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Editorial

Is There a Role for Vagus Nerve Stimulation in the Treatment of Posttraumatic Stress Disorder?

Pages 95-99 | Received 06 Mar 2018, Accepted 23 Mar 2018, Published online: 25 May 2018

References

  • Koenen KC , SumnerJA, GilsanzPet al. Post-traumatic stress disorder and cardiometabolic disease: improving causal inference to inform practice . Psychol. Med.47 (2), 209 – 225 (2017).
  • Kessler RC , Aguilar-GaxiolaS, AlonsoJet al. Trauma and PTSD in the WHO World Mental Health Surveys . Eur. J. Psychotraumatol.8 (sup5), 1353383 (2017).
  • Krystal JH , DavisLL, NeylanTCet al. It is time to address the crisis in the pharmacotherapy of post-traumatic stress disorder: a consensus statement of the PTSD Psychopharmacology Working Group . Biol. Psychiatry82 (7), e51 – e59 (2017).
  • Powers MB , HalpernJM, FerenschakMP, GillihanSJ, FoaEB . A meta-analytic review of prolonged exposure for post-traumatic stress disorder . Clin. Psychol. Rev.30 (6), 635 – 641 (2010).
  • Anderson KC , InselTR . The promise of extinction research for the prevention and treatment of anxiety disorders . Biol. Psychiatry60 (4), 319 – 321 (2006).
  • Milad MR , OrrSP, LaskoNB, ChangY, RauchSL, PitmanRK . Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study . J. Psychiatr. Res.42 (7), 515 – 520 (2008).
  • Boschen MJ , NeumannDL, WatersAM . Relapse of successfully treated anxiety and fear: theoretical issues and recommendations for clinical practice . Aust. N. Z. J. Psychiatry43 (2), 89 – 100 (2009).
  • Schottenbauer MA , GlassCR, ArnkoffDB, TendickV, GraySH . Nonresponse and dropout rates in outcome studies on PTSD: review and methodological considerations . Psychiatry 2008, 71 (2), 134 – 168 (2009).
  • Walker DL , ResslerKJ, LuKT, DavisM . Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats . J. Neurosci.22 (6), 2343 – 2351 (2002).
  • Davis M , ResslerK, RothbaumBO, RichardsonR . Effects of D-cycloserine on extinction: translation from preclinical to clinical work . Biol. Psychiatry60 (4), 369 – 375 (2006).
  • Litz BT , Salters-PedneaultK, SteenkampMMet al. A randomized placebo-controlled trial of D-cycloserine and exposure therapy for post-traumatic stress disorder . J. Psychiatr. Res.46 (9), 1184 – 1190 (2012).
  • Rothbaum BO , PriceM, JovanovicTet al. A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan war veterans . Am. J. Psychiatry171 (6), 640 – 648 (2014).
  • Tuerk PW , WangelinBC, PowersMBet al. Augmenting treatment efficiency in exposure therapy for PTSD: a randomized double-blind placebo-controlled trial of yohimbine HCl . Cogn. Behav. Ther.15, 1 – 21 (2018). ( Epub ahead of print).
  • LaLumiere RT , McGaughJL, McIntyreCK . Emotional modulation of learning and memory: pharmacological implications . Pharmacol. Rev.69 (3), 236 – 255 (2017).
  • McIntyre CK , McGaughJL, WilliamsCL . Interacting brain systems modulate memory consolidation . Neurosci. Biobehav. Rev.36 (7), 1750 – 1762 (2012).
  • Clark KB , KrahlSE, SmithDC, JensenRA . Post-training unilateral vagal stimulation enhances retention performance in the rat . Neurobiol. Learn Mem.63 (3), 213 – 216 (1995).
  • Clark KB , SmithDC, HassertDL, BrowningRA, NaritokuDK, JensenRA . Posttraining electrical stimulation of vagal afferents with concomitant vagal efferent inactivation enhances memory storage processes in the rat . Neurobiol. Learn Mem.70 (3), 364 – 373 (1998).
  • Clark KB , NaritokuDK, SmithDC, BrowningRA, JensenRA . Enhanced recognition memory following vagus nerve stimulation in human subjects . Nat. Neurosci.2 (1), 94 – 98 (1999).
  • Peña DF , EngineerND, McIntyreCK . Rapid remission of conditioned fear expression with extinction training paired with vagus nerve stimulation . Biol. Psychiatry73 (11), 1071 – 1077 (2013).
  • Hays SA . Enhancing rehabilitative therapies with vagus nerve stimulation . Neurotherapeutics13 (2), 382 – 394 (2016).
  • Hays SA , RennakerRL, KilgardMP . Targeting plasticity with vagus nerve stimulation to treat neurological disease . Prog. Brain Res.207, 275 – 299 (2013).
  • Hassert DL , MiyashitaT, WilliamsCL . The effects of peripheral vagal nerve stimulation at a memory-modulating intensity on norepinephrine output in the basolateral amygdala . Behav. Neurosci.118 (1), 79 – 88 (2004).
  • Hulsey DR , RileyJR, LoerwaldKW, RennakerRL, KilgardMP, HaysSA . Parametric characterization of neural activity in the locus coeruleus in response to vagus nerve stimulation . Exp. Neurol.289, 21 – 30 (2017).
  • Peña DF , ChildsJE, WillettS, VitalA, McIntyreCK, KroenerS . Vagus nerve stimulation enhances extinction of conditioned fear and modulates plasticity in the pathway from the ventromedial prefrontal cortex to the amygdala . Front. Behav. Neurosci.8, 327 (2014).
  • Alvarez-Dieppa AC , GriffinK, CavalierS, McIntyreCK . Vagus nerve stimulation enhances extinction of conditioned fear in rats and modulates Arc Protein, CaMKII, and GluN2B-Containing NMDA receptors in the basolateral amygdala . Neural Plast. 2016, 4273280 (2016).
  • Knox D , GeorgeSA, FitzpatrickCJ, RabinakCA, MarenS, LiberzonI . Single prolonged stress disrupts retention of extinguished fear in rats . Learn Mem.19 (2), 43 – 49 (2012).
  • Souza RR , NobleLJ, McIntyreCK . Using the single prolonged stress model to examine the pathophysiology of PTSD . Front. Pharmacol.8, 615 (2017).
  • Noble LJ , GonzalezIJ, MeruvaVBet al. Effects of vagus nerve stimulation on extinction of conditioned fear and post-traumatic stress disorder symptoms in rats . Transl. Psychiatry7 (8), e1217 (2017).
  • George MS , WardHE, NinanPTet al. A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders . Brain Stimul.1 (2), 112 – 121 (2008).
  • Furmaga H , ShahA, FrazerA . Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats . Biol. Psychiatry70 (10), 937 – 945 (2011).
  • Nemeroff CB , MaybergHS, KrahlSEet al. VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms . Neuropsychopharmacology31 (7), 1345 – 1355 (2006).
  • Henry TR , BakayRA, PennellPB, EpsteinCM, VotawJR . Brain blood-flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy: II. prolonged effects at high and low levels of stimulation . Epilepsia45 (9), 1064 – 1070 (2004).
  • Manta S , DongJ, DebonnelG, BlierP . Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation . J. Psychiatry Neurosci.34 (4), 272 – 280 (2009).
  • Roosevelt RW , SmithDC, CloughRW, JensenRA, BrowningRA . Increased extracellular concentrations of norepinephrine in cortex and hippocampus following vagus nerve stimulation in the rat . Brain Res.1119 (1), 124 – 132 (2006).
  • Krahl SE , ClarkKB, SmithDC, BrowningRA . Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation . Epilepsia39 (7), 709 – 714 (1998).
  • Howland RH . Vagus nerve stimulation . Curr. Behav. Neurosci. Rep.1 (2), 64 – 73 (2014).
  • Lanska DJ . J.L. Corning and vagal nerve stimulation for seizures in the 1880s . Neurology58 (3), 452 – 459 (2002).
  • Burger AM , VerkuilB, FenlonHet al. Mixed evidence for the potential of non-invasive transcutaneous vagal nerve stimulation to improve the extinction and retention of fear . Behav. Ther.97, 64 – 74 (2017).
  • Stefan H , KreiselmeyerG, KerlingFet al. Transcutaneous vagus nerve stimulation (t-VNS) in pharmacoresistant epilepsies: a proof of concept trial . Epilepsia53 (7), e115 – e118 (2012).
  • Lamb DG , PorgesEC, LewisGF, WilliamsonJB . Non-invasive vagal nerve stimulation effects on hyperarousal and autonomic state in patients with post-traumatic stress disorder and history of mild traumatic brain injury: preliminary evidence . Front. Med. (Lausanne)4, 124 (2017).
  • Agostoni E , ChinnockJE, De DalyMB, MurrayJG . Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat . J. Physiol.135 (1), 182 – 205 (1957).

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