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Review

YKL-40: A New Biomarker in Cardiovascular Disease?

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Pages 591-600 | Published online: 11 Aug 2010

Bibliography

  • Yusuf S , ReddyS, OunpuuS, AnandS: Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization.Circulation104(22) , 2746–2753 (2001).
  • Yusuf S , ReddyS, OunpuuS, AnandS: Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies.Circulation104(23) , 2855–2864 (2001).
  • Hansson GK : Inflammation, atherosclerosis, and coronary artery disease.N. Engl. J. Med.352(16) , 1685–1695 (2005).
  • Ross R : Atherosclerosis – an inflammatory disease.N. Engl. J. Med.340(2) , 115–126 (1999).
  • Koenig W , LowelH, BaumertJ, MeisingerC: C-reactive protein modulates risk prediction based on the Framingham Score: implications for future risk assessment: results from a large cohort study in southern Germany.Circulation109(11) , 1349–1353 (2004).
  • Luc G , BardJM, Juhan-VagueI yeet al.: C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study.Arterioscler. Thromb. Vasc. Biol.23(7) , 1255–1261 (2003).
  • Mueller C , BuettnerHJ, HodgsonJMet al.: Inflammation and long-term mortality after non-ST elevation acute coronary syndrome treated with a very early invasive strategy in 1042 consecutive patients.Circulation105(12) , 1412–1415 (2002).
  • Ridker PM , StampferMJ, RifaiN: Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease.JAMA285(19) , 2481–2485 (2001).
  • Kistorp C , RaymondI, PedersenF, GustafssonF, FaberJ, HildebrandtP: N-terminal pro-brain natriuretic peptide, C-reactive protein, and urinary albumin levels as predictors of mortality and cardiovascular events in older adults.JAMA293(13) , 1609–1616 (2005).
  • Olsen MH , HansenTW, ChristensenMKet al.: N-terminal pro-brain natriuretic peptide, but not high sensitivity C-reactive protein, improves cardiovascular risk prediction in the general population.Eur. Heart J.28(11) , 1374–1381 (2007).
  • Olsen MH , SehestedtT, LyngbaekSet al.: Urine albumin/creatinine ratio, high sensitivity C-reactive protein and N-terminal pro brain natriuretic peptide – three new cardiovascular risk markers – do they improve risk prediction and influence treatment?Curr. Vasc. Pharmacol.8(1) , 134–139 (2010).
  • Arnlov J , EvansJC, MeigsJBet al.: Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study.Circulation112(7) , 969–975 (2005).
  • Borch-Johnsen K , Feldt-RasmussenB, StrandgaardS, SchrollM, JensenJS: Urinary albumin excretion. An independent predictor of ischemic heart disease.Arterioscler. Thromb. Vasc. Biol.19(8) , 1992–1997 (1999).
  • Morrow DA , de Lemos JA: Benchmarks for the assessment of novel cardiovascular biomarkers. Circulation115(8) , 949–952 (2007).
  • Johansen JS : Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer.Dan. Med. Bull.53(2) , 172–209 (2006).
  • Johansen JS , WilliamsonMK, RiceJS, PricePA: Identification of proteins secreted by human osteoblastic cells in culture.J. Bone Miner. Res.7(5) , 501–512 (1992).
  • Hakala BE , WhiteC, ReckliesAD: Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.J. Biol. Chem.268(34) , 25803–25810 (1993).
  • Morrison BW , LederP: neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors.Oncogene9(12) , 3417–3426 (1994).
  • Shackelton LM , MannDM, MillisAJ: Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling.J. Biol. Chem.270(22) , 13076–13083 (1995).
  • Rehli M , KrauseSW, AndreesenR: Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation.Genomics43(2) , 221–225 (1997).
  • Harvey S , WeismanM, O‘DellJet al.: Chondrex: new marker of joint disease.Clin. Chem.44(3) , 509–516 (1998).
  • Mohanty AK , SinghG, ParamasivamMet al.: Crystal structure of a novel regulatory 40-kDa mammary gland protein (MGP-40) secreted during involution.J. Biol. Chem.278(16) , 14451–14460 (2003).
  • Malinda KM , PonceL, KleinmanHK, ShackeltonLM, MillisAJ: Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells.Exp. Cell. Res.250(1) , 168–173 (1999).
  • Nishikawa KC , MillisAJ: gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells.Exp. Cell. Res.287(1) , 79–87 (2003).
  • Recklies AD , WhiteC, LingH: The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signaling pathways.Biochem. J.365(Pt 1) , 119–126 (2002).
  • Ling H , ReckliesAD: The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-α.Biochem. J.380(Pt 3) , 651–659 (2004).
  • Swirski FK , LibbyP, AikawaEet al.: Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.J. Clin. Invest.117(1) , 195–205 (2007).
  • Libby P , BraunwaldE: Braunwald‘s Heart Disease (8th Edition). A Textbook of Cardiovascular Medicine.Saunders/Elsevier,PA, USA (2008).
  • Baeten D , BootsAM, SteenbakkersPGet al.: Human cartilage gp-39+,CD16+ monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis.Arthritis Rheum.43(6) , 1233–1243 (2000).
  • Kirkpatrick RB , MaticoRE, McNultyDE, StricklerJE, RosenbergM: An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages.Gene153(2) , 147–154 (1995).
  • Krause SW , RehliM, KreutzM, SchwarzfischerL, PaulauskisJD, AndreesenR: Differential screening identifies genetic markers of monocyte to macrophage maturation.J. Leukoc. Biol.60(4) , 540–545 (1996).
  • Rehli M , NillerHH, AmmonCet al. : Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation.J. Biol. Chem.278(45) , 44058–44067 (2003).
  • Boot RG ,vanAchterberg TA,vanAken BEet al.: Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages.Arterioscler. Thromb. Vasc. Biol.19(3) , 687–694 (1999).
  • Cintin C , JohansenJS, ChristensenIJ, PricePA, SorensenS, NielsenHJ: Serum YKL-40 and colorectal cancer.Br. J. Cancer79(9–10) , 1494–1499 (1999).
  • Cintin C , JohansenJS, ChristensenIJ, PricePA, SorensenS, NielsenHJ: High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival.Cancer95(2) , 267–274 (2002).
  • Johansen JS , DrivsholmL, PricePA, ChristensenIJ: High serum YKL-40 level in patients with small cell lung cancer is related to early death.Lung Cancer46(3) , 333–340 (2004).
  • Bi J , LauSH, LvZLet al. : Overexpression of YKL-40 is an independent prognostic marker in gastric cancer.Hum. Pathol.40(12) , 1790–1797 (2009).
  • Schmidt H , JohansenJS, GehlJ, GeertsenPF, FodeK,vonder MH: Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma.Cancer106(5) , 1130–1139 (2006).
  • Daugaard S , ChristensenLH, HogdallE: Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2–40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40.APMIS117(7) , 518–525 (2009).
  • Biggar RJ , JohansenJS, SmedbyKEet al. : Serum YKL-40 and interleukin 6 levels in Hodgkin lymphoma.Clin. Cancer Res.14(21) , 6974–6978 (2008).
  • Mitsuhashi A , MatsuiH, UsuiHet al. : Serum YKL-40 as a marker for cervical adenocarcinoma.Ann. Oncol.20(1) , 71–77 (2009).
  • Mylin AK , RasmussenT, JohansenJSet al. : Serum YKL-40 concentrations in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells.Eur. J. Haematol.77(5) , 416–424 (2006).
  • Bergmann OJ , JohansenJS, KlausenTWet al. : High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia.Clin. Cancer Res.11(24 Pt 1) , 8644–8652 (2005).
  • Jensen BV , JohansenJS, PricePA: High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer.Clin. Cancer Res.9(12) , 4423–4434 (2003).
  • Yamac D , OzturkB, CoskunUet al.: Serum YKL-40 levels as a prognostic factor in patients with locally advanced breast cancer.Adv. Ther.25(8) , 801–809 (2008).
  • Dupont J , TanwarMK, ThalerHTet al.: Early detection and prognosis of ovarian cancer using serum YKL-40.J. Clin. Oncol.22(16) , 3330–3339 (2004).
  • Hogdall EV , RingsholtM, HogdallCKet al.: YKL-40 tissue expression and plasma levels in patients with ovarian cancer.BMC Cancer9(8) , 8 (2009).
  • Yang GF , CaiPY, LiXM, DengHX, HeWP, XieD: Expression and clinical significance of YKL-40 protein in epithelial ovarian cancer tissues.Chin. J. Cancer28(2) , 142–145 (2009).
  • Kucur M , IsmanFK, BalciCet al. : Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia.Urol. Oncol.26(1) , 47–52 (2008).
  • Johansen JS , BojesenSE, MylinAK, Frikke-SchmidtR, PricePA, NordestgaardBG: Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population.J. Clin. Oncol.27(4) , 572–578 (2009).
  • Shao R , HamelK, PetersenLet al. : YKL-40, a secreted glycoprotein, promotes tumor angiogenesis.Oncogene28(50) , 4456–4468 (2009).
  • Volck B , JohansenJS, StoltenbergMet al. : Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology.Osteoarthritis Cartilage9(3) , 203–214 (2001).
  • Johansen JS , StoltenbergM, HansenMet al.: Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity.Rheumatol. (Oxf.)38(7) , 618–626 (1999).
  • Johansen JS , KirwanJR, PricePA, SharifM: Serum YKL-40 concentrations in patients with early rheumatoid arthritis: relation to joint destruction.Scand. J. Rheumatol.30(5) , 297–304 (2001).
  • Matsumoto T , TsurumotoT: Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laborarory parameters.Clin. Exp. Rheumatol.19(6) , 655–660 (2001).
  • Peltomaa R , PaimelaL, HarveyS, HelveT, Leirisalo-RepoM: Increased level of YKL-40 in sera from patients with early rheumatoid arthritis: a new marker for disease activity.Rheumatol. Int.20(5) , 192–196 (2001).
  • Zivanovic S , RackovLP, VojvodicD, VuceticD: Human cartilage glycoprotein 39 – biomarker of joint damage in knee osteoarthritis.Int. Orthop.33(4) , 1165–1170 (2009).
  • Koutroubakis IE , PetinakiE, DimouliosPet al. : Increased serum levels of YKL-40 in patients with inflammatory bowel disease.Int. J. Colorectal Dis.18(3) ,254–259 (2003).
  • Vind I , JohansenJS, PricePA, MunkholmP: Serum YKL-40, a potential new marker of disease activity in patients with inflammatory bowel disease.Scand. J. Gastroenterol.38(6) , 599–605 (2003).
  • Myasoedova E , GabrielSE: Cardiovascular disease in rheumatoid arthritis: a step forward.Curr. Opin. Rheumatol.22(3) , 342–347 (2010).
  • Chupp GL , LeeCG, JarjourNet al. : A chitinase-like protein in the lung and circulation of patients with severe asthma.N. Engl. J. Med.357(20) , 2016–2027 (2007).
  • Ober C , TanZ, SunYet al. : Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.N. Engl. J. Med.358(16) , 1682–1691 (2008).
  • Rathcke CN , HolmkvistJ, HusmoenLLet al. : Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults.PLoS One4(7) , E6106 (2009).
  • Hempen M , KoppHP, ElhenickyMet al. : YKL-40 is elevated in morbidly obese patients and declines after weight loss.Obes. Surg.19(11) , 1557–1563 (2009).
  • Nielsen AR , ErikstrupC, JohansenJSet al. : Plasma YKL-40: a BMI-independent marker of Type 2 diabetes.Diabetes57(11) , 3078–3082 (2008).
  • Rathcke CN , JohansenJS, VestergaardH: YKL-40, a biomarker of inflammation, is elevated in patients with Type 2 diabetes and is related to insulin resistance.Inflamm. Res.55(2) , 53–59 (2006).
  • Rathcke CN , PerssonF, TarnowL, RossingP, VestergaardH: YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with Type 1 diabetes and increases with levels of albuminuria.Diabetes Care32(2) , 323–328 (2009).
  • Gustafson B , GoggS, HedjazifarS, JenndahlL, HammarstedtA, SmithU: Inflammation and impaired adipogenesis in hypertrophic obesity in man.Am. J. Physiol. Endocrinol. Metab. DOI:10.1152/ajpendo.00377.2009 (2009) (Epub ahead of print).
  • Spalding KL , ArnerE, WestermarkPOet al.: Dynamics of fat cell turnover in humans.Nature453(7196) , 783–787 (2008).
  • Andersson CX , GustafsonB, HammarstedtA, HedjazifarS, SmithU: Inflamed adipose tissue, insulin resistance and vascular injury.Diabetes Metab. Res. Rev.24(8) , 595–603 (2008).
  • Mathieu P , LemieuxI, DespresJP: Obesity, inflammation, and cardiovascular risk.Clin. Pharmacol. Ther.87(4) , 407–416 (2010).
  • Johansen JS , KrabbeKS, MollerK, PedersenBK: Circulating YKL-40 levels during human endotoxaemia.Clin. Exp. Immunol.140(2) , 343–348 (2005).
  • Kronborg G , OstergaardC, WeisNet al. : Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease.Scand. J. Infect. Dis.34(5) , 323–326 (2002).
  • Hattori N , OdaS, SadahiroTet al. : YKL-40 identified by proteomic analysis as a biomarker of sepsis.Shock32(4) , 393–400 (2009).
  • Ostergaard C , JohansenJS, BenfieldT, PricePA, LundgrenJD: YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis.Clin. Diagn. Lab. Immunol.9(3) , 598–604 (2002).
  • Nojgaard C , HostNB, ChristensenIJet al. : Serum levels of YKL-40 increases in patients with acute myocardial infarction.Coron. Artery Dis.19(4) , 257–263 (2008).
  • Wang Y , RipaRS, JohansenJSet al. : YKL-40 a new biomarker in patients with acute coronary syndrome or stable coronary artery disease.Scand. Cardiovasc. J.42(5) , 295–302 (2008).
  • Hedegaard A , SejerstenRR, JohansenJS, JorgensenE, KastrupJ: Plasma YKL-40 and recovery of left ventricular function after acute myocardial infarction.Scand. J. Clin. Lab. Invest.70(2) , 80–86 (2010).
  • Hogdall EV , JohansenJS, KjaerSK, PricePA, BlaakjaerJ, HogdallCK: Stability of YKL-40 concentration in blood samples.Scand. J. Clin. Lab. Invest.60(4) , 247–251 (2000).
  • Johansen JS , JensenHS, PricePA: A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid.Br. J. Rheumatol.32(11) , 949–955 (1993).
  • Johansen JS , HvolrisJ, HansenM, BackerV, LorenzenI, PricePA: Serum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint.Br. J. Rheumatol.35(6) , 553–559 (1996).
  • Garnero P , PipernoM, GineytsE, ChristgauS, DelmasPD, VignonE: Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage.Ann. Rheum. Dis.60(6) , 619–626 (2001).
  • Kastrup J , JohansenJS, WinkelPet al.: High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease.Eur. Heart J.30(9) , 1066–1072 (2009).
  • Kucur M , IsmanFK, KaradagB, VuralVA, TavsanogluS: Serum YKL-40 levels in patients with coronary artery disease.Coron. Artery Dis.18(5) , 391–396 (2007).
  • Rathcke CN , RaymondI, KistorpC, HildebrandtP, FaberJ, VestergaardH: Low grade inflammation as measured by levels of YKL-40: association with an increased overall and cardiovascular mortality rate in an elderly population.Int. J. Cardiol.143(1) , 35–42 (2009).
  • Zheng JL , LuL, HuJet al. : Increased serum YKL-40 and C-reactive protein levels are associated with angiographic lesion progression in patients with coronary artery disease.Atherosclerosis210(2) , 590–595 (2010).
  • Rathcke CN , KistorpC, RaymondIet al. : Plasma YKL-40 levels are elevated in patients with chronic heart failure.Scand. Cardiovasc. J.44(2) , 92–99 (2010).
  • Baigent C , KeechA, KearneyPMet al. : Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.Lancet366(9493) , 1267–1278 (2005).
  • Scirica BM , MorrowDA: Is C-reactive protein an innocent bystander or proatherogenic culprit? The verdict is still out.Circulation113(17) , 2128–2134 (2006).
  • Bonnet J , McPhersonR, TedguiAet al. : Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin Pleiotropic effects) study.Clin. Ther.30(12) , 2298–2313 (2008).
  • Frustaci A , ChimentiC, BellocciF, MorganteE, RussoMA, MaseriA: Histological substrate of atrial biopsies in patients with lone atrial fibrillation.Circulation96(4) , 1180–1184 (1997).
  • Wijffels MC , KirchhofCJ, DorlandR, AllessieMA: Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats.Circulation92(7) , 1954–1968 (1995).
  • Chung MK , MartinDO, SprecherDet al. : C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation.Circulation104(24) , 2886–2891 (2001).
  • Engelmann MD , SvendsenJH: Inflammation in the genesis and perpetuation of atrial fibrillation.Eur. Heart J.26(20) , 2083–2092 (2005).
  • Henningsen KM , NilssonB, BruunsgaardH, ChenX, PedersenBK, SvendsenJH: Prognostic impact of hs-CRP and IL-6 in patients undergoing radiofrequency catheter ablation for atrial fibrillation.Scand. Cardiovasc. J.1–7 (2008).
  • Kallergis EM , ManiosEG, KanoupakisEMet al.: The role of the post-cardioversion time course of hs-CRP levels in clarifying the relationship between inflammation and persistence of atrial fibrillation.Heart94(2) , 200–204 (2008).
  • Loricchio ML , CianfroccaC, PasceriVet al. : Relation of C-reactive protein to long-term risk of recurrence of atrial fibrillation after electrical cardioversion.Am. J. Cardiol.99(10) , 1421–1424 (2007).
  • Watanabe E , ArakawaT, UchiyamaT, KodamaI, HishidaH: High-sensitivity C-reactive protein is predictive of successful cardioversion for atrial fibrillation and maintenance of sinus rhythm after conversion.Int. J. Cardiol.108(3) , 346–353 (2006).
  • Henningsen KM , TherkelsenSK, JohansenJS, BruunsgaardH, SvendsenJH: Plasma YKL-40, a new biomarker for atrial fibrillation?Europace11(8) , 1032–1036 (2009).
  • Henningsen KM , NilssonB, JohansenJ, ChenX, PehrsonS, SvendsenJH: Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation.Inflamm. Res.59(6) , 463–439 (2010).
  • Johansen JS , LottenburgerT, NielsenHJet al. : Diurnal, weekly, and long-time variation in serum concentrations of YKL-40 in healthy subjects.Cancer Epidemiol. Biomarkers Prev.17(10) , 2603–2608 (2008).

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