1,572
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Follow the Trace of Death: Methylation Analysis of Cell-Free DNA for Clinical Applications in Non-Cancerous Diseases

Pages 1169-1172 | Received 30 Jun 2016, Accepted 04 Jul 2016, Published online: 16 Aug 2016

References

  • Heitzer E , UlzP , GeiglJB . Circulating tumor DNA as a liquid biopsy for cancer . Clin. Chem.61 ( 1 ), 112 – 123 ( 2015 ).
  • Diaz LA Jr , BardelliA . Liquid biopsies: genotyping circulating tumor DNA . J. Clin. Oncol.32 ( 06 ), 579 – 586 ( 2014 ).
  • Wong FC , LoYM . Prenatal diagnosis innovation: genome sequencing of maternal plasma . Annu. Rev. Med.67 , 419 – 432 ( 2016 ).
  • Gielis EM , LedeganckKJ , De WinterBYet al. Cell-free DNA: an upcoming biomarker in transplantation . Am. J. Transplant.15 ( 10 ), 2541 – 2551 ( 2015 ).
  • How Kit A , NielsenHM , TostJ . DNA methylation based biomarkers: practical considerations and applications . Biochimie94 ( 11 ), 2314 – 2337 ( 2012 ).
  • Warton K , SamimiG . Methylation of cell-free circulating DNA in the diagnosis of cancer . Front. Mol. Biosci.2 , 13 ( 2015 ).
  • Payne SR . From discovery to the clinic: the novel DNA methylation biomarker mSEPT9 for the detection of colorectal cancer in blood . Epigenomics2 ( 4 ), 575 – 585 ( 2010 ).
  • Tost J . DNA methylation signatures in circulating cell-free DNA for the monitoring of at-risk populations progressing to lung cancer . EBioMedicine2 ( 8 ), 798 – 799 ( 2015 ).
  • Wielscher M , VierlingerK , KeglerU , ZiescheR , GsurA , WeinhauselA . Diagnostic performance of plasma DNA methylation profiles in lung cancer, pulmonary fibrosis and COPD . EBioMedicine2 ( 8 ), 927 – 934 ( 2015 ).
  • Chan RW , JiangP , PengXet al. Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing . Proc. Natl Acad. Sci. USA111 ( 49 ), E5302 – E5311 ( 2014 ).
  • Sun K , JiangP , ChanKCet al. Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments . Proc. Natl Acad. Sci. USA112 ( 40 ), E5503 – E5512 ( 2015 ).
  • Zeybel M , HardyT , WongYKet al. Multigenerational epigenetic adaptation of the hepatic wound-healing response . Nat. Med.18 ( 09 ), 1369 – 1377 ( 2012 ).
  • Angulo P , KleinerDE , Dam-LarsenSet al. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease . Gastroenterology149 ( 02 ), 389 – 397.e10 ( 2015 ).
  • Hardy T , ZeybelM , DayCPet al. Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease . Gut doi:10.1136/gutjnl-2016-311526 ( 2016 ) ( Epub ahead of print ).
  • Zhao Q , FanYC , ZhaoJ , GaoS , ZhaoZH , WangK . DNA methylation patterns of peroxisome proliferator-activated receptor gamma gene associated with liver fibrosis and inflammation in chronic hepatitis B . J. Viral Hepat.20 ( 06 ), 430 – 437 ( 2013 ).
  • Lehmann-Werman R , NeimanD , ZemmourHet al. Identification of tissue-specific cell death using methylation patterns of circulating DNA . Proc. Natl Acad. Sci. USA113 ( 13 ), E1826 – E1834 ( 2016 ).
  • Akirav EM , LebastchiJ , GalvanEMet al. Detection of beta cell death in diabetes using differentially methylated circulating DNA . Proc. Natl Acad. Sci. USA108 ( 47 ), 19018 – 19023 ( 2011 ).
  • Olsen JA , KennaLA , SpeliosMG , HessnerMJ , AkiravEM . Circulating differentially methylated amylin DNA as a biomarker of beta-cell loss in Type 1 diabetes . PLoS ONE11 ( 04 ), e0152662 ( 2016 ).
  • De Mattos-Arruda L , MayorR , NgCKet al. Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma . Nat. Commun.06 , 8839 ( 2015 ).
  • Roadmap Epigenomics C , KundajeA , MeulemanWet al. Integrative analysis of 111 reference human epigenomes . Nature518 ( 7539 ), 317 – 330 ( 2015 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.