References
- ClinicalTrials.gov . https://clinicaltrials.gov/ .
- Keating A . Mesenchymal stromal cells: new directions . Cell Stem Cell10 ( 6 ), 709 – 716 ( 2012 ).
- Friedenstein AJ , PetrakovaKV , KurolesovaAI , FrolovaGP . Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues . Transplantation6 ( 2 ), 230 – 247 ( 1968 ).
- Dominici M , Le BlancK , MuellerIet al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement . Cytotherapy8 ( 4 ), 315 – 317 ( 2006 ).
- Viswanathan S , KeatingA , DeansRet al. Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation . Stem Cells Dev.23 ( 11 ), 1157 – 1167 ( 2014 ).
- Frobel J , HemedaH , LenzMet al. Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells . Stem Cell Rep.3 ( 3 ), 414 – 422 ( 2014 ).
- Hematti P . Characterization of mesenchymal stromal cells: potency assay development . Transfusion56 ( 4 ), s32 – s35 ( 2016 ).
- Liao J , KarnikR , GuHet al. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells . Nat. Genet.47 ( 5 ), 469 – 478 ( 2015 ).
- Hematti P . Mesenchymal stromal cells and fibroblasts: a case of mistaken identity?Cytotherapy14 ( 5 ), 516 – 521 ( 2012 ).
- Lenz M , SchuldtBM , MüllerFJ , SchuppertA . Physiospace: relating gene expression experiments from heterogeneous sources using shared physiological processes . PLoS ONE8 ( 10 ), e7762 ( 2013 ).
- Rohart F , MasonEA , MatigianNet al. A molecular classification of human mesenchymal stromal cells . PeerJ4 , e1845 ( 2016 ).
- de Almeida DC , FerreiraMR , FranzenJet al. Epigenetic classification of human mesenchymal stromal cells . Stem Cell Rep.6 ( 2 ), 168 – 175 ( 2016 ).
- Cygenia . www.cygenia.com .
- Bianco P , RobeyPG , SimmonsPJ . Mesenchymal stem cells: revisiting history, concepts, and assays . Cell Stem Cell2 ( 4 ), 313 – 319 ( 2008 ).
- Wagner W , WeinF , SeckingerAet al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood . Exp. Hematol.33 ( 11 ), 1402 – 1416 ( 2005 ).
- Reinisch A , EtchartN , ThomasDet al. Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation . Blood125 ( 2 ), 249 – 260 ( 2015 ).
- Wagner W , RoderburgC , WeinFet al. Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors . Stem Cells25 ( 10 ), 2638 – 2647 ( 2007 ).
- Watson JT , FooT , WuJet al. CD271 as a marker for mesenchymal stem cells in bone marrow versus umbilical cord blood . Cells Tissues Organs197 ( 6 ), 496 – 504 ( 2013 ).
- Lepperdinger G . Inflammation and mesenchymal stem cell aging . Curr. Opin. Immunol.23 ( 4 ), 518 – 524 ( 2011 ).
- Schellenberg A , LinQ , SchulerHet al. Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks . Aging (Albany NY)3 ( 9 ), 873 – 888 ( 2011 ).
- Koch CM , SuschekCV , LinQet al. Specific age-associated DNA methylation changes in human dermal fibroblasts . PLoS ONE6 ( 2 ), e16679 ( 2011 ).
- Estrada JC , AlboC , BenguriaAet al. Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis . Cell Death Diff.19 ( 5 ), 743 – 755 ( 2012 ).
- Neuhuber B , SwangerSA , HowardL , MackayA , FischerI . Effects of plating density and culture time on bone marrow stromal cell characteristics . Exp. Hematol.36 ( 9 ), 1176 – 1185 ( 2008 ).
- Hemeda H , GiebelB , WagnerW . Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells . Cytotherapy16 ( 2 ), 170 – 180 ( 2014 ).
- Abdelrazik H , SpaggiariGM , ChiossoneL , MorettaL . Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T- and NK-cell proliferation and function . Eur. J. Immunol.41 ( 11 ), 3281 – 3290 ( 2011 ).
- Mark P , KleinsorgeM , GaebelRet al. Human mesenchymal stem cells display reduced expression of CD105 after culture in serum-free medium . Stem Cells Int.2013 , 698076 ( 2013 ).
- Hayflick L , MoorheadPS . The serial cultivation of human diploid cell strains . Exp. Cell Res.25 , 585 – 621 ( 1961 ).
- Wagner W , Fernandez-RebolloE , FrobelJ . DNA-methylation changes in replicative senescence and aging: two sides of the same coin?Epigenomics8 ( 1 ), 1 – 3 ( 2016 ).
- Wagner W , HornP , CastoldiMet al. Replicative senescence of mesenchymal stem cells: a continuous and organized process . PLoS ONE3 ( 5 ), e2213 ( 2008 ).
- Bork S , PfisterS , WittHet al. DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells . Aging Cell9 ( 1 ), 54 – 63 ( 2010 ).
- Koch CM , JoussenS , SchellenbergA , LinQ , ZenkeM , WagnerW . Monitoring of cellular senescence by DNA-methylation at specific CpG sites . Aging Cell11 ( 2 ), 366 – 369 ( 2012 ).
- Schellenberg A , MauenS , KochCM , JansR , de WaeleP , WagnerW . Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes . BMC Res. Notes7 , 254 ( 2014 ).
- Horvath S . DNA methylation age of human tissues and cell types . Genome Biol.14 ( 10 ), R115 ( 2013 ).
- Koch CM , WagnerW . Epigenetic-aging-signature to determine age in different tissues . Aging (Albany NY)3 ( 10 ), 1018 – 1027 ( 2011 ).
- Koch CM , ReckK , ShaoKet al. Pluripotent stem cells escape from senescence-associated DNA methylation changes . Genome Res.23 ( 2 ), 248 – 259 ( 2013 ).
- Samsonraj RM , RaiB , SathiyanathanPet al. Establishing criteria for human mesenchymal stem cell potency . Stem Cells33 ( 6 ), 1878 – 1891 ( 2015 ).
- Estrada JC , TorresY , BenguriaAet al. Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy . Cell Death Dis.4 , e691 ( 2013 ).
- Freeman BT , JungJP , OgleBM . Single-cell RNA-Seq of Bone marrow-derived mesenchymal stem cells reveals unique profiles of lineage priming . PLoS ONE10 ( 9 ), e0136199 ( 2015 ).
- Lorthongpanich C , CheowLF , BaluSet al. Single-cell DNA-methylation analysis reveals epigenetic chimerism in preimplantation embryos . Science341 ( 6150 ), 1110 – 1112 ( 2013 ).