Understanding the Influence of Antipsychotic Drugs on Global Methylation Events and Its Relevance in Treatment Response

References

• Ackenheil M , WeberK . Differing response to antipsychotic therapy in schizophrenia: pharmacogenomic aspects . Dialogues Clin. Neurosci.6 ( 1 ), 71 ( 2004 ).
   PubMedGoogle Scholar
• Smith E , WestonCA , LiebermanA . Schizophrenia (maintenance treatment) . BMJ Clin. Evid. 2009 , pii:1007 ( 2009 ).
   PubMedGoogle Scholar
• Broekema W , De GrootI , Van HartenP . Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics – a European study . Pharm. World Sci.29 ( 3 ), 126 – 130 ( 2007 ).
   PubMedGoogle Scholar
• Razzouk D , KayoM , SousaAet al. The impact of antipsychotic polytherapy costs in the public health care in Sao Paulo, Brazil . PLoS ONE10 ( 4 ), e0124791 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Harrington M , LelliottP , PatonC , OkochaC , DuffettR , SenskyT . The results of a multi-centre audit of the prescribing of antipsychotic drugs for in-patients in the UK . The Psychiatrist26 ( 11 ), 414 – 418 ( 2002 ).
   Google Scholar
• Jerrell JM , McintyreRS . Adverse events in children and adolescents treated with antipsychotic medications . Hum. Psychopharmacol.23 ( 4 ), 283 – 290 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Comer JS , OlfsonM , MojtabaiR . National trends in child and adolescent psychotropic polypharmacy in office-based practice, 1996–2007 . J. Am. Acad. Child Adolesc. Psychiatry49 ( 10 ), 1001 – 1010 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Barbui C , NosèM , MazziMAet al. Persistence with polypharmacy and excessive dosing in patients with schizophrenia treated in four European countries . Int. Clin. Psychopharmacol.21 ( 6 ), 355 – 362 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Fleischhacker WW , UchidaH . Critical review of antipsychotic polypharmacy in the treatment of schizophrenia . Int. J. Neuropsychopharmacol.17 ( 7 ), 1083 – 1093 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Rojo LE , GasparPA , SilvaHet al. Metabolic syndrome and obesity among users of second generation antipsychotics: a global challenge for modern psychopharmacology . Pharmacol. Res.101 , 74 – 85 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Eum S , LeeAM , BishopJR . Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations . Dialogues Clin. Neurosci.18 ( 3 ), 323 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Gressier F , PorcelliS , CalatiR , SerrettiA . Pharmacogenetics of clozapine response and induced weight gain: a comprehensive review and meta-analysis . Eur. Neuropsychopharmacol.26 ( 2 ), 163 – 185 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Ventola CL . Role of pharmacogenomic biomarkers in predicting and improving drug response: part 1: the clinical significance of pharmacogenetic variants . PT38 ( 9 ), 545 ( 2013 ).
   PubMedGoogle Scholar
• Ivanov M , KacevskaM , Ingelman-SundbergM . Epigenomics and interindividual differences in drug response . Clin. Pharmacol. Ther.92 ( 6 ), 727 – 736 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Swathy B , BanerjeeM . Understanding epigenetics of schizophrenia in the backdrop of its antipsychotic drug therapy . Epigenomics9 ( 5 ), 721 – 736 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Ingelman-Sundberg M , CascorbiI . Pharmacogenomic or -epigenomic biomarkers in drug treatment: two sides of the same medal?Clin. Pharmacol. Ther.99 ( 5 ), 478 – 480 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Sarabi MM , NaghibalhossainiF . Association of DNA methyltransferases expression with global and gene-specific DNA methylation in colorectal cancer cells . Cell Biochem. Funct.33 ( 7 ), 427 – 433 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Garzon R , LiuS , FabbriMet al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1 . Blood113 ( 25 ), 6411 – 6418 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Wu X , ZhangY . TET-mediated active DNA demethylation: mechanism, function and beyond . Nat. Rev. Genet.18 ( 9 ), 517 – 534 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Wu H , ZhangY . Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation . Genes Dev.25 ( 23 ), 2436 – 2452 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Morita S , HoriiT , KimuraM , OchiyaT , TajimaS , HatadaI . miR-29 represses the activities of DNA methyltransferases and DNA demethylases . Int. J. Mol. Sci.14 ( 7 ), 14647 – 14658 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Niu M , GaoD , WenQet al. MiR-29c regulates the expression of miR-34c and miR-449a by targeting DNA methyltransferase 3a and 3b in nasopharyngeal carcinoma . BMC Cancer16 ( 1 ), 218 ( 2016 ).
   PubMedGoogle Scholar
• Vijayan NN , MathewA , BalanSet al. Antipsychotic drug dosage and therapeutic response in schizophrenia is influenced by ABCB1 genotypes: a study from a south Indian perspective . Pharmacogenomics13 ( 10 ), 1119 – 1127 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Milutinovic S , D’alessioAC , DetichN , SzyfM . Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes . Carcinogenesis28 ( 3 ), 560 – 571 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Saradalekshmi KR , NeethaNV , SathyanS , NairIV , NairCM , BanerjeeM . DNA methyl transferase (DNMT) gene polymorphisms could be a primary event in epigenetic susceptibility to schizophrenia . PLoS ONE9 ( 5 ), e98182 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Bustin SA , BenesV , GarsonJAet al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments . Clin. Chem.55 ( 4 ), 611 – 622 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Gerets H , TilmantK , GerinBet al. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins . Cell Biol. Toxicol.28 ( 2 ), 69 – 87 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Raeder MB , Fern⊘J , Vik-MoAO , SteenVM . SREBP activation by antipsychotic-and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects?Mol. Cell. Biochem.289 ( 1–2 ), 167 – 173 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Bespalov A , MüllerR , ReloAL , HudzikT . Drug tolerance: a known unknown in translational neuroscience . Trends Pharmacol. Sci.37 ( 5 ), 364 – 378 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Swathy B , SaradalekshmiKR , NairIV , NairC , BanerjeeM . Pharmacoepigenomic responses of antipsychotic drugs on pharmacogenes are likely to be modulated by miRNAs . Epigenomics9 ( 6 ), 811 – 821 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Melas PA , RogdakiM , ÖsbyU , SchallingM , LavebrattC , EkströmTJ . Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset . FASEB J.26 ( 6 ), 2712 – 2718 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Shimabukuro M , SasakiT , ImamuraAet al. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia . J. Psychiatr. Res.41 ( 12 ), 1042 – 1046 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Bromberg A , LevineJ , NemetzB , BelmakerR , AgamG . No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients . Schizophr. Res.101 ( 1 ), 50 – 57 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Melka MG , LauferBI , McdonaldPet al. The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum . Clin. Epigenetics6 ( 1 ), 1 – 12 ( 2014 ).
   PubMedGoogle Scholar
• Veldic M , CarunchoH , LiuWet al. DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains . Proc. Natl Acad. Sci. USA101 ( 1 ), 348 – 353 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Zhubi A , VeldicM , PuriNet al. An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes . Schizophr. Res.111 ( 1 ), 115 – 122 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Amodio N , LeottaM , BellizziDet al. DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma . Oncotarget3 ( 10 ), 1246 – 1258 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Braconi C , KogureT , ValeriNet al. microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer . Oncogene30 ( 47 ), 4750 – 4756 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Fabbri M , GarzonR , CimminoAet al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B . Proc. Natl Acad. Sci. USA104 ( 40 ), 15805 – 15810 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Perkins DO , JeffriesCD , JarskogLFet al. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder . Genome Biol.8 ( 2 ), R27 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Gardiner E , BeveridgeN , WuJet al. Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells . Mol. Psychiatry17 ( 8 ), 827 – 840 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Santarelli DM , LiuB , DuncanCEet al. Gene-microRNA interactions associated with antipsychotic mechanisms and the metabolic side effects of olanzapine . Psychopharmacology227 ( 1 ), 67 – 78 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Sullivan PF , FanC , PerouCM . Evaluating the comparability of gene expression in blood and brain . Am. J. Med. Genet. B Neuropsychiatr. Genet.141 ( 3 ), 261 – 268 ( 2006 ).
   Google Scholar
• Tylee DS , KawaguchiDM , GlattSJ . On the outside, looking in: a review and evaluation of the comparability of blood and brain “-omes” . Am. J. Med. Genet. B Neuropsychiatr. Genet.162 ( 7 ), 595 – 603 ( 2013 ).
   Web of Science ®Google Scholar
• Lai C , LeeS , ScarrEet al. Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue . Transl. Psychiatry6 ( 1 ), e717 ( 2016 ).
   PubMedGoogle Scholar
• Swathy B , BanerjeeM . Haloperidol induces pharmacoepigenetic response by modulating miRNA expression, global DNA methylation and expression profiles of methylation maintenance genes and genes involved in neurotransmission in neuronal cells . PLoS ONE12 ( 9 ), e0184209 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Perneger TV . What’s wrong with Bonferroni adjustments?BMJ316 ( 7139 ), 1236 – 1238 ( 1998 ).
   PubMed Web of Science ®Google Scholar