Fetal Fibronectin as a Biomarker of Preterm Labor: A Review of the Literature and Advances in its Clinical Use

References

• Goldenberg RL , CulhaneJF , IamsJD , RomeroR. Epidemiology and causes of preterm birth.Lancet371 ( 9606 ), 75 – 84 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Blencowe H , CousensS , OestergaardMZet al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 379 ( 9832 ), 2162 – 2172 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• WHO: recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths. Modifications recommended by FIGO as amended October 14, 1976. Acta Obstet. Gynecol. Scand. 56 ( 3 ), 247 – 253 ( 1977 ).
   PubMed Web of Science ®Google Scholar
• Berghella V , HayesE , VisintineJ , BaxterJK. Fetal fibronectin testing for reducing the risk of preterm birth.Cochrane Database Syst. Rev.4 , CD006843 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Langhoff-Roos J , KesmodelU , JacobssonB , RasmussenS , VogelI. Spontaneous preterm delivery in primiparous women at low risk in Denmark: population based study.BMJ332 ( 7547 ), 937 – 939 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Slattery MM , MorrisonJJ. Preterm delivery.Lancet360 ( 9344 ), 1489 – 1497 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Morken NH . Preterm birth: new data on a global health priority.Lancet379 ( 9832 ), 2128 – 2130 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• March of Dimes, Perinatal Data Center. Special care nursery admissions (2011). www.marchofdimes.com
   Google Scholar
• Marlow N , WolkeD , BracewellMA , SamaraM ; EPICure Study Group. Neurologic and developmental disability at six years of age after extremely preterm birth.N. Engl. J. Med.352 ( 1 ), 9 – 19 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Mangham LJ , PetrouS , DoyleLW , DraperES , MarlowN. The cost of preterm birth throughout childhood in England and Wales.Pediatrics123 ( 2 ), e312 – e327 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Petrou S . The economic consequences of preterm birth during the first 10 years of life.BJOG112 ( Suppl. 1 ), 10 – 15 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Wood NS , MarlowN , CosteloeK , GibsonAT , WilkinsonAR. Neurologic and developmental disability after extremely preterm birth. EPICure Study Group.N. Engl. J. Med.343 ( 6 ), 378 – 384 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Lockwood CJ , KuczynskiE. Risk stratification and pathological mechanisms in preterm delivery.Paediatr. Perinat. Epidemiol.15 ( Suppl. 2 ), 78 – 89 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Creasy RK , GummerBA , LigginsGC. System for predicting spontaneous preterm birth.Obstet. Gynecol.55 ( 6 ), 692 – 695 ( 1980 ).
   PubMed Web of Science ®Google Scholar
• Honest H , BachmannLM , SundaramR , GuptaJK , KleijnenJ , KhanKS. The accuracy of risk scores in predicting preterm birth – a systematic review.J. Obstet. Gynaecol.24 ( 4 ), 343 – 359 ( 2004 ).
   PubMedGoogle Scholar
• Ness A , VisintineJ , RicciE , BerghellaV. Does knowledge of cervical length and fetal fibronectin affect management of women with threatened preterm labor? A randomized trial.Am. J. Obstet. Gynecol.197 ( 4 ), 426.e421 – 426.e427 ( 2007 ).
   Web of Science ®Google Scholar
• Matsuura H , HakomoriS. The oncofetal domain of fibronectin defined by monoclonal antibody FDC-6: its presence in fibronectins from fetal and tumor tissues and its absence in those from normal adult tissues and plasma.Proc. Natl Acad. Sci. USA82 ( 19 ), 6517 – 6521 ( 1985 ).
   PubMed Web of Science ®Google Scholar
• Dutta D , NormanJE. The efficacy of fetal fibronectin testing in minimising hospital admissions, length of hospital stay and cost savings in women presenting with symptoms of pre-term labour.J. Obstet. Gynecol.30 ( 8 ), 768 – 773 ( 2010 ).
   PubMedGoogle Scholar
• Lockwood CJ , SenyeiAE , DischeMRet al. Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. N. Engl. J. Med. 325 ( 10 ), 669 – 674 ( 1991 ).  
   PubMed Web of Science ®Google Scholar
• Honest H , BachmannLM , GuptaJK , KleijnenJ , KhanKS. Accuracy of cervicovaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: systematic review.BMJ325 ( 7359 ), 301 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Bittar RE , YamasakiAA , SasakiS , ZugaibM. Cervical fetal fibronectin in patients at increased risk for preterm delivery.Am. J. Obstet. Gynecol.175 ( 1 ), 178 – 181 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Goepfert AR , GoldenbergRL , MercerBet al. The Preterm Prediction Study: quantitative fetal fibronectin values and the prediction of spontaneous preterm birth. Am. J. Obstet. Gynecol. 183 ( 6 ), 1480 – 1483 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Iams JD , CasalD , McGregorJAet al. Fetal fibronectin improves the accuracy of diagnosis of preterm labor. Am. J. Obstet. Gynecol. 173 ( 1 ), 141 – 145 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Riboni F , VituloA , Dell’avanzoM , PlebaniM , BattagliarinG , PaternosterD. Biochemical markers predicting pre-term delivery in symptomatic patients: phosphorylated insulin-like growth factor binding protein-1 and fetal fibronectin.Arch. Obstet. Gynecol.284 ( 6 ), 1325 – 1329 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Bartnicki J , CasalD , KreadenUS , SalingE , VetterK. Fetal fibronectin in vaginal specimens predicts preterm delivery and very-low-birth-weight infants.Am. J. Obstet. Gynecol.174 ( 3 ), 971 – 974 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Sunagawa S , TakagiK , OnoK , MiyachiK , KikuchiA. Comparison of biochemical markers and cervical length for predicting preterm delivery.J. Obstet. Gynecol. Res.34 ( 5 ), 812 – 819 ( 2008 ).
   Google Scholar
• Gomez R , RomeroR , MedinaLet al. Cervicovaginal fibronectin improves the prediction of preterm delivery based on sonographic cervical length in patients with preterm uterine contractions and intact membranes. Am. J. Obstet. Gynecol. 192 ( 2 ), 350 – 359 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Peaceman AM , AndrewsWW , ThorpJMet al. Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicenter trial. Am. J. Obstet. Gynecol. 177 ( 1 ), 13 – 18 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Inglis SR , JeremiasJ , KunoKet al. Detection of tumor necrosis factor-alpha, interleukin-6, and fetal fibronectin in the lower genital tract during pregnancy: relation to outcome. Am. J. Obstet. Gynecol. 171 ( 1 ), 5 – 10 ( 1994 ).
   PubMed Web of Science ®Google Scholar
• Morrison JC , AllbertJR , McLaughlinBN , WhitworthNS , RobertsWE , MartinRW. Oncofetal fibronectin in patients with false labor as a predictor of preterm delivery.Am. J. Obstet. Gynecol.168 ( 2 ), 538 – 542 ( 1993 ).
   PubMed Web of Science ®Google Scholar
• Yoneda S , SakaiM , SasakiY , ShiozakiA , HidakaT , SaitoS. Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes.J. Obstet. Gynecol. Res.33 ( 1 ), 38 – 44 ( 2007 ).
   Google Scholar
• Sakai M , SasakiY , YamagishiN , TanebeK , YonedaS , SaitoS. The preterm labor index and fetal fibronectin for prediction of preterm delivery with intact membranes.Obstet. Gynecol.101 ( 1 ), 123 – 128 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Smith V , DevaneD , BegleyCM , ClarkeM , HigginsS. A systematic review and quality assessment of systematic reviews of fetal fibronectin and transvaginal length for predicting preterm birth.Eur. J. Obstet. Gynecol. Reprod. Biol.133 ( 2 ), 134 – 142 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Revah A , HannahME , Sue-A-QuanAK. Fetal fibronectin as a predictor of preterm birth: an overview.Am. J. Perinatol.15 ( 11 ), 613 – 621 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Leitich H , EgarterC , KaiderA , HohlagschwandtnerM , BerghammerP , HussleinP. Cervicovaginal fetal fibronectin as a marker for preterm delivery: a meta-analysis.Am. J. Obstet. Gynecol.180 ( 5 ), 1169 – 1176 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Faron G , BoulvainM , IrionO , BernardPM , FraserWD. Prediction of preterm delivery by fetal fibronectin: a meta-analysis.Obstet. Gynecol.92 ( 1 ), 153 – 158 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Chien PF , KhanKS , OgstonS , OwenP. The diagnostic accuracy of cervico-vaginal fetal fibronectin in predicting preterm delivery: an overview.Br. J. Obstet. Gynaecol.104 ( 4 ), 436 – 444 ( 1997 ).
   PubMedGoogle Scholar
• Grobman WA , WelshmanEE , CalhounEA. Does fetal fibronectin use in the diagnosis of preterm labor affect physician behavior and health care costs? A randomized trial.Am. J. Obstet. Gynecol.191 ( 1 ), 235 – 240 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Giles W , BisitsA , KnoxM , MadsenG , SmithR. The effect of fetal fibronectin testing on admissions to a tertiary maternal–fetal medicine unit and cost savings.Am. J. Obstet. Gynecol.182 ( 2 ), 439 – 442 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• van Baaren GJ , VisJY , GrobmanWA , BossuytPM , OpmeerBC , MolBW. Cost–effectiveness analysis of cervical length measurement and fibronectin testing in women with threatened preterm labor.Am. J. Obstet. Gynecol.209 ( 5 ), 436.e1 – 436.e8 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Goldenberg RL , MercerBM , MeisPJ , CopperRL , DasA , McnellisD. The preterm prediction study: fetal fibronectin testing and spontaneous preterm birth. NICHD Maternal Fetal Medicine Units Network.Obstet. Gynecol.87 ( 5 Pt 1 ), 643 – 648 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Goldenberg RL , IamsJD , MercerBMet al. The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births. NICHD MFMU Network. Am. J. Public Health 88 ( 2 ), 233 – 238 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Hellemans P , GerrisJ , VerdonkP. Fetal fibronectin detection for prediction of preterm birth in low risk women.Br. J. Obstet. Gynaecol.102 ( 3 ), 207 – 212 ( 1995 ).
   PubMedGoogle Scholar
• Nageotte MP , CasalD , SenyeiAE. Fetal fibronectin in patients at increased risk for premature birth.Am. J. Obstet. Gynecol.170 ( 1 Pt 1 ), 20 – 25 ( 1994 ).
   PubMed Web of Science ®Google Scholar
• Duhig KE , ChandiramaniM , SeedPT , BrileyAL , KenyonAP , ShennanAH. Fetal fibronectin as a predictor of spontaneous preterm labour in asymptomatic women with a cervical cerclage.BJOG116 ( 6 ), 799 – 803 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Bastek JA , HirshbergA , ChandrasekaranSet al. Biomarkers and cervical length to predict spontaneous preterm birth in asymptomatic high-risk women. Obstet. Gynecol. 122 ( 2 Pt 1 ), 283 – 289 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Bolt LA , ChandiramaniM , DeGreeff A , SeedP , ShennanAH. Does fetal fibronectin testing change patient management in women at risk of preterm labour?Eur.J. Obstet. Gynecol. Reprod. Biol.146 ( 2 ), 180 – 183 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Shennan A , JonesG , HawkenJet al. Fetal fibronectin test predicts delivery before 30 weeks of gestation in high risk women, but increases anxiety. BJOG 112 ( 3 ), 293 – 298 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Lowe MP , ZimmermanB , HansenW. Prospective randomized controlled trial of fetal fibronectin on preterm labor management in a tertiary care center.Am. J. Obstet. Gynecol.190 ( 2 ), 358 – 362 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Kurtzman J , ChandiramaniM , BrileyA , PostonL , DasA , ShennanA. Quantitative fetal fibronectin screening in asymptomatic high-risk patients and the spectrum of risk for recurrent preterm delivery.Am. J. Obstet. Gynecol.200 ( 3 ), 263.e1 – 263.e6 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Lu GC , GoldenbergRL , CliverSP , KreadenUS , AndrewsWW. Vaginal fetal fibronectin levels and spontaneous preterm birth in symptomatic women.Obstet. Gynecol.97 ( 2 ), 225 – 228 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Goldenberg RL , MercerBM , IamsJDet al. The preterm prediction study: patterns of cervicovaginal fetal fibronectin as predictors of spontaneous preterm delivery. Am. J. Obstet. Gynecol. 177 ( 1 ), 8 – 12 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Abbott DS , RadfordSK , SeedPT , TribeRM , ShennanAH. Evaluation of a quantitative fetal fibronectin test for spontaneous preterm birth in symptomatic women.Am. J. Obstet. Gynecol.208 ( 2 ), 122.e1 – 122.e6 ( 2013 ).  
   PubMed Web of Science ®Google Scholar
• Crane JM , HutchensD. Transvaginal sonographic measurement of cervical length to predict preterm birth in asymptomatic women at increased risk: a systematic review.Ultrasound Obstet. Gynecol.31 ( 5 ), 579 – 587 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Fox NS , Jean-PierreC , PredanicM , ChasenST. Short cervix: is a follow-up measurement useful?Ultrasound Obstet. Gynecol.29 ( 1 ), 44 – 46 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• To MS , SkentouCA , RoystonP , YuCK , NicolaidesKH. Prediction of patient-specific risk of early preterm delivery using maternal history and sonographic measurement of cervical length: a population-based prospective study.Ultrasound Obstet. Gynecol.27 ( 4 ), 362 – 367 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Chao AS , ChaoA , HsiehPC. Ultrasound assessment of cervical length in pregnancy.Taiwan. J. Obstet. Gynecol.47 ( 3 ), 291 – 295 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Kagan KO , ToM , TsoiE , NicolaidesKH. Preterm birth: the value of sonographic measurement of cervical length.BJOG113 ( Suppl. 3 ), 52 – 56 ( 2006 ).
   PubMedGoogle Scholar
• Bolt LA , ChandiramaniM , DeGreeff A , SeedPT , KurtzmanJ , ShennanAH. The value of combined cervical length measurement and fetal fibronectin testing to predict spontaneous preterm birth in asymptomatic high-risk women.J. Matern. Fetal Neonatal Med.24 ( 7 ), 928 – 932 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• DeFranco EA , LewisDF , OdiboAO. Improving the screening accuracy for preterm labor: is the combination of fetal fibronectin and cervical length in symptomatic patients a useful predictor of preterm birth? A systematic review.Am. J. Obstet. Gynecol.208 ( 3 ), 233.e1 – 233.e6 ( 2013 ).  
   PubMed Web of Science ®Google Scholar
• Yeast JD , LuG. Biochemical markers for the prediction of preterm delivery.Clin. Perinatol.34 ( 4 ), 573 – 586 , vi ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Goldenberg RL , IamsJD , MercerBMet al. The Preterm Prediction Study: toward a multiple-marker test for spontaneous preterm birth. Am. J. Obstet. Gynecol. 185 ( 3 ), 643 – 651 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Khambay H , BoltLA , ChandiramaniM , DeGreeff A , FilmerJE , ShennanAH. The Actim Partus test to predict pre-term birth in asymptomatic high-risk women.J. Obstet. Gynecol.32 ( 2 ), 132 – 134 ( 2012 ).
   PubMedGoogle Scholar
• Nikolova T , BayevO , NikolovaN , DiRenzo GC. Evaluation of a novel placental alpha microglobulin-1 (PAMG-1) test to predict spontaneous preterm delivery.J. Perinat. Med.13 , 1 – 5 ( 2013 ).
   Google Scholar
• Lukes AS , ThorpJMJr , EuckerB , Pahel-ShortL. Predictors of positivity for fetal fibronectin in patients with symptoms of preterm labor.Am. J. Obstet. Gynecol.176 ( 3 ), 639 – 641 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Martin JA , HamiltonBE , VenturaSJet al. Births: final data for 2009. Natl Vital Stat. Rep. 60 ( 1 ), 1 – 70 ( 2011 ).
   PubMedGoogle Scholar
• Reynolds MA , SchieveLA , MartinJA , JengG , MacalusoM. Trends in multiple births conceived using assisted reproductive technology, United States, 1997–2000.Pediatrics111 ( 5 Pt 2 ), 1159 – 1162 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Zork N , BiggioJ , TitaA , RouseD , Gyamfi-BannermanC. Decreasing prematurity in twin gestations: predicaments and possibilities.Obstet. Gynecol.122 ( 2 Pt 1 ), 375 – 379 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Conde-Agudelo A , RomeroR. Cervicovaginal fetal fibronectin for the prediction of spontaneous preterm birth in multiple pregnancies: a systematic review and meta-analysis.J. Matern. Fetal Neonatal Med.23 ( 12 ), 1365 – 1376 ( 2010 ).  
   PubMed Web of Science ®Google Scholar
• Fox NS , SaltzmanDH , KlauserCK , PeressD , GutierrezCV , RebarberA. Prediction of spontaneous preterm birth in asymptomatic twin pregnancies with the use of combined fetal fibronectin and cervical length.Am. J. Obstet. Gynecol.201 ( 3 ), 313.e1 – 313.e5 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Roman AS , PesselC , FoxN , KlauserCK , SaltzmanD , RebarberA. Vaginal fetal fibronectin as a predictor of spontaneous preterm delivery in triplet gestations.J. Matern. Fetal Neonatal Med.25 ( 10 ), 1921 – 1923 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Tolino A , RonsiniS , ZulloF , PellicanoM , RegineV , NappiC. Fetal fibronectin as a screening test for premature delivery in multiple pregnancies.Int. J. Gynaecol. Obstet.52 ( 1 ), 3 – 7 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Roman AS , RebarberA , SfakianakiAKet al. Vaginal fetal fibronectin as a predictor of spontaneous preterm delivery in the patient with cervical cerclage. Am. J. Obstet. Gynecol. 189 ( 5 ), 1368 – 1373 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Benson JE , LandyHJ , GhidiniA , DrassinowerD , PoggiSH. Fetal fibronectin for evaluation of preterm labor in the setting of cervical cerclage.J. Matern. Fetal Neonatal Med.25 ( 11 ), 2330 – 2332 ( 2012 ).
   PubMed Web of Science ®Google Scholar