RNA Sequencing of Exosomes Revealed Differentially Expressed Long Noncoding RNAs in Early-Stage Esophageal Squamous Cell Carcinoma and Benign Esophagitis

References

• Kalluri R . The biology and function of exosomes in cancer. J. Clin. Invest.126(4), 1208–1215 (2016).
   PubMed Web of Science ®Google Scholar
• Sato-Kuwabara Y , MeloSA , SoaresFA , CalinGA. The fusion of two worlds: noncoding RNAs and extracellular vesicles – diagnostic and therapeutic implications. Int. J. Oncol.46(1), 17–27 (2015).
   PubMed Web of Science ®Google Scholar
• Silva M , MeloSA. Noncoding RNAs in exosomes: new players in cancer biology. Curr. Genomics16(5), 295–303 (2015).
   PubMed Web of Science ®Google Scholar
• Mohankumar S , PatelT. Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer. Brief. Funct. Genomics15(3), 249–256 (2016).
   PubMed Web of Science ®Google Scholar
• Ahadi A , BrennanS , KennedyPJ , HutvagnerG , TranN. Long noncoding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes. Sci. Rep.6, 24922 (2016).
   PubMed Web of Science ®Google Scholar
• Taylor DD , Gercel-TaylorC. The origin, function, and diagnostic potential of RNA within extracellular vesicles present in human biological fluids. Front. Genet.4, 142 (2013).
   PubMedGoogle Scholar
• Pennathur A , GibsonMK , JobeBA , LuketichJD. Oesophageal carcinoma. Lancet381(9864), 400–412 (2013).
   PubMed Web of Science ®Google Scholar
• Rustgi AK , El-SeragHB. Esophageal carcinoma. N. Engl. J. Med.371(26), 2499–2509 (2014).
   PubMed Web of Science ®Google Scholar
• Derrien T , JohnsonR , BussottiGet al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res.22(9), 1775–1789 (2012).
   PubMed Web of Science ®Google Scholar
• Batista PJ , ChangHY. Long noncoding RNAs: cellular address codes in development and disease. Cell152(6), 1298–1307 (2013).
   PubMed Web of Science ®Google Scholar
• Iyer MK , NiknafsYS , MalikRet al. The landscape of long noncoding RNAs in the human transcriptome. Nat. Genet.47(3), 199–208 (2015).
   PubMed Web of Science ®Google Scholar
• Yan X , HuZ , FengYet al. Comprehensive genomic characterization of long noncoding RNAs across human cancers. Cancer Cell28(4), 529–540 (2015).
   PubMed Web of Science ®Google Scholar
• Bhan A , SoleimaniM , MandalSS. Long noncoding RNA and cancer: a new paradigm. Cancer Res.77(15), 3965–3981 (2017).
   PubMed Web of Science ®Google Scholar
• Li CQ , HuangGW , WuZYet al. Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. Oncogenesis6(2), e297 (2017).
   PubMedGoogle Scholar
• Deng HY , WangYC , NiPZ , LinYD , ChenLQ. Long noncoding RNAs are novel potential prognostic biomarkers for esophageal squamous cell carcinoma: an overview. J. Thorac. Dis.8(8), E653–E659 (2016).
   PubMed Web of Science ®Google Scholar
• Liu T , ZhangX , GaoSet al. Exosomal long noncoding RNA CRNDE-h as a novel serum-based biomarker for diagnosis and prognosis of colorectal cancer. Oncotarget7(51), 85551–85563 (2016).
   PubMed Web of Science ®Google Scholar
• Dong L , LinW , QiPet al. Circulating long RNAs in serum extracellular vesicles: their characterization and potential application as biomarkers for diagnosis of colorectal cancer. Cancer Epidemiol. Biomarkers Prev.25(7), 1158–1166 (2016).
   PubMed Web of Science ®Google Scholar
• Kornienko AE , DotterCP , GuenzlPMet al. Long noncoding RNAs display higher natural expression variation than protein-coding genes in healthy humans. Genome Biol.17, 14 (2016).
   PubMed Web of Science ®Google Scholar
• Ferguson SW , NguyenJ. Exosomes as therapeutics: the implications of molecular composition and exosomal heterogeneity. J. Control. Rel.228, 179–190 (2016).
   PubMed Web of Science ®Google Scholar
• Zhang L , ZhouY , ChengCet al. Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. Am. J. Hum. Genet.96(4), 597–611 (2015).
   PubMed Web of Science ®Google Scholar
• Manasanch EE , OrlowskiRZ. Proteasome inhibitors in cancer therapy. Nat. Rev. Clin. Oncol.14(7), 417–433 (2017).
   PubMed Web of Science ®Google Scholar
• Wang R , FangH , FangQ. Downregulation of FKBP14 by RNA interference inhibits the proliferation, adhesion and invasion of gastric cancer cells. Oncol. Lett.13( 4), 2811–2816 (2017).
   PubMed Web of Science ®Google Scholar
• Polak P , KimJ , BraunsteinLZet al. A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. Nat. Genet.49(10), 1476–1486 (2017).
   PubMed Web of Science ®Google Scholar
• Kitagawa M , KotakeY , OhhataT. Long noncoding RNAs involved in cancer development and cell fate determination. Curr. Drug Targets13(13), 1616–1621 (2012).
   PubMed Web of Science ®Google Scholar
• Ally A , BalasundaramM , CarlsenRet al. Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell169(7), 1327–1347.e23 (2017).
   PubMed Web of Science ®Google Scholar
• Bartonicek N , MaagJLV , DingerME. Long noncoding RNAs in cancer: mechanisms of action and technological advancements. Mol. Cancer15(1), 43 (2016).
   PubMed Web of Science ®Google Scholar
• Ulitsky I , BartelDP. LincRNAs: genomics, evolution, and mechanisms. Cell154(1), 26–46 (2013).
   PubMed Web of Science ®Google Scholar
• Kogure T , YanIK , LinWL , PatelT. Extracellular vesicle-mediated transfer of a novel long noncoding RNA TUC339: a mechanism of intercellular signaling in human hepatocellular cancer. Genes Cancer4(7–8), 261–272 (2013).
   PubMedGoogle Scholar
• Desdin-Mico G , MittelbrunnM. Role of exosomes in the protection of cellular homeostasis. Cell. Adh. Migr.11(2), 127–134 (2017).
   PubMed Web of Science ®Google Scholar
• Gezer U , OzgurE , CetinkayaM , IsinM , DalayN. Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes. Cell Biol. Int.38(9), 1076–1079 (2014).
   PubMed Web of Science ®Google Scholar
• Quek XC , ThomsonDW , MaagJLet al. LncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs. Nucleic Acids Res.43(Database issue), D168–D173 (2015).
   PubMedGoogle Scholar
• Tran T , ShatnawiA , ZhengX , KelleyKM , RatnamM. Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting. Cancer Res.65(10), 4431–4441 (2005).
   PubMed Web of Science ®Google Scholar
• Gibbs DD , ThetiDS , WoodNet al. BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors. Cancer Res.65(24), 11721–11728 (2005).
   PubMed Web of Science ®Google Scholar
• Bagnoli M , TomassettiA , FiginiMet al. Downmodulation of caveolin-1 expression in human ovarian carcinoma is directly related to alpha-folate receptor overexpression. Oncogene19(41), 4754–4763 (2000).
   PubMed Web of Science ®Google Scholar
• Ramsbottom SA , PownallME. Regulation of Hedgehog signalling inside and outside the cell. J. Dev. Biol.4(3), 23 (2016).
   PubMedGoogle Scholar
• Pak E , SegalRA. Hedgehog signal transduction: key players, oncogenic drivers, and cancer therapy. Dev. Cell.38(4), 333–344 (2016).
   PubMed Web of Science ®Google Scholar
• Agliano A , CalvoA , BoxC. The challenge of targeting cancer stem cells to halt metastasis. Semin. Cancer Biol.44, 25–42 (2017).
   PubMed Web of Science ®Google Scholar
• Yang L , WangLS , ChenXLet al. Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus. Int. J. Biochem. Mol. Biol.3(1), 46–57 (2012).
   PubMedGoogle Scholar
• Min S , XiaoyanX , FanghuiPet al. The glioma-associated oncogene homolog 1 promotes epithelial--mesenchymal transition in human esophageal squamous cell cancer by inhibiting E-cadherin via Snail. Cancer Gene Ther.20(7), 379–385 (2013).
   PubMed Web of Science ®Google Scholar
• Wei L , YanN , SunLet al. Interplay between the NF-κB and hedgehog signaling pathways predicts prognosis in esophageal squamous cell carcinoma following neoadjuvant chemoradiotherapy. Int. J. Mol. Med.41(5), 2961–2967 (2018).
   PubMed Web of Science ®Google Scholar
• Zhu W , YouZ , LiTet al. Correlation of hedgehog signal activation with chemoradiotherapy sensitivity and survival in esophageal squamous cell carcinomas. Jpn. J. Clin. Oncol.41(3), 386–393 (2011).
   PubMed Web of Science ®Google Scholar
• Zaidi AH , KomatsuY , KellyLAet al. Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells. Cancer Invest.31(7), 480–489 (2013).
   PubMed Web of Science ®Google Scholar
• Yang SC , ChenCL , YiCH , LiuTT , ShiehKR. Changes in gene expression patterns of circadian-clock, transient receptor potential vanilloid-1 and nerve growth factor in inflamed human esophagus. Sci. Rep.5, 13602 (2015).
   PubMed Web of Science ®Google Scholar
• Shieh KR , YangSC , TsengHLet al. Evidence for up-regulation of purinergic receptor genes associating with TRPV1 receptors and neurotrophic factors in the inflamed human esophagus. Curr. Mol. Med.14(9), 1205–1214 (2014).
   PubMed Web of Science ®Google Scholar
• Lee D , LeeKJ , KimKM , LimSK. Prevalence of asymptomatic erosive esophagitis and factors associated with symptom presentation of erosive esophagitis. Scand. J. Gastroenterol.48(8), 906–912 (2013).
   PubMed Web of Science ®Google Scholar
• Sigova AA , MullenAC , MolinieBet al. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. PNAS110(8), 2876–2881 (2013).
   PubMed Web of Science ®Google Scholar
• Chu C , QuK , ZhongFL , ArtandiSE , ChangHY. Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Mol. Cell.44(4), 667–678 (2011).
   PubMed Web of Science ®Google Scholar
• Guttman M , DonagheyJ , CareyBWet al. LincRNAs act in the circuitry controlling pluripotency and differentiation. Nature477(7364), 295–300 (2011).
   PubMed Web of Science ®Google Scholar
• Dong L , LinW , QiPet al. Circulating long RNAs in serum extracellular vesicles: their characterization and potential application as biomarkers for diagnosis of colorectal cancer. Cancer Epidemiol. Biomark. Prev.25(7), 1158–1166 (2016).
   PubMed Web of Science ®Google Scholar
• Gezer U , ÖzgürE , CetjnkayaM , IsinM , DalayN. Long noncoding RNAs with low expression levels in cells are enriched in secreted exosomes. Cell Biol. Int.38(9), 1076–1079 (2014).
   PubMed Web of Science ®Google Scholar
• Dragomir M , ChenB , CalinGA. Exosomal lncRNAs as new players in cell–to–cell communication. Transl. Cancer Res.7(Suppl. 2), 243–252 (2018).
   PubMedGoogle Scholar
• Sun L , SuY , LiuXet al. Serum and exosome long noncoding RNAs as potential biomarkers for hepatocellular carcinoma. J. Cancer9(15), 2631–2639 (2018).
   PubMed Web of Science ®Google Scholar
• Lin LY , YangL , ZengQet al. Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer. Mol. Cancer17(1), 84 (2018).
   PubMed Web of Science ®Google Scholar
• Li H , LiF. Exosomes from BM-MSCs increase the population of CSCs via transfer of miR-142-3p. Brit. J. Cancer119(6), 744–755 (2018).
   PubMed Web of Science ®Google Scholar
• Hu T , HuJ. Melanoma-derived exosomes induce reprogramming fibroblasts into cancer-associated fibroblasts via Gm26809 delivery. Cell Cycle18(22), 3085–3094 (2019).
   PubMed Web of Science ®Google Scholar
• Ham S , LimaLG , PeiEet al. Breast cancer-derived exosomes alter macrophage polarization via gp130/sTaT3 signaling. Front. Immunol.9, 871 (2018).
   PubMed Web of Science ®Google Scholar
• Che Y , ShiX , ShiYet al. Exosomes derived from miR-143-overexpressing MSCs inhibit cell migration and invasion in human prostate cancer by downregulating TFF3. Mol. Ther. Nucleic Acids18, 232–244 (2019).
   PubMedGoogle Scholar