The Unfavorable Clinical Outcome of COVID-19 in Smokers is Mediated by H3K4me3, H3K9me3 and H3K27me3 Histone Marks

References

• Youn JY , ZhangY , WuYet al. Therapeutic application of estrogen for COVID-19: attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells. Redox Biol.46, 102099 (2021).
   PubMed Web of Science ®Google Scholar
• Hou H , LiY , ZhangPet al. Smoking is independently associated with an increased risk for COVID-19 mortality: a systematic review and meta-analysis based on adjusted effect estimates. Nicotine Tob. Res.23(11), 1947–1951 (2021).
   PubMed Web of Science ®Google Scholar
• Li J , LongX , ZhangQet al. Tobacco smoking confers risk for severe COVID-19 unexplainable by pulmonary imaging. J. Intern. Med.289(4), 574–583 (2021).
   PubMed Web of Science ®Google Scholar
• Labor M , VrbicaŽ , GudeljIet al. Exhaled breath temperature as a novel marker of future development of COPD: results of a follow-up study in smokers. COPD J. Chronic Obstr. Pulm. Dis.13(6), 741–749 (2016).
   PubMed Web of Science ®Google Scholar
• Kumari Prasad S , SinghS , BoseAet al. Combined effect of coal dust exposure and smoking on the prevalence of respiratory impairment among coal miners of West Bengal, India. Arch. Environ. Occup. Health.74(6), 350–357 (2019).
   PubMed Web of Science ®Google Scholar
• Jit BP , QaziS , AryaR , SrivastavaAet al. An immune epigenetic insight to COVID-19 infection. Epigenomics13(6), 465–480 (2021).
   PubMedGoogle Scholar
• Castro de Moura M , DavalosV , Planas-SerraLet al. Epigenome-wide association study of COVID-19 severity with respiratory failure. EBioMedicine.66, 103339 (2021).
   PubMed Web of Science ®Google Scholar
• Corley MJ , PangAPS , DodyKet al. Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19. J. Leukoc. Biol.110(1), 21–26 (2021).
   PubMed Web of Science ®Google Scholar
• Sang ER , TianY , MillerLC , SangY. Epigenetic evolution of ACE2 and IL-6 genes: non-canonical interferon-stimulated genes correlate to COVID-19 susceptibility in vertebrates. Genes (Basel).12(2), 154 (2021).
   PubMed Web of Science ®Google Scholar
• Zhang Q , WadgaonkarP , XuLet al. Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism. Theranostics11(16), 7970–7983 (2021).
   PubMed Web of Science ®Google Scholar
• Stachecka J , KolodziejskiPA , NoakM , SzczerbalI. Alteration of active and repressive histone marks during adipogenic differentiation of porcine mesenchymal stem cells. Sci. Rep.11(1), 1325 (2021).
   PubMed Web of Science ®Google Scholar
• Zhang Y , LuY , YuanB-Zet al. The human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. Oncogene.24(31), 4873–4882 (2005).
   PubMed Web of Science ®Google Scholar
• Shi J , ThakurC , ZhaoYet al. Pathological and prognostic indications of the mdig gene in human lung cancer. Cell. Physiol. Biochem.55(S2), 13–28 (2021).
   PubMedGoogle Scholar
• Thakur C , ChenB , LiLet al. Loss of mdig expression enhances DNA and histone methylation and metastasis of aggressive breast cancer. Signal Transduct. Target. Ther.3(1), 25 (2018).
   PubMedGoogle Scholar
• Fasanelli F , BagliettoL , PonziEet al. Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts. Nat. Commun.6, 10192 (2015).
   PubMed Web of Science ®Google Scholar
• Melvin WJ , AuduCO , DavisFMet al. Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2. Proc. Natl Acad. Sci. USA118(38), e2101071118 (2021).
   PubMed Web of Science ®Google Scholar
• Shirvaliloo M . The blood–gas barrier in COVID-19: an overview of the effects of SARS-CoV-2 infection on the alveolar epithelial and endothelial cells of the lung. Tissue Barriers9(4), 1937013 (2021).
   PubMed Web of Science ®Google Scholar
• Lo PW , ShieJJ , ChenCHet al. O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2. Proc. Natl Acad. Sci.115(28), 7302–7307 (2018).
   PubMed Web of Science ®Google Scholar
• Li Y , LiH , ZhouL. EZH2-mediated H3K27me3 inhibits ACE2 expression. Biochem. Biophys. Res. Commun.526(4), 947–952 (2020).
   PubMed Web of Science ®Google Scholar
• Cantuti-Castelvetri L , OjhaR , PedroLDet al. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science370(6518), 856–860 (2020).
   PubMed Web of Science ®Google Scholar
• Daly JL , SimonettiB , KleinKet al. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science370(6518), 861–865 (2020).
   PubMed Web of Science ®Google Scholar
• Ogunlade BO , LazartiguesE , FilipeanuCM. Angiotensin type 1 receptor-dependent internalization of SARS-CoV-2 by angiotensin-converting enzyme 2. Hypertension.77(4), E42–E43 (2021).
   PubMed Web of Science ®Google Scholar
• Yeung ML , TengJLL , JiaLet al. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Cell184(8), 2212–2228.e12 (2021).
   PubMed Web of Science ®Google Scholar
• Kumar V , BeheraR , LohiteKet al. p38 Kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Cancer Res.70(24), 10381–10391 (2010).
   PubMed Web of Science ®Google Scholar
• Bai G , FurushimaD , NikiTet al. High levels of the cleaved form of galectin-9 and osteopontin in the plasma are associated with inflammatory markers that reflect the severity of COVID-19 pneumonia. Int. J. Mol. Sci.22(9), 4978 (2021).
   PubMed Web of Science ®Google Scholar
• Christensen B , SchackL , KläningE , SørensenES. Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D. J. Biol. Chem.285(11), 7929–7937 (2010).
   PubMed Web of Science ®Google Scholar
• Zhao MM , YangWL , YangFYet al. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct. Target. Ther.6(1), 134 (2021).
   PubMed Web of Science ®Google Scholar
• Ricke-Hoch M , StellingE , LasswitzLet al. Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease. PLoS ONE16(8 August), e0255335 (2021).
   PubMed Web of Science ®Google Scholar
• Sena K , FurueK , SetoguchiF , NoguchiK. Altered expression of SARS-CoV-2 entry and processing genes by Porphyromonas gingivalis-derived lipopolysaccharide, inflammatory cytokines and prostaglandin E2 in human gingival fibroblasts. Arch. Oral Biol.129, 105201 (2021).
   PubMed Web of Science ®Google Scholar
• Kasela S , DaniloskiZ , BollepalliSet al. Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus. Genome Biol.22(1), 242 (2021).
   PubMed Web of Science ®Google Scholar
• Vuille-dit-Bille RN , CamargoSM , EmmeneggerLet al. Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors. Amino Acids.47(4), 693–705 (2015).
   PubMed Web of Science ®Google Scholar
• Patra T , MeyerK , GeerlingLet al. SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells. PLoS Pathog.16(12), e1009128 (2020).
   PubMed Web of Science ®Google Scholar
• Wang Z , ZhangY , FangJet al. Decreased methylation level of H3K27me3 increases seizure susceptibility. Mol. Neurobiol.54(9), 7343–7352 (2017).
   PubMed Web of Science ®Google Scholar
• Li Z , BuckM. Neuropilin-1 assists SARS-CoV-2 infection by stimulating the separation of Spike protein S1 and S2. Biophys. J.120(14), 2828–2837 (2021).
   PubMed Web of Science ®Google Scholar
• Ackermann M , VerledenSE , KuehnelMet al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. N. Engl. J. Med.383(2), 120–128 (2020).
   PubMed Web of Science ®Google Scholar
• Huang J-R , LiP , WenJ-Het al. Determination of arsenic species in mainstream cigarette smoke based on inductively coupled plasma mass spectrometry. Spectrosc. Lett.51(6), 252–256 (2018).
   Web of Science ®Google Scholar
• Gisby J , ClarkeCL , Medjeral-ThomasNet al. Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death. Elife.10, e64827 (2021).
   PubMed Web of Science ®Google Scholar
• Watanabe Y , AllenJD , WrappDet al. Site-specific glycan analysis of the SARS-CoV-2 spike. Science369(6501), 330–333 (2020).
   PubMed Web of Science ®Google Scholar
• Baranova A , CaoH , ZhangF. Unraveling risk genes of COVID-19 by multi-omics integrative analyses. Front. Med.8, 738687 (2021).
   Web of Science ®Google Scholar
• Donlan AN , SutherlandTE , MarieCet al. IL-13 is a driver of COVID-19 severity. JCI Insight.6(15), e150107 (2021).
   PubMed Web of Science ®Google Scholar
• Wu D , YangXO. Dysregulation of pulmonary responses in severe COVID-19. Viruses13(6), 957 (2021).
   PubMed Web of Science ®Google Scholar
• Carmody LC , BlauH , DanisDet al. Significantly different clinical phenotypes associated with mutations in synthesis and transamidase + remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes. Orphanet J. Rare Dis.15(1), 40 (2020).
   PubMed Web of Science ®Google Scholar
• Vigetti D , ViolaM , KarousouEet al. Metabolic control of hyaluronan synthases. Matrix Biol.35, 8–13 (2014).
   PubMed Web of Science ®Google Scholar
• Thakur C , ChenF. Current understanding of mdig/MINA in human cancers. Genes Cancer.6(7–8), 288–302 (2015).
   PubMedGoogle Scholar
• Chen B , LiuJ , ChangQet al. JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic. Cell Cycle12(1), 112–121 (2013).
   PubMed Web of Science ®Google Scholar
• Liu F , KillianJK , YangMet al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene.29(25), 3650–3664 (2010).
   PubMed Web of Science ®Google Scholar
• Cheng C , WuY , XiaoTet al. METTL3-mediated m6A modification of ZBTB4 mRNA is involved in the smoking-induced EMT in cancer of the lung. Mol. Ther. – Nucleic Acids.23, 487–500 (2021).
   Google Scholar
• Šipoš IH , LaborS , JurićIet al. Dynamics of exhaled breath temperature after smoking a cigarette and its association with lung function changes predictive of COPD risk in smokers: a cross-sectional study. Arch. Ind. Hyg. Toxicol.70(2), 123–129 (2019).
   Google Scholar
• Egecioglu E , AnestenF , SchéleE , PalsdottirV. Interleukin-6 is important for regulation of core body temperature during long-term cold exposure in mice. Biomed. Reports.9(3), 206–212 (2018).
   PubMed Web of Science ®Google Scholar
• Izcovich A , RagusaMA , TortosaFet al. Prognostic factors for severity and mortality in patients infected with COVID-19: a systematic review. PLoS ONE15(11), e0241955 (2020).
   PubMed Web of Science ®Google Scholar
• Hasan MZ , IslamS , MatsumotoK , KawaiT. SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs. Sci. Rep.11(1), 16814 (2021).
   PubMed Web of Science ®Google Scholar
• Huang C , WangY , LiXet al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet395(10223), 497–506 (2020).
   PubMed Web of Science ®Google Scholar
• Ren J , LiB. The functional stability of FOXP3 and RORγt in Treg and Th17 and Their therapeutic applications. In: Advances in Protein Chemistry and Structural Biology.Academic Press Inc., Oxford, England, 155–189 (2017).
   Google Scholar
• Song MH , NairVS , OhKI. Vitamin C enhances the expression of IL17 in a Jmjd2-dependent manner. BMB Rep.50(1), 49–54 (2017).
   PubMed Web of Science ®Google Scholar
• Hong W , ChenY , YouKet al. Celebrex adjuvant therapy on coronavirus disease 2019: an experimental study. Front. Pharmacol.11, 561674 (2020).
   PubMed Web of Science ®Google Scholar
• Penke LR , SpethJM , DraijerCet al. PGE 2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking. Life Sci. Alliance3(11), e202000800 (2020).
   PubMed Web of Science ®Google Scholar
• Sørensen LT , ToftBG , RygaardJet al. Effect of smoking, smoking cessation, and nicotine patch on wound dimension, vitamin C, and systemic markers of collagen metabolism. Surgery148(5), 982–990 (2010).
   PubMed Web of Science ®Google Scholar
• Opolot JO , TheronAJ , MacPhailPet al. Effect of smoking on acute phase reactants, stress hormone responses and vitamin C in pulmonary tuberculosis. Afr. Health Sci.17(2), 337 (2017).
   PubMed Web of Science ®Google Scholar
• Piccirillo CA . Transcriptional and translational control of Foxp3+ regulatory T cell functional adaptation to inflammation. Curr. Opin. Immunol.67, 27–35 (2020).
   PubMed Web of Science ®Google Scholar
• Akrom A , PurnamasariTJ , NurfaizZet al. Nicotine level associated with decreasing Treg number in smoker healthy volunteers. Int. J. Public Heal. Sci.10(1), 88 (2021).
   Google Scholar
• de Almeida Nagata DE , TingH-A , CavassaniKAet al. Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection. Mucosal Immunol.8(5), 1131–1143 (2015).
   PubMed Web of Science ®Google Scholar
• Zhang H , MaS , HanTet al. Association of smoking history with severe and critical outcomes in COVID-19 patients: a systemic review and meta-analysis. Eur. J. Integr. Med.43, 101313 (2021).
   PubMed Web of Science ®Google Scholar
• Wang A , ChiouJ , PoirionOBet al. Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes. Elife9, 1–28 (2020).
   Web of Science ®Google Scholar