Development and Validation of A ferroptosis-Related Model for Three Digestive Tract Tumors Based on a Pan-Cancer Analysis

References

• Hochnadel I , Kossatz-BoehlertU , JedickeN , LenzenH , MannsMP , YevsaT. Cancer vaccines and immunotherapeutic approaches in hepatobiliary and pancreatic cancers. Hum Vaccin. Immunother.13(12), 2931–2952 (2017).
   PubMed Web of Science ®Google Scholar
• Bray F , FerlayJ , SoerjomataramI , SiegelRL , TorreLA , JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.68(6), 394–424 (2018).
   PubMed Web of Science ®Google Scholar
• Gentile D , DonadonM , DiTommaso Let al. Is the outcome after hepatectomy for transitional hepatocholangiocarcinoma different from that of hepatocellular carcinoma and mass-forming cholangiocarcinoma? Updates Surg. 72(3), 671–679 (2020).
   PubMed Web of Science ®Google Scholar
• Zhou Y , HuaZ , ZhuYet al. Upregulation of ARHGAP30 attenuates pancreatic cancer progression by inactivating the beta-catenin pathway. Cancer Cell Int.20, 225 (2020).
   PubMed Web of Science ®Google Scholar
• Zheng H , ZhangG , ZhangLet al. Comprehensive review of web servers and bioinformatics tools for cancer prognosis analysis. Front. Oncol.10, 68 (2020).
   PubMed Web of Science ®Google Scholar
• Ghurburrun E , BorbathI , LemaigreFP , JacqueminP. Liver and pancreas: do similar embryonic development and tissue organization lead to similar mechanisms of tumorigenesis?Gene Expr.18(3), 149–155 (2018).
   PubMedGoogle Scholar
• Yu J , ZhongB , XiaoQet al. Induction of programmed necrosis: a novel anti-cancer strategy for natural compounds. Pharmacol. Ther.214, 107593 (2020).
   PubMed Web of Science ®Google Scholar
• Qiu Y , CaoY , CaoW , JiaY , LuN. The application of ferroptosis in diseases. Pharmacol. Res.159, 104919 (2020).
   PubMed Web of Science ®Google Scholar
• American Association for Cancer Research . Cysteine is required for preventing ferroptosis in pancreatic cancer. Cancer Discov.10(6), 757 (2020).
   Web of Science ®Google Scholar
• Lippmann J , PetriK , FuldaS , LieseJ. Redox modulation and induction of ferroptosis as a new therapeutic strategy in hepatocellular carcinoma. Transl. Oncol.13(8), 100785 (2020).
   PubMed Web of Science ®Google Scholar
• Yoshihara K , ShahmoradgoliM , MartinezEet al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat. Commun.4, 2612 (2013).
   PubMed Web of Science ®Google Scholar
• Newman AM , LiuCL , GreenMRet al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods12(5), 453–457 (2015).
   PubMed Web of Science ®Google Scholar
• Zhang J , ShiK , HuangWet al. The DNA methylation profile of non-coding RNAs improves prognosis prediction for pancreatic adenocarcinoma. Cancer Cell Int.19, 107 (2019).
   PubMed Web of Science ®Google Scholar
• Pruitt K . Molecular and cellular changes during cancer progression resulting from genetic and epigenetic alterations. Prog. Mol. Biol. Transl. Sci.144, 3–47 (2016).
   PubMed Web of Science ®Google Scholar
• Huang Z , JohnsonTS , HanZet al. Deep learning-based cancer survival prognosis from RNA-seq data: approaches and evaluations. BMC Med. Genomics13(Suppl. 5), 41 (2020).
   PubMedGoogle Scholar
• Jia P , YangX , GuoLet al. MSIsensor-pro: fast, accurate, and matched-normal-sample-free detection of microsatellite instability. Genomics Proteomics Bioinformatics18(1), 65–71 (2020).
   PubMed Web of Science ®Google Scholar
• Malta TM , SokolovA , GentlesAJet al. Machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell173(2), 338–354e315 (2018).
   PubMed Web of Science ®Google Scholar
• Brown RAM , RichardsonKL , KabirTD , TrinderD , GanssR , LeedmanPJ. Altered iron metabolism and impact in cancer biology, metastasis, and immunology. Front. Oncol.10, 476 (2020).
   PubMed Web of Science ®Google Scholar
• Nie J , LinB , ZhouM , WuL , ZhengT. Role of ferroptosis in hepatocellular carcinoma. J. Cancer Res. Clin. Oncol.144(12), 2329–2337 (2018).
   PubMed Web of Science ®Google Scholar
• Badgley MA , KremerDM , MaurerHCet al. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science368(6486), 85–89 (2020).
   PubMed Web of Science ®Google Scholar
• Di Nunno V , FregaG , SantoniMet al. BAP1 in solid tumors. Future Oncol.15(18), 2151–2162 (2019).
   PubMed Web of Science ®Google Scholar
• Shang Y , LuoM , YaoF , WangS , YuanZ , YangY. Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells. Cell. Signal72, 109633 (2020).
   PubMed Web of Science ®Google Scholar
• Yuan H , LiX , ZhangX , KangR , TangD. Identification of ACSL4 as a biomarker and contributor of ferroptosis. Biochem. Biophys. Res. Commun.478(3), 1338–1343 (2016).
   PubMed Web of Science ®Google Scholar
• Zhang Y , LiuL , JinLet al. Oxidative stress-induced calreticulin expression and translocation: new insights into the destruction of melanocytes. J. Invest. Dermatol.134(1), 183–191 (2014).
   PubMed Web of Science ®Google Scholar
• Lai PB , ChiTY , ChenGG. Different levels of p53 induced either apoptosis or cell cycle arrest in a doxycycline-regulated hepatocellular carcinoma cell line in vitro. Apoptosis12(2), 387–393 (2007).
   PubMed Web of Science ®Google Scholar
• Dowell SP , WilsonPO , DeriasNW , LaneDP , HallPA. Clinical utility of the immunocytochemical detection of p53 protein in cytological specimens. Cancer Res.54(11), 2914–2918 (1994).
   PubMed Web of Science ®Google Scholar
• Jang JE , HajduCH , LiotC , MillerG , DustinML , Bar-SagiD. Crosstalk between regulatory T cells and tumor-associated dendritic cells negates anti-tumor immunity in pancreatic cancer. Cell Rep.20(3), 558–571 (2017).
   PubMed Web of Science ®Google Scholar
• Wang TT , ZhaoYL , PengLSet al. Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway. Gut66(11), 1900–1911 (2017).
   PubMed Web of Science ®Google Scholar
• Giraldo NA , BechtE , RemarkR , DamotteD , Sautes-FridmanC , FridmanWH. The immune contexture of primary and metastatic human tumours. Curr. Opin. Immunol.27, 8–15 (2014).
   PubMed Web of Science ®Google Scholar
• Jiang Y , XieJ , HanZet al. Immunomarker support vector machine classifier for prediction of gastric cancer survival and adjuvant chemotherapeutic benefit. Clin. Cancer Res.24(22), 5574–5584 (2018).
   PubMed Web of Science ®Google Scholar
• Tang R , XuJ , ZhangBet al. Ferroptosis, necroptosis, and pyroptosis in anticancer immunity. J. Hematol. Oncol.13(1), 110 (2020).
   PubMed Web of Science ®Google Scholar
• Gray SD . Histochemical analysis of capillary and fiber-type distributions in skeletal muscles of spontaneously hypertensive rats. Microvasc. Res.36(3), 228–238 (1988).
   PubMed Web of Science ®Google Scholar
• Deng L , LuD , BaiY , WangY , BuH , ZhengH. Immune profiles of tumor microenvironment and clinical prognosis among women with triple-negative breast cancer. Cancer Epidemiol. Biomarkers Prev.28(12), 1977–1985 (2019).
   PubMed Web of Science ®Google Scholar
• Yang LY , LuoQ , LuLet al. Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response. J. Hematol. Oncol.13(1), 3 (2020).
   PubMed Web of Science ®Google Scholar
• Dejima M , HashimotoH , SasajimaY , NomuraN , SugitaM , MorikawaT. Uterine cervical squamous cell carcinoma with reactive multinucleated giant cells expressing cluster of differentiation 204: a case report and literature review. J. Obstet. Gynaecol. Res.46(10), 2174–2178 (2020).
   PubMed Web of Science ®Google Scholar
• Chen J , ZhengDX , YuXJet al. Macrophages induce CD47 upregulation via IL-6 and correlate with poor survival in hepatocellular carcinoma patients. Oncoimmunology8(11), e1652540 (2019).
   PubMed Web of Science ®Google Scholar
• Ye L , LiY , TangHet al. CD8 + CXCR5 + T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis. Aging (Albany)11(20), 8879–8891 (2019).
   PubMedGoogle Scholar
• Romano S , TufanoM , D’ArrigoP , VigoritoV , RussoS , RomanoMF. Cell stemness, epithelial-to-mesenchymal transition, and immunoevasion: intertwined aspects in cancer metastasis. Semin. Cancer Biol.60, 181–190 (2020).
   PubMed Web of Science ®Google Scholar
• Ford K , HanleyCJ , MelloneMet al. NOX4 inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors. Cancer Res.80(9), 1846–1860 (2020).
   PubMed Web of Science ®Google Scholar
• Gagliardi M , CotellaD , SantoroCet al. Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis. Cell Death Dis.10(12), 902 (2019).
   PubMedGoogle Scholar
• Kajarabille N , Latunde-DadaGO. Programmed cell-death by ferroptosis: antioxidants as mitigators. Int. J. Mol. Sci.20(19), 4968 (2019).
   PubMed Web of Science ®Google Scholar
• Dietrich P , GazaA , WormserL , FritzV , HellerbrandC , BosserhoffAK. Neuroblastoma RAS viral oncogene homolog (NRAS) is a novel prognostic marker and contributes to sorafenib resistance in hepatocellular carcinoma. Neoplasia21(3), 257–268 (2019).
   PubMed Web of Science ®Google Scholar
• Comincini S , FerraraV , AriasAet al. Diagnostic value of PRND gene expression profiles in astrocytomas: relationship to tumor grades of malignancy. Oncol. Rep.17(5), 989–996 (2007).
   PubMed Web of Science ®Google Scholar
• Shen Y , LiX , ZhaoBet al. Iron metabolism gene expression and prognostic features of hepatocellular carcinoma. J. Cell. Biochem.119(11), 9178–9204 (2018).
   PubMed Web of Science ®Google Scholar
• Wang Z , QinJ , ZhaoJet al. Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer. Theranostics10(16), 7178–7192 (2020).
   PubMed Web of Science ®Google Scholar