Progress in Understanding the Genomic Basis for Adverse Drug Reactions: A Comprehensive Review and Focus on the Role of Ethnicity

References

• Daly AK . Genome-wide association studies in pharmacogenomics . Nat. Rev. Genet.11 ( 4 ), 241 – 246 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• GWAS catalog . www.genome.gov/gwastudies .
   Google Scholar
• Tohkin M , KaniwaN , SaitoYet al. A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients . Pharmacogenomics J.13 ( 1 ), 60 – 69 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Génin E , SchumacherM , RoujeauJ-Cet al. Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe . Orphanet J. Rare Dis.6 ( 1 ), 52 ( 2011 ).
   PubMedGoogle Scholar
• Lucena MI , MolokhiaM , ShenYet al. Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles . Gastroenterology141 ( 1 ), 338 – 347 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Behr ER , RitchieMD , TanakaTet al. Genome wide analysis of drug-induced torsades de pointes: Lack of common variants with large effect sizes . PLoS ONE8 ( 11 ), e78511 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Menke A , DomschkeK , CzamaraDet al. Genome-wide association study of antidepressant treatment-emergent suicidal ideation . Neuropsychopharmacology37 ( 3 ), 797 – 807 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Clark SL , AdkinsDE , AbergKet al. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D . Psychol. Med.42 ( 06 ), 1151 – 1162 ( 2012 ).
   PubMedGoogle Scholar
• Kurose K , HiratsukaK , IshiwataKet al. Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression . Psychiatry Res.198 ( 3 ), 424 – 429 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Ingle JN , SchaidDJ , GossPEet al. Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors . J. Clin. Oncol.28 ( 31 ), 4674 – 4682 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Chen S-H , PeiD , YangWet al. Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity . Clin. Pharmacol. Ther.88 ( 2 ), 191 – 196 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Park BL , KimT-H , KimJ-Het al. Genome-wide association study of aspirin-exacerbated respiratory disease in a Korean population . Hum. Genet.132 ( 3 ), 313 – 321 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Schneider BP , LiL , ShenFet al. Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100 . Br. J. Cancer.111 , 1241 – 1248 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Nicoletti P , CartsosVM , PalaskaPK , ShenY , FloratosA , ZavrasAI . Genomewide pharmacogenetics of bisphosphonate-induced osteonecrosis of the jaw: the role of RBMS3 . Oncologist17 ( 2 ), 279 – 287 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• McCormack M , AlfirevicA , BourgeoisSet al. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans . N. Engl. J. Med.364 ( 12 ), 1134 – 1143 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Ozeki T , MushirodaT , YowangAet al. Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population . Hum. Mol. Genet.20 ( 5 ), 1034 – 41 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Low S-K , ChungS , TakahashiAet al. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan . Cancer Sci.104 ( 8 ), 1074 – 1082 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Srinivasan Y , SasaM , HondaJet al. Genome-wide association study of epirubicin-induced leukopenia in Japanese patients . Pharmacogenet. Genomics21 ( 9 ), 552 – 558 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Chung S , LowS-K , ZembutsuHet al. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients . Breast Cancer Res.15 ( 5 ), R81 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Xu H , RobinsonGW , HuangJet al. Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss . Nat. Genet.47 ( 3 ), 263 – 266 . ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Adkins DE , ClarkSL , ÅbergKet al. Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D . Transl. Psychiatry2 , e129 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Goldstein JI , JarskogLF , HilliardCet al. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles . Nat. Commun.5 , 4757 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Zhang FR , LiuH , IrwantoAet al. HLA-B*13:01 and the dapsone hypersensitivity syndrome . N. Engl. J. Med.369 ( 17 ), 1620 – 1628 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Vandell a. G , McdonoughCW , GongYet al. Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study . J. Intern. Med.276 ( 5 ), 486 – 497 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Singer JB , LewitzkyS , LeroyEet al. A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury . Nat. Genet.42 ( 8 ), 711 – 714 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Chantarangsu S , MushirodaT , MahasirimongkolSet al. Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash . Clin. Infect. Dis.53 ( 4 ), 341 – 348 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Baldwin R , OwzarK , ZembutsuHet al. A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101 . Clin. Cancer Res.18 ( 18 ), 5099 – 5109 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Leandro-García LJ , Inglada-PérezL , PitaGet al. Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy . J. Med. Genet.50 ( 9 ), 599 – 605 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Fellay J , ThompsonAJ , GeDet al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C . Nature464 ( 7287 ), 405 – 408 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Ochi H , MaekawaT , AbeHet al. ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy–a genome-wide study of Japanese HCV virus patients . Gastroenterology139 ( 4 ), 1190 – 1197 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Thompson AJ , ClarkPJ , SinghAet al. Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients . J. Hepatol.56 ( 2 ), 313 – 319 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Tanaka Y , KurosakiM , NishidaNet al. Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C . Hum. Mol. Genet.20 ( 17 ), 3507 – 3516 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Iio E , MatsuuraK , NishidaNet al. Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C . Hum. Genet.134 , 279 – 289 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Guéant J-L , RomanoA , Cornejo-GarciaJ-Aet al. HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping . J. Allergy Clin. Immunol.135 ( 1 ), 253 – 259 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Chung W-H , ChangW-C , LeeY-Set al. Genetic variants associated with phenytoin-related severe cutaneous adverse reactions . JAMA312 ( 5 ), 525 – 534 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Adkins DE , AbergK , McClayJLet al. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs . Mol. Psychiatry16 ( 3 ), 321 – 332 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Malhotra AK , CorrellCU , ChowdhuryNIet al. Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain . Arch. Gen. Psychiatry69 ( 9 ), 904 – 912 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Heap G a , WeedonMN , BewsheaCMet al. HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants . Nat. Genet.46 ( 10 ), 1131 – 1134 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Yang S-K , HongM , BaekJet al. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia . Nat. Genet.46 ( 9 ), 1017 – 1020 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Shen Y , NicolettiP , FloratosAet al. Genome-wide association study of serious blistering skin rash caused by drugs . Pharmacogenomics J.12 ( 2 ), 96 – 104 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Nelson MR , BacanuS , MostellerMet al. Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions . Pharmacogenomics J.9 ( 1 ), 23 – 33 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Pichler WJ . Delayed drug hypersensitivity reactions . Ann. Intern. Med.139 ( 8 ), 683 – 693 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Daly AK . Using genome-wide association studies to identify genes important in serious adverse drug reactions . Annu. Rev. Pharmacol. Toxicol.52 ( 1 ), 21 – 35 ( 2012 ).
   PubMedGoogle Scholar
• Hetherington S , HughesAR , MostellerMet al. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir . Lancet359 ( 9312 ), 1121 – 1122 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Mallal S , NolanD , WittCet al. Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir . Lancet359 ( 9308 ), 727 – 732 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Mallal S , PhillipsE , CarosiGet al. HLA-B*5701 screening for hypersensitivity to abacavir . N. Engl. J. Med.358 ( 6 ), 568 – 579 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Rauch A , NolanD , ThurnheerCet al. Refining abacavir hypersensitivity diagnoses using a structured clinical assessment and genetic testing in the Swiss HIV Cohort Study . Antivir. Ther.13 ( 8 ), 1019 – 1028 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Young B , SquiresK , PatelPet al. First large, multicenter, open-label study utilizing HLA-B*5701 screening for abacavir hypersensitivity in North America . AIDS22 ( 13 ), 1673 – 1675 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Chung W-H , HungS-I , HongH-Set al. A marker for Stevens-Johnson syndrome . Nature428 , 486 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Locharernkul C , LoplumlertJ , LimotaiCet al. Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population . Epilepsia49 , 2087 – 2091 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Tassaneeyakul W , TiamkaoS , JantararoungtongTet al. Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population . Epilepsia51 , 926 – 930 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Ding WY , LeeCK , ChoonSE . Cutaneous adverse drug reactions seen in a tertiary hospital in Johor, Malaysia . Int. J. Dermatol.49 , 834 – 841 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Maurano MT , HumbertR , RynesEet al. Systematic localization of common disease-associated variation in regulatory DNA . Science337 ( 6099 ), 1190 – 1195 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• SEARCH Collaborative Group , LinkE , ParishSet al.SLCO1B1 variants and statin-induced myopathy–a genomewide study . N. Engl. J. Med.359 ( 8 ), 789 – 799 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Voora D , ShahSH , SpasojevicIet al. The SLCO1B1*5 genetic variant is associated with statin-induced side effects . J. Am. Coll. Cardiol.54 , 1609 – 1616 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Brunham LR , LansbergPJ , ZhangLet al. Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin . Pharmacogenomics J.12 ( 3 ), 233 – 237 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Pasanen MK , NeuvonenM , NeuvonenPJ , NiemiM . SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid . Pharmacogenet. Genomics16 ( 12 ), 873 – 879 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Chen C-H , LeeC-S , LeeM-TMet al. Variant GADL1 and response to lithium therapy in bipolar I disorder . N. Engl. J. Med.370 ( 2 ), 119 – 128 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Schaub MA , BoyleAP , KundajeA , BatzoglouS , SnyderM . Linking disease associations with regulatory information in the human genome . Genome Res.22 ( 9 ), 1748 – 1759 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Boyle AP , HongEL , HariharanMet al. Annotation of functional variation in personal genomes using RegulomeDB . Genome Res.22 ( 9 ), 1790 – 1797 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Gamazon ER , PereraM . Genome-wide approaches in pharmacogenomics: heritability estimation and pharmacoethnicity as primary challenges . Pharmacogenomics13 ( 10 ), 1101 – 1104 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Bradford LD . CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants . Pharmacogenomics3 ( 2 ), 229 – 243 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Chowbay B , ZhouS , LeeEJD . An interethnic comparison of polymorphisms of the genes encoding drug-metabolizing enzymes and drug transporters: experience in Singapore . Drug Metab. Rev.37 ( 2 ), 327 – 378 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Cropp CD , YeeSW , GiacominiKM . Genetic variation in drug transporters in ethnic populations . Clin. Pharmacol. Ther.84 ( 3 ), 412 – 416 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Sistonen J , SajantilaA , LaoO , CoranderJ , BarbujaniG , FuselliS . CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure . Pharmacogenet. Genomics17 ( 2 ), 93 – 101 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Solus JF , AriettaBJ , HarrisJRet al. Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population . Pharmacogenomics5 ( 7 ), 895 – 931 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Man M , FarmenM , DumaualCet al. Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major east asian subpopulations with comparison to Caucasians and Africans . J. Clin. Pharmacol.50 ( 8 ), 929 – 940 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Ramos E , DoumateyA , ElkahlounAGet al. Pharmacogenomics, ancestry and clinical decision making for global populations . Pharmacogenomics J.14 ( 3 ), 217 – 222 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Brunham LR , ChanSL , LiRet al. Pharmacogenomic diversity in Singaporean populations and Europeans . Pharmacogenomics J.14 ( 6 ), 555 – 563 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Aminkeng F , RossCJD , RassekhSRet al. Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent . Pharmacogenomics J.14 ( 2 ), 160 – 170 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Lee S-C , NgS-S , OldenburgJet al. Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population . Clin. Pharmacol. Ther.79 ( 3 ), 197 – 205 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Limdi NA , WadeliusM , CavallariLet al. Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups . Blood115 ( 18 ), 3827 – 3834 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment . Eur. Heart J.34 ( 17 ), 1279 – 1291 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• 1000 Genomes: A Deep Catalog of Human Genetic Variation . www.1000genomes.org .
   Google Scholar
• Hu K-Q , FreilichB , BrownRS , BrassC , JacobsonIM . Impact of Hispanic or Asian ethnicity on the treatment outcomes of chronic hepatitis C: results from the WIN-R trial . J. Clin. Gastroenterol.45 ( 8 ), 720 – 726 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Gonçalo M , CoutinhoI , TeixeiraVet al. HLA-B*58:01 is a risk factor for allopurinol-induced DRESS and Stevens-Johnson syndrome/toxic epidermal necrolysis in a Portuguese population . Br. J. Dermatol.169 ( 3 ), 660 – 665 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Niihara H , KanekoS , ItoTet al. HLA-B*58:01 strongly associates with allopurinol-induced adverse drug reactions in a Japanese sample population . J. Dermatol. Sci.71 ( 2 ), 150 – 152 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Cao Z , WeiZ , ZhuQet al. HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese . Pharmacogenomics13 ( 10 ), 1193 – 1201 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Cristallo AF , SchroederJ , CitterioAet al. A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis . Int. J. Immunogenet.38 ( 4 ), 303 – 309 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Somkrua R , EickmanEE , SaokaewS , LohitnavyM , ChaiyakunaprukN . Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis . BMC Med. Genet.12 , 118 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Dekker JW , NizankowskaE , Schmitz-SchumannMet al. Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes . Clin. Exp. Allergy27 ( 5 ), 574 – 577 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Choi JH , LeeKW , OhHBet al. HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population . J. Allergy Clin. Immunol.113 ( 3 ), 562 – 564 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Lympany PA , WelshKI , ChristiePE , Schmitz-SchumannM , KemenyDM , LeeTH . An analysis with sequence-specific oligonucleotide probes of the association between aspirin-induced asthma and antigens of the HLA system . J. Allergy Clin. Immunol.92 ( 1 Pt 1 ), 114 – 123 ( 1993 ).
   PubMed Web of Science ®Google Scholar
• Niihara H , KakamuT , FujitaY , KanekoS , MoritaE . HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population . J. Dermatol.39 ( 7 ), 594 – 601 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Hung S-I , ChungW-H , JeeS-Het al. Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions . Pharmacogenet. Genomics16 ( 4 ), 297 – 306 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Shi Y-W , MinF-L , QinBet al. Association between HLA and Stevens-Johnson syndrome induced by carbamazepine in Southern Han Chinese: genetic markers besides B*1502? Basic Clin. Pharmacol. Toxicol. 111 ( 1 ), 58 – 64 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Hsiao Y-H , HuiRC-Y , WuTet al. Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: strength and clinical correlations . J. Dermatol. Sci.73 ( 2 ), 101 – 109 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Genin E , ChenD-P , HungS-Iet al. HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis . Pharmacogenomics J.14 ( 3 ), 281 – 288 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Lieberman JA , YunisJ , EgeaE , CanosoRT , KaneJM , YunisEJ . HLA-B38, DR4, DQw3 and clozapine-induced agranulocytosis in Jewish patients with schizophrenia . Arch. Gen. Psychiatry47 ( 10 ), 945 – 948 ( 1990 ).
   PubMed Web of Science ®Google Scholar
• Yunis JJ , CorzoD , SalazarM , LiebermanJA , HowardA , YunisEJ . HLA associations in clozapine-induced agranulocytosis . Blood86 ( 3 ), 1177 – 1183 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Valevski A , KleinT , GazitEet al. HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients . Eur. J. Immunogenet.25 ( 1 ), 11 – 13 ( 1998 ).
   PubMedGoogle Scholar
• Athanasiou MC , DettlingM , CascorbiIet al. Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis . J. Clin. Psychiatry72 ( 4 ), 458 – 463 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Amar A , SegmanRH , ShtrussbergSet al. An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201 . Int. J. Neuropsychopharmacol.1 ( 1 ), 41 – 44 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Seto W-K , TsangOT-Y , LiuKet al. Role of IL28B and inosine triphosphatase polymorphisms in the treatment of chronic hepatitis C virus genotype 6 infection . J. Viral Hepat.20 ( 7 ), 470 – 477 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Motomura T , ShirabeK , FurusyoNet al. Effect of laparoscopic splenectomy in patients with Hepatitis C and cirrhosis carrying IL28B minor genotype . BMC Gastroenterol.12 , 158 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Ogawa E , FurusyoN , NakamutaMet al. Clinical milestones for the prediction of severe anemia by chronic hepatitis C patients receiving telaprevir-based triple therapy . J. Hepatol.59 ( 4 ), 667 – 674 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Rembeck K , WaldenströmJ , HellstrandKet al. Variants of the inosine triphosphate pyrophosphatase gene are associated with reduced relapse risk following treatment for HCV genotype 2/3 . Hepatology59 ( 6 ), 2131 – 2139 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Hwang J-J , LoC-C , LinC-Het al. Association between IPTA gene polymorphisms and hematological abnormalities in hepatitis C virus-infected patients receiving combination therapy . Gut Liver8 ( 6 ), 605 – 611 ( 2014 ).
   PubMedGoogle Scholar
• Holmes JA , RobertsSK , AliRJet al. ITPA genotype protects against anemia during peginterferon and ribavirin therapy but does not influence virological response . Hepatology59 ( 6 ), 2152 – 2160 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Clark PJ , AghemoA , DegasperiEet al. Inosine triphosphatase deficiency helps predict anaemia, anaemia management and response in chronic hepatitis C therapy . J. Viral Hepat.20 ( 12 ), 858 – 866 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• D’Avolio A , De NicolòA , CusatoJet al. Association of ITPA polymorphisms rs6051702/rs1127354 instead of rs7270101/rs1127354 as predictor of ribavirin-associated anemia in chronic hepatitis C treated patients . Antiviral Res.100 ( 1 ), 114 – 119 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Tsubota A , ShimadaN , AbeHet al. Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C . World J. Gastroenterol.18 ( 41 ), 5879 – 5888 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• D’Avolio A , CiancioA , SiccardiMet al. Inosine triphosphatase polymorphisms and ribavirin pharmacokinetics as determinants of ribavirin-associate anemia in patients receiving standard anti-HCV treatment . Ther. Drug Monit.34 ( 2 ), 165 – 170 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Naggie S , RallonNI , BenitoJMet al. Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia in HIV/HCV-coinfected patients with all HCV genotypes . J. Infect. Dis.205 ( 3 ), 376 – 383 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Thompson AJ , FellayJ , PatelKet al. Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction . Gastroenterology139 ( 4 ), 1181 – 1189 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Suzuki F , SuzukiY , AkutaNet al. Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir . Hepatology53 ( 2 ), 415 – 421 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Thompson AJ , SantoroR , PiazzollaVet al. Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVR . Hepatology53 ( 2 ), 389 – 395 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Lee A-Y , KimM-J , CheyW-Y , ChoiJ , KimB-G . Genetic polymorphism of cytochrome P450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions . Eur. J. Clin. Pharmacol.60 ( 3 ), 155 – 159 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Ikeda M , KondoK , IwataN . Variant GADL1 and response to lithium in bipolar I disorder . N. Engl. J. Med.370 ( 19 ), 1856 – 1857 ( 2014 ).
   PubMedGoogle Scholar
• Consortium on Lithium Genetics , HouL , HeilbronnerUet al.Variant GADL1 and response to lithium in bipolar I disorder . N. Engl. J. Med.370 ( 19 ), 1857 – 1859 ( 2014 ).
   PubMedGoogle Scholar
• Kotambail A , MathurA , BhatSM , RaiPS , SharmaPS , SatyamoorthyK . GADL1 gene polymorphisms and lithium response in bipolar I disorder: lack of association from an Indian population . Psychiatr. Genet.25 ( 1 ), 39 – 40 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Caudle KE , RettieAE , Whirl-CarrilloMet al. Clinical pharmacogenetics implementation consortium guidelines for CYP2C9 and HLA-B genotypes and phenytoin dosing . Clin. Pharmacol. Ther.96 ( 5 ), 542 – 548 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Leckband SG , KelsoeJR , DunnenbergerHMet al. Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing . Clin. Pharmacol. Ther.94 ( 3 ), 324 – 328 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Relling M V , GardnerEE , SandbornWJet al. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing . Clin. Pharmacol. Ther.89 ( 3 ), 387 – 391 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Takatsu N , MatsuiT , MurakamiYet al. Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease . J. Gastroenterol. Hepatol.24 ( 7 ), 1258 – 1264 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Ross CJD , Katzov-EckertH , DubéM-Pet al. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy . Nat. Genet.41 ( 12 ), 1345 – 1349 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Pussegoda K , RossCJ , VisscherHet al. Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children . Clin. Pharmacol. Ther.94 ( 2 ), 243 – 251 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Kimmel SE , FrenchB , KasnerSEet al. A pharmacogenetic versus a clinical algorithm for warfarin dosing . N. Engl. J. Med.369 ( 24 ), 2283 – 2293 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Perera MA , CavallariLH , LimdiNAet al. Genetic variants associated with warfarin dose in African–American individuals: a genome-wide association study . Lancet382 ( 9894 ), 790 – 796 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Cooper GM , JohnsonJA , LangaeeTYet al. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose . Blood112 ( 4 ), 1022 – 1027 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Takeuchi F , McGinnisR , BourgeoisSet al. A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose . PLoS Genet.5 ( 3 ), e1000433 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Cha P-C , MushirodaT , TakahashiAet al. Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese . Hum. Mol. Genet.19 ( 23 ), 4735 – 4744 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Perera MA , GamazonE , CavallariLHet al. The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans . Clin. Pharmacol. Ther.89 ( 3 ), 408 – 415 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Daneshjou R , GamazonER , BurkleyBet al. Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans . Blood124 ( 14 ), 2298 – 2305 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Teo YY , OngRTH , SimX , TaiE-S , ChiaK-S . Identifying candidate causal variants via trans-population fine-mapping . Genet. Epidemiol.34 ( 7 ), 653 – 664 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Wu Y , WaiteLL , JacksonAUet al. Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained . PLoS Genet.9 ( 3 ), e1003379 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Peters U , NorthKE , SethupathyPet al. A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African–Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study . PLoS Genet.9 ( 1 ), e1003171 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• 1000 Genomes Project Consortium , AbecasisGR , AutonAet al.An integrated map of genetic variation from 1,092 human genomes . Nature491 ( 7422 ), 56 – 65 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Li J , LaoX , ZhangC , TianL , LuD , XuS . Increased genetic diversity of ADME genes in African Americans compared with their putative ancestral source populations and implications for pharmacogenomics . BMC Genet.15 , 52 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Ortega VE , MeyersDA . Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine . J. Allergy Clin. Immunol.133 ( 1 ), 16 – 26 ( 2014 ).
   PubMed Web of Science ®Google Scholar