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Review

Three-Dimensional Printing for Drug Delivery Devices: A State-Of-The-Art Survey

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Pages 95-109 | Received 01 Oct 2018, Accepted 04 Feb 2019, Published online: 30 May 2019

References

  • Lipson H , KurmanM. Fabricated the New World of 3D Printing. John Wiley & Sons, Inc., IN, USA (2013).
  • Prasad LK , SmythH. 3D printing technologies for drug delivery: a review. Drug Dev. Ind. Pharm.42(7), 1019–1031 (2016).
  • Norman J , MaduraweRD, MooreCMV, KhanMA, KhairuzzamanA. A new chapter in pharmaceutical manufacturing: 3D-printed drug products. Adv. Drug Deliv. Rev.108, 39–50 (2017).
  • Palo M , HolländerJ, SuominenJ, YliruusiJ, SandlerN. 3D printed drug delivery devices: perspectives and technical challenges. Expert Rev. Med. Devices14(9), 685–696 (2017).
  • Fina F , GoyanesA, GaisfordS, BasitAW. Selective laser sintering (SLS) 3D printing of medicines. Int. J. Pharm.529(1–2), 285–293 (2017).
  • Banks J . Adding value in additive manufacturing: researchers in the United Kingdom and Europe look to 3D printing for customization. IEEE Pulse4(6), 22–26 (2013).
  • Ventola CL . Medical applications for 3D printing: current and projected uses. P. T.39(10), 704–711 (2014).
  • Chia HN , WuBM. Recent advances in 3D printing of biomaterials. J. Biol. Eng.9(4), 1–14 (2015).
  • Jamróz W , SzafraniecJ, KurekM, JachowiczR. 3D printing in pharmaceutical and medical applications – recent achievements and challenges. Pharm. Res.35(9), 1–22 (2018).
  • Hsiao W , LorberB, ReitsamerHet al. Expert opinion on drug delivery 3D printing of oral drugs: a new reality or hype? Expert Opin. Drug Deliv. 15(1), 1–4 (2018).
  • Trenfield SJ , AwadA, GoyanesA, GaisfordS, BasitAW. 3D printing pharmaceuticals: drug development to frontline care. Trends Pharmacol. Sci.39(5), 440–451 (2018).
  • Lim SH , KathuriaH, TanJJY, KangL. 3D printed drug delivery and testing systems – a passing fad or the future?Adv. Drug Deliv. Rev.132, 139–168 (2018).
  • Wu G , WuW, ZhengQ, LiJ, ZhouJ, HuZ. Experimental study of PLLA/INH slow release implant fabricated by three dimensional printing technique and drug release characteristics in vitro. Biomed. Eng. Online13(97), 1–11 (2014).
  • Inzana JA , TrombettaRP, SchwarzEM, KatesSL, AwadHA. 3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection. Eur. Cells Mater.30, 232–247 (2015).
  • Sun Y , SohS. Printing tablets with fully customizable release profiles for personalized medicine. Adv. Mater.27(47), 7847–7853 (2015).
  • Khaled SA , BurleyJC, AlexanderMR, YangJ, RobertsCJ. 3D printing of tablets containing multiple drugs with defined release profiles. Int. J. Pharm.494(2), 643–650 (2015).
  • Wu W , YeC, ZhengQ, WuG, ChengZ. A therapeutic delivery system for chronic osteomyelitis via a multi-drug implant based on three-dimensional printing technology. J. Biomater. Appl.31(2), 250–260 (2016).
  • Zema L , MelocchiA, MaroniA, GazzanigaA. Three-dimensional printing of medicinal products and the challenge of personalized therapy. J. Pharm. Sci.106(7), 1697–1705 (2017).
  • Aprecia Pharmaceuticals . ZipDose(R) technology (2018). www.aprecia.com/technology/zipdose
  • Sandler N , PreisM. Printed drug-delivery systems for improved patient treatment. Trends Pharmacol. Sci.37(12), 1070–1080 (2016).
  • Stratasys Ltd . FDM technology for 3D printing. www.stratasys.com/de/fdm-technology
  • Kadry H , Al-HilalTA, KeshavarzAet al. Multi-purposable filaments of HPMC for 3D printing of medications with tailored drug release and timed-absorption. Int. J. Pharm.544(1), 285–296 (2018).
  • Goyanes A , BuanzABM, BasitAW, GaisfordS. Fused-filament 3D printing (3DP) for fabrication of tablets. Int. J. Pharm.476(1), 88–92 (2014).
  • Zhang J , FengX, PatilH, TiwariR V, RepkaMA. Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets. Int. J. Pharm.519(1–2), 186–197 (2017).
  • Solanki NG , TahsinM, ShahA V, SerajuddinATM. Formulation of 3D printed tablet for rapid drug release by fused deposition modeling: screening polymers for drug release, drug–polymer miscibility and printability. J. Pharm. Sci.107(1), 390–401 (2018).
  • Pietrzak K , IsrebA, AlhnanMA. A flexible-dose dispenser for immediate and extended release 3D printed tablets. Eur. J. Pharm. Biopharm.96, 380–387 (2015).
  • Yang Y , WangH, LiH, OuZ, YangG. 3D printed tablets with internal scaffold structure using ethyl cellulose to achieve sustained ibuprofen release. Eur. J. Pharm. Sci.115, 11–18 (2018).
  • Maroni A , MelocchiA, PariettiF, FoppoliA, ZemaL, GazzanigaA. 3D printed multi-compartment capsular devices for two-pulse oral drug delivery. J. Control. Rel.268, 10–18 (2017).
  • Beck RCR , ChavesPS, GoyanesAet al. 3D printed tablets loaded with polymeric nanocapsules: an innovative approach to produce customized drug delivery systems. Int. J. Pharm.528(1–2), 268–279 (2017).
  • Genina N , HolländerJ, JukarainenH, MäkiläE, SalonenJ, SandlerN. Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices. Eur. J. Pharm. Sci.90, 53–63 (2016).
  • Holländer J , GeninaN, JukarainenHet al. Three-dimensional printed PCL-based implantable prototypes of medical devices for controlled drug delivery. J. Pharm. Sci.105(9), 2665–2676 (2016).
  • Maincent J , WilliamsRO 3rd. Sustained-release amorphous solid dispersions. Drug Deliv. Transl. Res.8 (6), 1714–1725, (2018).
  • Taboas JM , MaddoxRD, KrebsbachPH, HollisterSJ. Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer–ceramic scaffolds. Biomaterials24(1), 181–194 (2003).
  • Liang K , CarmoneS, BrambillaD, LerouxJ-C. 3D printing of a wearable personalized oral delivery device: a first-in-human study. Appl. Sci. Eng.4, 1–11 (2018).
  • Kollamaram G , CrokerDM, WalkerGM, GoyanesA, BasitAW, GaisfordS. Low temperature fused deposition modeling (FDM) 3D printing of thermolabile drugs. Int. J. Pharm.545(1-2), 144–152 (2018).
  • Kempin W , DomstaV, GrathoffGet al. Immediate release 3D-printed tablets produced via fused deposition modeling of a thermo-sensitive drug. Pharm. Res.35(124), 1–12 (2018).
  • Tappa K , JammalamadakaU. Novel biomaterials used in medical 3D printing techniques. J. Funct. Biomater.9(17), 1–16 (2018).
  • Mishra M . Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. MishraM ( Ed.). CRC Press, Boca Raton, FL, USA (2017).
  • Holländer J , HakalaR, SuominenJ, MoritzN, YliruusiJ, SandlerN. 3D printed UV light cured polydimethylsiloxane devices for drug delivery. Int. J. Pharm.544(2), 433–442 (2018).
  • Khaled SA , BurleyJC, AlexanderMR, YangJ, RobertsCJ. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. J. Control. Rel.217, 308–314 (2015).
  • Khaled SA , BurleyJC, AlexanderMR, RobertsCJ. Desktop 3D printing of controlled release pharmaceutical bilayer tablets. Int. J. Pharm.461(1-2), 105–111 (2014).
  • Yi HG , ChoiYJ, KangKSet al. A 3D-printed local drug delivery patch for pancreatic cancer growth suppression. J. Control. Rel.238, 231–241 (2016).
  • Jose RR , RodriguezMJ, DixonTA, OmenettoF, KaplanDL. Evolution of bioinks and additive manufacturing technologies for 3D bioprinting. ACS Biomater. Sci. Eng.2(10), 1662–1678 (2016).
  • Alhnan MA , OkwuosaTC, SadiaM, WanKW, AhmedW, ArafatB. Emergence of 3D printed dosage forms: opportunities and challenges. Pharm. Res.33(8), 1817–1832 (2016).
  • Jacob J , CoyleN, WestT, MonkhouseD, JainN: US9339489B2 (2016).
  • Aprecia Pharmaseuticals . Spritam(R). www.spritam.com/#/patient
  • El Aita I , BreitkreutzJ, QuodbachJ. On-demand manufacturing of immediate release levetiracetam tablets using pressure-assisted microsyringe printing. Eur. J. Pharm. Biopharm.134, 29–36 (2019).
  • Van Hooreweder B , MoensD, BoonenR, KruthJP, SasP. On the difference in material structure and fatigue properties of nylon specimens produced by injection molding and selective laser sintering. Polym. Test.32(5), 972–981 (2013).
  • Kolan K , LeuM, HilmasG, ComteT. Effect of architecture and porosity on mechanical properties of borate glass scaffolds made by selective laser sintering. Presented at: 24th International SFF Symposium – An Additive Manufacturing Conference, SFF 2013 pp.University of Texas at Austin(freeform),Austin, TX, USA, (12–14 August 2013).
  • Shuai C , MaoZ, LuH, NieY, HuH, PengS. Fabrication of porous polyvinyl alcohol scaffold for bone tissue engineering via selective laser sintering. Biofabrication5(1), 1–8 (2013).
  • Mazzoli A , FerrettiC, GiganteA, SalvoliniE, Mattioli-BelmonteM. Selective laser sintering manufacturing of polycaprolactone bone scaffolds for applications in bone tissue engineering. Rapid Prototyp J.21(4), 386–392 (2015).
  • Salmoria GV , KlaussP, ZeponKM, KanisLA. The effects of laser energy density and particle size in the selective laser sintering of polycaprolactone/progesterone specimens: morphology and drug release. Int. J. Adv. Manuf. Technol.66(5–8), 1113–1118 (2013).
  • Fina F , MadlaCM, GoyanesA, ZhangJ, GaisfordS, BasitAW. Fabricating 3D printed orally disintegrating printlets using selective laser sintering. Int. J. Pharm.541(1–2), 101–107 (2018).
  • Martinez PR , GoyanesA, BasitAW, GaisfordS. Fabrication of drug-loaded hydrogels with stereolithographic 3D printing. Int. J. Pharm.532(1), 313–317 (2017).
  • He Y , TuckCJ, PrinaEet al. A new photocrosslinkable polycaprolactone-based ink for three-dimensional inkjet printing. J. Biomed. Mater. Res. B Appl. Biomater.105(6), 1645–1657 (2017).
  • Wang J , GoyanesA, GaisfordS, BasitAW. Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. Int. J. Pharm.503(1–2), 207–212 (2016).
  • Goyanes A , BuanzABM, HattonGB, GaisfordS, BasitAW. 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. Eur. J. Pharm. Biopharm.89, 157–162 (2015).
  • Goyanes A , Det-AmornratU, WangJ, BasitAW, GaisfordS. 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems. J. Control. Rel.234, 41–48 (2016).
  • Larush L , KanerI, FluksmanAet al. 3D printing of responsive hydrogels for drug-delivery systems. J. 3D Print. Med.1(4), 219–229 (2017).
  • Vehse M , PetersenS, SternbergK, SchmitzKP, SeitzH. Drug delivery from poly(ethylene glycol) diacrylate scaffolds produced by DLC based micro-stereolithography. Macromol. Symp.346(1), 43–47 (2014).
  • Yun H , KimH. Development of DMD-based micro-stereolithography apparatus for biodegradable multi-material micro-needle fabrication. J. Mech. Sci. Technol.27(10), 2973–2978 (2013).
  • Economidou SN , LamprouDA, DouroumisD. 3D printing applications for transdermal drug delivery. Int. J. Pharm.544(2), 415–424 (2018).
  • Ali Z , TüreyenEB, KarpatY, ÇakmakciM. Fabrication of polymer micro needles for transdermal drug delivery system using DLP based projection stereo-lithography. Procedia. CIRP42, 87–90 (2016).
  • Lu Y , ManthaSN, CrowderDCet al. Microstereolithography and characterization of poly(propylene fumarate)-based drug-loaded microneedle arrays. Biofabrication7(4), 1–13 (2015).
  • Pere CPP , EconomidouSN, LallGet al. 3D printed microneedles for insulin skin delivery. Int. J. Pharm.544(2), 425–432 (2018).
  • Tumbleston JR , ShirvanyantsD, ErmoshkinNet al. Continuous liquid interface production of 3D objects. Science347(6228), 1349–1352 (2015).
  • Johnson AR , CaudillCL, TumblestonJRet al. Single-step fabrication of computationally designed microneedles by continuous liquid interface production. PLoS ONE11(9), 1–17 (2016).
  • De Gans BJ , DuineveldPC, SchubertUS. Inkjet printing of polymers: state of the art and future developments. Adv. Mater.16(3), 203–213 (2004).
  • Scoutaris N , RossS, DouroumisD. Current trends on medical and pharmaceutical applications of inkjet printing technology. Pharm. Res.33(8), 1799–1816 (2016).
  • Daly R , HarringtonTS, MartinGD, HutchingsIM. Inkjet printing for pharmaceutics – a review of research and manufacturing. Int. J. Pharm.494(2), 554–567 (2015).
  • Edinger M , Bar-ShalomD, SandlerN, RantanenJ, GeninaN. QR encoded smart oral dosage forms by inkjet printing. Int. J. Pharm.536(1), 138–145 (2018).
  • Clark EA , AlexanderMR, IrvineDJet al. 3D printing of tablets using inkjet with UV photoinitiation. Int. J. Pharm.529(1–2), 523–530 (2017).
  • Dishman L . How inkjet printers are helping scientists discover new drugs (2013). www.popsci.com/science/article/2013-03/how-inkjet-printers-are-helping-scientists-discover-new-drugs
  • Louzao I , KochB, TarescoVet al. Identification of novel ‘inks’ for 3D printing using high-throughput screening: bioresorbable photocurable polymers for controlled drug delivery. ACS Appl. Mater. Interfaces10(8), 6841–6848 (2018).
  • Acosta-Vélez G , LinsleyC, CraigM, WuB. Photocurable bioink for the inkjet 3D pharming of hydrophilic drugs. Bioengineering4(1), 11 (2017).
  • Raijada D , GeninaN, ForsDet al. A step toward development of printable dosage forms for poorly soluble drugs. J. Pharm. Sci.102(10), 3694–3704 (2013).
  • Alomari M , VuddandaPR, TrenfieldSJet al. Printing T3 and T4 oral drug combinations as a novel strategy for hypothyroidism. Int. J. Pharm.549(1–2), 363–369 (2018).
  • Montenegro-nicolini M , ReyesPE, JaraMOet al. The effect of inkjet printing over polymeric films as potential buccal biologics delivery systems. AAPS PharmSciTech. (19( 8), 3376–3387 (2018).
  • Boehm RD , MillerPR, SchellWA, PerfectJR, NarayanRJ. Inkjet printing of amphotericin B onto biodegradable microneedles using piezoelectric inkjet printing. JOM65(4), 525–533 (2013).
  • Ross S , ScoutarisN, LamprouD, MallinsonD, DouroumisD. Inkjet printing of insulin microneedles for transdermal delivery. Drug Deliv. Transl. Res.5(4), 451–461 (2015).
  • Uddin MJ , ScoutarisN, KlepetsanisP, ChowdhryB, PrausnitzMR, DouroumisD. Inkjet printing of transdermal microneedles for the delivery of anticancer agents. Int. J. Pharm.494(2), 593–602 (2015).
  • Kirby AJ . US8192787B2. (2012).
  • Innoture . RADARA (TM) targeted skincare. http://radara.co.uk/
  • Fox CB , NemethCL, ChevalierRWet al. Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading. Bioeng. Transl. Med.2(1), 9–16 (2017).
  • Kyobula M , AdedejiA, AlexanderMRet al. 3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release. J. Control. Rel.261, 207–215 (2017).
  • Shpigel T , UzielA, LewitusDY. SPHRINT – printing drug delivery microspheres from polymeric melts. Eur. J. Pharm. Biopharm.127, 398–406 (2018).
  • Shpigel T , CohenTaguri G, LewitusDY. Controlling drug delivery from polymer microspheres by exploiting the complex interrelationship of excipient and drug crystallization. J. Appl. Polym. Sci.136, 47227 (2019).

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