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Editorial

New Opportunities for Organ Transplantation Research: Epigenetics is Likely to be an Important Determinant of the Host Immune Response

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Pages 243-246 | Published online: 11 Jun 2013

References

  • Lim PS , ShannonMF, HardyK. Epigenetic control of inducible gene expression in the immune system. Epigenomics2(6) , 775–795 (2010).
  • Wilson CB , RowellE, SekimataM. Epigenetic control of T-helper-cell differentiation. Nat. Rev. Immunol.9(2) , 91–105 (2009).
  • Dawson MA , KouzaridesT. Cancer epigenetics: from mechanism to therapy. Cell150(1) , 12–27 (2012).
  • Brooks WH , DantecCL, Pers J-O, Youinou P, Renaudineau Y. Epigenetics and autoimmunity. J. Autoimmun.34(3) , J207–J219 (2010).
  • Parker MD , ChambersPA, LodgeJPA, PrattJR. Ischemia–reperfusion injury and its influence on the epigenetic modification of the donor kidney genome. Transplantation86(12) , 1818–1823 (2008).
  • Granger A , AbdullahI, HuebnerF et al. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB J. 22(10) , 3549–3560 (2008).
  • Rodriguez RM , Suarez-AlvarezB, SalvanésR et al. DNA methylation dynamics in blood after hematopoietic cell transplant. PLoS ONE 8(2) , e56931 (2013).
  • Hartono C , MuthukumarT, SuthanthiranM. Noninvasive diagnosis of acute rejection of renal allografts. Curr. Opin. Organ Trans.15(1) , 35–41 (2010).
  • Fullwood MJ , LiuMH, PanYF et al. An oestrogen-receptor-α-bound human chromatin interactome. Nature 462(7269) , 58–64 (2009).
  • Adli M , BernsteinBE. Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq. Nat. Protoc.6(10) , 1656–1668 (2011).
  • Olkhov-Mitsel E , BapatB. Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers. Cancer Med.1(2) , 237–260 (2012).
  • Komori HK , LaMereSA, TorkamaniA et al. Application of microdroplet PCR for large-scale targeted bisulfite sequencing. Genome Res. 21(10) , 1738–1745 (2011).
  • Barski A , CuddapahS, CuiK et al. High-resolution profiling of histone methylations in the human genome. Cell 129 , 823–837 (2007).
  • Cuddapah S , BarskiA, ZhaoK. Epigenomics of T cell activation, differentiation, and memory. Curr. Opin. Immunol.22(3) , 341–347 (2010).
  • Li Y , ChenG, MaL et al. Plasticity of DNA methylation in mouse T cell activation and differentiation. BMC Mol. Biol. 13 , 16 (2012).
  • Li Y , OhmsSJ, ShannonFM, SunC, FanJY. IL-2 and GM-CSF are regulated by DNA demethylation during activation of T cells, B cells and macrophages. Biochem. Biophys. Res. Commun.419(4) , 748–753 (2012).
  • Hirahara K , VahediG, GhoreschiK et al. Helper T-cell differentiation and plasticity: insights from epigenetics. Immunology 134(3) , 235–245 (2011).
  • Kanno Y , VahediG, HiraharaK, SingletonK, O‘SheaJJ. Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu. Rev. Immunol.30(1) , 707–731 (2012).
  • Lee C -G, Sahoo A, Im S-H. Epigenetic regulation of cytokine gene expression in T lymphocytes. Yonsei Med. J.50(3) , 322–330 (2009).
  • Vahedi G , C Poholek A, Hand TW et al. Helper T-cell identity and evolution of differential transcriptomes and epigenomes. Immunol. Rev.252(1) , 24–40 (2013).
  • Zhu J , YamaneH, PaulWE. Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol.28(1) , 445–489 (2010).
  • Lal G , BrombergJS. Epigenetic mechanisms of regulation of Foxp3 expression. Blood114(18) , 3727–3735 (2009).
  • de Groote ML , VerschurePJ, RotsMG. Epigenetic editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res.40(21) , 10596–10613 (2012).
  • Clouaire T , WebbS, SkeneP et al. Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Genes Dev. 26(15) , 1714–1728 (2012).
  • Margaritis T , OrealV, BrabersN et al. Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3´-end antisense transcription. PLoS Genet. 8(9) , e1002952 (2012).
  • Cohen I , PorebaE, KamieniarzK, SchneiderR. Histone modifiers in cancer: friends or foes?. Genes Cancer2(6) , 631–647 (2011).
  • McCaughan JA , McKnightAJ, CourtneyAE, MaxwellAP. Epigenetics: time to translate into transplantation. Transplantation94(1) , 1–7 (2012).
  • Gros C , FahyJ, HalbyL et al. DNA methylation inhibitors in cancer: recent and future approaches. Biochimie 94(11) , 2280–2296 (2012).
  • Hancock WW , AkimovaT, BeierUH, LiuY, WangL. HDAC inhibitor therapy in autoimmunity and transplantation. Ann. Rheum. Dis.71(Suppl. 2) , i46–i54 (2012).

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