differential bone metabolism between postmenopausal women with osteoarthritis and osteoporosis.J. Bone Miner. Res.23, 475–483(2008).
  • Stewart A , BlackA, RobinsSP, ReidDM: Bone density and bone turnover in patients with osteoarthritis and osteoporosis.J. Rheumatol.26, 622–626(1999).
  • Campion GV , DelmasPD, DieppePA: Serum and synovial fluid osteocalcin (bone gla protein) levels in joint disease.Br. J. Rheumatol.28, 393–398(1989).
  • Sowers M , LachanceL, JamadarDet al. : The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women.Arthritis Rheum.42, 483–489(1999).
  • Wang Y , EbelingPR, HannaF, O‘SullivanR, CicuttiniFM: Relationship between bone markers and knee cartilage volume in healthy men.J. Rheumatol.32, 2200–2204(2005).
  • Bruyere O , ColletteJH, EthgenOet al. : Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis.J. Rheumatol.30, 1043–1050(2003).
  • Berger CE , KronerA, StieglerH, LeithaT, EngelA: Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip.Int. Orthop.29, 1–5(2005).
  • Withold W , SchulteU, ReinauerH: Method for determination of bone alkaline phosphatase activity: analytical performance and clinical usefulness in patients with metabolic and malignant bone diseases.Clin. Chem.42, 210–217(1996).
  • Jenkins DK : Review series: bone alkaline phosphatase, a serum bone turnover assay: usefulness in managing postmenopausal women receiving threrapy to prevent or treat osteoporosis. Quidel Corporation, CA, USA (2001).
  • El Miedany YM , MehannaAN, El Baddini MA: Altered bone mineral metabolism in patients with osteoarthritis. Joint Bone Spine67, 521–527(2000).
  • Seibel MJ , DuncanA, RobinsSP: Urinary hydroxy–pyridinium crosslinks provide indices of cartilage and bone involvement in arthritic diseases.J. Rheumatol.16, 964–970(1989).
  • Spacek P , AdamM: Pentosidine in osteoarthritis: HPLC determination in body fluids and in tissues.Rheumatol. Int.26, 923–927(2006).
  • Abe M , TakahashiM, NaitouK, OhmuraK, NaganoA: Investigation of generalized osteoarthritis by combining X-ray grading of the knee, spine and hand using biochemical markers for arthritis in patients with knee osteoarthritis.Clin. Rheumatol.22, 425–431(2003).
  • Takahashi M , NaitoK, AbeM, SawadaT, NaganoA: Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis.Arthritis Res. Ther.6, R208–R212 (2004).
  • Bank RA , VerzijlN, LafeberFP, TekoppeleJM: Putative role of lysyl hydroxylation and pyridinoline cross-linking during adolescence in the occurrence of osteoarthritis at old age.Osteoarthr. Cartil.10, 127–134(2002).
  • Graverand MP , TronAM, IchouMet al. : Assessment of urinary hydroxypyridinium cross-links measurement in osteoarthritis.Br. J. Rheumatol.35, 1091–1095(1996).
  • Rovetta G , MonteforteP, GrignoloMC, BrignoneA, BuffriniL: Hematic levels of type I collagen C-telopeptide in erosive versus nonerosive osteoarthritis of the hands.Int. J. Tissue React.25, 25–28(2003).
  • Naitou K , KushidaK, TakahashiM, OhishiT, InoueT: Bone mineral density and bone turnover in patients with knee osteoarthritis compared with generalized osteoarthritis.Calcif. Tissue Int.66, 325–329(2000).
  • Withold W , ArmbrusterFP, KarmatschekM, ReinauerH: Bone sialoprotein in serum of patients with malignant bone diseases.Clin. Chem.43, 85–91(1997).
  • Conrozier T , SaxneT, FanCSet al. : Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: a one year prospective study.Ann. Rheum. Dis.57, 527–532(1998).
  • Elliott AL , KrausVB, LutaGet al. : Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project.Arthritis Rheum.52, 105–111(2005).
  • Chua SD Jr, Messier SP, Legault C, Lenz ME, Thonar EJ, Loeser RF: Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee. Osteoarthr. Cartil.16(9), 1047–1053(2008).
  • Belo JN , BergerMY, ReijmanM, KoesBW, Bierma-ZeinstraSM: Prognostic factors of progression of osteoarthritis of the knee: a systematic review of observational studies.Arthritis Rheum.57, 13–26(2007).
  • Mazieres B , GarneroP, GueguenAet al. : Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort.Ann. Rheum. Dis.65, 354–359(2006).
  • Gineyts E , GarneroP, DelmasPD: Urinary excretion of glucosyl–galactosyl pyridinoline: a specific biochemical marker of synovium degradation.Rheumatology (Oxford)40, 315–323(2001).
  • Gineyts E , MoJA, KoAet al. : Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritis.Ann. Rheum. Dis.63, 857–861(2004).
  • Rathcke CN , VestergaardH: YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis.Inflamm. Res.55, 221–227(2006).
  • Volck B , JohansenJS, StoltenbergMet al. : Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology.Osteoarthr. Cartil.9, 203–214(2001).
  • Conrozier T , CarlierMC, MathieuPet al. : Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional study.Ann. Rheum. Dis.59, 828–831(2000).
  • Pavelka K , ForejtovaS, OlejarovaMet al. : Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis.Osteoarthr. Cartil.12, 277–283(2004).
  • Lamers RJ , van NesselrooijJH, KrausVBet al.: Identification of an urinary metabolite profile associated with osteoarthritis. Osteoarthr. Cartil.13, 762–768(2005).
  • Hunter DJ , ConaghanPG: Imaging outcomes and their role in determining outcomes in osteoarthritis and rheumatoid arthritis.Curr. Opin. Rheumatol.18, 157–162(2006).
  • Hunter DJ , ZhangY, NiuJet al. : Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis.Arthritis Rheum.54, 1529–1535(2006).
  • Eckstein F , CicuttiniF, RaynauldJP, WatertonJC, PeterfyC: Magnetic resonance imaging (MRI) of articular cartilage in knee osteoarthritis (OA): morphological assessment.Osteoarthr. Cartil.14(Suppl. A), A46–A75 (2006).
  • Burstein D , GrayML: Is MRI fulfilling its promise for molecular imaging of cartilage in arthritis?Osteoarthr. Cartil.14, 1087–1090(2006).
  • Eckstein F , BursteinD, LinkTM: Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis.NMR Biomed.19, 822–854(2006).
  • Wheaton AJ , BorthakurA, DodgeGR, KneelandJB, SchumacherHR, ReddyR: Sodium magnetic resonance imaging of proteoglycan depletion in an in vivo model of osteoarthritis.Acad. Radiol.11, 21–28(2004).
  • Borthakur A , MellonE, NiyogiS, WitscheyW, KneelandJB, ReddyR: Sodium and T1r MRI for molecular and diagnostic imaging of articular cartilage.NMR Biomed.19, 781–821(2006).
  • Shapiro EM , BorthakurA, GougoutasA, ReddyR: 23Na MRI accurately measures fixed charge density in articular cartilage.Magn. Reson. Med.47, 284–291(2002).
  • Burstein D : MRI for development of disease-modifying osteoarthritis drugs.NMR Biomed.19, 669–680(2006).
  • Tiderius CJ , OlssonLE, LeanderP, EkbergO, DahlbergL: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis.Magn. Reson. Med.49, 488–492(2003).
  • Williams A , SharmaL, McKenzieCA, PrasadPV, BursteinD: Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in knee osteoarthritis: findings at different radiographic stages of disease and relationship to malalignment.Arthritis Rheum.52, 3528–3535(2005).

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