Dysregulated Expression of miRNAs in Immune Thrombocytopenia

References

• Ou Y , YangY , XiangX , WuY. Relationship between the IL-10 (-1082 A/G) polymorphism and the risk of immune/idiopathic thrombocytopenic purpura: a meta-analysis. Cytokine125, 154820 (2020).
   PubMed Web of Science ®Google Scholar
• Li J , SullivanJA , NiH. Pathophysiology of immune thrombocytopenia. Curr. Opin. Hematol.25(5), 373–381 (2018).
   PubMed Web of Science ®Google Scholar
• Onisai M , VladareanuAM , SpinuA , GamanM , BumbeaH. Idiopathic thrombocytopenic purpura (ITP) – new era for an old disease. Rom. J. Intern. Med.57(4), 273–283 (2019).
   PubMed Web of Science ®Google Scholar
• Cines DB , BusselJB , LiebmanHA , LuningPrak ET. The ITP syndrome: pathogenic and clinical diversity. Blood113(26), 6511–6521 (2009).
   PubMed Web of Science ®Google Scholar
• Tao L , ZengQ , LiJet al. Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia. J. Hematol. Oncol.10(1), 46 (2017).
   PubMedGoogle Scholar
• Zeng Q , ZhuL , TaoLet al. Relative efficacy of steroid therapy in immune thrombocytopenia mediated by anti-platelet GPIIbIIIa versus GPIbα antibodies. Am. J. Hematol.87(2), 206–208 (2012).
   PubMed Web of Science ®Google Scholar
• Peng J , MaSH , LiuJet al. Association of autoantibody specificity and response to intravenous immunoglobulin G therapy in immune thrombocytopenia: a multicenter cohort study. J. Thromb. Haemost.12(4), 497–504 (2014).
   PubMed Web of Science ®Google Scholar
• Hymes KB , KarpatkinS. In vitro suppressor T lymphocyte dysfunction in autoimmune thrombocytopenic purpura associated with a complement‐fixing antibody. Br. J. Haematol.74(3), 330–335 (1990).
   PubMed Web of Science ®Google Scholar
• Hicks SM , CouplandLA , JahangiriA , ChoiPY , GardinerEE. Novel scientific approaches and future research directions in understanding ITP. Platelets31(3), 315–321 (2020).
   PubMed Web of Science ®Google Scholar
• Qiu J , LiuX , LiXet al. CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia. Sci. Rep.6, 27445 (2016).
   PubMed Web of Science ®Google Scholar
• Ma L , SimpsonE , LiJet al. CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia. Blood126(2), 247–256 (2015).
   PubMed Web of Science ®Google Scholar
• Chow L , AslamR , SpeckERet al. A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy. Blood.115(6), 1247–1253 (2010).
   PubMed Web of Science ®Google Scholar
• Olsson B , AnderssonPO , JernåsMet al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat. Med.9(9), 1123–1124 (2003).
   PubMed Web of Science ®Google Scholar
• Kostic M , ZivkovicN , CvetanovicA , MarjanovićG. CD4+ T cell phenotypes in the pathogenesis of immune thrombocytopenia. Cell. Immunol.351, 104096 (2020).
   PubMed Web of Science ®Google Scholar
• Wang SC , YangKD , LinCYet al. Intravenous immunoglobulin therapy enhances suppressive regulatory T cells and decreases innate lymphoid cells in children with immune thrombocytopenia. Pediatr. Blood. Cancer67(2), e28075 (2020).
   PubMed Web of Science ®Google Scholar
• Ji X , ZhangL , PengJ , HouM. T cell immune abnormalities in immune thrombocytopenia. J. Hematol. Oncol.7, 72 (2014).
   PubMed Web of Science ®Google Scholar
• Semple JW , RebetzJ , MaouiaA , KapurR. An update on the pathophysiology of immune thrombocytopenia. Curr. Opin. Hematol.27(6), 423–429 (2020).
   PubMed Web of Science ®Google Scholar
• Zhang X-M , LiuC-Y , ShaoZ-H. Advances in the role of helper T cells in autoimmune diseases. Chin. Med. J.133(8), 968 (2020).
   PubMed Web of Science ®Google Scholar
• Liu J , WuC-P , LuB-F , JiangJ-T. Mechanism of T cell regulation by microRNAs. Cancer. Biol. Med.10(3), 131–137 (2013).
   PubMedGoogle Scholar
• Liu L , HuaM , LiuC , HeN , LiZ , MaD. The aberrant expression of microRNAs and correlations with T cell subsets in patients with immune thrombocytopenia. Oncotarget7(47), 76453–76463 (2016).
   PubMedGoogle Scholar
• Raisch J , Darfeuille-MichaudA , NguyenHT. Role of microRNAs in the immune system, inflammation and cancer. World. J. Gastroenterol.19(20), 2985–2996 (2013).
   PubMed Web of Science ®Google Scholar
• Zevallos RaC , ReisEM. Noncoding gene families of the human genome. In: Human Genome Structure, Function and Clinical Considerations.Springer, Schoonhoven, The Netherlands, 139–180 (2021).
   Google Scholar
• Dahiya N , SarachanaT , VuLet al. Platelet microRNAs: an overview. Transfus. Med. Rev.29(4), 215–219 (2015).
   PubMed Web of Science ®Google Scholar
• Chandan K , GuptaM , SarwatM. Role of host and pathogen-derived microRNAs in immune regulation during infectious and inflammatory diseases. Front. immunol.10, 3081 (2020).
   PubMed Web of Science ®Google Scholar
• Fattizzo B , BarcelliniW. Autoimmune cytopenias in chronic lymphocytic leukemia: focus on molecular aspects. Front. Oncol.9, 1435 (2020).
   PubMed Web of Science ®Google Scholar
• Lin L-N , ZhangQ-M , GeY-Y , LuoB , XieX-X. A Review of miR-326 and Female Related Diseases. Acta. Histochem. Cytochem.54(3), 79–86. (2021).
   PubMed Web of Science ®Google Scholar
• Bay A , CoskunE , OztuzcuS , ErgunS , YilmazF , AktekinE. Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. Blood. Coagul. Fibrinolysis.25(4), 379–383 (2014).
   PubMed Web of Science ®Google Scholar
• Qian BH , YeX , ZhangLet al. Increased miR-155 expression in peripheral blood mononuclear cells of primary immune thrombocytopenia patients was correlated with serum cytokine profiles. Acta. Haematol.133(3), 257–263 (2015).
   PubMed Web of Science ®Google Scholar
• Chang Y , ChenX , TianYet al. Downregulation of microRNA-155-5p prevents immune thrombocytopenia by promoting macrophage M2 polarization via the SOCS1-dependent PD1/PDL1 pathway. Life. Sci.257, 118057 (2020).
   PubMed Web of Science ®Google Scholar
• He Y , WeiXH , ZaoXM. Value of MiR-155 in prognostic evaluation of elderly patients with primary immune thrombocytopenia. J. Exp. Hematol.28(4), 1338–1343 (2020).
   Google Scholar
• Qian C , YanW , LiTet al. Differential expression of MiR-106b-5p and MiR-200c-3p in newly diagnosed versus chronic primary immune thrombocytopenia patients based on systematic Analysis. Cell. Physiol. Biochem.45(1), 301–318 (2018).
   PubMedGoogle Scholar
• Zuo B , ZhaiJ , YouLet al. Plasma microRNAs characterising patients with immune thrombocytopenic purpura. Thromb. Haemost.117(7), 1420–1431 (2017).
   PubMed Web of Science ®Google Scholar
• Sui T , MaL , LiXet al. Plasma microRNA profile in immune thrombocytopenia: screening and verification. Zhonghua. Yi. Xue. Za. Zhi.94(14), 1083–1086 (2014).
   PubMedGoogle Scholar
• Hua M , LiJ , WangCet al. Aberrant expression of microRNA in CD4(+) cells contributes to Th17/Treg imbalance in primary immune thrombocytopenia. Thromb. Res.177, 70–78 (2019).
   PubMed Web of Science ®Google Scholar
• Wu XF , LiJQ , HuSYet al. Pathogenesis of immune thrombocytopenic purpura (ITP) by MiRNA-30a-Mediated Th17 cell differentiation. J. Exp. Hematol.28(2), 588–594 (2020).
   Google Scholar
• Deng G , YuS , HeYet al. MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction. Mol. Med. Rep.16(3), 2835–2843 (2017).
   PubMed Web of Science ®Google Scholar
• Feng Y , GengLL , LiXQ , NanN. Expression of MicroRNA-15a in children with primary immune thrombocytopenia and its significance. J. Exp. Hematol.25(6), 1772–1775 (2017).
   Google Scholar
• Li H , ZhaoH , XueFet al. Reduced expression of MIR409-3p in primary immune thrombocytopenia. Br. J. Haematol.161(1), 128–35 (2013).
   PubMed Web of Science ®Google Scholar
• Zhao H , LiH , DuWet al. Reduced MIR130A is involved in primary immune thrombocytopenia via targeting TGFB1 and IL18. Br. J. Haematol.166(5), 767–773 (2014).
   PubMed Web of Science ®Google Scholar
• Zhu Y , ZhuH , XieX , ZhengZ , LingY. MicroRNA expression profile in Treg cells in the course of primary immune thrombocytopenia. J. Investig. Med.67(8), 1118–1124 (2019).
   PubMed Web of Science ®Google Scholar
• Jia X , HuX , HanSet al. Increased M1 macrophages in young miR-15a/16(-/-) mice with tumour grafts or dextran sulphate sodium-induced colitis. Scand. J. Immunol.88(3), e12703 (2018).
   PubMed Web of Science ®Google Scholar
• Li JQ , HuSY , WangZYet al. MicroRNA-125-5p targeted CXCL13: a potential biomarker associated with immune thrombocytopenia. Am. J. Transl. Res.7(4), 772–780 (2015).
   PubMed Web of Science ®Google Scholar
• Panitsas FP , TheodoropoulouM , KouraklisAet al. Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood103(7), 2645–2647 (2004).
   PubMed Web of Science ®Google Scholar
• Zhao H , DuW , WangDet al. The expression of IFN-gamma, IL-4, Foxp3 and perforin genes are not correlated with DNA methylation status in patients with immune thrombocytopenic purpura. Platelets.21(2), 137–143 (2010).
   PubMed Web of Science ®Google Scholar
• Talaat RM , ElmaghrabyAM , BarakatSS , El-ShahatM. Alterations in immune cell subsets and their cytokine secretion profile in childhood idiopathic thrombocytopenic purpura (ITP). Clin. Exp. Immunol.176(2), 291–300 (2014).
   PubMed Web of Science ®Google Scholar
• Shan NN , HuY , HouMet al. Decreased Tim-3 and its correlation with Th1 cells in patients with immune thrombocytopenia. Thromb. Res.133(1), 52–56 (2014).
   PubMed Web of Science ®Google Scholar
• Zhao C , LiX , ZhangF , WangL , PengJ , HouM. Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies. Haematologica.93(9), 1428–1430 (2008).
   PubMed Web of Science ®Google Scholar
• Alivernini S , GremeseE , McsharryCet al. MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis. Front. Immunol.8, 1932–1932 (2018).
   PubMed Web of Science ®Google Scholar
• Malmhäll C , AlawiehS , LuYet al. MicroRNA-155 is essential for T(h)2-mediated allergen-induced eosinophilic inflammation in the lung. J. Allergy. Clin Immunol.133(5), 1429–1438;e1–7 (2014).
   PubMed Web of Science ®Google Scholar
• Arroyo M , SalkaK , ChorvinskyEet al. Airway mir-155 responses are associated with Th1 cytokine polarization in young children with viral respiratory infections. PLoS ONE.15(5), e0233352 (2020).
   PubMed Web of Science ®Google Scholar
• Shan NN , ZhuXJ , PengJet al. Interleukin 18 and interleukin 18 binding protein in patients with idiopathic thrombocytopenic purpura. Br. J. Haematol.144(5), 755–761 (2009).
   PubMed Web of Science ®Google Scholar
• Kostic M , ZivkovicN , CvetanovicA , MarjanovićG. CD4(+) T cell phenotypes in the pathogenesis of immune thrombocytopenia. Cell. Immunol.351, 104096 (2020).
   PubMed Web of Science ®Google Scholar
• Zhou L , XuF , ChangC , TaoY , SongL , LiX Interleukin-17-producing CD4+ T lymphocytes are increased in patients with primary immune thrombocytopenia. Blood. Coagul. Fibrinolysis.27(3), 301–7 (2016).
   PubMed Web of Science ®Google Scholar
• Wang Q , LiJ , YuTSet al. Disrupted balance of CD4(+) T-cell subsets in bone marrow of patients with primary immune thrombocytopenia. Int. J. Biol. Sci.15(13), 2798–2814 (2019).
   PubMed Web of Science ®Google Scholar
• Li JQ , HuSY , WangZYet al. Long non-coding RNA MEG3 inhibits microRNA-125a-5p expression and induces immune imbalance of Treg/Th17 in immune thrombocytopenic purpura. Biomed. Pharmacother.83, 905–911 (2016).
   PubMed Web of Science ®Google Scholar
• Zhu Y , ZhuH , XieX , ZhengZ , LingY. MicroRNA expression profile in Treg cells in the course of primary immune thrombocytopenia. J. Investig. Med.67(8), 1118–1124 (2019).
   PubMed Web of Science ®Google Scholar
• Lu LF , BoldinMP , ChaudhryAet al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell.142(6), 914–929 (2010).
   PubMed Web of Science ®Google Scholar
• Zhai PF , WangF , SuRet al. The regulatory roles of microRNA-146b-5p and its target platelet-derived growth factor receptor α (PDGFRA) in erythropoiesis and megakaryocytopoiesis. J. Biol. Chem.289(33), 22600–22613 (2014).
   PubMed Web of Science ®Google Scholar
• Jafarzadeh A , LarussaT , NematiM , JalapourS. T cell subsets play an important role in the determination of the clinical outcome of Helicobacter pylori infection. Microb. Pathog.116, 227–236 (2018).
   PubMed Web of Science ®Google Scholar
• Nemati M , MallaN , YadavM , KhorramdelazadH , JafarzadehA. Humoral and T cell-mediated immune response against trichomoniasis. Parasite. Immunol.40(3), (2018).
   PubMed Web of Science ®Google Scholar
• Hu Y , LiH , ZhangL , ShanB , XuX , LiHet al. Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia. Hum. Immunol.73(6), 629–635 (2012).
   PubMed Web of Science ®Google Scholar
• Cao J , ChenC , LiLet al. Effects of high-dose dexamethasone on regulating interleukin-22 production and correcting Th1 and Th22 polarization in immune thrombocytopenia. J. Clin. Immunol.32(3), 523–529 (2012).
   PubMed Web of Science ®Google Scholar
• Chu YL , HoCT , ChungJG , RajasekaranR , SheenLY. Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. J. Agric. Food. Chem.60(34), 8363–8371 (2012).
   PubMed Web of Science ®Google Scholar
• Muñoz M , EidenschenkC , OtaNet al. Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection. Immunity42(2), 321–331 (2015).
   PubMed Web of Science ®Google Scholar
• Tacchini-Cottier F , VesinC , RedardM , BuurmanW , PiguetPF. Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice. J. Immunol.160(12), 6182–6186 (1998).
   PubMed Web of Science ®Google Scholar
• Qiao J , LiX , WuYet al. An increased expression profile of Th9/IL-9 correlated with Th17/IL-17 in patients with immune thrombocytopenia. Platelets28(3), 287–294 (2017).
   PubMed Web of Science ®Google Scholar
• Zhou ZJ , ZhangYS , LiangCX , YangZY. Role of Th9, Th17, Treg cells levels and IL-9, IL-17 and TGF-β expression in peripheral blood of patients with ITP in pathogenesis of ITP. J. Exp. Hematol.27(1), 180–184 (2019).
   Google Scholar
• Singh Y , GardenOA , LangF , CobbBS. MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2α as an important regulator of T helper 9 and regulatory T-cell differentiation. Immunology.149(1), 74–86 (2016).
   PubMed Web of Science ®Google Scholar
• Wang CR , ZhuHF , ZhuY. Knockout of MicroRNA-155 ameliorates the Th17/Th9 immune response and promotes wound healing. Curr. Med. Sci.39(6), 954–964 (2019).
   PubMed Web of Science ®Google Scholar
• Qiu X , ShiQ , HuangY , JiangH , QinS. miR-143/145 inhibits Th9 cell differentiation by targeting NFATc1. Mol. Immunol.132, 184–191 (2021).
   PubMed Web of Science ®Google Scholar
• Law H , VenturiV , KelleherA , MunierCML. Tfh cells in health and immunity: potential targets for systems biology approaches to vaccination. Int. J. Mol. Sci.21(22), 8524 (2020).
   PubMed Web of Science ®Google Scholar
• Vainchenker W , DeschampsJF , BastinJMet al. Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivio cells from normal and leukemic patients. Blood.59(3), 514–21 (1982).
   PubMed Web of Science ®Google Scholar
• Hoffman R , ZaknoenS , YangHHet al. An antibody cytotoxic to megakaryocyte progenitor cells in a patient with immune thrombocytopenic purpura. N. Engl. J. Med.312(18), 1170–1174 (1985).
   PubMed Web of Science ®Google Scholar
• Stahl CP , Zucker-FranklinD , McdonaldTP. Incomplete antigenic cross-reactivity between platelets and megakaryocytes: relevance to ITP. Blood67(2), 421–428 (1986).
   PubMed Web of Science ®Google Scholar
• Audia S , RossatoM , SantegoetsKet al. Splenic Tfh expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia. Blood124(18), 2858–2866 (2014).
   PubMed Web of Science ®Google Scholar
• Dai L , HeL , WangZet al. Altered circulating T follicular helper cells in patients with chronic immune thrombocytopenia. Exp. Ther. Med.16(3), 2471–2477 (2018).
   PubMed Web of Science ®Google Scholar
• Xie J , CuiD , LiuYet al. Changes in follicular helper T cells in idiopathic thrombocytopenic purpura patients. Int. J. Biol. Sci.11(2), 220–229 (2015).
   PubMed Web of Science ®Google Scholar
• Dai L , HeL , WangZet al. Altered circulating T follicular helper cells in patients with chronic immune thrombocytopenia. Exp. Ther. Med.16(3), 2471–2477 (2018).
   PubMed Web of Science ®Google Scholar
• Audia S , RossatoM , SantegoetsKet al. Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia. Blood124(18), 2858–2866 (2014).
   PubMed Web of Science ®Google Scholar
• Guo Y , QuW , WangYHet al. The role of miR-155 in pathogenesis of immune thrombocytopenia. J. Exp. Hematol.96(14), 1103–1107 (2016).
   Google Scholar
• Jafarzadeh A , NematiM , JafarzadehS. The important role played by chemokines influence the clinical outcome of Helicobacter pylori infection. Life. Sci.231, 116688 (2019).
   PubMed Web of Science ®Google Scholar
• Li J-Q , HuS-Y , WangZ-Yet al. MicroRNA-125-5p targeted CXCL13: a potential biomarker associated with immune thrombocytopenia. Am. J. Transl. Res.7(4), 772–780 (2015).
   PubMed Web of Science ®Google Scholar
• Garabet L , GhanimaW , RangbergAet al. Circulating microRNAs in patients with immune thrombocytopenia before and after treatment with thrombopoietin-receptor agonists. Platelets.31(2), 198–205 (2020).
   PubMed Web of Science ®Google Scholar
• Zhao H , ZhangY , XueF , XuJ , FangZ. Has-mir-146a rs2910164 polymorphism and risk of immune thrombocytopenia. Autoimmunity.47(3), 173–176 (2014).
   PubMed Web of Science ®Google Scholar
• Kim BJ , KimHS , JangHJ , KimJH. Helicobacter pylori eradication in idiopathic thrombocytopenic purpura: a meta-analysis of randomized trials. Gastroenterol. Res. Pract.2018, 6090878 (2018).
   PubMed Web of Science ®Google Scholar
• Cadamuro AC , RossiAF , ManiezzoNM , SilvaAE. Helicobacter pylori infection: host immune response, implications on gene expression and microRNAs. World. J. Gastroenterol.20(6), 1424–1437 (2014).
   PubMed Web of Science ®Google Scholar
• Wang Y , HuangR , SongC , HuH , ZhangM. Some viral microRNAs were up-regulated in megakaryocytes incubated with immune thrombocytopenia plasma. Eur. J. Haematol.90(3), 220–227 (2013).
   PubMed Web of Science ®Google Scholar