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Future Cardiology Volume 11, 2015 - Issue 4
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Commentary

The Link Between lipids, Statins and Cancer: is There a Role for cardio-oncology?

Eiman Jahangir1 John Ochsner Heart & Vascular Institute Ochsner Clinical School The University of Queensland School of Medicine 1514 Jefferson HighwayNew OrleansLA70121USACorrespondence[email protected]
,
Nichole M Polin1 John Ochsner Heart & Vascular Institute Ochsner Clinical School The University of Queensland School of Medicine 1514 Jefferson HighwayNew OrleansLA70121USA
,
Carl J Lavie1 John Ochsner Heart & Vascular Institute Ochsner Clinical School The University of Queensland School of Medicine 1514 Jefferson HighwayNew OrleansLA70121USA
&
Sergio Fazio2 Center for Preventive Cardiology Oregon Health & Science University; 3181 Sam Jackson Park RoadPortlandOR97239USA
Pages 389-393 | Published online: 04 Aug 2015

References

  • Huang C , FreterC . Lipid metabolism, apoptosis and cancer therapy . Int. J. Mol. Sci.16 ( 1 ), 924 – 949 ( 2015 ).
  • Jacobs D , BlackburnH, HigginsMet al. Report of the conference on low blood cholesterol: mortality associations . Circulation86 ( 3 ), 1046 – 1060 ( 1992 ).
  • Law MR , ThompsonSG, WaldNJ . Assessing possible hazards of reducing serum cholesterol . BMJ308 ( 6925 ), 373 – 379 ( 1994 ).
  • Newman TB , HulleySB . Carcinogenicity of lipid-lowering drugs . JAMA275 ( 1 ), 55 – 60 ( 1996 ).
  • Hebert PR , GazianoJM, ChanKS, HennekensCH . Cholesterol lowering with statin drugs, risk of stroke, and total mortality. An overview of randomized trials . JAMA278 ( 4 ), 313 – 321 ( 1997 ).
  • Kitahara CM , Berrington De GonzalezAet al. Total cholesterol and cancer risk in a large prospective study in Korea . J. Clin. Oncol.29 ( 12 ), 1592 – 1598 ( 2011 ).
  • Nelson ER , ChangCY, McdonnellDP . Cholesterol and breast cancer pathophysiology . Trends Endocrinol. Metabol.25 ( 12 ), 649 – 655 ( 2014 ).
  • Nelson ER , WardellSE, JasperJSet al. 27-hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology . Science342 ( 6162 ), 1094 – 1098 ( 2013 ).
  • Allott EH , HowardLE, CooperbergMRet al. Serum lipid profile and risk of prostate cancer recurrence: results from the search database . Cancer Epidemiol. Biomarkers Prev.23 ( 11 ), 2349 – 2356 ( 2014 ).
  • Chen H , QinS, WangM, ZhangT, ZhangS . Association between cholesterol intake and pancreatic cancer risk: evidence from a meta-analysis . Sci. Rep.5, 8243 ( 2015 ).
  • Coppola JA , ShrubsoleMJ, CaiQet al. Plasma lipid levels and colorectal adenoma risk . Cancer Causes Control26 ( 4 ), 635 – 643 ( 2015 ).
  • Goldstein JL , BrownMS . Regulation of the mevalonate pathway . Nature343 ( 6257 ), 425 – 430 ( 1990 ).
  • Larosa JC . Pleiotropic effects of statins and their clinical significance . Am. J. Cardiol.88 ( 3 ), 291 – 293 ( 2001 ).
  • Ahern TP , PedersenL, TarpMet al. Statin prescriptions and breast cancer recurrence risk: a Danish nationwide prospective cohort study . J. Natl Cancer Inst.103 ( 19 ), 1461 – 1468 ( 2011 ).
  • Cholesterol Treatment Trialists C , BaigentC, BlackwellLet al.Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials . Lancet376 ( 9753 ), 1670 – 1681 ( 2010 ).
  • Garwood ER , KumarAS, BaehnerFLet al. Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer . Breast Cancer Res. Treat.119 ( 1 ), 137 – 144 ( 2010 ).
  • Hamilton RJ , BanezLL, AronsonWJet al. Statin medication use and the risk of biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) Database . Cancer116 ( 14 ), 3389 – 3398 ( 2010 ).
  • Shi M , ZhengH, NieB, GongW, CuiX . Statin use and risk of liver cancer: an update meta-analysis . BMJ Open4 ( 9 ), e005399 ( 2014 ).
  • Walker EJ , KoAH, HollyEA, BracciPM . Statin use and risk of pancreatic cancer: results from a large, clinic-based case–control study . Cancer121 ( 8 ), 1287 – 1294 ( 2015 ).
  • Nielsen SF , NordestgaardBG, BojesenSE . Statin use and reduced cancer-related mortality . N. Engl. J. Med.367 ( 19 ), 1792 – 1802 ( 2012 ).
  • Pazzaglia S , SaranA, ParisetLet al. Sensitivity of C3H 10T1/2 cells to radiation-induced killing and neoplastic transformation as a function of cell cycle . Int. J. Radiat. Biol.69 ( 1 ), 57 – 65 ( 1996 ).
  • Feleszko W , MlynarczukI, Balkowiec-IskraEZet al. Lovastatin potentiates antitumor activity and attenuates cardiotoxicity of doxorubicin in three tumor models in mice . Clin. Cancer. Res.6 ( 5 ), 2044 – 2052 ( 2000 ).
  • Acar Z , KaleA, TurgutMet al. Efficiency of atorvastatin in the protection of anthracycline-induced cardiomyopathy . J. Am. Coll. Cardiol.58 ( 9 ), 988 – 989 ( 2011 ).
  • Cholesterol Treatment Trialists C , EmbersonJR, KearneyPMet al.Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy . PLoS ONE7 ( 1 ), e29849 ( 2012 ).
  • ClinicalTrials Database: NCT01988571 . https://clinicaltrials.gov/ct2/show/NCT01988571 .

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