Added value of H-FABP as a plasma biomarker for the early evaluation of suspected acute coronary syndrome

References

• WHO. Cardiovascular diseases (CVDs). www.who.int/mediacentre/factsheets/fs317/en
   Google Scholar
• Hamm CW, Bassand J-P, Agewall S et al. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur. Heart J. 32, 2999–3054 (2011).
   Google Scholar
• Bruins Slot MH, Rutten FH, Van der Heijden GJ, Geersing GJ, Glatz JFC, Hoes AW. Diagnosing acute coronary syndrome in primary care: comparison of the physicians’ risk estimation and a clinical decision rule. Fam. Pract. 28, 323–328 (2011).
   Google Scholar
• Goodacre S, Thokala P, Carroll C et al. Systematic review, meta-analysis and economic modelling of diagnostic strategies for suspected acute coronary syndrome. Health Technol. Assess. 17(1), 1–188 (2013).
   Google Scholar
• McConaghy JR, Oza RS. Outpatient diagnosis of acute chest pain in adults. Am. Fam. Physician 87, 177–182 (2013).
   Google Scholar
• Thygesen K, Alpert JS, Jaffe AS et al. Third universal definition of myocardial infarction. Eur. Heart J. 33, 2551–2567 (2012).
   Google Scholar
• Hooghoudt THE, Lamfers EJP, Uppelschoten A et al. Study of time intervals in myocardial ischemic syndromes (STIMIS). Cardiologie 5, 23–30, (1998).
   Google Scholar
• Glatz JFC, Van der Vusse GJ. Nomenclature of fatty acid-binding proteins. Mol. Cell. Biochem. 98, 231–235 (1990).
   Google Scholar
• Keller T, Zeller T, Ojeda F et al. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. J. Am. Med. Assoc. 306, 2684–2693 (2011). •• extensive study comparing a great number of plasma marker proteins for their use in the diagnosis of acute myocardial infarction.
   Google Scholar
• Collinson PO, Gaze DC, Thokala P, Goodacre S. Randomised assessment of treatment using panel assay of cardiac markers – contemporary biomarker evaluation (RATPAC CBE). Health Technol. Assess. 17(15), 1–122 (2013).
   Google Scholar
• Schaap FG, Van der Vusse GJ, Glatz JFC. Fatty acid-binding proteins in the heart. Mol. Cell. Biochem. 180, 43–51 (1998).
   Google Scholar
• Glatz JFC, Van Bilsen M, Paulussen RJ, Veerkamp JH, Van der Vusse GJ, Reneman RS. Release of fatty acid-binding protein from isolated rat heart subjected to ischemia and reperfusion or to the calcium paradox. Biochim. Biophys. Acta 961, 148–152 (1988).
   Google Scholar
• Van Nieuwenhoven FA, Musters RJP, Post JA, Verkleij AJ, Van der Vusse GJ, Glatz JFC. Release of proteins from isolated neonatal rat cardiomyocytes subjected to simulated ischemia or metabolic inhibition is independent of molecular mass. J. Mol. Cell. Cardiol. 28, 1429–1434 (1996).
   Google Scholar
• Glatz JFC. Fatty acid-binding protein as a plasma marker for the early detection of myocardial injury. Dev. Cardiovasc. Med. 205, 73–84 (1998).
   Google Scholar
• Glatz JFC, Van der Voort D, Hermens WT. Fatty acid-binding protein as the earliest available plasma marker of acute myocardial injury. J. Clin. Ligand Assay 25, 167–177 (2002).
   Google Scholar
• Glatz JFC, Kleine AH, Van Nieuwenhoven FA, Hermens WT, Van Dieijen-Visser MP, Van der Vusse GJ. Fatty-acid-binding protein as a plasma marker for the estimation of myocardial infarct size in humans. Br. Heart J. 71, 135–140 (1994).
   Google Scholar
• De Groot MJM, Wodzig KWH, Simoons ML, Glatz JFC, Hermens WT. Measurement of myocardial infarct size from plasma fatty acid-binding protein or myoglobin, using individually estimated clearance rates. Cardiovasc. Res. 44, 315–324 (1999).
   Google Scholar
• Wodzig KWH, Kragten JA, Hermens WT, Glatz JFC, Van Dieijen-Visser MP. Estimation of myocardial infarct size from plasma myoglobin or fatty acid-binding protein. Influence of renal function. Eur. J. Clin. Chem. Clin. Biochem. 35, 191–198 (1997).
   Google Scholar
• Pelsers MMAL, Chapelle JP, Knapen M et al. Influence of age and sex and day-to-day and within-day biological variation on plasma concentrations of fatty acid-binding protein and myoglobin in healthy subjects. Clin. Chem. 45, 441–443 (1999).
   Google Scholar
• Pagani F, Bonora R, Bonetti G, Panteghini M. Evaluation of a sandwich enzyme-linked immunosorbent assay for the measurement of serum heart fatty acid-binding protein. Ann. Clin. Biochem. 39, 404–405 (2002).
   Google Scholar
• Niizeki T, Takeishi Y, Takabatake N et al. Circulating levels of heart-type fatty acid-binding protein in a general Japanese population – effects of age, gender and physiological characteristics. Circ. J. 71, 1452–1457 (2007).
   Google Scholar
• Bathia DP, Carless DR, Viswanathan K, Hall AS, Barth JH. Serum 99th centile values for two heart-type fatty acid binding protein assays. Ann. Clin. Biochem. 46, 464–467 (2009).
   Google Scholar
• Glatz JFC, Mohren R. Plasma reference value of heart-type fatty acid-binding protein, the earliest available plasma biomarker of acute myocardial infarction. Health 5, 1206–1209 (2013).
   Google Scholar
• Vork MM, Glatz JFC, Van der Vusse GJ. On the mechanism of long-chain fatty acid transport in cardiomyocytes as facilitated by cytoplasmic fatty acid-binding protein. J. Theor. Biol. 160, 207–222 (1993).
   Google Scholar
• Pelsers MMAL, Hermens WT, Glatz JFC. Fatty acid-binding proteins as plasma markers of tissue injury (review). Clin. Chim. Acta 352, 15–35 (2005). • Describes the application of the various members of the fatty acid-binding protein family for detection of injury of specific tissues.
   Google Scholar
• Van Nieuwenhoven FA, Kleine AH, Wodzig KWH et al. Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein. Circulation 92, 2848–2854 (1995).
   Google Scholar
• Katrukha A, Bereznikova A, Filatov V. Improved detection of minor ischemic cardiac injury in patients with unstable angina by measurement of cTnI and fatty acid-binding protein (FABP). Clin. Chem. 45, A139 (1999).
   Google Scholar
• Valle HA, Garcia-Castrillo Riesgo L, Bel MS, Gonzalo FE, Sanchez MS, Oliva LI. Clinical assessment of heart-type fatty acid binding protein in early diagnosis of acute coronary syndrome. Eur. J. Emerg. Med. 15, 140–144 (2008).
   Google Scholar
• Hamm CW, Ravkilde J, Gerhardt W et al. The prognostic value of serum troponin T in unstable angina. N. Engl. J. Med. 16, 146–150 (1992).
   Google Scholar
• Basar Ö, Akbal E, Köklü S et al. Increased H-FABP concentrations in nonalcoholic fatty liver disease. Herz 38, 417–422 (2013).
   Google Scholar
• Gravning J, Kjekshus J. The perfect biomarker in acute coronary syndrome: a challenge for diagnosis, prognosis, and treatment. Eur. Heart J. 29, 2827–2828 (2008). •• Excellent overview of the requirements for plasma markers in acute coronary syndrome and whether these can be met with the currently known biomarkers.
   Google Scholar
• Sorichter S, Mair J, Koller A, Pelsers MMAL, Puschendorf B, Glatz JFC. Plasma fatty acid-binding protein allows early assessment of exercise-induced skeletal muscle injury. Br. J. Sports Med. 32, 121–124 (1998).
   Google Scholar
• Randox. www.randox.com
   Google Scholar
• Carless DR, Wnek M, Knox C et al. Clinical and analytical evaluation of an immunoturbidimetric heart-type fatty acid-binding protein assay. Scand. J. Clin. Lab. Invest. 73, 48–53 (2013).
   Google Scholar
• Robers M, Van der Hulst FF, Fischer MAJG et al. Development of a rapid microparticle-enhanced turbidimetric immuno-assay for plasma fatty acid-binding protein, an early marker of acute myocardial infarction. Clin. Chem. 44, 1564–1567 (1998).
   Google Scholar
• BMassay. www.bmassay.com
   Google Scholar
• Hycultbiotech. www.hycultbiotech.com
   Google Scholar
• Wodzig KWH, Pelsers MMAL, Van der Vusse GJ, Roos W, Glatz JFC. One-step enzyme-linked immunosorbent assay (ELISA) for plasma fatty acid-binding protein. Ann. Clin. Biochem. 34, 263–268 (1997).
   Google Scholar
• OxisResearch. www.oxisresearch.com
   Google Scholar
• Watanabe T, Ohkubo Y, Matsuoka H et al. Development of a simple whole blood panel test for detection of human heart-type fatty acid binding protein. Clin. Biochem. 34, 257–263 (2001).
   Google Scholar
• 8sens.biognostic. www.biognostic.de
   Google Scholar
• Liao J, Chan CP, Cheung Y et al. Human heart-type fatty acid-binding protein for on-site diagnosis of early acute myocardial infarction. Int. J. Cardiol. 133, 420–423 (2008).
   Google Scholar
• FABPulous. www.fabpulous.com
   Google Scholar
• Ishii J, Wang JH, Naruse H et al. Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction. Clin. Chem. 43, 1372–1378 (1997).
   Google Scholar
• Glatz JFC, Van der Vusse GJ, Simoons ML, Kragten JA, Van Dieijen-Visser MP, Hermens WT. Fatty acid-binding protein and the early detection of acute myocardial infarction. Clin. Chim. Acta 272, 87–92 (1998).
   Google Scholar
• Haastrup B, Gill S, Kristensen SR et al. Biochemical markers of ischaemia for the early identification of acute myocardial infarction without ST segment elevation. Cardiology 94, 254–261 (2000).
   Google Scholar
• Okamoto F, Sohmiya K, Ohkaru Y et al. Human heart-type cytoplasmic fatty acid-binding protein (H-FABP) for the diagnosis of acute myocardial infarction. Clinical evaluation of H-FABP in comparison with myoglobin and creatine kinase isoenzyme MB. Clin. Chem. Lab. Med. 38, 231–238 (2000).
   Google Scholar
• Ghani F, Wu AH, Graff L et al. Role of heart-type fatty acid-binding protein in early detection of acute myocardial infarction. Clin. Chem. 46, 718–719 (2000).
   Google Scholar
• Seino Y, Ogata K, Takano T et al. Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: comparison with rapid troponin T and myoglobin tests. Am. J. Med. 115, 185–190 (2003).
   Google Scholar
• Chan CPY, Sanderson JE, Glatz JFC, Cheng WS, Hempel A, Renneberg R. A superior early myocardial infarction marker: Human heart-type fatty acid-binding protein. Z. Kardiol. 93, 388–397 (2004).
   Google Scholar
• Mion MM, Novello E, Altinier S, Rocco S, Zaninotto M, Plebani M. Analytical and clinical performance of a fully automated cardiac multi-markers strategy based on protein biochip microarray technology. Clin. Biochem. 40, 1245–1251 (2007).
   Google Scholar
• McCann CJ, Glover BM, Menown IBA et al. Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T. Eur. Heart J. 29, 2843–2850 (2008).
   Google Scholar
• Haltern G, Peiniger S, Bufe A, Reiss G, Gülker H, Scheffold T. Comparison of usefulness of heart-type fatty acid binding protein versus cardiac troponin T for diagnosis of acute myocardial infarction. Am. J. Cardiol. 105, 1–9 (2010). •• Evaluation of the use of H-FABP and of troponin at various time intervals after onset of chest pain.
   Google Scholar
• Alhadi HA, Fox KAA. Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction. The potential for influencing patient management. SQU Med. J. 10, 41–49 (2010).
   Google Scholar
• Gururajan P, Gurumurthy P, Nayar P et al. Heart fatty acid binding protein (H-FABP) as a diagnostic biomarker in patients with acute coronary syndrome. Heart Lung Circ. 19, 660–664 (2010).
   Google Scholar
• Kurz K, Giannitsis E, Becker M, Hess G, Zdunek D, Katus HA. Comparison of the new high sensitivity cardiac troponin T with myoglobin, h-FABP and cTnT for early identification of myocardial necrosis in the acute coronary syndrome. Clin. Res. Cardiol. 100, 209–215 (2011).
   Google Scholar
• Body R, McDowell G, Carley S, Wibberley C, Ferguson J, Mackway-Jones K. A FABP-ulous ‘rule out’ strategy? Heart fatty acid binding protein and troponin for rapid exclusion of acute myocardial infarction. Resuscitation 82, 1041–1046 (2011).
   Google Scholar
• McMahon CG, Lamont JV, Curtin E et al. Diagnostic accuracy of heart-type fatty acid-binding protein for the early diagnosis of acute myocardial infarction. Am. J. Emerg. Med. 30, 267–274 (2012).
   Google Scholar
• Ruff CT, Bonaca MP, Kosowsky JM et al. Evaluation of the diagnostic performance of heart-type fatty acid binding protein in the BWH-TIMI ED chest pain study. J. Thromb. Thrombol. 36, 361–367 (2013).
   Google Scholar
• Eggers KM, Venge P, Lindahl B. High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain. Clin. Chim. Acta 413, 1135–1140 (2012).
   Google Scholar
• Kagawa Y, Toyofuku M, Masaoka Y et al. Comparison of heart-type fatty acid binding protein and sensitive troponin for the diagnosis of early acute myocardial infarction. Int. J. Cardiol. 166, 347–351 (2013).
   Google Scholar
• Reiter M, Twerenbold R, Reichlin T et al. Heart-type fatty acid binding protein in the early diagnosis of acute myocardial infarction. Heart 99, 708–714 (2013).
   Google Scholar
• Cappellini F, Da Molin S, Signorini S et al. Heart-type fatty acid-binding protein may exclude acute myocardial infarction on admission to emergency department for chest pain. Acute Card. Care 15, 83–87 (2013).
   Google Scholar
• Bruins Slot MHE, Reitsma JB, Rutten FH, Hoes AW, Van der Heijden GJMG. Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction: a systematic review and meta-analysis. Heart 96, 1957–1963 (2010).
   Google Scholar
• Carroll C, Al Khalaf M, Stevens JW et al. Heart-type fatty acid binding protein as early marker for myocardial infarction: systematic review and meta-analysis. Emerg. Med. J. 30, 280–286 (2013). • Useful systematic overview of the use of either H-FABP and troponin separately or in combination for diagnosing acute myocardial infarction.
   Google Scholar
• Lippi G, Mattiuzzi C, Cervellin G. Critical review and meta-analysis on the combination of heart-type fatty acid binding protein (H-FABP) and troponin for early diagnosis of acute myocardial infarction. Clin. Biochem. 46, 26–30 (2013).
   Google Scholar
• Pope JH, Aufderheide TP, Ruthazer R et al. Missed diagnosis of acute cardiac ischemia in the emergency department. N. Engl. J. Med. 342, 1163–1170 (2000).
   Google Scholar
• Nilsson S, Scheike M, Engblom D et al. Chest pain and ischaemic heart disease in primary care. Br. J. Gen. Practice 53, 378–382 (2003).
   Google Scholar
• Dekker MS, Mosterd A, Van ‘t Hof AWJ, Hoes AW. Novel biochemical markers in suspected acute coronary syndrome: systematic review and critical appraisal. Heart 96, 1001–1010 (2010).
   Google Scholar
• Freund Y, Chenevier-Gobeaux C, Leumani F et al. Heart-type fatty acid binding protein and the diagnosis of acute coronary syndrome in the ED. Am. J. Emerg. Med. 30, 1378–1384 (2012).
   Google Scholar
• Willemsen R, Dinant G-J, Buntinx F Heart-type fatty acid binding protein compared with high-sensitive troponin T for early exclusion of acute myocardial infarction. Presented at: 6th Annual Scientific Meeting of the European Primary Care Cardiovascular Society (EPCCS). London, UK, 5–6 September 2013.
   Google Scholar
• ClinicalTrials.gov. www.clinicaltrials.gov
   Google Scholar
• Ishii J, Ozaki Y, Lu J et al. Prognostic value of serum concentration of heart-type fatty acid-binding protein relative to troponin T on admission in the early hours of acute coronary syndrome. Clin. Chem. 51, 1397–1404 (2005).
   Google Scholar
• Erlikh AD, Katrukha AG, Trifonov IR, Bereznikova AV, Gratsianskii NA. Prognostic significance of heart fatty acid binding protein in patients with non-ST elevation acute coronary syndrome: results of follow-up for twelve months. Kardiologiia 45, 13–21 (2005).
   Google Scholar
• O’Donoghue M, De Lemos J, Morrow DA et al. Prognostic utility of heart-type fatty acid binding protein in patients with acute coronary syndromes. Circulation 114, 550–557 (2006).
   Google Scholar
• Kilcullen N, Viswanathan K, Das R et al. Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk patients across the range of troponin values. J. Am. Coll. Cardiol. 50, 2061–2067 (2007).
   Google Scholar
• McCann CJ, Glover BM, Menown IBA et al. Prognostic value of a multimarker approach for patients presenting to hospital with acute chest pain. Am. J. Cardiol. 103, 22–28 (2009). •• Landmark publication on the prognostic utility of plasma H-FABP.
   Google Scholar
• Garcia-Valdecasas S, Ruiz-Alvarez MJ, Garcia de Tena J et al. Diagnostic and prognostic value of heart-type fatty acid-binding protein in the early hours of acute myocardial infarction. Acta Cardiol. 66, 315–321 (2011).
   Google Scholar
• Viswanathan K, Kilcullen N, Morrell C et al. Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutive patients with suspected acute coronary syndrome who are troponin-negative. J. Am. Coll. Cardiol. 55, 2590–2598 (2010).
   Google Scholar
• Niizeki T, Takeishi Y, Arimoto T et al. Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure. Circ. J. 72, 109–114 (2008).
   Google Scholar
• Hayabuchi Y, Inoue M, Watanabe N, Sakata M, Ohnishi T, Kagami S. Serum concentration of heart-type fatty acid-binding protein in children and adolescents with congenital heart disease. Circ. J. 75, 1992–1997 (2011).
   Google Scholar
• Kutsuzawa D, Arimoto T, Watanabe T et al. Ongoing myocardial damage in patients with heart failure and preserved ejection fraction. J. Cardiol. 60, 454–461 (2012).
   Google Scholar
• Muehlschlegel JD, Perry TE, Liu KY et al. Heart-type fatty acid binding protein is an independent predictor of death and ventricular dysfunction after coronary artery bypass graft surgery. Anesth. Analg. 111, 1101–1109 (2010).
   Google Scholar
• Kaczynska A, Pelsers MMAL, Bochowicz A, Kostrubiec M, Glatz JFC, Pruszczyk P. Plasma heart-type fatty acid binding protein is superior to troponin and myoglobin for rapid risk stratification in acute pulmonary embolism. Clin. Chim. Acta 371, 117–123 (2006).
   Google Scholar
• Puls M, Dellas C, Lankeit M et al. Heart-type fatty acid-binding protein permits early risk stratification of pulmonary embolism. Eur. Heart J. 28, 224–229 (2007).
   Google Scholar
• Dellas C, Puls M, Lankeit M et al. Elevated heart-type fatty acid-binding protein levels on admission predict an adverse outcome in normotensive patients with acute pulmonary embolism. J. Am. Coll. Cardiol. 55, 2150–2157 (2010).
   Google Scholar
• Boscheri A, Wunderlich C, Langer M et al. Correlation of heart-type fatty acid-binding protein with mortality and echocardiographic data in patients with pulmonary embolism at intermediate risk. Am. Heart J. 160, 294–300 (2010).
   Google Scholar
• Jo YH, Kim K, Lee JH et al. Heart-type fatty acid-binding protein as a prognostic factor in patients with severe sepsis and septic shock. Am. J. Emerg. Med. 30, 1749–1755 (2012).
   Google Scholar
• Zhang Z, Dai H, Yu Y, Yang J, Hu C. Usefulness of heart-type fatty acid-binding protein in patients with severe sepsis. J. Crit. Care 27, 415.e13–415.e18 (2012).
   Google Scholar
• Matsumoto S, Nakatani D, Sakata Y et al. Elevated serum heart-type fatty acid-binding protein in the covalescent stage predicts long-term outcome in patients surviving acute myocardial infarction. Circ. J. 77, 1026–1032 (2013).
   Google Scholar
• Leung W, Chan CP, Leung M et al. Novel ‘digital-style’ rapid test simultaneously detecting heart attack and predicting cardiovascular disease risk. Anal. Lett. 38, 423–439 (2005).
   Google Scholar
• Chan CP, Sum KW, Cheung KY et al. Development of a quantitative lateral-flow assay for rapid detection of fatty acid-binding protein. J. Immunol. Methods 279, 91–100 (2003).
   Google Scholar
• Zie PY, Li YP, Chan CP, Cheung KY, Cautherley GW, Renneberg R. A one-step immunotest for rapid detection of heart-type fatty acid-binding protein in patients with acute coronary syndromes. J. Immunoassay Immunochem. 31, 24–32 (2010).
   Google Scholar
• Liang Y, Chan CP, Cheung KY et al. CardioDetect rapid test for the diagnosis of early acute myocardial infarction. J. Immunoassay Immunochem. 32, 342–352 (2011).
   Google Scholar
• Hiura M, Nakajima O, Mori T, Kitano K. Performance of a semi-quantitative whole blood test for human heart-type fatty acid-binding protein (H-FABP). Clin. Biochem. 38, 948–950 (2005).
   Google Scholar
• Alhashemi JA. Diagnostic accuracy of a bedside qualitative immunochromatographic test for acute myocardial infarction. Am. J. Emerg. Med. 24, 149–155 (2006).
   Google Scholar
• Lefèvre G, Fayet J-M, Graïne H et al. Multicenter evaluation of H-FABP semi-quantitative assay (CardioDetect) in central laboratory: the point in acute myocardial infarction diagnosis. Ann. Biol. Clin. 65, 377–384 (2007).
   Google Scholar
• Mad P, Domanovits H, Fazelnia C et al. Human heart-type fatty-acid-binding protein as a point-of-care test in he early diagnosis of acute myocardial infarction. Q. J. Med. 100, 203–210 (2007).
   Google Scholar
• Figiel L, Kasprzak JD, Peruga J et al. Heart-type fatty acid binding protein – a reliable marker of myocardil necrosis in a heterogenous group of patients with acute coronary syndrome without persistent ST elevation. Kardiol. Polska 66, 253–259 (2008).
   Google Scholar
• Naroo GY, Ali SM, Butros V et al. Elevated heart-type fatty acid-binding protein predicts early myocardial injury and aids in the diagnosis of non-ST elevation myocardial infarction. Hong Kong J. Emerg. Med. 16, 141–147 (2009).
   Google Scholar
• Charpentier S, Ducassé JL, Cournot M et al. Clinical assessment of ischemia-modified albumin and heart fatty acid-binding protein in the early diagnosis of non-STelevation acute coronary syndrome in the emergency department. Acad. Emerg. Med. 17, 27–35 (2010).
   Google Scholar
• Cete Y, Eken C, Eray O, Goksu E, Kiyan S, Atilla R. The value of point-of-care fatty acid binding protein in patients with chest pain in determining myocardial infarction in the emergency setting. Hong Kong J. Emerg. Med. 17, 224–229 (2010).
   Google Scholar
• Charpentier S, Maupas-Schwalm F, Cournot M et al. Diagnostic accuracy of quantitative heart-fatty acid binding protein assays compared with CardioDetect in the early detection of acute coronary syndrome. Arch. Cardiovasc. Dis. 104, 524–529 (2011).
   Google Scholar
• Figiel L, Wraga M, Bednarkiewicz Z et al. Direct comparison of the diagnostic value of point-of-care tests detecting heart-type fatty acid binding protein or glycogen phosphorylase isoenzyme BB in patients with acute coronary syndromes with persistent ST-segment elevation. Kardiol. Polska 69, 1–6 (2011).
   Google Scholar
• Kim KS, Lee HJ, Kim K et al. Heart-type fatty acid binding protein as an adjunct to cardiac troponin-I for the diagnosis of myocardial infarction. J. Korean Med. Sci. 26, 47–52 (2011).
   Google Scholar
• Bruins Slot MHE, Rutten FH, Van der Heijden GJMG et al. Diagnostic value of a heart-type fatty acid-binding protein (H-FABP) bedside test in suspected acute coronary syndrome in primary care. Int. J. Cardiol. 168, 1481–1489 (2013).
   Google Scholar
• McDonnell B, Hearty S, Leonard P, O’Kennedy R. Cardiac biomarkers and the case for point-of-care testing. Review. Clin. Biochem. 42, 549–561 (2009).
   Google Scholar
• Viswanathan K, Hall AS, Barth JH. An evidence-based approach to the assessment of heart-type fatty acid binding protein in acute coronary syndrome (review). Clin. Biochem. Rev. 33, 3–11 (2012).
   Google Scholar
• Body R. Heart fatty acid binding protein and troponin: a match made in heaven? Clin. Lab. Int. 36, 6–10 (2012).
   Google Scholar
• Lackner KJ. Laboratory diagnostics of myocardial infarction – troponins and beyond. Clin. Chem. Lab. Med. 51, 83–89 (2013).
   Google Scholar
• Renneberg R, Glatz JFC. Fabulous FABP. The earliest plasma marker for myocardial infarction. Labor & More 2, 14–19 (2013).
   Google Scholar
• Franssen EJ, Maessen JG, Hermens WT, Glatz JFC. Demonstration of ischemia-reperfusion injury separate from postoperative infarction in coronary artery bypass graft patients. Ann. Thorac. Surg. 65, 48–53 (1998).
   Google Scholar
• Rader F, Pujara AC, Pattakos G et al. Perioperative heart-type fatty acid binding protein levels in atrial fibrillation after cardiac surgery. Heart Rhythm 10, 153–157 (2013).
   Google Scholar
• Jeremias A, Gibson M. Narrative review: alternative causes for elevated cardiac troponin levels when acute coronary syndromes are excluded. Ann. Intern. Med. 142, 786–791 (2005).
   Google Scholar
• Tate JR. Troponin revisited 2008: assay performance. Clin. Chem. Lab. Med. 46, 1489–1500 (2008).
   Google Scholar
• Morrow DA. Clinical application of sensitive troponin assays. N. Engl. J. Med. 361, 913–915 (2009).
   Google Scholar
• Scharnhorst V, Krasznai K, Van ‘t Veer M, Michels RH. Variation of cardiac troponin I and T measured with sensitive assays in emergency department patients with noncardiac chest pain. Clin. Chem. 58, 1208–1214 (2012).
   Google Scholar
• Mingels A, Jacobs L, Michielsen E, Swaanenburg J, Wodzig W, Van Dieijen-Visser M. Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays. Clin. Chem. 55, 101–108 (2009).
   Google Scholar
• Feng L-N, Bian Z-P, Peng J et al. Ultrasensitive multianalyte electrochemical immunoassay based on metal ion functionalized titanium phosphate nanospheres. Anal. Chem. 84, 7810–7815 (2012).
   Google Scholar
• Lee-Lewandrowski E, Januzzi JL, Grisson R, Mohammed AA, Lewandrowski G, Lewandrowski K. Evaluation of first-draw whole blood, point-of-care cardiac markers in the context of the universal definition of myocardial infarction. Arch. Pathol. Lab. Med. 135, 459–463 (2011).
   Google Scholar
• Schneider HG, Ablitt P, Taylor J. Improved sensitivity of point of care troponin I values using reporting to below the 99th percentile of normals. Clin. Biochem. 46, 979–982 (2013).
   Google Scholar
• Ramparany L, Ramirez J, Nizou J-Y, Le Saux D, Richard V, Talarmin A. Evaluation of four rapid immunochromatographic tests for the detection of cardiac troponin I. Clin. Vacc. Immunol. 18, 414–417 (2011).
   Google Scholar
• Venge P, Ohberg C, Flodin M, Lindahl B. Early and late outcome prediction of death in the emergency room setting by point-of-care and laboratory assays of cardiac troponin I. Am. Heart J. 835–841 (2010).
   Google Scholar
• Bruins Slot MH, Van der Heijden GJ, Stelpstra SD, Hoes AW, Rutten FH. Point-of-care tests in suspected myocardial infarction: a systematic review. Int. J. Cardiol. 168, 5355–5362 (2013).
   Google Scholar