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Review

Demethylation and Re-Expression of Epigenetically Silenced Tumor Suppressor Genes: Sensitization of Cancer Cells by Combination Therapy

, , , &
Pages 87-94 | Published online: 15 Feb 2013

References

  • Cedar H , BergmanY. Linking DNA methylation and histone modification: patterns and paradigms. Nat. Rev. Genet.10 , 295–304 (2009).
  • Gardiner-Garden M , FrommerM. CpG islands in vertebrate genomes. J. Mol. Biol.196 , 261–282 (1987).
  • Takai D , JonesPA. Comprehensive analysis of CpG islands in human chromosomes 21 & 22. Proc. Natl Acad. Sci. USA99 , 3740–3745 (2002).
  • Li E , BestorTH, JaenischR. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell69 , 915–926 (1992).
  • Okano M , BellDW, HaberDA et al. DNA methyl transferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 , 247–257 (1999).
  • Kafri T , ArielM, BrandeisM et al. Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev. 6 , 705–714 (1992).
  • Robertson KD , KeyomarsiK, GonzalesA et al. Differential mRNA expression of the human DNA methyl transferases (DNMTs) 1, 3a, 3b during the Go/G1 to S phase transition in normal and tumor cells. Nucleic Acid Res. 28 , 2108–2113 (2000).
  • Hogart A , LichtenbergJ, AjayS et al. Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res. 22 , 1407–1418 (2012).
  • Sarkar S , AbujamraAL, LoewJE, FormanLW, PerrineSP, FallerDV. Histone deacetylase inhibitors reverse CpG methylation by regulating DNMT1 through ERK signaling. Anticancer Res.31 , 2723–2732 (2011).
  • Turcotte M , Garcia-OjalvoJ, SuelGM. A genetic timer through noise-induced stabilization of an unstable state. Proc. Natl Acad. Sci. USA105 , 15732–15737 (2008).
  • Bock C , WalterJ, PaulsenM, LengauerT. CpG island mapping by epigenome prediction. PLoS Comput. Biol.3(6) , 1055–1070 (2007).
  • Lewandowska J , BartoszekA. DNA methylation in cancer development diagnosis and therapy – multiple opportunities for genotoxic agents to act as methylome disruptors or remediators. Mutagenesis26(4) , 1–13 (2011).
  • Tsatsanis C , SpandidosD. The role of oncogenic kinases in human cancer. Int. J. Mol. Med.5 , 583–590 (2000).
  • Mataga M , RosenthalS, HeerbothS et al. Anti-breast cancer effects of histone deacetylase inhibitors and calpain inhibitor. Anticancer Res. 32 , 2523–2530 (2012).
  • Renaud S , LoukinovD, AbdullaevZ et al. Dual role of DNA methylation inside and outside of CTCF- binding regions in the transcriptional regulation of the telomerase hTERT gene. Nucleic Acids Res. 35 , 1245–1256 (2007).
  • Li CT , HsiaoYM, WuTC et al. Vorinostat, SAHA, represses telomerase activity via epigenetic regulation of telomerase reverse transcriptase in non-small cell lung cancer cells. J. Cell Biochem. 112 , 3044–3053 (2011).
  • Zinn RL , PruittK, EguchiS et al. hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site. Cancer Res. 67(1) , 194–201 (2007).
  • Knudson A . Mutation and cancer: statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA68(4) , 820–823 (1971).
  • Hanahan D , WeinbergRA. Hallmarks of cancer: the next generation. Cell144(5) , 646–674 (2011).
  • Vogelstein B , KinzlerK. Cancer genes and the pathways they control. Nat. Med.10(8) , 789–799 (2004).
  • Chen J , LiY, Tzong-ShiueY et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488(7412) , 522–526 (2012).
  • Driessens G , BeckB, CaauweA et al. Defining the mode of tumor growth by clonal analysis. Nature 488(7412) , 527–530 (2012).
  • Schepers AG , SnippertHJ, StangeDE et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 337(6095) , 730–735 (2012).
  • Moschos S , DrogowskiL, ReppertS et al. Integrins and cancer. Oncology 21(9) , 13–20 (2007).
  • Lee EJ , LeeBB, JanJ et al. CpG island hypermethylation of E-cadherin (CDH1) and integrin alpha4 is associated with recurrence of early stage esophageal squamous cell carcinoma. Int. J. Cancer. 123(9) , 2973–2079 (2008).
  • Guerrero-Preston R , SoudryE, AceoJ et al. NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva. Cancer Prev. Res. (Phila).4 , 1061–1072 (2011).
  • Bruniquel D , SchwartzRH. Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat. Immunol.4 , 235–240 (2003).
  • Lucarelli M , FusoA, StromR et al. The dynamics of myogenin site-specific demthylation is strongly correlated with its expression and with muscle differentation. J. Biol. Chem. 276 , 7500–7506 (2001).
  • Rai K , SarkarS, BroadbentT et al. DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell 142(6) , 930–942 (2010).
  • Melki J , ClarkS. DNA methylation changes in leukemia. Semin. Cancer Biol.12 , 347–357 (2002).
  • Pastor W , PapeU, HuangY et al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 473(7347) , 394–397 (2011).
  • Wong A , LeeS. Mechanisms of resistance to trastuzumab and novel therapeutic strategies in HER2-positive breast cancer. Int. J. Breast Cancer1–13 (2012) (2012).
  • Merlos-Suarez A , BarrigaF, JungP et al. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Nature 8 , 511–524 (2011).
  • Sarkar S . Platelets related to thrombosis and fibrinolysis. Clin. Lipidol.2(5S) , 596 (2008).
  • Mani SK , BalasubramanianS, ZavadzkasJ et al. Calpain inhibition preserves myocardial structure and function following myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 297(5) , 1744–1751 (2009).
  • Camins A , Crespo-BielN, JunyentF et al. Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium. Curr. Drug Metab. 10(5) , 433–437 (2009).
  • Storr SJ , CarragherNO, FrameMC et al. The calpain system and cancer. Nat. Rev. Cancer 11(5) , 364–374 (2011).
  • Housman G , MatagaAM, DevalapalliA et al. Demethylation and re-expression of tumor suppressor genes by HDAC inhibitors and calpain inhibitors in cancer cells: a study related to synergistic type growth inhibition and reduction of motility. Presented at: The Epigenetics World Congress , MA, USA, 26–27 April 2011 (Abstract 206).
  • Mitra R , SrirangamA, HawesJ et al. Calpain inhibition down regulates akt and induces death of non-cycling breast cancer cells. Proc. Am. Assoc. Cancer Res. 45, Abstract 4834 (2004).
  • Cowley M , OakeyRJ. Retrotransposition and genomic imprinting. Brief Funct. Genomics.9 , 340–346 (2010).
  • Sarkar S , FallerDV. T-oligos inhibit growth and induce apoptosis in human ovarian cancer cells. Oligonucleotides21(1) , 47–53 (2011).
  • Frew AJ , LindemannRK, MartinBP et al. Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist. Proc. Natl Acad. Sci. USA 105(32) , 11317–11322 (2008).
  • Juergens R , WrangleJ, VendettiF et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov. 1 , 598–607 (2011).
  • Blach C , YanP, Craft,T et al. Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer. Mol. Cancer. Therapy 4(10) , 1505–1514 (2005).
  • Hagemann S , HeilO, LykoF et al. Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PLoS ONE 6(3) , 1–11 (2011).

▪ Patent

  • Sarkar S, Freedman J, Varghese S: US0124512. Pending (2010).

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