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Research Article

FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects

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Pages 1279-1286 | Published online: 06 Sep 2017

References

  • Oster H , ChalletE , OttVet al. The functional and clinical significance of the 24-h rhythm of circulating glucocorticoids . Endocr. Rev.38 ( 1 ), 3 – 45 ( 2017 ).
  • Schulz J , FreyKR , CooperMSet al. Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency . Eur. J. Endocrinol.174 ( 4 ), 531 – 538 ( 2016 ).
  • Koetz KR , VentzM , DiederichS , QuinklerM . Bone mineral density is not significantly reduced in adult patients on low-dose glucocorticoid replacement therapy . J. Clin. Endocrinol. Metab.97 ( 1 ), 85 – 92 ( 2012 ).
  • Gruener AM , SharmaP , AmeenS , AhmedF . Severe corticosteroid-induced ocular hypertension requiring bilateral trabeculectomies in a patient with Takayasu’s arteritis . Case Rep. Ophthalmol. Med. 2016 , 5253029 ( 2016 ).
  • Harbeck B , HaasCS , MönigH . Effect of hydrocortisone replacement therapy on body mass index after pituitary surgery . J. Endocrinol. Invest.38 ( 2 ), 183 – 184 ( 2015 ).
  • Johannsson G , RagnarssonO . Cardiovascular and metabolic impact of glucocorticoid replacement therapy . Front. Horm. Res.43 , 33 – 44 ( 2014 ).
  • Tiemensma J , AndelaCD , KapteinAAet al. Psychological morbidity and impaired quality of life in patients with stable treatment for primary adrenal insufficiency: cross-sectional study and review of the literature . Eur. J. Endocrinol.171 ( 2 ), 171 – 182 ( 2014 ).
  • Van der Valk ES , SmansLC , HofstetterHet al. Decreased physical activity, reduced QoL and presence of debilitating fatigue in patients with Addison’s disease . Clin. Endocrinol.85 ( 3 ), 354 – 360 ( 2016 ).
  • Behan LA , CarmodyD , RogersBet al. Low-dose hydrocortisone replacement is associated with improved arterial stiffness index and blood pressure dynamics in severely adrenocorticotrophin-deficient male hypopituitary male patients . Eur. J. Endocrinol.174 ( 6 ), 791 – 799 ( 2016 ).
  • Grossman A , JohannssonG , QuinklerM , ZelissenP . Therapy of endocrine disease: perspectives on the management of adrenal insufficiency: clinical insighets from across Europe . Eur. J. Endocrinol.169 ( 6 ), R165 – R175 ( 2013 ).
  • Oksnes M , BjörnsdottirS , IsakssonMet al. Continuous subcutaneous hydrocortisone infusion versus oral hydrocortisone replacement for treatment of Addison’s disease: a randomizend clinical trial . J. Clin. Endocrinol. Metab.99 ( 5 ), 1665 – 1274 ( 2014 ).
  • Petersons CJ , MangelsdorfBL , ThompsonCH , BurtMG . Acute effect of increasing glucocorticoid replacement dose on cardiovascular risk and insulin sensitivity in patients with adrenocorticotrophin deficiency . J. Clin. Endocrinol. Metab.99 ( 6 ), 2269 – 2276 ( 2014 ).
  • Lee RS , TamashiroKL , YangXet al. A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice . Psychopharmacology (Berl.)218 ( 1 ), 303 – 312 ( 2011 ).
  • Binder EB . The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders . Psychoneuroendocrinology34 ( Suppl. 1 ), 186 – 195 ( 2009 ).
  • Ewald ER , WandGS , SeifuddinFet al. Alterations in DNA methylation of Fkbp5 as a determinant of blood-brain correlation of glucocorticoid exposure . Psychononeuroendocrinology44 , 112 – 122 ( 2014 ).
  • Yang X , EwaldER , HuoYet al. Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5 . Biochem. Biophys. Res. Commun.420 ( 3 ), 570 – 575 ( 2012 ).
  • Klengel T , MehtaD , AnackerCet al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions . Nat. Neurosci.16 ( 1 ), 33 – 41 ( 2013 ).
  • Matsuda A , AsadaY , TakakuwaKet al. DNA methylation analysis of human trabecular meshwork cells during dexamethasone stimulation DNA methylation analysis of trabecular meshwork cells . Invest. Ophthalmol. Vis. Sci.56 ( 6 ), 3801 – 3809 ( 2015 ).
  • Resmini E , SantosA , AulinasAet al. Reduced DNA methylation of FKBP5 in Cushing’s syndrome . Endocrine54 ( 3 ), 768 – 777 ( 2016 ).
  • Glad CA , Andersson-AssarssonJC , BerglundPet al. Reduced DNA methylation and psychopathology following endogenous hypercortisolism – a genome-wide study . Sci. Rep.7 , 44445 ( 2017 ).
  • Bali Utsav , PhillipsTim , HuntHazelet al. FKBP5 mRNA expression is a biomarker for GR antagonism . J. Clin. Endocrinol. Metab.101 ( 11 ), 4305 – 4312 ( 2016 ).
  • Houseman EA , AccomandoWP , KoestlerDCet al. DNA methylation arrays as surrogate measures of cell mixture distribution . BMC Bioinformatics13 , 86 ( 2012 ).

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