Advanced search
Publication Cover
Aging Health Volume 5, 2009 - Issue 5
Journal homepage
37
Views
0
CrossRef citations to date
0
Altmetric
Review

Vitamin D Supplementation in Older Persons: Benefits and Requirements

Silvina Levisa Geriatric Research, Education, and Clinical Center & Research Service, Miami Veterans Affairs Healthcare System; and Geriatrics Institute & Division of Gerontology & Geriatric Medicine, Department of Medicine, Miller School of Medicine, University of Miami, PO Box 016960 (C-211), Miami, FL33136, USA. [email protected]Correspondence[email protected]
View further author information
,
E Paul Cherniackb Geriatric Research, Education, & Clinical Center & Research Service, Miami Veterans Affairs Healthcare System; Geriatrics Institute and Division of Gerontology & Geriatric Medicine, Department of Medicine, Miller School of Medicine, University of Miami; VAMC GRECC (11GRC), 1201 NW 16 St, Miami, FL33125, USA. [email protected]View further author information
,
Hermes Florezc Geriatric Research, Education, and Clinical Center & Research Service, Miami Veterans Affairs Healthcare System; Geriatrics Institute & Divisions of Gerontology & Geriatric Medicine & of Endocrinology, Diabetes & Metabolism, Departments of Medicine & Epidemiology, Miller School of Medicine, University of Miami, VAMC GRECC (11GRC), 1201 NW 16 St, Miami, FL33125, USA. [email protected]View further author information
,
Bernard A Roosd Geriatric Research, Education, and Clinical Center & Research Service, Miami Veterans Affairs Healthcare System; Geriatrics Institute & Division of Gerontology & Geriatric Medicine, Department of Medicine, Miller School of Medicine, University of Miami; and Stein Gerontological Institute, VAMC GRECC (11GRC), 1201 NW 16 St, Miami, FL33125, USA. [email protected]View further author information
&
Bruce R Troene Geriatric Research, Education, and Clinical Center & Research Service, Miami Veterans Affairs Healthcare System; Geriatrics Institute & Division of Gerontology & Geriatric Medicine, Department of Medicine, Miller School of Medicine, University of Miami; VAMC GRECC (11GRC), 1201 NW 16 St, Miami, FL33125, USA. [email protected]View further author information
Pages 701-709 | Published online: 06 Oct 2009

Bibliography

  • Levis S , GomezA, JimenezCet al.: Vitamin D deficiency and seasonal variation in an adult south Florida population.J. Clin. Endocrinol. Metab.90(3), 1557–1562(2005).
  • Ginde AA , LiuMC, CamargoCA: Demographic differences and trends of vitamin D insufficiency in the US population, 1988–2004.Arch. Int. Med.169, 626–632(2009).
  • Cormier C , Souberbielle J-C: New definition of optimal vitamin D status and redefining serum parathyroid hormone reference range. Rev. Med. Interne27, 684–689(2006).
  • Webb AR , PilbeamC, HanafinN, HolickMF: An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston.Am. J. Clin. Nutr.51, 1075–1081(1990).
  • Tjellesen L , ChristiansenC: Vitamin D metabolites in normal subjects during one year. A longitudinal study.Scand. J. Clin. Lab. Invest.43, 85–89(1983).
  • DeLuca HF : Overview of general physiologic features and functions of vitamin D.Am. J. Clin. Nutr.806 (Suppl.), S1689–S1696 (2004).
  • Harris SS , SoteriadesE, Stina-CoolidgeJA, MudgalS, Dawson-HughesB: Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population.J. Clin. Endocrinol. Metab.85, 4125–4130(2000).
  • Heaney PR , DaviesKM, ChenTC, HolickMF, Barger-LuxMJ: Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol.Am. J. Clin. Nutr.77, 204–210(2003).
  • Holick MF , SirisES, BinkleyNet al.: Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy.J. Clin. Endocrinol. Metab.90, 3215–3224(2005).
  • Heaney RP : The vitamin D requirement in health and disease.J. Steroid Biochem. Mol. Biol.97, 13–19(2005).
  • Vieth R , LadakY, WalfishPG: Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D.J. Clin. Endocrinol. Metab.88(1), 185–191(2003).
  • Maggio D , CherubiniA, LauretaniFet al.: 25(OH) vitamin D serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults.J. Gerontol. A Biol. Sci. Med. Sci.60(11), 1414–1419(2005).
  • Chapuy MC , PreziosiP, MaamerMet al.: Prevalence of vitamin D insufficiency in an adult normal population.Osteoporos. Int.7, 439–443(1997).
  • Meier C , WoitgeHW, WitteK, LemmerB, SeibelMJ: Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial.J. Bone Miner. Res.19, 1221–1230(2004).
  • Vecino-Vecino C , GrattonM, KremerR, Rodriguez-ManasL, DuqueG: Seasonal variance in serum levels of vitamin D determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec.Gerontology52, 33–39(2006).
  • Allali F , El Aichaoui S, Khazani H et al.: High prevalence of hypovitaminosis D in Morocco: relationship to lifestyle, physical performance, bone markers, and bone mineral density. Semin. Arthritis Rheum.38(6), 444–451(2009).
  • Clemens TL , AdamsJS, HendersonSL, HolickMF: Increased skin pigment reduces the capacity of skin to synthesize vitamin D3.Lancet1, 74–76(1982).
  • Semba RD , GarrettE, JohnsonBA, GuralnikJM, FriedLP: Vitamin D deficiency among older women with and without disability.Am. J. Clin. Nutr.72, 1529–1534(2000).
  • Wortsman J , MatsuokaLY, ChenTC, LuZ, HolickMF: Decreased bioavailability of vitamin D in obesity.Am. J. Clin. Nutr.72(3), 690–693(2000).
  • Snijder MB , van Dam RM, Visser M et al.: Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J. Clin. Endocrinol. Metab. (7), 4119–4123(2005).
  • Bruyere O , DecockC, DelhezM, ColletteJ, ReginsterJY: Highest prevalence of vitamin D inadequacy in institutionalized women compared with noninstitutionalized women: a case-control study.Womens Health5, 49–54(2009).
  • Lips P : Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.Endocr. Rev.22, 477–501(2001).
  • Reid IR , GallagherDJ, BosworthJ: Prophylaxis against vitamin D deficiency in the elderly by regular sunlight exposure.Age Ageing1, 15, 35–34(1986).
  • Harris SS , Dawson-HughesB: Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3.J. Am. Coll. Nutr.21, 357–362(2002).
  • Dawson-Hughes B , HeaneyRP, HolickMF, LipsP, MeunierPI, ViethR: Estimates of optimal vitamin D status.Osteoporos. Int.16, 713–716(2005).
  • McKenna MJ : Differences in vitamin D status between countries in young adults and the elderly.Am. J. Med.93, 69–77(1992).
  • Heaney RP : Functional indices of vitamin D status and ramifications of vitamin D deficiency.Am. J. Clin. Nutr.80 (Suppl.), 1706S–1709S (2004).
  • Melamed ML , MichosED, PostW, AstorB: 25-Hydroxyvitamin D levels and the risk of mortality in the general population.Arch. Intern. Med.168(15), 1629–1637(2008).
  • Bischoff-Ferrari HA , DietrichT, OravEJ, Dawson-HughesB: Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults.Am. J. Med.116, 634–639(2004).
  • Bischoff-Ferrari HA , GiovannucciE, WillettWC, DietrichT, Dawson-HughesB: Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes.Am. J. Clin. Nutr.84, 18–28(2006).
  • Bischoff-Ferrari HA : Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes.Adv. Exp. Med. Biol.624, 55–71(2008).
  • Aloia JF , PatelM, DimaanoRet al.: Vitamin D intake to attain a desired 25-hydroxyvitamin D concentration.Am. J. Clin. Nutr.87, 1952–1958(2008).
  • Bischoff-Ferrari HA , WillettWC, WongJBet al.: Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.JAMA293, 2257–2264(2005).
  • Porthouse J , CockayneS, KingCet al.: Randomized controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care.BMJ330, 1003 (2005).
  • The RECORD Trial Group: Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomized Evaluation of Calcium and/or Vitamin D, RECORD): a randomized placebo-controlled trial. Lancet365, 1621–1628(2005).
  • Jackson RD , LaCroixAZ, GassMet al.: Calcium plus vitamin D supplementation and the risk of fractures.N. Engl. J. Med.354, 669–683(2006).
  • Holick MF : Vitamin D deficiency.N. Engl. J. Med.357, 266–281(2007).
  • Dusso AS , BrownAJ, SlatopolskyE: Vitamin D.Am. J. Physiol. Renal Physiol.289, F8–F28 (2005).
  • Nagpal S , NaS, TathnachalamR: Noncalcemic actions of vitamin D receptor ligands.Endocr. Rev.26, 662–687(2005).
  • Apperly FL : The relation of solar radiation to cancer mortality in North America.Cancer Res.1, 191–195(1941).
  • Grant WB : An estimate of premature cancer mortality in the US due to inadequate doses of solar ultraviolet-B radiation.Cancer94, 1867–1975(2002).
  • Giovannucci E , LiuY, RimmEBet al.: Prospective study of predictors of vitamin D status and cancer incidence and mortality in men.J. Natl Cancer Inst.98, 451–459(2006).
  • Feskanich D , MaJ, FuchsCSet al.: Plasma vitamin D metabolites and the risk of colorectal cancer in women.Cancer Epidemiol. Biomarkers Prev.13, 1502–1508(2004).
  • Kricker A , ArmstrongB: Does sunlight have a beneficial influence on certain cancers?Prog. Biophys. Mol. Biol.92(1), 132–139(2006).
  • Chan JS , BeerTM, QuinnDIet al.: A Phase II study of high-dose calcitriol combined with mitoxantrone and prednisone for androgen-independent prostate cancer.BJU Int.102(11), 1601–1606(2008).
  • Lappe JM , Travers-GustafsonD, DaviesKM, ReckerRR, HeaneyRP: Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial.Am. J. Clin. Nutr.85(6), 1586–1591(2007).
  • Garland CF , GrantWB, MohrSB, GorhamED, GarlandFC: What is the dose–response relationship between vitamin D and cancer risk?Nutr. Rev.65(8 Pt 2), S91–S95 (2007).
  • Cannell JJ , ZasloffM, GarlandCF, ScraggR, GiovannucciE: On the epidemiology of influenza.Virol. J.5, 29 (2008).
  • Laaksi I , RuoholaJP, TuohimaaPet al.: An association of serum vitamin D concentrations < 40 nmol/l with acute respiratory tract infection in young Finnish men.Am. J. Clin. Nutr.86, 714–717(2007).
  • van Etten E , MathieuC: Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts.J. Steroid Biochem. Mol. Biol.97(1–2), 93–101(2005).
  • Adams JS , LiuPT, ChunR, ModlinRL, HewisonM: Vitamin D in defense of the human immune response.Ann. NY Acad. Sci.1117, 94–105(2007).
  • Ginde AA , MansbachJM, CamargoCA: Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey.Arch. Intern. Med.169(4), 384–390(2009).
  • Liu PT , StengerS, LiHet al.: Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.Science311(5768), 1770–1773(2006).
  • Oelzner P , FrankeS, MüllerA, HeinG, SteinG: Relationship between soluble markers of immune activation and bone turnover in post-menopausal women with rheumatoid arthritis.Rheumatology (Oxford)38, 841–847(1999).
  • Borba VZ , VieiraJG, KasamatsuT, RadominskiSC, SatoEI, Lazaretti-CastroM:.Vitamin D deficiency in patients with active systemic lupus erythematosus. Osteoporos. Int.20(3), 427–433(2009).
  • Ponsonby AL , LucasRM, van der Mei IA: UVR, vitamin D and three autoimmune diseases, multiple sclerosis, Type 1 diabetes, rheumatoid arthritis, Photochem. Photobiol.81, 1267–1275(2005).
  • Boxer RS , DauserDA, WalshSJ, HagerWD, KennyAM: The association between vitamin D and inflammation with the 6-minute walk and frailty in patients with heart failure.J. Am. Geriatr. Soc.56, 454–461(2008).
  • Wilheim M , ThienR, SchrattbauerKet al.: Regulatory effects of 1,25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes.J. Clin. Endocrinol. Metab.84, 3739–3744(1999).
  • Pittas AG , Dawson-HughesB, LiTet al.: Vitamin D and calcium intake in relation to Type 2 diabetes in women.Diabetes Care29, 650–656(2006).
  • Ford ES , AjaniUA, McGuireLC, LiuS: Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults.Diabetes Care28, 1228–1230(2005).
  • Mathieu C , GysemansC, GiuliettiA, BouillonR: Vitamin D and diabetes.Diabetologia48, 1247–1257(2005).
  • Chiu KC , ChuA, GoVL, SaadMF: Hypovitaminosis D is associated with insulin resistance and β cell dysfunction.Am. J. Clin. Nutr.79, 820–825(2004).
  • Palomer X , Gonzalez-ClementeJM, Blanco-VacaF, MauricioD: Role of vitamin D in the pathogenesis of Type 2 diabetes mellitus.Diabetes Obes. Metab.10(3), 185–197(2008).
  • Lee JH , O‘KeefeJH, BellD, HensrudDD, HolickMF: Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?J. Am. Coll. Cardiol.52, 1949–1956(2008).
  • Wang TJ , PencinaMJ, BoothSLet al.: Vitamin D deficiency and risk of cardiovascular disease.Circulation17, 503–511(2008).
  • Giovannuci E , LiuY, HollisBW, RimmEB: 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study.Arch. Intern. Med.168, 1174–1180(2008).
  • Pilz S , MärzW, WellnitzBet al.: Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography.J. Clin. Endocrinol. Metab.94(2), 418–420(2009).
  • Zittermann A , KoerferR: Protective and toxic effects of vitamin D on vascular calcification: clinical implications.Mol. Aspects Med.29(6), 423–432(2008).
  • Autier P , GandiniS: Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials.Arch. Intern. Med.167(16), 1730–1737(2007).
  • Schleithoff SS , ZittermannA, TenderichGet al.: Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.Am. J. Clin. Nutr.83, 754–759(2006).
  • Simpson RU , ThomasGA, ArnoldAJ: Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle.J. Biol. Chem.60, 8882–8891(1985).
  • Bischoff HA , StahelinHB, UrschelerNet al.: Muscle strength in the elderly: its relation to vitamin D metabolites.Arch. Phys. Med. Rehabil.80, 54–58(1999).
  • Bischoff HA , BorchersM, GudatFet al.: In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue.Histochem. J.33, 19–24(2001).
  • Sorensen OH , LundBI, SaltinBet al.: Myopathy in bone loss of ageing: improvement by treatment with 1a-hydroxycholecalciferol and calcium.Clin. Science56, 157–161(1979).
  • Boland R : Role of vitamin D in skeletal muscle function.Endocr. Rev.7, 434–447(1986).
  • Bischoff-Ferrari HA , Dawson-HughesB, WillettWCet al.: Effect of vitamin D on falls: a meta-analysis.JAMA291, 1999–2006(2004).
  • Broe KE , ChenTC, WeinbergJet al.: A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study.J. Am. Geriatr. Soc.55(2), 234–239(2007).
  • Dhesi JK , JacksonSH, BearneLMet al.: Vitamin D supplementation improves neuromuscular function in older people who fall.Age Ageing33(6), 589–595(2004).
  • Pfeifer M , DobnigH, BegerowB, SuppanK: Effects of vitamin D and calcium supplementation on falls and parameters of muscle function – a prospective, randomized, double-blind, multi-center study.J. Bone Miner. Res.19(Suppl. 1), S58 (2004).
  • DiMonaco M , ValeroF, TapperoR, CavannaA: 25-hydroxyvitamin D, parathyroid hormone, and functional recovery after hip fracture in elderly patients.J. Bone Miner. Metab.24, 42–47(2006).
  • Zamboni M , ZoicoE, TosoniP: Relation between vitamin D, physical performance, and disability in elderly persons.J. Gerontol. Med. Sci.57, M7–M11 (2002).
  • Houston DK , CesariM, FerrucciLet al.: Association between vitamin D status and physical performance: the InChianti Study.J. Gerontol. Med. Sci.62A, 440–446(2007).
  • Bischoff-Ferrari HA , DietrichT, OravEJ, Dawson-HughesB: Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged ≥ 60 years.Am. J. Clin. Nutr.80, 752–758(2004).
  • Verreault R , SembaRD, VolpatoSet al.: Low serum vitamin D does not predict new disability or loss of muscle strength in older women.J. Am. Geriatr. Soc.50, 912–917(2002).
  • Bischoff-Ferrari HA , ConzelmannM, StahelinHBet al.: Is fall prevention by vitamin D mediated by a change in postural or dynamic balance?Osteoporos. Int.17, 656–663(2006).
  • Glerup H , MikkelsenK, PoulsenLet al.: Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement.Calcif. Tissue Int.66, 419–424(2000).
  • Bunout D , BarreraG, LeivaLet al.: Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects.Exp. Gerontol.41, 746–752(2006).
  • Kenny AM , BiskupB, RobbinsB, MarcellaG, BurlesonJA: Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men.J. Am. Geriatr. Soc.51(12), 1762–1767(2003).
  • Hollis BW : Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D.J. Nutr.135(2), 317–322(2005).
  • Vieth R : Why the optimal requirement for vitamin D3 is probably much higher than what is officially recommended for adults.J. Steroid Biochem. Mol. Biol.89–90, 575–579 (2004).
  • Diamond TH , HoKW, RohlPG, MeerkinM: Annual intramuscular injection of a megadose of cholecalciferol for treatment of vitamin D deficiency: efficacy and safety data.Med. J. Aust.183, 10–12(2005).
  • Vieth R : The mechanisms of vitamin D toxicity.Bone Miner.11, 267–272(1990).
  • Vieth R : Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.Am. J. Clin. Nutr.69, 842–856(1999).
  • Heaney RP : Serum 25-hydroxyvitamin D and parathyroid hormone exhibit threshold behavior.J. Endocrinol. Invest.28, 180–182(2005).
  • Mocanu V , StittPA, CostanARet al.: Long-term effects of living nursing home residents bread fortified with 125 µg (5000 IU) vitamin D3 per daily serving.Am. J. Clin. Nutr.89, 1–6(2009).
  • Heaney RP , DaviesKM, ChenTC, HolickMF, Barger-LuxMJ: Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol.Am. J. Clin. Nutr.77, 204–210(2003).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.