1,906
Views
0
CrossRef citations to date
0
Altmetric
Editorial

How to Link Genomics to Physiology Through Epigenomics

&
Pages 285-287 | Received 08 Jan 2020, Accepted 08 Jan 2020, Published online: 21 Feb 2020

References

  • Boyle EA , LiY , PritchardJK. An expanded view of complex traits: from polygenic to omnigenic. Cell169, 1177–1186 (2017).
  • Baverstock K . Polygenic scores: are they a public health hazard?Prog. Biophys. Mol. Biol.149, 4–8 (2019).
  • Waddington CH . The Strategy of the Gene.Allen and Unwin, London, UK (1957).
  • Waddington CH . Canalization of development and the inheritance of acquired characteristics. Nature150, 563–565 (1942).
  • Noble D . Differential and integral views of genetics in computational systems biology. Interface Focus1, 7–15 (2011).
  • DiFrancesco D , CammJA. Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs64, 1757–1765 (2004).
  • Hillenmeyer ME , FungE , WildenhainJet al. The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science320, 362–365 (2008).
  • Bycroft C , FreemanC , PetkovaDet al. The UK Biobank resource with deep phenotyping and genomic data. Nature562, 203–209 (2018).
  • Debruyne JP , NotonE , LambertCM , MaywoodES , WeaverDR , ReppertSM. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron50(3), 465–477 (2006).
  • Polderman TJC , BenjaminB , DeLeeuw CAet al. Meta-analysis of the heritability of human traits based on fifty years of twin studies. Nat. Genetics47, 702–709 (2015).
  • Bathgate KE , BagleyJR , JoEet al. Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits. Eur. J. Appl. Physiol.118(10), 2097–2110 (2018).
  • Mirams GR , CuiY , SherAet al. Simulation of multiple ion channel block provides improved prediction of compounds’ clinical torsadogenic risk. Cardiovasc. Res.91(1), 53–61 (2011).
  • Wainberg M , Sinnott-ArmstrongN , MancusoNet al. Opportunities and challenges for transcriptome-wide association studies. Nat. Genet.51(4), 592–599 (2019).
  • Gawthrop PJ , CursonsJ , CrampinEJ. Hierarchical bond graph modeling of biochemical networks. Proc. R. Soc. A Math. Phys. Eng. Sci.471(2184) (2015).
  • Shapiro JA . Evolution: A View from the 21st Century.Pearson Education Inc, NJ, USA (2011).
  • Shapiro JA . Epigenetic control of mobile DNA as an interface between experience and genome change. Front. Genet.5, 87 (2014).
  • Noble D . Dance to the Tune of Life: Biological Relativity.Cambridge University Press, Cambridge, UK (2016).
  • Noble D . Central dogma or central debate?Physiology33(4), 246–249 (2018).