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Research Article

Promoter Methylation of PGC1A and PGC1B Predicts Cancer Incidence in a Veteran Cohort

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Pages 733-743 | Received 24 Oct 2017, Accepted 07 Feb 2018, Published online: 11 Jun 2018

References

  • Navarrete-Reyes AP , Soto-Pérez-de-CelisE , HurriaA . Cancer and aging: a complex biological association . Rev. Invest. Clin.68 ( 1 ), 17 – 24 ( 2016 ).
  • Siegel RL , MillerKD , JemalA . Cancer statistics, 2017 . CA Cancer J. Clin.67 ( 1 ), 7 – 30 ( 2017 ).
  • Finkel T , SerranoM , BlascoMA . The common biology of cancer and ageing . Nature448 ( 7155 ), 767 – 774 ( 2007 ).
  • Kong Y , TrabuccoSE , ZhangH . Oxidative stress, mitochondrial dysfunction and the mitochondria theory of aging . Interdiscip. Top. Gerontol.39 , 86 – 107 ( 2014 ).
  • Wang CH , WuSB , WuYT , WeiYH . Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging . Exp. Biol. Med. (Maywood)238 ( 5 ), 450 – 460 ( 2013 ).
  • Mikhed Y , DaiberA , StevenS . Mitochondrial oxidative stress, mitochondrial DNA damage and their role in age-related vascular dysfunction . Int. J. Mol. Sci.16 ( 7 ), 15918 – 15953 ( 2015 ).
  • Demissie S , LevyD , BenjaminEJet al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart study . Aging Cell5 ( 4 ), 325 – 330 ( 2006 ).
  • von Zglinicki T . Oxidative stress shortens telomeres . Trends Biochem. Sci.27 ( 7 ), 339 – 344 ( 2002 ).
  • Kawanishi S , OikawaS . Mechanism of telomere shortening by oxidative stress . Ann. NY Acad. Sci.1019 , 278 – 284 ( 2004 ).
  • Fouquerel E , LormandJ , BoseAet al. Oxidative guanine base damage regulates human telomerase activity . Nat. Struct. Mol. Biol.23 ( 12 ), 1092 – 1100 ( 2016 ).
  • De Luca A , FiorilloM , Peiris-PagèsMet al. Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells . Oncotarget6 ( 17 ), 14777 – 14795 ( 2015 ).
  • Shen J , GopalakrishnanV , LeeJE , FangS , ZhaoH . Mitochondrial DNA copy number in peripheral blood and melanoma risk . PLoS ONE10 ( 6 ), e0131649 ( 2015 ).
  • He Y , GongY , GuJ , LeeJJ , LippmanSM , WuX . Increased leukocyte mitochondrial DNA copy number is associated with oral premalignant lesions: an epidemiology study . Carcinogenesis35 ( 8 ), 1760 – 1764 ( 2014 ).
  • Xu E , SunW , GuJ , ChowWH , AjaniJA , WuX . Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk of esophageal adenocarcinoma . Carcinogenesis34 ( 11 ), 2521 – 2524 ( 2013 ).
  • Sanders JL , NewmanAB . Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither?Epidemiol. Rev.35 , 112 – 131 ( 2013 ).
  • Du J , ZhuX , XieCet al. Telomere length, genetic variants and gastric cancer risk in a Chinese population . Carcinogenesis36 ( 9 ), 963 – 970 ( 2015 ).
  • Hurwitz LM , HeaphyCM , JoshuCEet al. Telomere length as a risk factor for hereditary prostate cancer . Prostate74 ( 4 ), 359 – 364 ( 2014 ).
  • Shen J , TerryMB , GurvichI , LiaoY , SenieRT , SantellaRM . Short telomere length and breast cancer risk: a study in sister sets . Cancer Res.67 ( 11 ), 5538 – 5544 ( 2007 ).
  • Willeit P , WilleitJ , MayrAet al. Telomere length and risk of incident cancer and cancer mortality . JAMA304 ( 1 ), 69 – 75 ( 2010 ).
  • Sahin E , CollaS , LiesaMet al. Telomere dysfunction induces metabolic and mitochondrial compromise . Nature470 ( 7334 ), 359 – 365 ( 2011 ).
  • Finkel T . Telomeres and mitochondrial function . Circ. Res.108 ( 8 ), 903 – 904 ( 2011 ).
  • Bell B , RoseC , DamonA . The normative aging study: an interdisciplinary and longitudinal study of health and aging . Int. J. Aging Hum. Dev.3 ( 1 ), 5 – 17 ( 1972 ).
  • Cawthon RM . Telomere measurement by quantitative PCR . Nucleic Acids Res.30 ( 10 ), e47 ( 2002 ).
  • Hou L , SavageSA , BlaserMJet al. Telomere length in peripheral leukocyte DNA and gastric cancer risk . Cancer Epidemiol. Biomarkers Prev.18 ( 11 ), 3103 – 3109 ( 2009 ).
  • Hou L , JoyceBT , GaoTet al. Blood telomere length attrition and cancer development in the normative aging study cohort . EBioMedicine2 ( 6 ), 591 – 596 ( 2015 ).
  • Du P , ZhangX , HuangCCet al. Comparison of β-value and M-value methods for quantifying methylation levels by microarray analysis . BMC Bioinformatics11 , 587 ( 2010 ).
  • Zhong J , CayirA , TrevisiLet al. Traffic-related air pollution, blood pressure, and adaptive response of mitochondrial abundance . Circulation133 ( 4 ), 378 – 387 ( 2016 ).
  • Malik AN , CzajkaA . Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?Mitochondrion13 ( 5 ), 481 – 492 ( 2013 ).
  • Malik AN , ParsadeCK , AjazSet al. Altered circulating mitochondrial DNA and increased inflammation in patients with diabetic retinopathy . Diabetes Res. Clin. Pract.110 ( 3 ), 257 – 265 ( 2015 ).
  • Andreu AL , MartinezR , MartiR , García-ArumíE . Quantification of mitochondrial DNA copy number: pre-analytical factors . Mitochondrion9 ( 4 ), 242 – 246 ( 2009 ).
  • Lin CS , WangLS , TsaiCM , WeiYH . Low copy number and low oxidative damage of mitochondrial DNA are associated with tumor progression in lung cancer tissues after neoadjuvant chemotherapy . Interact. Cardiovasc. Thorac. Surg.7 ( 6 ), 954 – 958 ( 2008 ).
  • Lin CS , WangLS , ChouTYet al. Cigarette smoking and hOGG1 Ser326Cys polymorphism are associated with 8-OHdG accumulation on mitochondrial DNA in thoracic esophageal squamous cell carcinoma . Ann. Surg. Oncol.20 ( Suppl. 3 ), S379 – S388 ( 2013 ).
  • Benjamini Y , HochbergY . Controlling the false discovery rate: a practical and powerful approach to multiple testing . J R Stat. Soc. Series B Stat. Methodol.57 , 289 – 300 ( 1995 ).
  • Moslehi J , DePinhoRA , SahinE . Telomeres and mitochondria in the aging heart . Circ. Res.110 ( 9 ), 1226 – 1237 ( 2012 ).
  • Sahin E , DePinhoRA . Axis of ageing: telomeres, p53 and mitochondria . Nat. Rev. Mol. Cell Biol.13 ( 6 ), 397 – 404 ( 2012 ).
  • Grewal SI , MoazedD . Heterochromatin and epigenetic control of gene expression . Science301 ( 5634 ), 798 – 802 ( 2003 ).
  • Berkers CR , MaddocksOD , CheungEC , MorI , VousdenKH . Metabolic regulation by p53 family members . Cell Metab.18 ( 5 ), 617 – 633 ( 2013 ).
  • Permuth-Wey J , ChenYA , TsaiYYet al. Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk . Cancer Epidemiol. Biomarkers Prev.20 ( 6 ), 1131 – 1145 ( 2011 ).
  • Wirtenberger M , TchatchouS , HemminkiKet al. Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer . Carcinogenesis27 ( 11 ), 2201 – 2208 ( 2006 ).
  • Cho YA , LeeJ , OhJHet al. Genetic variation in PPARGC1A may affect the role of diet-associated inflammation in colorectal carcinogenesis . Oncotarget8 ( 5 ), 8550 – 8558 ( 2017 ).
  • Martínez-Nava GA , Burguete-GarcíaAI , López-CarrilloL , Hernández-RamírezRU , Madrid-MarinaV , CebriánME . PPARγ and PPARGC1B polymorphisms modify the association between phthalate metabolites and breast cancer risk . Biomarkers18 ( 6 ), 493 – 501 ( 2013 ).
  • Li Y , WedrénS , LiGet al. Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer . Breast Cancer Res.13 ( 1 ), R10 ( 2011 ).
  • Lou S , LeeHM , QinHet al. Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation . Genome Biol.15 ( 7 ), 408 ( 2014 ).
  • Haycock PC , BurgessS , NounuAet al. Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study . JAMA Oncol.3 ( 5 ), 636 – 651 ( 2017 ).
  • Julin B , ShuiI , HeaphyCMet al. Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer . Br. J. Cancer112 ( 4 ), 769 – 776 ( 2015 ).
  • Svenson U , RoosG , WikströmP . Long leukocyte telomere length in prostate cancer patients at diagnosis is associated with poor metastasis-free and cancer-specific survival . Tumour Biol.39 ( 2 ), 1010428317692236 ( 2017 ).
  • Caini S , RaimondiS , JohanssonHet al. Telomere length and the risk of cutaneous melanoma and non-melanoma skin cancer: a review of the literature and meta-analysis . J. Dermatol. Sci.80 ( 3 ), 168 – 174 ( 2015 ).
  • Myers RM , StamatoyannopoulosJ , SnyderMet al. A user’s guide to the encyclopedia of DNA elements (ENCODE) . PLoS Biol.9 ( 4 ), e1001046 ( 2011 ).
  • Jones PA . Functions of DNA methylation: islands, start sites, gene bodies and beyond . Nat. Rev. Genet.13 ( 7 ), 484 – 492 ( 2012 ).
  • Rauscher GH , KresovichJK , PoulinMet al. Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation . BMC Cancer15 , 816 ( 2015 ).

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