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Review

Molecular Biomarkers in Stroke Diagnosis and Prognosis

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Pages 363-383 | Published online: 06 Aug 2009

Bibliography

  • Rosamond W , FlegalK, FurieKet al.: Heart disease and stroke statistics – 2008 update: a report from the american heart association statistics committee and stroke statistics subcommittee.Circulation117(4), e25–e146 (2008).
  • Goldstein LB , AdamsR, AlbertsMJet al.: Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: the American Academy of Neurology affirms the value of this guideline.Stroke37(6), 1583–1633 (2006).
  • Sacco RL , AdamsR, AlbersGet al.: Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline.Stroke37(2), 577–617 (2006).
  • Adams RJ , AlbersG, AlbertsMJet al.: Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack.Stroke39(5), 1647–1652 (2008).
  • Alpert JS , ThygesenK, AntmanE, BassandJP: Myocardial infarction redefined – a consensus document of the joint european society of Cardiology/American college of cardiology committee for the redefinition of myocardial infarction.J. Am. Coll. Cardiol.36(3), 959–969 (2000).
  • Dirnagl U , IadecolaC, MoskowitzMA: Pathobiology of ischaemic stroke: an integrated view.Trends Neurosci.22(9), 391–397 (1999).
  • Lee JM , ZipfelGJ, ChoiDW: The changing landscape of ischaemic brain injury mechanisms.Nature399(6738), A7–A14 (1999).
  • Schaller B , GrafR: Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy.J. Cereb. Blood Flow Metab.24(4), 351–371 (2004).
  • Doyle KP , SimonRP, Stenzel-PooreMP: Mechanisms of ischemic brain damage.Neuropharmacology55(3), 310–318 (2008).
  • Hallenbeck JM : The many faces of tumor necrosis factor in stroke.Nat. Med.8(12), 1363–1368 (2002).
  • Mun-Bryce S , RosenbergGA: Matrix metalloproteinases in cerebrovascular disease.J. Cereb. Blood Flow Metab.18(11), 1163–1172 (1998).
  • Rose JC , MayerSA: Optimizing blood pressure in neurological emergencies.Neurocrit. Care1(3), 287–299 (2004).
  • Adhami F , LiaoG, MorozovYMet al.: Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.Am. J. Pathol.169(2), 566–583 (2006).
  • Kögel D , PetersM, KönigHGet al.: S100B potently activates p65/c-rel transcriptional complexes in hippocampal neurons: clinical implications for the role of S100B in excitotoxic brain injury.Neuroscience127(4), 913–920 (2004).
  • Rothermundt M , PetersM, PrehnJH, AroltV: S100B in brain damage and neurodegeneration.Microsc. Res. Tech.60(6), 614–632 (2003).
  • Foerch C , OttoB, SingerOCet al.: Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion.Stroke35(9), 2160–2164 (2004).
  • Persson L , HardemarkH, EdnerG, RonneE, Mendel-HartvigI, PahlmanS: S-100 protein in cerebrospinal fluid of patients with subarachnoid haemorrhage: a potential marker of brain damage.Acta Neurochir. (Wien)93(3–4), 116–122 (1988).
  • Jauch EC , LindsellC, BroderickJet al.: Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator stroke study.Stroke37(10), 2508–2513 (2006).
  • Foerch C , WunderlichMT, DvorakFet al.: Elevated serum S100B levels indicate a higher risk of hemorrhagic transformation after thrombolytic therapy in acute stroke.Stroke38(9), 2491–2495 (2007).
  • Delgado P , Alvarez-SabínJ, SantamarinaEet al.: Plasma S100B level after acute spontaneous intracerebral hemorrhage.Stroke37(11), 2837–2839 (2006).
  • Hill MD , JackowskiG, BayerN, LawrenceM, JaeschkeR: Biochemical markers in acute ischemic stroke.CMAJ162(8), 1139–1140 (2000).
  • Anderson RE , HanssonLO, NilssonO, Dijlai-MerzougR, SettergrenG: High serum S100B levels for trauma patients without head injuries.Neurosurgery48(6), 1255–1258; discussion 1258–1260 (2001).
  • Fazio V , BhudiaSK, MarchiN, AumayrB, JanigroD: Peripheral detection of S100β during cardiothoracic surgery: what are we really measuring?Ann. Thorac. Surg.78(1), 46–43 (2004).
  • Anderson RE , HanssonLO, NilssonO, LiskaJ, SettergrenG, VaageJ: Increase in serum S100A1-B and S100BB during cardiac surgery arises from extracerebral sources.Ann. Thorac. Surg.71(5), 1512–1517 (2001).
  • Rainer TH , WongKS, LamW, LamNY, GrahamCA, LoYM: Comparison of plasma β-globin DNA and S-100 protein concentrations in acute stroke.Clin. Chim. Acta376(1–2), 190–196 (2007).
  • Marchi N , CavagliaM, FazioV, BhudiaS, HalleneK, JanigroD: Peripheral markers of blood-brain barrier damage.Clin. Chim. Acta342(1–2), 1–12 (2004).
  • Vogelbaum MA , MasarykT, MazzonePet al.: S100b as a predictor of brain metastases: brain versus cerebrovascular damage.Cancer104(4), 817–824 (2005).
  • Pelinka LE , KroepflA, SchmidhammerRet al.: Glial fibrillary acidic protein in serum after traumatic brain injury and multiple trauma.J. Trauma57(5), 1006-1012 (2004).
  • Aurell A , RosengrenLE, KarlssonB, OlssonJE, ZbornikovaV, HaglidKG: Determination of S-100 and glial fibrillary acidic protein concentrations in cerebrospinal fluid after brain infarction.Stroke22(10), 1254–1258 (1991).
  • Herrmann M , VosP, WunderlichMT, de BruijnC, LamersKJ: Release of glial tissue-specific proteins after acute stroke: a comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein. Stroke31(11), 2670–2677 (2000).
  • Foerch C , CurdtI, YanBet al.: Serum glial fibrillary acidic protein as a biomarker for intracerebral haemorrhage in patients with acute stroke.J. Neurol. Neurosurg. Psychiatr.77(2), 181–184 (2006).
  • Cohen SR , BrooksBR, HerndonRM, McKhannGM: A diagnostic index of active demyelination: myelin basic protein in cerebrospinal fluid.Ann. Neurol.8(1), 25–31 (1980).
  • Matias-Guiu J , Martinez-VazquezJ, RuibalA, ColomerR, BoadaM, CodinaA: Myelin basic protein and creatine kinase BB isoenzyme as CSF markers of intracranial tumors and stroke.Acta Neurol. Scand.73(5), 461–465 (1986).
  • Veerkamp JH , ZimmermanAW: Fatty acid-binding proteins of nervous tissue.J. Mol. Neurosci.16(2–3), 133–137 (2001).
  • Wunderlich MT , HanhoffT, GoertlerMet al.: Release of brain-type and heart-type fatty acid-binding proteins in serum after acute ischaemic stroke.J. Neurol.252(6), 718–724 (2005).
  • Pelsers MM , HanhoffT, Van dV et al.: Brain- and heart-type fatty acid-binding proteins in the brain: tissue distribution and clinical utility. Clin. Chem.50(9), 1568–1575 (2004).
  • Liao J , ChanCP, CheungYCet al.: Human heart-type fatty acid-binding protein for on-site diagnosis of early acute myocardial infarction.Int. J. Cardiol.133(3), 420–423 (2009).
  • Zimmerman AW , van MoerkerkH, VeerkampJH: Ligand specificity and conformational stability of human fatty acid-binding proteins. Int. J. Biochem. Cell Biol.33(9), 865–876 (2001).
  • Zimmermann-Ivol CG , BurkhardPR, Le Floch-RohrJ, AllardL, HochstrasserDF, SanchezJC: Fatty acid binding protein as a serum marker for the early diagnosis of stroke: a pilot study. Mol. Cell. Proteomics3(1), 66–72 (2004).
  • Persson L , HardemarkHG, GustafssonJet al.: S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system.Stroke18(5), 911–918 (1987).
  • Anand N , SteadLG: Neuron-specific enolase as a marker for acute ischemic stroke: a systematic review.Cerebrovasc. Dis.20(4), 213–219 (2005).
  • Fassbender K , SchmidtR, SchreinerAet al.: Leakage of brain-originated proteins in peripheral blood: temporal profile and diagnostic value in early ischemic stroke.J. Neurol. Sci.148(1), 101–105 (1997).
  • Casmiro M , MaitanS, De Pasquale F et al.: Cerebrospinal fluid and serum neuron-specific enolase concentrations in a normal population. Eur. J. Neurol.12(5), 369–374 (2005).
  • Wunderlich MT , LinsH, SkalejM, WalleschCW, GoertlerM: Neuron-specific enolase and tau protein as neurobiochemical markers of neuronal damage are related to early clinical course and long-term outcome in acute ischemic stroke.Clin. Neurol. Neurosurg.108(6), 558–563 (2006).
  • Stevens H , JakobsC, de JagerA, CunninghamRT, KorfJ: Neurone-specific enolase and N-acetyl-aspartate as potential peripheral markers of ischaemic stroke. Eur. J. Clin. Invest.29(1), 6–11 (1999).
  • Williams DR : Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau.Intern. Med. J.36(10), 652–660 (2006).
  • Hesse C , RosengrenL, VanmechelenEet al.: Cerebrospinal fluid markers for Alzheimer‘s disease evaluated after acute ischemic stroke.J. Alzheimers Dis.2(3–4), 199–206 (2000).
  • Hesse C , RosengrenL, AndreasenNet al.: Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke.Neurosci. Lett.297(3), 187–190 (2001).
  • Lidstrom AM , HesseC, RosengrenL, FredmanP, DavidssonP, BlennowK: Normal levels of clusterin in cerebrospinal fluid in Alzheimer‘s disease, and no change after acute ischemic stroke.J. Alzheimers Dis.3(5), 435–442 (2001).
  • Rosengren LE , KarlssonJE, KarlssonJO, PerssonLI, Wikkels⊘C: Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF.J. Neurochem.67(5), 2013–2018 (1996).
  • Baslow MH : Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review.Neurochem. Int.40(4), 295–300 (2002).
  • Petroff OA , GrahamGD, BlamireAMet al.: Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes.Neurology42(7), 1349–1354 (1992).
  • Sager TN , LaursenH, HansenAJ: Changes in N-acetyl-aspartate content during focal and global brain ischemia of the rat.J. Cereb. Blood Flow Metab.15(4), 639–646 (1995).
  • Sager TN , HansenAJ, LaursenH: Correlation between N-acetylaspartate levels and histopathologic changes in cortical infarcts of mice after middle cerebral artery occlusion.J. Cereb. Blood Flow Metab.20(5), 780–788 (2000).
  • Pereira AC , SaundersDE, DoyleVLet al.: Measurement of initial N-acetyl aspartate concentration by magnetic resonance spectroscopy and initial infarct volume by MRI predicts outcome in patients with middle cerebral artery territory infarction.Stroke30(8), 1577–1582 (1999).
  • Saunders DE : MR spectroscopy in stroke.Br. Med. Bull.56(2), 334–345 (2000).
  • Walker PM , Ben SalemD, LalandeA, GiroudM, BrunotteF: Time course of NAA T2 and ADC(w) in ischaemic stroke patients: 1H MRS imaging and diffusion-weighted MRI. J. Neurol. Sci.220(1–2), 23–28 (2004).
  • Elting JW , SulterGA, LangedijkM, LuijckxGJ, TeelkenAW, De KeyserJ: N-acetylaspartate: serum marker of reperfusion in ischemic stroke. J. Stroke Cerebrovasc. Dis.13(6), 254–258 (2004).
  • Dambinova SA , KhounteevGA, SkorometsAA: Multiple panel of biomarkers for TIA/stroke evaluation.Stroke33(5), 1181–1182 (2002).
  • Dambinova SA , KhounteevGA, IzykenovaGA, ZavolokovIG, IlyukhinaAY, SkorometsAA: Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke.Clin. Chem.49(10), 1752–1762 (2003).
  • Allard L , LescuyerP, BurgessJet al.: ApoC-I and ApoC-III as potential plasmatic markers to distinguish between ischemic and hemorrhagic stroke.Proteomics4(8), 2242–2251 (2004).
  • Dai FF , ZhangY, KangYet al.: The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion.J. Biol. Chem.281(31), 21942–21953 (2006).
  • Laterza OF , ModurVR, CrimminsDLet al.: Identification of novel brain biomarkers.Clin. Chem.52(9), 1713–1721 (2006).
  • Tran ND , WongVL, SchreiberSS, BreadyJV, FisherM: Regulation of brain capillary endothelial thrombomodulin mRNA expression.Stroke27(12), 2304–2301 (1996).
  • Olivot JM , LabreucheJ, De Broucker T et al.: Thrombomodulin gene polymorphisms in brain infarction and mortality after stroke. J. Neurol.255(4), 514–519 (2008).
  • Olivot JM , LabreucheJ, AiachM, AmarencoP, InvestigatorsG: Soluble thrombomodulin and brain infarction: case–control and prospective study.Stroke35(8), 1946–1951 (2004).
  • Nomura E , KohriyamaT, KozukaK, KajikawaH, NakamuraS, MatsumotoM: Significance of serum soluble thrombomodulin level in acute cerebral infarction.Eur. J. Neurol.11(5), 329–334 (2004).
  • Kozuka K , KohriyamaT, NomuraE, IkedaJ, KajikawaH, NakamuraS: Endothelial markers and adhesion molecules in acute ischemic stroke – sequential change and differences in stroke subtype.Atherosclerosis161(1), 161–168 (2002).
  • Bushnell C , SiddiqiZ, MorgenlanderJ, GoldsteinL: Use of specialized coagulation testing in the evaluation of patients with acute ischemic stroke.Neurology56(5), 624–627 (2001).
  • Bushnell C , SiddiqiZ, GoldsteinL: Improving patient selection for coagulopathy testing in the setting of acute ischemic stroke.Neurology57(7), 1333–1335 (2001).
  • Levine SR , BreyRL, TilleyBCet al.: Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke.JAMA291(5), 576–584 (2004).
  • Tapson VF : Acute pulmonary embolism.N. Engl. J. Med.358(10), 1037–1052 (2008).
  • Beamer NB , CoullBM, ClarkWM, HazelJS, SilbergerJR: Interleukin-6 and interleukin-1 receptor antagonist in acute stroke.Ann. Neurol.37(6), 800–805 (1995).
  • Di Napoli M , PapaF, BocolaV: Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke.Stroke32(1), 133–138 (2001).
  • Di Napoli M , SinghP: Is plasma fibrinogen useful in evaluating ischemic stroke patients? why, how, and when.Stroke40(5), 1549–1552 (2009).
  • Barber M , LanghorneP, RumleyA, LoweGD, StottDJ: Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression.Stroke35(6), 1421–1425 (2004).
  • Barber M , LanghorneP, RumleyA, LoweGD, StottDJ: D-dimer predicts early clinical progression in ischemic stroke: confirmation using routine clinical assays.Stroke37(4), 1113–1115 (2006).
  • Delgado P , Alvarez-SabínJ, AbilleiraSet al.: Plasma D-dimer predicts poor outcome after acute intracerebral hemorrhage.Neurology67(1), 94–98 (2006).
  • Welsh P , BarberM, LanghorneP, RumleyA, LoweGD, StottDJ: Associations of inflammatory and haemostatic biomarkers with poor outcome in acute ischaemic stroke.Cerebrovasc. Dis.27(3), 247–253 (2009).
  • Feinberg WM , EricksonLP, BruckD, KittelsonJ: Hemostatic markers in acute ischemic stroke. association with stroke type, severity, and outcome.Stroke27(8), 1296–1300 (1996).
  • Carter AM , CattoAJ, MansfieldMW, BamfordJM, GrantPJ: Predictive variables for mortality after acute ischemic stroke.Stroke38(6), 1873–1880 (2007).
  • Fon EA , MackeyA, CôtéRet al.: Hemostatic markers in acute transient ischemic attacks.Stroke25(2), 282–286 (1994).
  • Carrieri P , OreficeG, IndacoA: No effect of acetylsalicylic acid on B-thromboglobulin and platelet factor 4 plasma levels in patients with transient ischaemic attacks.Stroke17(6), 1153–1155 (1986).
  • Shah AB , BeamerN, CoullBM: Enhanced in vivo platelet activation in subtypes of ischemic stroke.Stroke16(4), 643–647 (1985).
  • Kang DW , YooSH, ChunSet al.: Inflammatory and hemostatic biomarkers associated with early recurrent ischemic lesions in acute ischemic stroke.Stroke40(5), 1653–165 8 (2009).
  • Haapaniemi E , TatlisumakT: Is D-dimer helpful in evaluating stroke patients? A systematic review.Acta Neurol. Scand.119(3), 141–150 (2009).
  • Ay H , ArsavaEM, GungorLet al.: Admission international normalized ratio and acute infarct volume in ischemic stroke.Ann. Neurol.64(5), 499–506 (2008).
  • Montaner J , RibóM, MonasterioJ, MolinaCA, Alvarez-SabínJ: Thrombin-activable fibrinolysis inhibitor levels in the acute phase of ischemic stroke.Stroke34(4), 1038–1040 (2003).
  • Arenillas JF , Alvarez-SabínJ, MolinaCAet al.: Progression of symptomatic intracranial large artery atherosclerosis is associated with a proinflammatory state and impaired fibrinolysis.Stroke39(5), 1456–1463 (2008).
  • Ribó M , MontanerJ, MolinaCA, ArenillasJF, SantamarinaE, Alvarez-SabínJ: Admission fibrinolytic profile predicts clot lysis resistance in stroke patients treated with tissue plasminogen activator.Thromb. Haemost.91(6), 1146–1151 (2004).
  • Ribó M , MontanerJ, MolinaCAet al.: Admission fibrinolytic profile is associated with symptomatic hemorrhagic transformation in stroke patients treated with tissue plasminogen activator.Stroke35(9), 2123–2127 (2004).
  • Fernandez-Cadenas I , Alvarez-SabínJ, RiboMet al.: Influence of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 gene polymorphisms on tissue-type plasminogen activator-induced recanalization in ischemic stroke patients.J. Thromb. Haemost.5(9), 1862–1868 (2007).
  • Emsley HC , SmithCJ, GavinCMet al.: Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production.BMC Neurol.7, 5 (2007).
  • Kim JS , YoonSS, KimYH, RyuJS: Serial measurement of interleukin-6, transforming growth factor-β, and S-100 protein in patients with acute stroke.Stroke27(9), 1553–1557 (1996).
  • Montaner J , Alvarez-SabínJ, BarberáGet al.: Correlation between the expression of proinflammatory cytokines and matrix metalloproteinases in the acute phase of an ischemic stroke.Rev. Neurol.33(2), 115–118 (2001).
  • Dziedzic T , BartusS, KlimkowiczA, MotylM, SlowikA, SzczudlikA: Intracerebral hemorrhage triggers interleukin-6 and interleukin-10 release in blood.Stroke33(9), 2334–2335 (2002).
  • Montaner J , RoviraA, MolinaCAet al.: Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke.J. Cereb. Blood Flow Metab.23(12), 1403–1407 (2003).
  • Montaner J , ChacónP, KrupinskiJet al.: Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial.Eur. J. Neurol.15(1), 82–90 (2008).
  • Emsley HC , SmithCJ, GavinCMet al.: An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis.J. Neuroimmunol.139(1–2), 93–101 (2003).
  • Sotgiu S , ZandaB, MarchettiBet al.: Inflammatory biomarkers in blood of patients with acute brain ischemia.Eur. J. Neurol.13(5), 505–513 (2006).
  • Sotgiu S , BaroneR, ZandaBet al.: Chitotriosidase in patients with acute ischemic stroke.Eur. Neurol.54(3), 149–153 (2005).
  • Vila N , CastilloJ, DávalosA, ChamorroA: Proinflammatory cytokines and early neurological worsening in ischemic stroke.Stroke31(10), 2325–2329 (2000).
  • Vila N , CastilloJ, DávalosA, EsteveA, PlanasAM, ChamorroA: Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke.Stroke34(3), 671–675 (2003).
  • Smith CJ , EmsleyHC, GavinCMet al.: Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome.BMC Neurol.4, 2 (2004).
  • Qizilbash N , LewingtonSL, Lopez-ArrietaJM: Corticosteroids for acute ischaemic stroke.Cochrane Database Syst. Rev.2(2), CD000064 (2002).
  • Casas JP , ShahT, HingoraniAD, DaneshJ, PepysMB: C-reactive protein and coronary heart disease: a critical review.J. Intern. Med.264(4), 295–314 (2008).
  • Kuhlmann CR , LibrizziL, CloshenDet al.: Mechanisms of C-reactive protein-induced blood–brain barrier disruption.Stroke40(4), 1458-66 (2009).
  • Rost NS , WolfPA, KaseCSet al.: Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study.Stroke32(11), 2575–2579 (2001).
  • Montaner J , Fernandez-CadenasI, MolinaCAet al.: Poststroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis.Stroke37(5), 1205–1210 (2006).
  • Arenillas JF , Alvarez-SabínJ, MolinaCAet al.: C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease.Stroke34(10), 2463–2468 (2003).
  • Purroy F , MontanerJ, MolinaCAet al.: C-reactive protein predicts further ischemic events in transient ischemic attack patients.Acta Neurol. Scand.115(1), 60–66 (2007).
  • Rosell A , Ortega-AznarA, Alvarez-SabánJet al.: Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke.Stroke37(6), 1399–1406 (2006).
  • Abilleira S , MontanerJ, MolinaCA, MonasterioJ, CastilloJ, Alvarez-SabínJ: Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage.J. Neurosurg.99(1), 65–70 (2003).
  • Montaner J , Alvarez-SabínJ, MolinaCet al.: Matrix metalloproteinase expression after human cardioembolic stroke: temporal profile and relation to neurological impairment.Stroke32(8), 1759–1766 (2001).
  • Montaner J , Alvarez-SabínJ, MolinaCAet al.: Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke.Stroke32(12), 2762–2767 (2001).
  • Montaner J , MolinaCA, MonasterioJet al.: Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke.Circulation107(4), 598–603 (2003).
  • Ning M , FurieKL, KoroshetzWJet al.: Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke.Neurology66(10), 1550–1555 (2006).
  • Castellanos M , SobrinoT, MillanMet al.: Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: a multicenter confirmatory study.Stroke38(6), 1855–1859 (2007).
  • Rosell A , Alvarez-SabínJ, ArenillasJFet al.: A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke.Stroke36(7), 1415–1420 (2005).
  • Alvarez-Sabín J , DelgadoP, AbilleiraSet al.: Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome.Stroke35(6), 1316–1322 (2004).
  • Rabuffetti M , ScioratiC, TarozzoG, ClementiE, ManfrediAA, BeltramoM: Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines.J. Neurosci.20(12), 4398–4404 (2000).
  • Cohen GM : Caspases: the executioners of apoptosis.Biochem. J.326(Pt 1), 1–16 (1997).
  • Bratton SB , MacFarlaneM, CainK, CohenGM: Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis.Exp. Cell Res.256(1), 27–33 (2000).
  • Broughton BR , ReutensDC, SobeyCG: Apoptotic mechanisms after cerebral ischemia.Stroke40(5), e331–e339 (2009).
  • Rosell A , CuadradoE, Alvarez-SabínJet al.: Caspase-3 is related to infarct growth after human ischemic stroke.Neurosci. Lett.430(1), 1–6 (2008).
  • Delgado P , CuadradoE, RosellAet al.: Fas system activation in perihematomal areas after spontaneous intracerebral hemorrhage.Stroke39(6), 1730–1734 (2008).
  • Rainer TH , WongLK, LamWet al.: Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke.Clin. Chem.49(4), 562–569 (2003).
  • Cherubini A , RuggieroC, PolidoriMC, MecocciP: Potential markers of oxidative stress in stroke.Free Radic. Biol. Med.39(7), 841–852 (2005).
  • Heistad DD , WakisakaY, MillerJ, ChuY, Pena-SilvaR: Novel aspects of oxidative stress in cardiovascular diseases.Circ. J.73(2), 201–207 (2009).
  • Alexandrova M , BochevP, MarkovaVet al.: Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome.J. Clin. Neurosci.11(5), 501–506 (2004).
  • Kelly PJ , MorrowJD, NingMet al.: Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the biomarker evaluation for antioxidant therapies in stroke (BEAT-stroke) study.Stroke39(1), 100–104 (2008).
  • Liu H , UnoM, KitazatoKTet al.: Peripheral oxidative biomarkers constitute a valuable indicator of the severity of oxidative brain damage in acute cerebral infarction.Brain Res.1025(1–2), 43–50 (2004).
  • Sinha MK , GazeDC, TippinsJR, CollinsonPO, KaskiJC: Ischemia modified albumin is a sensitive marker of myocardial ischemia after percutaneous coronary intervention.Circulation107(19), 2403–2405 (2003).
  • Gunduz A , MenteseA, TurediSet al.: Serum ischaemia-modified albumin increases in critical lower limb ischaemia.Emerg. Med. J.25(6), 351–353 (2008).
  • Gunduz A , TurediS, MenteseAet al.: Ischemia-modified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study.Am. J. Emerg. Med.26(2), 202–205 (2008).
  • Mentese A , MenteseU, TurediSet al.: Effect of deep vein thrombosis on ischaemia-modified albumin levels.Emerg. Med. J.25(12), 811–814 (2008).
  • Abboud H , LabreucheJ, MeseguerEet al.: Ischemia-modified albumin in acute strokeCerebrovasc. Dis.23(2–3), 216–220 (2007).
  • Allard L , BurkhardPR, LescuyerPet al.: PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke.Clin. Chem.51(11), 2043–2051 (2005).
  • Tomitori H , UsuiT, SaekiNet al.: Polyamine oxidase and acrolein as novel biochemical markers for diagnosis of cerebral stroke.Stroke36(12), 2609–2613 (2005).
  • Allard L , TurckN, BurkhardPRet al.: Ubiquitin fusion degradation protein 1 as a blood marker for the early diagnosis of ischemic stroke.Biomark. Insights2, 155–164 (2007).
  • Turck N , AllardL, WalterNet al.: GSTP1 and UFD1 as early blood biomarkers of acute stroke.Cerebrovasc. Dis.21, 125 (2006).
  • A classification and outline of cerebrovascular diseases. II. Stroke6, 564–616 (1975).
  • Kidwell CS , AlgerJR, Di Salle F et al.: Diffusion MRI in patients with transient ischemic attacks. Stroke30(6), 1174–1180 (1999).
  • Engelter ST , ProvenzaleJM, PetrellaJR, AlbertsMJ: Diffusion MR imaging and transient ischemic attacks.Stroke30(12), 2762–2763 (1999).
  • Albers GW , CaplanLR, EastonJDet al.: Transient ischemic attack – proposal for a new definition.N. Engl. J. Med.347(21), 1713–1716 (2002).
  • Hill MD : Diagnostic biomarkers for stroke: a stroke neurologist‘s perspective.Clin. Chem.51(11), 2001–2002 (2005).
  • Whiteley W , TsengMC, SandercockP: Blood biomarkers in the diagnosis of ischemic stroke: a systematic review.Stroke39(10), 2902–2909 (2008).
  • Noppe M , CrolsR, AndriesD, LowenthalA: Determination in human cerebrospinal fluid of glial fibrillary acidic protein, S-100 and myelin basic protein as indices of non-specific or specific central nervous tissue pathology.Clin. Chim. Acta155(2), 143–150 (1986).
  • Lamers KJ , van EngelenBG, GabreelsFJ, HommesOR, BormGF, WeversRA: Cerebrospinal neuron-specific enolase, S-100 and myelin basic protein in neurological disorders. Acta Neurol. Scand.92(3), 247–251 (1995).
  • Lamers KJ , VosP, VerbeekMM, RosmalenF, van GeelWJ, van EngelenBG: Protein S-100B, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients. Brain Res. Bull.61(3), 261–264 (2003).
  • van Engelen BG , LamersKJ, GabreelsFJ, WeversRA, van GeelWJ, BormGF: Age-related changes of neuron-specific enolase, S-100 protein, and myelin basic protein concentrations in cerebrospinal fluid. Clin. Chem.38(6), 813–816 (1992).
  • Segal MB : The choroid plexuses and the barriers between the blood and the cerebrospinal fluid.Cell Mol. Neurobiol.20(2), 183–196 (2000).
  • Wardlaw JM , DoubalF, ArmitagePet al.: Lacunar stroke is associated with diffuse blood–brain barrier dysfunction.Ann. Neurol.65(2), 194–202 (2009).
  • Marchi N , RasmussenP, KapuralMet al.: Peripheral markers of brain damage and blood–brain barrier dysfunction.Restor. Neurol. Neurosci.21(3–4), 109–121 (2003).
  • Anderson RE , WinnerkvistA, HanssonLOet al.: Biochemical markers of cerebrospinal ischemia after repair of aneurysms of the descending and thoracoabdominal aorta.J. Cardiothorac. Vasc. Anesth.17(5), 598–603 (2003).
  • Marchi N , FazioV, CuculloLet al.: Serum transthyretin monomer as a possible marker of blood-to-CSF barrier disruption.J. Neurosci.23(5), 1949–1955 (2003).
  • Engelter ST , ProvenzaleJM, PetrellaJR, DeLongDM, AlbertsMJ: Infarct volume on apparent diffusion coefficient maps correlates with length of stay and outcome after middle cerebral artery stroke.Cerebrovasc. Dis.15(3), 188–191 (2003).
  • Ay H , KoroshetzWJ, VangelMet al.: Conversion of ischemic brain tissue into infarction increases with age.Stroke36(12), 2632–2636 (2005).
  • Ay H , ArsavaEM, RosandJet al.: Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke.Stroke39(5), 1409–1413 (2008).
  • Wu O , KoroshetzWJ, OstergaardLet al.: Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging.Stroke32(4), 933–942 (2001).
  • Beaulieu C , de CrespignyA, TongDC, MoseleyME, AlbersGW, MarksMP: Longitudinal magnetic resonance imaging study of perfusion and diffusion in stroke: evolution of lesion volume and correlation with clinical outcome. Ann. Neurol.46(4), 568–578 (1999).
  • Menezes NM , AyH, Wang ZhuMet al.: The real estate factor: quantifying the impact of infarct location on stroke severity. Stroke38(1), 194–197 (2007).
  • Thijs VN , LansbergMG, BeaulieuC, MarksMP, MoseleyME, AlbersGW: Is early ischemic lesion volume on diffusion-weighted imaging an independent predictor of stroke outcome? A multivariable analysis.Stroke31(11), 2597–2602 (2000).
  • Schiemanck SK , KwakkelG, PostMW, KappelleLJ, PrevoAJ: Predicting long-term independency in activities of daily living after middle cerebral artery stroke: does information from MRI have added predictive value compared with clinical information?Stroke37(4), 1050–1054 (2006).
  • Schiemanck SK , KwakkelG, PostMW, PrevoAJ: Predictive value of ischemic lesion volume assessed with magnetic resonance imaging for neurological deficits and functional outcome poststroke: a critical review of the literature.Neurorehabil. Neural Repair20(4), 492–502 (2006).
  • Lynch JR , BlessingR, WhiteWD, GrocottHP, NewmanMF, LaskowitzDT: Novel diagnostic test for acute stroke.Stroke35(1), 57–63 (2004).
  • Reynolds MA , KirchickHJ, DahlenJRet al.: Early biomarkers of stroke.Clin. Chem.49(10), 1733–1739 (2003).
  • Laskowitz DT , KasnerSE, SaverJ, RemmelKS, JauchEC; BRAIN Study Group: Clinical usefulness of a biomarker-based diagnostic test for acute stroke: the biomarker rapid assessment in ischemic injury (BRAIN) study. Stroke40(1), 77–85 (2009).
  • Montaner J , Perea-GainzaM, DelgadoPet al.: Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers.Stroke39(8), 2280–2287 (2008).
  • Castellanos M , SerenaJ: Applicability of biomarkers in ischemic stroke.Cerebrovasc. Dis.24(Suppl. 1), 7–15 (2007).
  • Montaner J : Stroke biomarkers: can they help us to guide stroke thrombolysis?Timely Top. Med. Cardiovasc. Dis.11, E11 (2007).
  • Lynch JR , WangH, McGirtMJet al.: Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: Results of a pilot randomized clinical trial.Stroke36(9), 2024–2026 (2005).
  • Pettigrew LC , KasnerSE, GormanMet al.: Effect of arundic acid on serum S-100b in ischemic stroke.J. Neurol. Sci.251(1–2), 57–61 (2006).
  • Fisher M , CheungK, HowardG, WarachS: New pathways for evaluating potential acute stroke therapies.Int. J. Stroke1(2), 52–58 (2006).

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