Endostatin: A Promising Biomarker in the Cardiovascular Continuum?

References

• Seppinen L , PihlajaniemiT. The multiple functions of collagen XVIII in development and disease. Matrix Biol.30(2), 83–92 (2011).
   PubMed Web of Science ®Google Scholar
• Felbor U , DreierL, BryantRA, PloeghHL, OlsenBR, MothesW. Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J.19(6), 1187–1194 (2000).
   PubMed Web of Science ®Google Scholar
• Heljasvaara R , NybergP, LuostarinenJet al. Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases. Exp. Cell Res.307(2), 292–304 (2005).
   PubMed Web of Science ®Google Scholar
• O'reilly MS , BoehmT, ShingYet al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell88(2), 277–285 (1997).
   PubMed Web of Science ®Google Scholar
• Tjin Tham Sjin RM , Satchi-FainaroR, BirsnerAE, RamanujamVM, FolkmanJ, JavaherianK. A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity. Cancer Res.65(9), 3656–3663 (2005).
   PubMed Web of Science ®Google Scholar
• Yamaguchi Y , TakiharaT, ChambersRA, VeraldiKL, LarreginaAT, Feghali-BostwickCA. A peptide derived from endostatin ameliorates organ fibrosis. Sci. Transl. Med.4(136), 136ra171 (2012).
   Web of Science ®Google Scholar
• Sund M , XieL, KalluriR. The contribution of vascular basement membranes and extracellular matrix to the mechanics of tumor angiogenesis. APMIS112(7–8), 450–462 (2004).
   PubMed Web of Science ®Google Scholar
• Sund M , KalluriR. Tumor stroma derived biomarkers in cancer. Cancer Metastasis Rev.28(1–2), 177–183 (2009).
   PubMed Web of Science ®Google Scholar
• Rong B , YangS, LiW, ZhangW, MingZ. Systematic review and meta-analysis of Endostar (rh-endostatin) combined with chemotherapy versus chemotherapy alone for treating advanced non-small cell lung cancer. World J. Surg. Oncol.10, 170 (2012).
   PubMed Web of Science ®Google Scholar
• Gu JW , ShparagoM, TanW, BaileyAP. Tissue endostatin correlates inversely with capillary network in rat heart and skeletal muscles. Angiogenesis9(2), 93–99 (2006).
   PubMedGoogle Scholar
• Sottile J . Regulation of angiogenesis by extracellular matrix. Biochim. Biophys. Acta1654(1), 13–22 (2004).
   PubMed Web of Science ®Google Scholar
• Moulton KS , OlsenBR, SonnS, FukaiN, ZurakowskiD, ZengX. Loss of collagen XVIII enhances neovascularization and vascular permeability in atherosclerosis. Circulation110(10), 1330–1336 (2004).
   PubMed Web of Science ®Google Scholar
• Eklund L , PiuholaJ, KomulainenJet al. Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc. Natl Acad. Sci. USA98(3), 1194–1199 (2001).
   PubMed Web of Science ®Google Scholar
• Ren B , WangY, RabassedaX, WangYZ. Recombinant human endostatin is beneficial to endothelial cell growth exposed to mildly oxidized low-density lipoproteins. Methods Find. Exp. Clin. Pharmacol.24(4), 195–199 (2002).
   PubMedGoogle Scholar
• Moulton KS , HellerE, KonerdingMA, FlynnE, PalinskiW, FolkmanJ. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation99(13), 1726–1732 (1999).
   PubMed Web of Science ®Google Scholar
• Mao W , KongJ, DaiJet al. Evaluation of recombinant endostatin in the treatment of atherosclerotic plaques and neovascularization in rabbits. J. Zhejiang Univ. Sci. B11(8), 599–607 (2010).
   PubMed Web of Science ®Google Scholar
• Could a promising cancer drug cure atherosclerosis? Harv. Heart Lett. 10(1), 1–3 (1999).
   Google Scholar
• Xu X , MaoW, ChaiYet al. Angiogenesis inhibitor, endostar, prevents vasa vasorum neovascularization in a swine atherosclerosis model. J. Atheroscler. Thromb.22(10), 1100–1112 (2015).
   PubMed Web of Science ®Google Scholar
• Pu Z , WangY, ZhangYet al. The therapeuatic effect of Endostar on soft carotid plaque neovascularization in patients with non-small cell lung cancer. Sci. Rep.5, 8956 (2015).
   PubMed Web of Science ®Google Scholar
• Isobe K , KubaK, MaejimaY, SuzukiJ, KubotaS, IsobeM. Inhibition of endostatin/collagen XVIII deteriorates left ventricular remodeling and heart failure in rat myocardial infarction model. Circ. J.74(1), 109–119 (2010).
   PubMed Web of Science ®Google Scholar
• Hutter R , SauterBV, ReisEDet al. Decreased reendothelialization and increased neointima formation with endostatin overexpression in a mouse model of arterial injury. Circulation107(12), 1658–1663 (2003).
   PubMed Web of Science ®Google Scholar
• Zeng X , ChenJ, MillerYI, JavaherianK, MoultonKS. Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis. J. Lipid Res.46(9), 1849–1859 (2005).
   PubMed Web of Science ®Google Scholar
• Tian HL , ChenH, CuiYH, XuT, ZhouLF. Increased protein and mRNA expression of endostatin in the ischemic brain tissue of rabbits after middle cerebral artery occlusion. Neurosci. Bull.23(1), 35–40 (2007).
   PubMedGoogle Scholar
• Hou Q , LingL, WangF, XingS, PeiZ, ZengJ. Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke. Brain Res.1311, 182–188 (2010).
   PubMed Web of Science ®Google Scholar
• Panchal VR , RehmanJ, NguyenATet al. Reduced pericardial levels of endostatin correlate with collateral development in patients with ischemic heart disease. J. Am. Coll. Cardiol.43(8), 1383–1387 (2004).
   PubMed Web of Science ®Google Scholar
• Mitsuma W , KodamaM, HanawaHet al. Serum endostatin in the coronary circulation of patients with coronary heart disease and its relation to coronary collateral formation. Am. J. Cardiol.99(4), 494–498 (2007).
   PubMed Web of Science ®Google Scholar
• Liou JY , ShyuKG, LuMJ, ChaoHH, WangBW, KuanPL. Pericardial fluid and serum levels of vascular endothelial growth factor and endostatin in patients with or without coronary artery disease. J. Formos. Med. Assoc.105(5), 377–383 (2006).
   PubMed Web of Science ®Google Scholar
• Dzau V , BraunwaldE. Resolved and unresolved issues in the prevention and treatment of coronary artery disease: a workshop consensus statement. Am. Heart J.121(4 Pt 1), 1244–1263 (1991).
   PubMed Web of Science ®Google Scholar
• Gu JW , GadonskiG, WangJ, MakeyI, AdairTH. Exercise increases endostatin in circulation of healthy volunteers. BMC Physiol.4, 2 (2004).
   PubMedGoogle Scholar
• Bruserud O , GrovanF, LindasR, Blymke MoinichenC, OsterhusKK. Serum levels of angioregulatory mediators in healthy individuals depend on age and physical activity: studies of angiogenin, basic fibroblast growth factor, leptin and endostatin. Scand. J. Clin. Lab. Invest.65(6), 505–511 (2005).
   PubMed Web of Science ®Google Scholar
• Rullman E , RundqvistH, WagsaterDet al. A single bout of exercise activates matrix metalloproteinase in human skeletal muscle. J. Appl. Physiol. (1985)102(6), 2346–2351 (2007).
   PubMed Web of Science ®Google Scholar
• Suhr F , BrixiusK, De MareesMet al. Effects of short-term vibration and hypoxia during high-intensity cycling exercise on circulating levels of angiogenic regulators in humans. J. Appl. Physiol. (1985)103(2), 474–483 (2007).
   PubMed Web of Science ®Google Scholar
• Brixius K , SchoenbergerS, LadageDet al. Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50–60 years. Br. J. Sports Med.42(2), 126–129; discussion 129 (2008).
   PubMed Web of Science ®Google Scholar
• Makey KL , PattersonSG, RobinsonJet al. Increased plasma levels of soluble vascular endothelial growth factor receptor 1 (sFlt-1) in women by moderate exercise and increased plasma levels of vascular endothelial growth factor in overweight/obese women. Eur. J. Cancer Prev.22(1), 83–89 (2013).
   PubMed Web of Science ®Google Scholar
• Sponder M , DanglD, KampfS, Fritzer-SzekeresM, Strametz-JuranekJ. Exercise increases serum endostatin levels in female and male patients with diabetes and controls. Cardiovasc. Diabetol.13, 6 (2014).
   PubMed Web of Science ®Google Scholar
• Sponder M , SepiolK, LankischSet al. Endostatin and physical exercise in young female and male athletes and controls. Int. J. Sports Med.35(13), 1138–1142 (2014).
   PubMed Web of Science ®Google Scholar
• Vasiliadis AV , ZafeiridisA, DiplaKet al. Circulating angiogenic biomolecules at rest and in response to upper-limb exercise in individuals with spinal cord injury. J. Spinal Cord Med.37(2), 226–232 (2014).
   PubMed Web of Science ®Google Scholar
• Sponder M , Fritzer-SzekeresM, MarculescuR, LitschauerB, Strametz-JuranekJ. Physical inactivity increases endostatin and osteopontin in patients with coronary artery disease. Heart Vessels31(10), 1603–1608 (2016).
   PubMed Web of Science ®Google Scholar
• Silha JV , KrsekM, SuchardaP, MurphyLJ. Angiogenic factors are elevated in overweight and obese individuals. Int. J. Obes. (Lond.)29(11), 1308–1314 (2005).
   PubMed Web of Science ®Google Scholar
• Komorowski J , Jankiewicz-WikaJ, KolomeckiKet al. Systemic blood osteopontin, endostatin, and E-selectin concentrations after vertical banding surgery in severely obese adults. Cytokine55(1), 56–61 (2011).
   PubMed Web of Science ®Google Scholar
• Carlsson AC , RugeT, SundstromJet al. Association between circulating endostatin, hypertension duration, and hypertensive target-organ damage. Hypertension62(6), 1146–1151 (2013).
   PubMed Web of Science ®Google Scholar
• Marek-Trzonkowska N , KwieczynskaA, Reiwer-GostomskaM, KolinskiT, MoliszA, SiebertJ. Arterial hypertension is characterized by imbalance of pro-angiogenic versus anti-angiogenic factors. PLoS ONE10(5), e0126190 (2015).
   PubMed Web of Science ®Google Scholar
• Carlsson AC , OstgrenCJ, LanneT, LarssonA, NystromFH, ArnlovJ. The association between endostatin and kidney disease and mortality in patients with type 2 diabetes. Diabetes Metab.42(5), 351–357 (2016).
   PubMed Web of Science ®Google Scholar
• Futrakul N , ButthepP, LaohareungpanyaN, ChaisuriyaP, RatanabanangkoonK. A defective angiogenesis in chronic kidney disease. Ren. Fail.30(2), 215–217 (2008).
   PubMed Web of Science ®Google Scholar
• Rydzewska-Rosolowska A , BorawskiJ, MysliwiecM. High plasma endostatin level unaffected by low-molecular weight heparin in hemodialysis patients – a preliminary report. Adv. Med. Sci.54(2), 199–202 (2009).
   PubMed Web of Science ®Google Scholar
• Watorek E , PaprockaM, DusD, KopecW, KlingerM. Endostatin and vascular endothelial growth factor: potential regulators of endothelial progenitor cell number in chronic kidney disease. Pol. Arch. Med. Wewn.121(9), 296–301 (2011).
   PubMed Web of Science ®Google Scholar
• Chen J , HammLL, KleinpeterMAet al. Elevated plasma levels of endostatin are associated with chronic kidney disease. Am. J. Nephrol.35(4), 335–340 (2012).
   PubMed Web of Science ®Google Scholar
• Ruge T , CarlssonAC, LarssonTEet al. Endostatin level is associated with kidney injury in the elderly: findings from two community-based cohorts. Am. J. Nephrol.40(5), 417–424 (2014).
   PubMed Web of Science ®Google Scholar
• Carlsson AC , CarreroJJ, StenvinkelPet al. Endostatin, Cathepsin S, and Cathepsin L, and their association with inflammatory markers and mortality in patients undergoing hemodialysis. Blood Purif.39(4), 259–265 (2015).
   PubMed Web of Science ®Google Scholar
• Seko Y , FukudaS, NagaiR. Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy. Clin. Sci. (Lond.)106(5), 439–442 (2004).
   PubMed Web of Science ®Google Scholar
• Arenillas JF , Alvarez-SabinJ, MontanerJet al. Angiogenesis in symptomatic intracranial atherosclerosis: predominance of the inhibitor endostatin is related to a greater extent and risk of recurrence. Stroke36(1), 92–97 (2005).
   PubMed Web of Science ®Google Scholar
• Navarro-Sobrino M , RosellA, Hernandez-GuillamonMet al. A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke. Atherosclerosis216(1), 205–211 (2011).
   PubMed Web of Science ®Google Scholar
• Iqbal CW , DeanPG, IshitaniMB. Early-onset coronary artery disease after pediatric kidney transplantation: implicating the angiogenesis inhibitor, endostatin. Am. Surg.77(6), 731–735 (2011).
   PubMed Web of Science ®Google Scholar
• Golledge J , ClancyP, HankeyGJ, YeapBB, NormanPE. Serum endostatin concentrations are higher in men with symptoms of intermittent claudication. Dis. Markers 2014 , 298239 (2014).
   PubMed Web of Science ®Google Scholar
• Iribarren C , HerrintonLJ, DarbinianJAet al. Does the association between serum endostatin, an endogenous anti-angiogenic protein, and acute myocardial infarction differ by race? Vasc. Med. 11(1), 13–20 (2006).
   PubMed Web of Science ®Google Scholar
• Kanbay M , AfsarB, SiriopolDet al. Endostatin in chronic kidney disease: associations with inflammation, vascular abnormalities, cardiovascular events and survival. Eur. J. Intern. Med.33, 81–87 (2016).
   PubMed Web of Science ®Google Scholar
• Jungbauer CG , RiedlingerJ, BlockDet al. Panel of emerging cardiac biomarkers contributes for prognosis rather than diagnosis in chronic heart failure. Biomark. Med.8(6), 777–789 (2014).
   PubMed Web of Science ®Google Scholar
• Damico R , KolbTM, ValeraLet al. Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med.191(2), 208–218 (2015).
   PubMed Web of Science ®Google Scholar
• Ueland T , AukrustP, NymoSHet al. Predictive value of endostatin in chronic heart failure patients with poor kidney function. Cardiology130(1), 17–22 (2015).
   PubMed Web of Science ®Google Scholar
• Eleuteri E , Di StefanoA, GiordanoAet al. Prognostic value of angiopoietin-2 in patients with chronic heart failure. Int. J. Cardiol.212, 364–368 (2016).
   PubMed Web of Science ®Google Scholar
• Arnlov J , RugeT, IngelssonE, LarssonA, SundstromJ, LindL. Serum endostatin and risk of mortality in the elderly: findings from 2 community-based cohorts. Arterioscler. Thromb. Vasc. Biol.33(11), 2689–2695 (2013).
   PubMed Web of Science ®Google Scholar
• Gouya G , Siller-MatulaJM, Fritzer-SzekeresMet al. Association of endostatin with mortality in patients with chronic heart failure. Eur. J. Clin. Invest.44(2), 125–135 (2014).
   PubMed Web of Science ®Google Scholar
• Zorick TS , MustacchiZ, BandoSYet al. High serum endostatin levels in Down syndrome: implications for improved treatment and prevention of solid tumours. Eur. J. Hum. Genet.9(11), 811–814 (2001).
   PubMed Web of Science ®Google Scholar
• Bloor CM . Angiogenesis during exercise and training. Angiogenesis8(3), 263–271 (2005).
   PubMedGoogle Scholar
• Zhang Y , YuanH, SunY, WangY, WangA. The effects of ethanol on angiogenesis after myocardial infarction, and preservation of angiogenesis with rosuvastatin after heavy drinking. Alcohol54, 27–32 (2016).
   PubMed Web of Science ®Google Scholar
• Elmadhun NY , SabeAA, LassalettaAD, SellkeFW. Ethanol promotes new vessel growth in remote nonischemic myocardium. J. Surg. Res.193(2), 536–542 (2015).
   PubMed Web of Science ®Google Scholar
• Rupnick MA , PanigrahyD, ZhangCYet al. Adipose tissue mass can be regulated through the vasculature. Proc. Natl Acad. Sci. USA99(16), 10730–10735 (2002).
   PubMed Web of Science ®Google Scholar
• Wang H , ChenY, LuXA, LiuG, FuY, LuoY. Endostatin prevents dietary-induced obesity by inhibiting adipogenesis and angiogenesis. Diabetes64(7), 2442–2456 (2015).
   PubMed Web of Science ®Google Scholar
• Marchesi C , EssalmaniR, LemarieCAet al. Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. J. Mol. Med. (Berl.)89(11), 1103–1111 (2011).
   PubMed Web of Science ®Google Scholar
• Van Varik BJ , RennenbergRJ, ReutelingspergerCP, KroonAA, De LeeuwPW, SchurgersLJ. Mechanisms of arterial remodeling: lessons from genetic diseases. Front. Genet.3, 290 (2012).
   PubMedGoogle Scholar
• Sunshine SB , DallabridaSM, DurandEet al. Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition. Proc. Natl Acad. Sci. USA109(28), 11306–11311 (2012).
   PubMed Web of Science ®Google Scholar
• Wenzel D , SchmidtA, ReimannKet al. Endostatin, the proteolytic fragment of collagen XVIII, induces vasorelaxation. Circ. Res.98(9), 1203–1211 (2006).
   PubMed Web of Science ®Google Scholar
• Bugger H , AbelED. Molecular mechanisms of diabetic cardiomyopathy. Diabetologia57(4), 660–671 (2014).
   PubMed Web of Science ®Google Scholar
• Fioretto P , MauerM. Histopathology of diabetic nephropathy. Semin. Nephrol.27(2), 195–207 (2007).
   PubMed Web of Science ®Google Scholar
• Berria R , WangL, RichardsonDKet al. Increased collagen content in insulin-resistant skeletal muscle. Am. J. Physiol. Endocrinol. Metab.290(3), E560–E565 (2006).
   PubMed Web of Science ®Google Scholar
• Lin , ChunTH, KangL. Adipose extracellular matrix remodelling in obesity and insulin resistance. Biochem. Pharmacol.119, 8–16 (2016).
   PubMed Web of Science ®Google Scholar
• Sodha NR , BoodhwaniM, ClementsRT, XuSH, KhabbazKR, SellkeFW. Increased antiangiogenic protein expression in the skeletal muscle of diabetic swine and patients. Arch. Surg.143(5), 463–470 (2008).
   PubMedGoogle Scholar
• Matyal R , MahmoodF, RobichMet al. Chronic type II diabetes mellitus leads to changes in neuropeptide Y receptor expression and distribution in human myocardial tissue. Eur. J. Pharmacol.665(1–3), 19–28 (2011).
   PubMed Web of Science ®Google Scholar
• Sodha NR , ClementsRT, BoodhwaniMet al. Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. Am. J. Physiol. Heart Circ. Physiol.296(2), H428–H434 (2009).
   PubMed Web of Science ®Google Scholar
• Shimizu M , FurusyoN, TanakaYet al. The relation of postprandial plasma glucose and serum endostatin to the urinary albumin excretion of residents with prediabetes: results from the Kyushu and Okinawa Population Study (KOPS). Int. Urol. Nephrol.48(6), 851–857 (2016).
   PubMed Web of Science ®Google Scholar
• Hamano Y , OkudeT, ShiraiRet al. Lack of collagen XVIII/endostatin exacerbates immune-mediated glomerulonephritis. J. Am. Soc. Nephrol.21(9), 1445–1455 (2010).
   PubMed Web of Science ®Google Scholar
• Maciel TT , CoutinhoEL, SoaresD, AcharE, SchorN, BelliniMH. Endostatin, an antiangiogenic protein, is expressed in the unilateral ureteral obstruction mice model. J. Nephrol.21(5), 753–760 (2008).
   PubMed Web of Science ®Google Scholar
• Rudnicki M , PercoP, EnrichJet al. Hypoxia response and VEGF-A expression in human proximal tubular epithelial cells in stable and progressive renal disease. Lab. Invest.89(3), 337–346 (2009).
   PubMed Web of Science ®Google Scholar
• Tanaka T , NangakuM. Angiogenesis and hypoxia in the kidney. Nat. Rev. Nephrol.9(4), 211–222 (2013).
   PubMed Web of Science ®Google Scholar
• Yang XX , HuZP, ChanE, DuanW, ZhouS. Pharmacokinetics of recombinant human endostatin in rats. Curr. Drug Metab.7(6), 565–576 (2006).
   PubMed Web of Science ®Google Scholar
• Inker LA , EckfeldtJ, LeveyASet al. Expressing the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) cystatin C equations for estimating GFR with standardized serum cystatin C values. Am. J. Kidney Dis.58(4), 682–684 (2011).
   PubMed Web of Science ®Google Scholar
• Campbell DJ , SomaratneJB, JenkinsAJet al. Reduced microvascular density in non-ischemic myocardium of patients with recent non-ST-segment-elevation myocardial infarction. Int. J. Cardiol.167(3), 1027–1037 (2013).
   PubMed Web of Science ®Google Scholar
• Suri MF , JohnstonSC. Epidemiology of intracranial stenosis. J. Neuroimaging19(Suppl. 1), S11–S16 (2009).
   PubMed Web of Science ®Google Scholar
• Arenillas JF , Alvarez-SabinJ. Basic mechanisms in intracranial large-artery atherosclerosis: advances and challenges. Cerebrovasc. Dis.20(Suppl. 2), 75–83 (2005).
   PubMedGoogle Scholar
• Jing Q , XinyuQ, RougchengL. Recombinant human endostatin-associated acute left heart failure. Clin. Oncol. (R. Coll. Radiol.)20(3), 268 (2008).
   PubMed Web of Science ®Google Scholar
• Qin J , ZhangPH, QianXY, KangSJ, LuoRC, WangYG. [Assessment of the cardiotoxicity of recombinant human endostatin using myocardial biochemical markers in cancer patients]. Nan Fang Yi Ke Da Xue Xue Bao28(6), 930–932 (2008).
   PubMedGoogle Scholar
• Hefler L , TempferC, KainzC, ObermairA. Serum concentrations of endostatin in patients with vulvar cancer. Gynecol. Oncol.74(1), 151–152 (1999).
   PubMedGoogle Scholar
• Wickstrom SA . Endostatin in the Regulation of Endothelial Cell–Matrix Interactions and Pericellular Proteolysis (E-thesis), ISBN952-10-1724-4. Biomedicum, Helsinki, Finland (2004). http://ethesis.helsinki.fi.
   Google Scholar