221
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Regulation of UGT1A expression by miR-298 in human livers from the Han Chinese population and in human cell lines

, , , , , , & show all
Pages 43-57 | Received 20 May 2017, Accepted 25 Sep 2017, Published online: 27 Nov 2017

References

  • Rowland A , MinersJO , MackenziePI . The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification . Int. J. Biochem. Cell B.45 ( 6 ), 1121 – 1132 ( 2013 ).
  • Mackenzie PI , BockKW , BurchellBet al. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily . Pharmacogenet. Genomics15 ( 10 ), 677 – 685 ( 2005 ).
  • Gong QH , ChoJW , HuangTet al. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus . Pharmacogenetics11 ( 4 ), 357 – 368 ( 2001 ).
  • Guillemette C , LevesqueE , HarveyM , BellemareJ , MenardV . UGT genomic diversity: beyond gene duplication . Drug Metab. Rev.42 ( 1 ), 24 – 44 ( 2010 ).
  • Ohno S , NakajinS . Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptase-polymerase chain reaction . Drug Metab. Dispos.37 ( 1 ), 32 – 40 ( 2008 ).
  • Court MH , ZhangX , DingXet al. Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues . Xenobiotica42 ( 3 ), 266 – 277 ( 2012 ).
  • Liu W , RamirezJ , GamazonERet al. Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver . Hum. Mol. Genet.23 ( 20 ), 5558 – 5569 ( 2014 ).
  • Tukey RH , StrassburgCP . Human UDP-glucuronosyltransferases: metabolism, expression, and disease . Annu. Rev. Pharmacol.40 ( 1 ), 581 – 616 ( 2000 ).
  • Bosma PJ , ChowdhuryJR , BakkerCet al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert’s syndrome . N. Engl. J. Med.333 ( 18 ), 1171 – 1175 ( 1995 ).
  • Kiang T , EnsomM , ChangT . UDP-glucuronosyltransferases and clinical drug–drug interactions . Pharmacol. Ther.106 ( 1 ), 97 – 132 ( 2005 ).
  • Court MH , DuanSX , MoltkeLLet al. Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms . J. Pharmacol. Exp. Ther.299 ( 3 ), 998 – 1006 ( 2001 ).
  • Kostrubsky SE . Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes . Toxicol. Sci.87 ( 1 ), 146 – 155 ( 2005 ).
  • Sugatani J . Function genetic polymorphism, and transcriptional regulation of human UDP-glucuronosyltransferase (UGT) 1A1 . Drug Metab. Pharmacol.28 ( 2 ), 83 – 92 ( 2013 ).
  • Sugatani J , UchidaT , KurosawaMet al. Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein . Drug Metab. Dispos.40 ( 10 ), 2031 – 2040 ( 2012 ).
  • Zheng B , HuG , YuJ , LiuZ . Crigler–Najjar syndrome type II in a Chinese boy resulting from three mutations in the bilirubin uridine 5′-diphosphate-glucuronosyltransferase (UGT1A1) gene and a family genetic analysis . BMC Pediatr.14 ( 1 ), 267 ( 2014 ).
  • Oda S , FukamiT , YokoiT , NakajimaM . Epigenetic regulation is a crucial factor in the repression of UGT1A1 expression in the human kidney . Drug Metab. Dispos.41 ( 10 ), 1738 – 1743 ( 2013 ).
  • Oda S , FukamiT , YokoiT , NakajimaM . Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10 . Biochem. Pharmacol.87 ( 4 ), 660 – 667 ( 2014 ).
  • Izukawa T , NakajimaM , FujiwaraRet al. Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers . Drug Metab. Dispos.37 ( 8 ), 1759 – 1768 ( 2009 ).
  • Ohtsuki S , SchaeferO , KawakamiHet al. Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities . Drug Metab. Dispos.40 ( 1 ), 83 – 92 ( 2011 ).
  • Koturbash I , TollesonWH , GuoLet al. microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment . Biomark. Med.9 ( 11 ), 1153 – 1176 ( 2015 ).
  • Duursma AM , KeddeM , SchrierM , le SageC , AgamiR . miR-148 targets human DNMT3b protein coding region . RNA14 ( 5 ), 872 – 877 ( 2008 ).
  • Ørom UA , NielsenFC , LundAH . MicroRNA-10a binds the 5′UTR of ribosomal protein mRNAs and enhances their translation . Mol. Cell30 ( 4 ), 460 – 471 ( 2008 ).
  • Garzon R , MarcucciG , CroceCM . Targeting microRNAs in cancer: rationale, strategies and challenges . Nat. Rev. Drug Discov.9 ( 10 ), 775 – 789 ( 2010 ).
  • Lewis BP , BurgeCB , BartelDP . Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets . Cell120 ( 1 ), 15 – 20 ( 2005 ).
  • Yan L , LiuJ , ZhaoYet al. Suppression of miR-628–3p and miR-641 is involved in rifampin-mediated CYP3A4 induction in HepaRG cells . Pharmacogenomics18 ( 1 ), 57 – 64 ( 2017 ).
  • Wei Z , JiangS , ZhangYet al. The effect of microRNAs in the regulation of human CYP3A4: a systematic study using a mathematical model . Sci. Rep.4 ( 1 ), 4283 ( 2015 ).
  • Shi Y , LiuY , WeiZet al. Hsa-miR-27a is involved in the regulation of CYP3A4 expression in human livers from Chinese Han population . Pharmacogenomics16 ( 12 ), 1379 – 1386 ( 2015 ).
  • He Y , ChevilletJR , LiuG , KimTK , WangK . The effects of microRNA on the absorption, distribution, metabolism and excretion of drugs . Br. J. Pharmacol.172 ( 11 ), 2733 – 2747 ( 2015 ).
  • Dluzen DF , SunD , SalzbergACet al. Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491–3p . J. Pharmacol. Exp. Ther.348 ( 3 ), 465 – 477 ( 2014 ).
  • Wei ZY , ChenMJ , ZhangYTet al. No correlation of hsa-miR-148a with expression of PXR or CYP3A4 in humanlivers from Chinese Han population . PLoS ONE8 ( 3 ), e59141 ( 2013 ).
  • Strassburg CP . Pharmacogenetics of Gilbert’s syndrome . Pharmacogenomics9 ( 6 ), 703 – 715 ( 2008 ).
  • Tracy TS , ChaudhryAS , PrasadBet al. Interindividual variability in cytochrome P450-mediated drug metabolism . Drug Metab. Dispos.44 ( 3 ), 343 – 351 ( 2016 ).
  • Sim SC , KacevskaM , Ingelman-SundbergM . Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects . Pharmacogenomics J.13 ( 1 ), 1 – 11 ( 2012 ).
  • Dluzen DF , LazarusP . MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors . Drug Metab. Rev.47 ( 3 ), 320 – 334 ( 2015 ).
  • Ramamoorthy A , LiL , GaedigkAet al. In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4 expression . Drug Metab. Dispos.40 ( 4 ), 726 – 733 ( 2012 ).
  • Haas U , SczakielG , LauferS . MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3′-UTR via altered RNA structure . RNA Biol.9 ( 6 ), 924 – 937 ( 2014 ).
  • Long D , LeeR , WilliamsPet al. Potent effect of target structure on microRNA function . Nat. Struct. Mol. Biol.14 ( 4 ), 287 – 294 ( 2007 ).
  • Takagi S , NakajimaM , MohriT , YokoiT . Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4 . J. Biol. Chem.283 ( 15 ), 9674 – 9680 ( 2008 ).
  • Oda Y , NakajimaM , TsuneyamaKet al. Retinoid X receptor α in human liver is regulated by miR-34a . Biochem. Pharmacol.90 ( 2 ), 179 – 187 ( 2014 ).
  • Tsuchiya Y , NakajimaM , TakagiS , TaniyaT , YokoiT . MicroRNA regulates the expression of human cytochrome P4501B1 . Cancer Res.66 ( 18 ), 9090 – 9098 ( 2006 ).
  • Kida K , NakajimaM , MohriTet al. PPARα is regulated by miR-21 and miR-27b in human liver . Pharm. Res.28 ( 10 ), 2467 – 2476 ( 2011 ).
  • Wei Hu , WangX , DingXet al. MicroRNA-141 represses HBV replication by targeting PPARA . PLoS ONE7 ( 3 ), e34165 ( 2012 ).
  • He Y , ChevilletJR , LiuG , KimTK , WangK . The effects of microRNA on the absorption, distribution, metabolism and excretion of drugs . Br. J. Pharmacol.172 ( 11 ), 2733 – 2747 ( 2015 ).
  • Riches Z , CollierAC . Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases . Expert. Opin. Drug Met.11 ( 6 ), 949 – 965 ( 2015 ).
  • Basu NK , KoleL , OwensIS . Evidence for phosphorylation requirement for human bilirubin UDP-glucuronosyltransferase (UGT1A1) activity . Biochem. Biophys. Res. Commun.303 ( 1 ), 98 – 104 ( 2003 ).
  • Williams JA , HylandR , JonesBCet al. Drug–drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCI/AUC) ratios . Drug Metab. Dispos.32 ( 11 ), 1201 – 1208 ( 2004 ).
  • Cheng L , LiM , HuJet al. UGT1A1*6 polymorphisms are correlated with irinotecan-induced toxicity: a system review and meta-analysis in Asians . Cancer Chemother. Pharm.73 ( 3 ), 551 – 560 ( 2014 ).
  • Hu DG , MeechR , McKinnonRA , MackenziePI . Transcriptional regulation of human UDP-glucuronosyltransferase genes . Drug Metab. Rev.46 ( 4 ), 421 – 458 ( 2014 ).
  • Nie Y , HeH , LiJet al. Hepatic expression of transcription factors affecting developmental regulation of UGT1A1 in the Han Chinese population . Eur. J. Clin. Pharmacol.73 ( 1 ), 29 – 37 ( 2016 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.