Managing Late-Life Bipolar Disorder: An Update

• Kessler RC , BerglundP, DemlerO et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch. Gen. Psychiatry 62(6) , 593–602 (2005).
   PubMed Web of Science ®Google Scholar
• Weissman MM , BlandRC, CaninoGJ et al. Cross-national epidemiology of major depression and bipolar disorder. JAMA 276(4) , 293–299 (1996).
   PubMed Web of Science ®Google Scholar
• Kessler RC , McGonagleKA, ZhaoS et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the national comorbidity survey. Arch. Gen. Psychiatry 51(1) , 8–19 (1994).
   PubMed Web of Science ®Google Scholar
• Regier DA , BoydJH, BurkeJD Jr et al. One-month prevalence of mental disorders in the United States. Based on five epidemiologic catchment area sites. Arch. Gen. Psychiatry45(11) , 977–986 (1988).
   PubMed Web of Science ®Google Scholar
• Judd LL , AkiskalHS. The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases. J. Affect. Disord.73(1–2) , 123–131 (2003).
   PubMed Web of Science ®Google Scholar
• Akiskal HS , BourgeoisML, AngstJ et al. Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. J. Affect. Disord. 59(Suppl. 1) , S5–S30 (2000).
   PubMed Web of Science ®Google Scholar
• Szadoczky E , PappZ, VitraiJ et al. The prevalence of major depressive and bipolar disorders in Hungary. Results from a national epidemiologic survey. J. Affect. Disord. 50(2–3) , 153–162 (1998).
   PubMed Web of Science ®Google Scholar
• Chen P , AhmedM, SajatovicM. Bipolar disorder in later life. Aging Health2(2) , 333–347 (2006).
   Google Scholar
• Weissman MM , LeafPJ, TischlerGL et al. Affective disorders in five United States communities. Psychol. Med. 18(1) , 141–153 (1988).
   PubMed Web of Science ®Google Scholar
• Unutzer J , SimonG, PabiniakC et al. The treated prevalence of bipolar disorder in a large staff-model HMO. Psychiatr. Serv. 49(8) , 1072–1078 (1998).
   PubMed Web of Science ®Google Scholar
• Hirschfeld RM , CalabreseJR, WeissmanMM et al. Screening for bipolar disorder in the community. J. Clin. Psychiatry 64(1) , 53–59 (2003).
   PubMed Web of Science ®Google Scholar
• Almeida OP , FennerS. Bipolar disorder: similarities and differences between patients with illness onset before and after 65 years of age. Int. Psychogeriatr.14(3) , 311–322 (2002).
   PubMed Web of Science ®Google Scholar
• Yassa R , NairV, NastaseC et al. Prevalence of bipolar disorder in a psychogeriatric population. J. Affect. Disord. 14(3) , 197–201 (1988).
   PubMed Web of Science ®Google Scholar
• Depp CA , LindamerLA, FolsomDP et al. Differences in clinical features and mental health service use in bipolar disorder across the lifespan. Am. J. Geriatr. Psychiatry 13(4) , 290–298 (2005).
   PubMed Web of Science ®Google Scholar
• Depp CA , JesteDV. Bipolar disorder in older adults: a critical review. Bipolar Disord.6(5) , 343–367 (2004).
   PubMed Web of Science ®Google Scholar
• Morgan VA , MitchellPB, JablenskyAV. The epidemiology of bipolar disorder: sociodemographic, disability and service utilization data from the Australian national study of low prevalence (psychotic) disorders. Bipolar Disord.7(4) , 326–337 (2005).
   PubMed Web of Science ®Google Scholar
• Meeks S . Bipolar disorder in the latter half of life: symptom presentation, global functioning and age of onset. J. Affect. Disord.52(1–3) , 161–167 (1999).
   PubMed Web of Science ®Google Scholar
• Sajatovic M , BlowFC, IgnacioRV et al. New-onset bipolar disorder in later life. Am. J. Geriatr. Psychiatry 13(4) , 282–289 (2005).
   PubMed Web of Science ®Google Scholar
• Vasudev A , ThomasA. ‘Bipolar disorder‘ in the elderly: what‘s in a name? Maturitas66(3) , 231–235 (2010).
   PubMed Web of Science ®Google Scholar
• Kessing LV . Diagnostic subtypes of bipolar disorder in older versus younger adults. Bipolar Disord.8(1) , 56–64 (2006).
   PubMed Web of Science ®Google Scholar
• Lehmann SW , RabinsPV. Factors related to hospitalization in elderly manic patients with early and late onset bipolar disorder. Int. J. Geriatr. Psychiatry21(11) , 1060–1064 (2006).
   PubMed Web of Science ®Google Scholar
• Goldstein BI , HerrmannN, ShulmanKI. Comorbidity in bipolar disorder among the elderly: results from an epidemiological community sample. Am. J. Psychiatry163(2) , 319–321 (2006).
   PubMed Web of Science ®Google Scholar
• Beyer JL , KuchibhatlaM, CassidyF et al. Stressful life events in older bipolar patients. Int. J. Geriatr. Psychiatry 23(12) , 1271–1275 (2008).
   PubMed Web of Science ®Google Scholar
• Radanovic M , NunesPV, GattazWF et al. Language impairment in euthymic, elderly patients with bipolar disorder but no dementia. Int. Psychogeriatr. 20(4) , 687–696 (2008).
   PubMed Web of Science ®Google Scholar
• Gildengers AG , MulsantBH, BegleyA et al. The longitudinal course of cognition in older adults with bipolar disorder. Bipolar Disord. 11(7) , 744–752 (2009).
   PubMed Web of Science ®Google Scholar
• Gunning-Dixon FM , MurphyCF, AlexopoulosGS et al. Executive dysfunction in elderly bipolar manic patients. Am. J. Geriatr. Psychiatry 16(6) , 506–512 (2008).
   PubMed Web of Science ®Google Scholar
• Prakash O , KumarCN, ShivakumarPT et al. Clinical presentation of mania compared with depression: data from a geriatric clinic in India. Int. Psychogeriatr. 21(4) , 764–767 (2009).
   PubMed Web of Science ®Google Scholar
• Depp CA , MooreDJ, SitzerD et al. Neurocognitive impairment in middle-aged and older adults with bipolar disorder: comparison to schizophrenia and normal comparison subjects. J. Affect. Disord. 101(1–3) , 201–209 (2007).
   PubMed Web of Science ®Google Scholar
• Schouws SN , ZoetemanJB, ComijsHC et al. Cognitive functioning in elderly patients with early onset bipolar disorder. Int. J. Geriatr. Psychiatry 22(9) , 856–861 (2007).
   PubMed Web of Science ®Google Scholar
• Gildengers AG , ButtersMA, ChisholmD et al. Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder. Am. J. Geriatr. Psychiatry 15(2) , 174–179 (2007).
   PubMed Web of Science ®Google Scholar
• Delaloye C , MoyG, BaudoisS et al. Cognitive features in euthymic bipolar patients in old age. Bipolar Disord. 11(7) , 735–743 (2009).
   PubMed Web of Science ®Google Scholar
• Tsai SY , LeeHC, ChenCC et al. Cognitive impairment in later life in patients with early-onset bipolar disorder. Bipolar Disord. 9(8) , 868–875 (2007).
   PubMed Web of Science ®Google Scholar
• Tsai SY , KuoCJ, ChungKH et al. Cognitive dysfunction and medical morbidity in elderly outpatients with bipolar disorder. Am. J. Geriatr. Psychiatry 17(12) , 1004–1011 (2009).
   PubMed Web of Science ®Google Scholar
• Subramaniam H , DennisMS, ByrneEJ. The role of vascular risk factors in late onset bipolar disorder. Int. J. Geriatr. Psychiatry22(8) , 733–737 (2007).
   PubMed Web of Science ®Google Scholar
• Krauthammer C , KlermanGL. Secondary mania: manic syndromes associated with antecedent physical illness or drugs. Arch. Gen. Psychiatry35(11) , 1333–1339 (1978).
   PubMed Web of Science ®Google Scholar
• Van Gerpen MW , JohnsonJE, WinsteadDK. Mania in the geriatric patient population: a review of the literature. Am. J. Geriatr. Psychiatry7(3) , 188–202 (1999).
   PubMed Web of Science ®Google Scholar
• Ganzini L , MillarSB, WalshJR. Drug-induced mania in the elderly. Drugs Aging3(5) , 428–435 (1993).
   PubMed Web of Science ®Google Scholar
• Abouesh A , StoneC, HobbsWR. Antimicrobial-induced mania (antibiomania): a review of spontaneous reports. J. Clin. Psychopharmacol.22(1) , 71–81 (2002).
   PubMed Web of Science ®Google Scholar
• Robinson RG . Mood disorders secondary to stroke. Semin. Clin. Neuropsychiatry2(4) , 244–251 (1997).
   PubMedGoogle Scholar
• Nakimuli-Mpungu E , MusisiS, Kiwuwa Mpungu S et al. Early-onset versus late onset HIV-related secondary mania in Uganda. Psychosomatics49(6) , 530–534 (2008).
   PubMed Web of Science ®Google Scholar
• Owe-Larsson B , SallL, SalamonE et al. HIV infection and psychiatric illness. Afr. J. Psychiatry (Johannesbg) 12(2) , 115–128 (2009).
   PubMedGoogle Scholar
• Sajatovic M . Treatment of bipolar disorder in older adults. Int. J. Geriatr. Psychiatry17(9) , 865–873 (2002).
   PubMed Web of Science ®Google Scholar
• Catterson ML , PreskornSH, MartinRL. Pharmacodynamic and pharmacokinetic considerations in geriatric psychopharmacology. Psychiatr. Clin. N. Am.20(1) , 205–218 (1997).
   PubMed Web of Science ®Google Scholar
• Sunderland T . Neurotransmission in the aging central nervous system. In: Clinical geriatric Psychopharmacology. Salzman C (Ed.). Lippincott Williams & Wilkins, PA, USA, 63–86 (2005).
   Google Scholar
• Bowden CL , BruggerAM, SwannAC et al. Efficacy of divalproex lithium and placebo in the treatment of mania. The depakote mania study group. JAMA 271(12) , 918–924 (1994).
   PubMed Web of Science ®Google Scholar
• Bowden CL , MosolovS, HranovL et al. Efficacy of valproate versus lithium in mania or mixed mania: a randomized, open 12-week trial. Int. Clin. Psychopharmacol. 25(2) , 60–67 (2010).
   PubMed Web of Science ®Google Scholar
• BALANCE Investigators and Collaborators; Geddes JR, Goodwin GM, Rendell J et al. Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial. Lancet375(9712) , 385–395 (2010).
   PubMed Web of Science ®Google Scholar
• Kessing LV , SondergardL, KvistK et al. Suicide risk in patients treated with lithium. Arch. Gen. Psychiatry 62(8) , 860–866 (2005).
   PubMed Web of Science ®Google Scholar
• Schaffer CB , GarveyMJ. Use of lithium in acutely manic elderly patients. Clin. Gerontol.3 , 58–60 (1984).
   Google Scholar
• Shulman KI , RochonP, SykoraK et al. Changing prescription patterns for lithium and valproic acid in old age: shifting practice without evidence. BMJ 326(7396) , 960–961 (2003).
   PubMedGoogle Scholar
• Blanco C , LajeG, OlfsonM et al. Trends in the treatment of bipolar disorder by outpatient psychiatrists. Am. J. Psychiatry 159(6) , 1005–1010 (2002).
   PubMed Web of Science ®Google Scholar
• Young RC , SchulbergHC, GildengersAG et al. Conceptual and methodological issues in designing a randomized, controlled treatment trial for geriatric bipolar disorder: GERI-BD. Bipolar Disord. 12(1) , 56–67 (2010).
   PubMed Web of Science ®Google Scholar
• Forester BP , StreeterCC, BerlowYA et al. Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: a lithium-7 magnetic resonance spectroscopy study. Am. J. Geriatr. Psychiatry 17(1) , 13–23 (2009).
   PubMed Web of Science ®Google Scholar
• Juurlink DN , MamdaniMM, KoppA et al. Drug-induced lithium toxicity in the elderly: a population-based study. J. Am. Geriatr. Soc. 52(5) , 794–798 (2004).
   PubMed Web of Science ®Google Scholar
• Shulman KI , SykoraK, GillSS et al. New thyroxine treatment in older adults beginning lithium therapy: implications for clinical practice. Am. J. Geriatr. Psychiatry 13(4) , 299–304 (2005).
   PubMed Web of Science ®Google Scholar
• Vestergaard P , RejnmarkL, MosekildeL. Reduced relative risk of fractures among users of lithium. Calcif. Tissue Int.77(1) , 1–8 (2005).
   PubMed Web of Science ®Google Scholar
• Gildengers AG , MulsantBH, BegleyAE et al. A pilot study of standardized treatment in geriatric bipolar disorder. Am. J. Geriatr. Psychiatry 13(4) , 319–323 (2005).
   PubMed Web of Science ®Google Scholar
• Allen MH , HirschfeldRM, WozniakPJ et al. Linear relationship of valproate serum concentration to response and optimal serum levels for acute mania. Am. J. Psychiatry 163(2) , 272–275 (2006).
   PubMed Web of Science ®Google Scholar
• Chen ST , AltshulerLL, MelnykKA et al. Efficacy of lithium. Valproate in the treatment of mania in the elderly: a retrospective study. J. Clin. Psychiatry 60(3) , 181–186 (1999).
   PubMed Web of Science ®Google Scholar
• Sandson NB , MarcucciC, BourkeDL et al. An interaction between aspirin and valproate: the relevance of plasma protein displacement drug–drug interactions. Am. J. Psychiatry 163(11) , 1891–1896 (2006).
   PubMed Web of Science ®Google Scholar
• Bowden CL , LawsonDM, CunninghamM. The role of divalproex in the treatment of bipolar disorder. Psychiatry Ann.32(12) , 742–750 (2002).
   Web of Science ®Google Scholar
• Post RM , UhdeTW, Roy-ByrnePP et al. Correlates of antimanic response to carbamazepine. Psychiatry Res. 21(1) , 71–83 (1987).
   PubMed Web of Science ®Google Scholar
• Evans DL , ByerlyMJ, GreerRA. Secondary mania: diagnosis and treatment. J. Clin. Psychiatry56(Suppl. 3) , 31–37 (1995).
   PubMedGoogle Scholar
• Battino D , CrociD, RossiniA et al. Serum carbamazepine concentrations in elderly patients: a case-matched pharmacokinetic evaluation based on therapeutic drug monitoring data. Epilepsia 44(7) , 923–929 (2003).
   PubMed Web of Science ®Google Scholar
• Chen PJ . The efficacy and blood concentration monitoring of carbamazepine on mania. Zhonghua Shen Jing Jing Shen Ke Za Zhi23(5) , 261–265, 318 (1990).
   PubMedGoogle Scholar
• Leppik IE . Issues in the treatment of epilepsy. Epilepsia.42(Suppl. 4) , 1–6 (2001).
   PubMedGoogle Scholar
• Fuller M , SajatovicM. Drug Information Handbook for Psychiatry Lexi-Comp, Inc., Cleveland, OH, USA (2009).
   Google Scholar
• Calabrese JR , BowdenCL, SachsG et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J. Clin. Psychiatry 64(9) , 1013–1024 (2003).
   PubMed Web of Science ®Google Scholar
• Bowden CL , CalabreseJR, SachsG et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch. Gen. Psychiatry 60(4) , 392–400 (2003).
   PubMed Web of Science ®Google Scholar
• Sajatovic M , GyulaiL, CalabreseJR et al. Maintenance treatment outcomes in older patients with bipolar I disorder. Am. J. Geriatr. Psychiatry 13(4) , 305–311 (2005).
   PubMed Web of Science ®Google Scholar
• Sajatovic M , GildengersA, Al Jurdi RK et al. Multi-site, open-label, prospective trial of lamotrigine for geriatric bipolar depression (2010). Presented at: The American Psychiatric Association Conference. New Orleans, LA, USA, 14–16 May 2010.
   Google Scholar
• Willmore LJ , MessenheimerJA. Adult experience with lamotrigine. J. Child Neurol.12(Suppl. 1) , S16–S18 (1997).
   PubMed Web of Science ®Google Scholar
• Messenheimer JA . Lamotrigine. Epilepsia.36(Suppl. 3) , S87–S94 (1995).
   PubMed Web of Science ®Google Scholar
• Beyer JL , SiegalA, KennedyJS. Olanzapine, divalproex and placebo treatment, non-head to head comparisons of older adults acute mania. Presented at: 10th Congress of the International Psychogeriatric Association. Nice, France, 9–14 September 2001.
   Google Scholar
• Sajatovic M , CoconceaN, IgnacioRV et al. Aripiprazole therapy in 20 older adults with bipolar disorder: a 12-week, open-label trial. J. Clin. Psychiatry 69(1) , 41–46 (2008).
   PubMed Web of Science ®Google Scholar
• Sajatovic M . Quetiapine for the treatment of depressive episodes in adults aged 55 to 65 years with bipolar disorder. Presented at: American Association of Geriatric Psychiatry (AAGP) Annual Meeting. New Orleans, LA, USA, 1–4 March 2007.
   Google Scholar
• Madhusoodanan S , BrennerR, AraujoL et al. Efficacy of risperidone treatment for psychoses associated with schizophrenia, schizoaffective disorder, bipolar disorder, or senile dementia in 11 geriatric patients: a case series. J. Clin. Psychiatry 56(11) , 514–518 (1995).
   PubMed Web of Science ®Google Scholar
• Madhusoodanan S , SureshP, BrennerR et al. Experience with the atypical antipsychotics – risperidone and olanzapine in the elderly. Ann. Clin. Psychiatry 11(3) , 113–118 (1999).
   PubMedGoogle Scholar
• Shulman RW , SinghA, ShulmanKI. Treatment of elderly institutionalized bipolar patients with clozapine. Psychopharmacol. Bull.33(1) , 113–118 (1997).
   PubMedGoogle Scholar
• American Diabetes Association, American Psychiatric Association, American Association of Clinical Endocrinologists, North American Association for the Study of Obesity. Consensus development conference on antipsychotic drugs and obesity and diabetes. Diabetes Care27(2) , 596–601 (2004).
   PubMed Web of Science ®Google Scholar
• Wang PS , SchneeweissS, AvornJ et al. Risk of death in elderly users of conventional atypical antipsychotic medications. N. Engl. J. Med. 353(22) , 2335–2341 (2005).
   PubMed Web of Science ®Google Scholar
• Kales HC , ValensteinM, KimHM et al. Mortality risk in patients with dementia treated with antipsychotics versus other psychiatric medications. Am. J. Psychiatry 164(10) , 1568–1576 (2007).
   PubMed Web of Science ®Google Scholar
• Aziz R , LorbergB, TampiRR. Treatments for late-life bipolar disorder. Am. J. Geriatr. Pharmacother.4(4) , 347–364 (2006).
   PubMedGoogle Scholar
• Crystal S , OlfsonM, HuangC et al. Broadened use of atypical antipsychotics: safety, effectiveness, and policy challenges. Health Aff. (Millwood) 28(5) , W770–W781 (2009).
   PubMed Web of Science ®Google Scholar
• Sachs GS , NierenbergAA, CalabreseJR et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N. Engl J. Med. 356(17) , 1711–1722 (2007).
   PubMed Web of Science ®Google Scholar
• Goldberg JF , PerlisRH, GhaemiSN et al. Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD. Am. J. Psychiatry 164(9) , 1348–1355 (2007).
   PubMed Web of Science ®Google Scholar
• Schaffer A , MamdaniM, LevittA et al. Effect of antidepressant use on admissions to hospital among elderly bipolar patients. Int. J. Geriatr. Psychiatry 21(3) , 275–280 (2006).
   PubMed Web of Science ®Google Scholar
• Aizenberg D , OlmerA, BarakY. Suicide attempts amongst elderly bipolar patients. J. Affect. Disord.91(1) , 91–94 (2006).
   PubMed Web of Science ®Google Scholar
• Leverich GS , AltshulerLL, FryeMA et al. Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers. Am. J. Psychiatry 163(2) , 232–239 (2006).
   PubMed Web of Science ®Google Scholar
• Duboky SL . Treatment of bipolar depression. Psychiatr. Clin. North Am.28(2) , 349–370 (2005).
   Google Scholar
• Weiner RD , CoffeyCE, FochtmannLJ et al. The Practice of Electroconvulsive Therapy. Recommendations for the Treatment, Training, and Privileging: A Task Force Report of the American Psychiatric Association Washington. American Psychiatric Association, Washington, DC, USA (2001).
   Google Scholar
• Mukherjee S , SackeimHA, SchnurDB. Electroconvulsive therapy of acute manic episodes: a review of 50 years‘ experience. Am. J. Psychiatry151(2) , 169–176 (1994).
   PubMed Web of Science ®Google Scholar
• Ciapparelli A , Dell‘OssoL, TundoA et al. Electroconvulsive therapy in medication-nonresponsive patients with mixed mania and bipolar depression. J. Clin. Psychiatry 62(7) , 552–555 (2001).
   PubMed Web of Science ®Google Scholar
• Devanand DP , PolancoP, CruzR et al. The efficacy of ECT in mixed affective states. J. ECT 16(1) , 32–37 (2000).
   PubMed Web of Science ®Google Scholar
• Gruber NP , DilsaverSC, ShoaibAM et al. ECT in mixed affective states: a case series. J. ECT 16(2) , 183–188 (2000).
   PubMed Web of Science ®Google Scholar
• Medda P , PerugiG, ZanelloS et al. Response to ECT in bipolar I, bipolar II and unipolar depression. J. Affect. Disord. 118(1–3) , 55–59 (2009).
   PubMed Web of Science ®Google Scholar
• Daly JJ , PrudicJ, DevanandDP et al. ECT in bipolar and unipolar depression: differences in speed of response. Bipolar Disord. 3(2) , 95–104 (2001).
   PubMed Web of Science ®Google Scholar
• Grunhaus L , SchreiberS, DolbergOT et al. Response to ECT in major depression: are there differences between unipolar and bipolar depression? Bipolar Disord. 4(Suppl. 1) , 91–93 (2002).
   PubMed Web of Science ®Google Scholar
• Bailine S , FinkM, KnappR et al. Electroconvulsive therapy is equally effective in unipolar and bipolar depression. Acta Psychiatr. Scand. 121(6) , 431–436 (2010).
   PubMed Web of Science ®Google Scholar
• Hallam KT , SmithDI, BerkM. Differences between subjective and objective assessments of the utility of electroconvulsive therapy in patients with bipolar and unipolar depression. J. Affect. Disord.112(1–3) , 212–218 (2009).
   PubMed Web of Science ®Google Scholar
• Tew JD Jr, Mulsant BH, Haskett RF et al. Acute efficacy of ECT in the treatment of major depression in the old-old. Am. J. Psychiatry156(12) , 1865–1870 (1999).
   PubMed Web of Science ®Google Scholar
• O‘Connor MK , KnappR, HusainM et al. The influence of age on the response of major depression to electroconvulsive therapy: A C.O.R.E. Report. Am. J. Geriatric. Psychiatry 9 , 382–390 (2001).
   PubMed Web of Science ®Google Scholar
• Dombroki AY , MulsantBH, HaskettRF et al. Predictors of remission after electroconvulsive therapy in unipolar major depression. J. Clin. Psychiatry 66 , 1043–1049 (2005).
   PubMed Web of Science ®Google Scholar
• Damm J , EserD, SchuleC et al. Influence of age on effectiveness and tolerability of electroconvulsive therapy. J. ECT 26(4) , 282–288 (2010).
   PubMed Web of Science ®Google Scholar
• Manly DT , OakleySP Jr, Bloch RM. Electroconvulsive therapy in old-old patients. Am. J. Geriatr. Psychiatry8(3) , 232–236 (2000).
   PubMed Web of Science ®Google Scholar
• Sackeim HA , PrudicJ, FullerR et al. The cognitive effects of electroconvulsive therapy in community settings. Neuropsychopharmacology 32(1) , 244–254 (2007).
   PubMed Web of Science ®Google Scholar
• Kujala I , RosenvingeB, BekkelundSI. Clinical outcome and adverse effects of electroconvulsive therapy in elderly psychiatric patients. J. Geriatr. Psychiatry Neurol.15(2) , 73–76 (2002).
   PubMed Web of Science ®Google Scholar
• Russell JC , RasmussenKG, O‘ConnorMK et al. Long-term maintenance ECT: a retrospective review of efficacy and cognitive outcome. J. ECT 19(1) , 4–9 (2003).
   PubMed Web of Science ®Google Scholar
• Vaidya NA , MahableshwarkarAR, ShahidR. Continuation and maintenance ECT in treatment-resistant bipolar disorder. J. ECT19(1) , 10–16 (2003).
   PubMed Web of Science ®Google Scholar
• Hallett M . Transcranial magnetic stimulation and the human brain. Nature406(6792) , 147–150 (2000).
   PubMed Web of Science ®Google Scholar
• Hoogendam JM , RamakersGM, Di Lazzaro V. Physiology of repetitive transcranial magnetic stimulation of the human brain. Brain Stimul.3(2) , 95–118 (2010).
   PubMed Web of Science ®Google Scholar
• Milev R , AbrahamG, HaseyG et al. Repetitive transcranial magnetic stimulation for treatment of medication-resistant depression in older adults: a case series. J. ECT 25(1) , 44–49 (2009).
   PubMed Web of Science ®Google Scholar
• Abraham G , MilevR, LazowskiL et al. Repetitive transcranial magnetic stimulation for treatment of elderly patients with depression – an open label trial. Neuropsychiatr. Dis. Treat. 3(6) , 919–924 (2007).
   PubMedGoogle Scholar
• Mosimann UP , SchmittW, GreenbergBD et al. Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patients. Psychiatry Res. 126(2) , 123–133 (2004).
   PubMed Web of Science ®Google Scholar
• Manes F , JorgeR, MorcuendeM et al. A controlled study of repetitive transcranial magnetic stimulation as a treatment of depression in the elderly. Int. Psychogeriatr. 13(2) , 225–231 (2001).
   PubMed Web of Science ®Google Scholar
• Nahas Z , LiX, KozelFA et al. Safety and benefits of distance-adjusted prefrontal transcranial magnetic stimulation in depressed patients 55–75 years of age: a pilot study. Depress. Anxiety 19(4) , 249–256 (2004).
   PubMed Web of Science ®Google Scholar
• Cohen RB , BrunoniAR, BoggioPS et al. Clinical predictors associated with duration of repetitive transcranial magnetic stimulation treatment for remission in bipolar depression: a naturalistic study. J. Nerv. Ment. Dis. 198(9) , 679–681 (2010).
   PubMed Web of Science ®Google Scholar
• Loo CK , MitchellPB. A review of the efficacy of transcranial magnetic stimulation (TMS) treatment for depression, and current and future strategies to optimize efficacy. J. Affect. Disord.88(3) , 255–267 (2005).
   PubMed Web of Science ®Google Scholar
• Rachid F , BertschyG. Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of depression: a critical appraisal of the last 10 years. Neurophysiol. Clin.36(3) , 157–183 (2006).
   PubMed Web of Science ®Google Scholar
• Xia G , GajwaniP, MuzinaDJ et al. Treatment-emergent mania in unipolar and bipolar depression: focus on repetitive transcranial magnetic stimulation. Int. J. Neuropsychopharmacol. 11(1) , 119–130 (2008).
   PubMed Web of Science ®Google Scholar
• Moser DJ , JorgeRE, ManesF et al. Improved executive functioning following repetitive transcranial magnetic stimulation. Neurology 58(8) , 1288–1290 (2002).
   PubMed Web of Science ®Google Scholar
• Huang CC , WeiIH, ChouYH et al. Effect of age, gender, menopausal status, and ovarian hormonal level on rTMS in treatment-resistant depression. Psychoneuroendocrinology 33(6) , 821–831 (2008).
   PubMed Web of Science ®Google Scholar
• Hamani C , NobregaJN. Deep brain stimulation in clinical trials and animal models of depression. Eur. J. Neurosci.32(7) , 1109–1117 (2010).
   PubMed Web of Science ®Google Scholar
• Lipsman N , McIntyreRS, GiacobbeP et al. Neurosurgical treatment of bipolar depression: defining treatment resistance and identifying surgical targets. Bipolar Disord. 12(7) , 691–701 (2010).
   PubMed Web of Science ®Google Scholar
• Neiberg RH , AickinM, GrzywaczJG et al. Occurrence and co-occurrence of types of complementary and alternative medicine use by age, gender, ethnicity, and education among adults in the United States: the 2002 national health interview survey (NHIS). J. Altern. Complement Med. 17(4) , 363–370 (2011).
   PubMed Web of Science ®Google Scholar
• Keaton D , LamkinN, CassidyKA et al. Utilization of herbal and nutritional compounds among older adults with bipolar disorder and with major depression. Int. J. Geriatr. Psychiatry 24(10) , 1087–1093 (2009).
   PubMed Web of Science ®Google Scholar
• Miklowitz DJ , OttoMW, FrankE et al. Psychosocial treatments for bipolar depression: a 1-year randomized trial from the systematic treatment enhancement program. Arch. Gen. Psychiatry 64(4) , 419–426 (2007).
   PubMed Web of Science ®Google Scholar
• Miklowitz DJ , OttoMW, WisniewskiSR et al. Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorder. Psychiatr. Serv. 57(7) , 959–965 (2006).
   PubMed Web of Science ®Google Scholar
• Frank E , SorecaI, SwartzHA et al. The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder. Am. J. Psychiatry 165(12) , 1559–1565 (2008).
   PubMed Web of Science ®Google Scholar
• Clarkin JF , CarpenterD, HullJ et al. Effects of psychoeducational intervention for married patients with bipolar disorder and their spouses. Psychiatr. Serv. 49(4) , 531–533 (1998).
   PubMed Web of Science ®Google Scholar
• Miklowitz DJ . Adjunctive psychotherapy for bipolar disorder: state of the evidence. Am. J. Psychiatry165(11) , 1408–1419 (2008).
   PubMed Web of Science ®Google Scholar
• Antognini F : Psychotherapy with Depressed Older Adults. In: Depression in Later Life: A Multidisciplinary Psychiatric Approach. Ellison JM, Verma S (Eds.), Marcel Dekker, New York, NY, USA, 257–296 (2003).
   Google Scholar
• Simon NM , SmollerJW, McNamaraKL et al. Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging. Biol. Psychiatry 60(5) , 432–435 (2006).
   PubMed Web of Science ®Google Scholar
• Yatham LN , KapczinskiF, AndreazzaAC et al. Accelerated age-related decrease in brain-derived neurotrophic factor levels in bipolar disorder. Int. J. Neuropsychopharmacol. 12(1) , 137–139 (2009).
   PubMed Web of Science ®Google Scholar
• Berk M . Neuroprogression: pathways to progressive brain changes in bipolar disorder. Int. J. Neuropsychopharmacol.12(4) , 441–445 (2009).
   PubMed Web of Science ®Google Scholar
• Kapczinski F , VietaE, AndreazzaAC et al. Allostatic load in bipolar disorder: implications for pathophysiology and treatment. Neurosci. Biobehav. Rev. 32(4) , 675–692 (2008).
   PubMed Web of Science ®Google Scholar
• Kessing LV , AndersenPK. Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder? J. Neurol. Neurosurg. Psychiatry75(12) , 1662–1666 (2004).
   PubMed Web of Science ®Google Scholar
• Sajatovic M , BlowFC, KalesHC et al. Age comparison of treatment adherence with antipsychotic medications among individuals with bipolar disorder. Int. J. Geriatr. Psychiatry 22(10) , 992–998 (2007).
   PubMed Web of Science ®Google Scholar

Websites

• US FDA. FDA Public Health Advisory: Deaths with antipsychotics in elderly patients with behavioral disturbances(2005) www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformation forPatientsandProviders/DrugSafety InformationforHeathcareProfessionals/PublicHealthAdvisories/UCM053171 (Accessed 2December2010)
   Google Scholar
• US FDA. Atypical antipsychotic drugs (2010) www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm150688.htm (Accessed 2December2010)
   Google Scholar
• US FDA. FDA requests boxed warnings on older class of antipsychotic drugs (2010) www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2008/ucm116912.htm (Accessed 2December2010).
   Google Scholar