Advanced search
Publication Cover
Epigenomics Volume 13, 2021 - Issue 22
Submit an article Journal homepage
100
Views
0
CrossRef citations to date
0
Altmetric
Editorial

How does m6A Regulation Affect the Differentiation and Fate of Embryonic Stem Cells?

Shude Yang1 Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, PR China;2 Liaoning Provincial Key Laboratory of Oral Diseases, School of Stomatology & Department of Oral Pathology, School of Stomatology, China Medical University, Shenyang, 110001, Liaoning Province, PR ChinaORCID Iconhttps://orcid.org/0000-0002-7926-7394
ORCID Icon,
Ning Wang1 Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, PR China
&
Shu Guo1 Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, PR ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9094-1602
ORCID Icon
Pages 1787-1789 | Received 29 Aug 2021, Accepted 24 Sep 2021, Published online: 09 Nov 2021

References

  • Fu Y , DominissiniD , RechaviG , HeC. Gene expression regulation mediated through reversible m6A RNA methylation. Nat. Rev. Genet.15(5), 293–306 (2014).
  • Livneh I , Moshitch-MoshkovitzS , AmariglioN , RechaviG , DominissiniD. The m6A epitranscriptome: transcriptome plasticity in brain development and function. Nat. Rev. Neurosci.21(1), 36–51 (2020).
  • Zaccara S , RiesRJ , JaffreySR. Reading, writing and erasing mRNA methylation. Nat. Rev. Mol. Cell Biol.20(10), 608–624 (2019).
  • Meyer KD , JaffreySR. Rethinking m6A readers, writers, and erasers. Annu. Rev. Cell Dev. Biol.33, 319–342 (2017).
  • Patil DP , PickeringBF , JaffreySR. Reading m6A in the transcriptome: m6A-binding proteins. Trends Cell Biol.28(2), 113–127 (2018).
  • Huang W , ChenTQ , FangK , ZengZC , YeH , ChenYQ. N6-methyladenosine methyltransferases: functions, regulation, and clinical potential. J. Hematol. Oncol.14(1), 117 (2021).
  • Jiang X , LiuB , NieZet al. The role of m6A modification in the biological functions and diseases. Signal Transduct. Target. Ther.6(1), 74 (2021).
  • Wang Y , LiY , TothJI , PetroskiMD , ZhangZ , ZhaoJC. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat. Cell Biol.16(2), 191–198 (2014).
  • Batista PJ , MolinieB , WangJet al. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell15(6), 707–719 (2014).
  • Geula S , Moshitch-MoshkovitzS , DominissiniDet al. Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science347(6225), 1002–1006 (2015).
  • Kasowitz SD , MaJ , AndersonSJet al. Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet.14(5), e1007412 (2018).
  • Ivanova I , MuchC , DiGiacomo Met al. The RNA m6A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence. Mol. Cell67(6), 1059–1067.e1054 (2017).
  • Barbieri I , TzelepisK , PandolfiniLet al. Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. Nature552(7683), 126–131 (2017).
  • Wang Y , LiY , YueMet al. N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat. Neurosci.21(2), 195–206 (2018).
  • Liu J , DouX , ChenCet al. N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. Science367(6477), 580–586 (2020).
  • Xu W , LiJ , HeCet al. METTL3 regulates heterochromatin in mouse embryonic stem cells. Nature591(7849), 317–321 (2021).
  • Liu J , GaoM , HeJet al. The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity. Nature591(7849), 322–326 (2021).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.