The Roles of Jumonji-Type Oxygenases in Human Disease

References

• Loenarz C , SchofieldCJ . Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases . Trends Biochem. Sci.36 ( 1 ), 7 – 18 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Takeuchi T , YamazakiY , Katoh-FukuiYet al. Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation . Genes Dev.9 ( 10 ), 1211 – 1222 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Takeuchi T , WatanabeY , Takano-ShimizuT , KondoS . Roles of jumonji and jumonji family genes in chromatin regulation and development . Dev. Dyn.235 ( 9 ), 2449 – 2459 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Balciunas D , RonneH . Evidence of domain swapping within the jumonji family of transcription factors . Trends Biochem. Sci.25 ( 6 ), 274 – 276 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Clissold PM , PontingCP . Jmj C: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta . Trends Biochem Sci.26 ( 1 ), 7 – 9 ( 2001 ).  
   PubMed Web of Science ®Google Scholar
• Ng SS , KavanaghKL , McdonoughMAet al. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity . Nature448 ( 7149 ), 87 – 91 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Shi Y , LanF , MatsonCet al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 . Cell119 ( 7 ), 941 – 953 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Mcdonough MA , KavanaghKL , ButlerD , SearlsT , OppermannU , SchofieldCJ . Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease . J. Biol. Chem.280 ( 49 ), 41101 – 41110 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Leung IK , KrojerTJ , KochanGTet al. Structural and mechanistic studies on gamma-butyrobetaine hydroxylase . Chem. Biol17 ( 12 ), 1316 – 1324 ( 2010 ).
   PubMedGoogle Scholar
• Hautala T , ByersMG , EddyRL , ShowsTB , KivirikkoKI , MyllylaR . Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3—-p36.2 . Genomics13 ( 1 ), 62 – 69 ( 1992 ).
   PubMed Web of Science ®Google Scholar
• Clifton IJ , McdonoughMA , EhrismannD , KershawNJ , GranatinoN , SchofieldCJ . Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins . J. Inorganic Biochem.100 ( 4 ), 644 – 669 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Klose RJ , KallinEM , ZhangY . JmjC-domain-containing proteins and histone demethylation . Nat. Rev. Genet.7 ( 9 ), 715 – 727 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Mcdonough MA , LoenarzC , ChowdhuryR , CliftonIJ , SchofieldCJ . Structural studies on human 2-oxoglutarate dependent oxygenases . Curr. Opin Struct. Biol.20 ( 6 ), 659 – 672 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Han Z , NiuT , ChangJet al. Crystal structure of the FTO protein reveals basis for its substrate specificity . Nature464 ( 7292 ), 1205 – 1209 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Tsukada Y , FangJ , Erdjument-BromageHet al. Histone demethylation by a family of JmjC domain-containing proteins . Nature439 ( 7078 ), 811 – 816 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Frescas D , GuardavaccaroD , BassermannF , Koyama-NasuR , PaganoM . JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes . Nature450 ( 7167 ), 309 – 313 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Lu T , JacksonMw , WangBet al. Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65 . Proc. Natl Acad. Sci. USA107 ( 1 ), 46 – 51 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Yamane K , ToumazouC , TsukadaYet al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor . Cell125 ( 3 ), 483 – 495 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Brauchle M , YaoZ , AroraRet al. Protein Complex Interactor Analysis and Differential Activity of KDM3 Subfamily Members Towards H3K9 Methylation . PLoS ONE8 ( 4 ), e60549 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Hillringhaus L , YueWW , RoseNRet al. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family . J. Biol. Chem.286 ( 48 ), 41616 – 41625 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Ponnaluri VK , VavilalaDT , PuttyS , GutheilWG , MukherjiM . Identification of non-histone substrates for JMJD2A-C histone demethylases . Biochem. Biophys. Res. Commun.390 ( 2 ), 280 – 284 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Trojer P , ZhangJ , YonezawaMet al. Dynamic histone H1 isotype 4 methylation and demethylation by histone lysine methyltransferase G9a/KMT1C and the Jumonji domain-containing JMJD2/KDM4 proteins . J Biol Chem284 ( 13 ), 8395 – 8405 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Christensen J , AggerK , CloosPaet al. RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3 . Cell128 ( 6 ), 1063 – 1076 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Iwase S , LanF , BaylissPet al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases . Cell128 ( 6 ), 1077 – 1088 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Klose RJ , YanQ , TothovaZet al. The retinoblastoma binding protein RBP2 is an H3K4 demethylase . Cell128 ( 5 ), 889 – 900 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Lee MG , NormanJ , ShilatifardA , ShiekhattarR . Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein . Cell128 ( 5 ), 877 – 887 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Seward DJ , CubberleyG , KimSet al. Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins . Nat. Struct. Mol. Biol.14 ( 3 ), 240 – 242 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• De Santa F , TotaroMG , ProsperiniE , NotarbartoloS , TestaG , NatoliG . The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing . Cell130 ( 6 ), 1083 – 1094 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Hong S , ChoYW , YuLR , YuH , VeenstraTD , GeK . Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases . Proc. Natl Acad. Sci. USA104 ( 47 ), 18439 – 18444 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Lan F , BaylissPE , RinnJLet al. A histone H3 lysine 27 demethylase regulates animal posterior development . Nature449 ( 7163 ), 689 – 694 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Lee MG , VillaR , TrojerPet al. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination . Science318 ( 5849 ), 447 – 450 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Xiang Y , ZhuZ , HanG , LinH , XuL , ChenCD . JMJD3 is a histone H3K27 demethylase . Cell Res.17 ( 10 ), 850 – 857 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Wen H , LiJ , SongTet al. Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation . J. Biol. Chem.285 ( 13 ), 9322 – 9326 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Horton JR , UpadhyayAK , QiHH , ZhangX , ShiY , ChengX . Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases . Nat. Struct. Mol. Biol.17 ( 1 ), 38 – 43 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Zhu Z , WangY , LiXet al. PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis . Cell Res.20 ( 7 ), 794 – 801 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Qi HH , SarkissianM , HuGGet al. Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development . Nature466 ( 7305 ), 503 – 507 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Tsukada Y , IshitaniT , NakayamaKI . KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development . Genes Dev.24 ( 5 ), 432 – 437 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Yue Ww , HozjanV , GeWet al. Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase . FEBS Lett.584 ( 4 ), 825 – 830 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Ge W , WolfA , FengTet al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans . Nat. Chem. Biol.8 ( 12 ), 960 – 962 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Sinha KM , YasudaH , CoombesMM , DentSY , DeCrombrugghe B . Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase . EMBO J.29 ( 1 ), 68 – 79 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Lu Y , BeezholdK , ChangQet al. Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3 . Cell Cycle8 ( 13 ), 2101 – 2109 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Hsia DA , TepperCG , PochampalliMRet al. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation . Proc. Natl Acad. Sci. USA107 ( 21 ), 9671 – 9676 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Youn M-Y , YokoyamaA , Fujiyama-NakamuraSet al. JMJD5, a Jumonji C (JmjC) domain-containing protein, negatively regulates osteoclastogenesis by facilitating NFATc1 protein degradation . J. Biol. Chem.287 ( 16 ), 12994 – 13004 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Chang B , ChenY , ZhaoY , BruickRK . JMJD6 is a histone arginine demethylase . Science318 ( 5849 ), 444 – 447 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Webby Cj , WolfA , GromakNet al. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing . Science325 ( 5936 ), 90 – 93 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Mantri M , LoikND , HamedRB , ClaridgeTDW , MccullaghJSO , SchofieldCJ . The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues . ChemBioChem12 ( 4 ), 531 – 534 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Unoki M , MasudaA , DohmaeNet al. Lysyl 5-hydroxylation, a novel hstone modification, by Jumonji domain containing 6 (JMJD6) . J. Biol. Chem.288 ( 9 ), 6053 – 6062 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Yang M , ChowdhuryR , GeWet al. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains . FEBS J.278 ( 7 ), 1086 – 1097 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Yang M , GeW , ChowdhuryRet al. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor . J. Biol. Chem.286 ( 9 ), 7648 – 7660 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Cockman ME , LancasterDE , StolzeIPet al. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) . Proc. Natl Acad. Sci. USA103 ( 40 ), 14767 – 14772 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Lando D , PeetDJ , GormanJJ , WhelanDA , WhitelawML , BruickRK . FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor . Genes Dev.16 ( 12 ), 1466 – 1471 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Noma A , IshitaniR , KatoM , NagaoA , NurekiO , SuzukiT . Expanding role of the jumonji C domain as an RNA hydroxylase . J. Biol. Chem.285 ( 45 ), 34503 – 34507 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Sedgwick B . Repairing DNA-methylation damage . Nat. Rev. Mol. Cell Biol.5 ( 2 ), 148 – 157 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Duncan T , TrewickSC , KoivistoP , BatesPA , LindahlT , SedgwickB . Reversal of DNA alkylation damage by two human dioxygenases . Proc. Natl Acad. Sci. USA99 ( 26 ), 16660 – 16665 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Li Mm , NilsenA , ShiYet al. ALKBH4-dependent demethylation of actin regulates actomyosin dynamics . Nat. Commun.4 , 1832 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Zheng G , DahlJA , NiuYet al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility . Mol. Cell49 ( 1 ), 18 – 29 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Fu D , BrophyJA , ChanCTet al. Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival . Mol. Cell Biol.30 ( 10 ), 2449 – 2459 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Tahiliani M , KohKP , ShenYet al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 . Science324 ( 5929 ), 930 – 935 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Ito S , ShenL , DaiQet al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine . Science333 ( 6047 ), 1300 – 1303 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Gerken T , GirardCA , TungYCet al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase . Science318 ( 5855 ), 1469 – 1472 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Jia G , YangCg , YangSet al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO . FEBS Lett.582 ( 23–24 ), 3313 – 3319 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Landeira D , SauerS , PootRet al. Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators . Nat. Cell. Biol.12 ( 6 ), 618 – 624 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Pasini D , CloosPA , WalfridssonJet al. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells . Nature464 ( 7286 ), 306 – 310 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Peng JC , ValouevA , SwigutTet al. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells . Cell139 ( 7 ), 1290 – 1302 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Shen X , KimW , FujiwaraYet al. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells . Cell139 ( 7 ), 1303 – 1314 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Lewis EB . A gene complex controlling segmentation in Drosophila . Nature276 ( 5688 ), 565 – 570 ( 1978 ).
   PubMed Web of Science ®Google Scholar
• Struhl G . A gene product required for correct initiation of segmental determination in Drosophila . Nature293 ( 5827 ), 36 – 41 ( 1981 ).
   PubMed Web of Science ®Google Scholar
• Bracken AP , HelinK . Polycomb group proteins: navigators of lineage pathways led astray in cancer . Nat. Rev. Cancer9 ( 11 ), 773 – 784 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Metzger E , WissmannM , YinNet al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription . Nature437 ( 7057 ), 436 – 439 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Allis CD , BergerSL , CoteJet al. New nomenclature for chromatin-modifying enzymes . Cell131 ( 4 ), 633 – 636 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Bernstein BE , BirneyE , DunhamI , GreenED , GunterC , SnyderM . An integrated encyclopedia of DNA elements in the human genome . Nature489 ( 7414 ), 57 – 74 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Ng SS , YueWW , OppermannU , KloseRJ . Dynamic protein methylation in chromatin biology . Cell. Mol. Life Sci.66 ( 3 ), 407 – 422 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Kooistra SM , HelinK . Molecular mechanisms and potential functions of histone demethylases . Nat. Rev. Mol. Cell Biol.13 ( 5 ), 297 – 311 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Pedersen MT , HelinK . Histone demethylases in development and disease . Trends Cell Biol.20 ( 11 ), 662 – 671 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Dawson MA , KouzaridesT . Cancer epigenetics: from mechanism to therapy . Cell150 ( 1 ), 12 – 27 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Greer El , ShiY . Histone methylation: a dynamic mark in health, disease and inheritance . Nat. Rev. Genet.13 ( 5 ), 343 – 357 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Mosammaparast N , ShiY . Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases . Annu. Rev. Biochem.79 , 155 – 179 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Ciccone DN , SuH , HeviSet al. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints . Nature461 ( 7262 ), 415 – 418 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Karytinos A , FornerisF , ProfumoAet al. A novel mammalian flavin-dependent histone demethylase . J. Biol. Chem.284 ( 26 ), 17775 – 17782 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Wang J , HeviS , KurashJKet al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation . Nat. Genet.41 ( 1 ), 125 – 129 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Kerenyi Ma , ShaoZ , HsuYJet al. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation . Elife2 , e00633 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Sprussel A , SchulteJH , WeberSet al. Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation . Leukemia26 ( 9 ), 2039 – 2051 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Schenk T , ChenWc , GollnerSet al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia . Nat Med18 ( 4 ), 605 – 611 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Wang J , LuF , RenQet al. Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties . Cancer Res71 ( 23 ), 7238 – 7249 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Tsai Mc , ManorO , WanYet al. Long noncoding RNA as modular scaffold of histone modification complexes . Science329 ( 5992 ), 689 – 693 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Wang Y , ZhangH , ChenYet al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer . Cell138 ( 4 ), 660 – 672 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Garcia-Bassets I , KwonYs , TeleseFet al. Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors . Cell128 ( 3 ), 505 – 518 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Huang J , SenguptaR , EspejoABet al. p53 is regulated by the lysine demethylase LSD1 . Nature449 ( 7158 ), 105 – 108 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Deaton Am , BirdA . CpG islands and the regulation of transcription . Genes Dev25 ( 10 ), 1010 – 1022 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Blackledge NP , ZhouJC , TolstorukovMY , FarcasAM , ParkPJ , KloseRJ . CpG islands recruit a histone H3 lysine 36 demethylase . Molecular cell38 ( 2 ), 179 – 190 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Farcas Am , BlackledgeNp , SudberyIet al. KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands . Elife1 , e00205 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• He J , ShenL , WanM , TaranovaO , WuH , ZhangY . Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes . Nat. Cell Biol.15 ( 4 ), 373 – 384 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Wu X , JohansenJV , HelinK . Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation . Mol. Cell49 ( 6 ), 1134 – 1146 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Lagarou A , Mohd-SaripA , MoshkinYMet al. dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing . Genes Dev.22 ( 20 ), 2799 – 2810 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Bartke T , VermeulenM , XhemalceB , RobsonSC , MannM , KouzaridesT . Nucleosome-interacting proteins regulated by DNA and histone methylation . Cell143 ( 3 ), 470 – 484 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Tanaka Y , OkamotoK , TeyeKet al. JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation . EMBO J.29 ( 9 ), 1510 – 1522 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Barrero MJ , IzpisuaBelmonte JC . Polycomb complex recruitment in pluripotent stem cells . Nat. Cell Biol.15 ( 4 ), 348 – 350 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Du J , MaY , MaP , WangS , FanZ . Demethylation of epiregulin gene by histone demethylase FBXL11 and BCL6 corepressor inhibits osteo/dentinogenic differentiation . Stem Cells31 ( 1 ), 126 – 136 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Gao R , DongR , DuJ , MaP , WangS , FanZ . Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15(INK4B) and p27 (Kip1.) . Mol. Cellular Biochemistry379 ( 1–2 ), 115 – 122 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Iuchi S , GreenH . Lysine-specific demethylase 2A (KDM2A) normalizes human embryonic stem cell derived keratinocytes . Proc. Natl Acad. Sci. USA109 ( 24 ), 9442 – 9447 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Liang G , HeJ , ZhangY . Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming . Nat. Cell. Biol.14 ( 5 ), 457 – 466 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Wang T , ChenK , ZengXet al. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner . Cell Stem Cell9 ( 6 ), 575 – 587 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Gearhart MD , CorcoranCM , WamstadJA , BardwellVJ . Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets . Mol. Cell Biol.26 ( 18 ), 6880 – 6889 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• He J , KallinEM , TsukadaY , ZhangY . The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b) . Nat. Struct. Mol. Biol.15 ( 11 ), 1169 – 1175 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Tzatsos A , PfauR , KampranisSC , TsichlisPN . Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus . Proc. Natl Acad. Sci. USA106 ( 8 ), 2641 – 2646 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• He J , NguyenAt , ZhangY . KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia . Blood117 ( 14 ), 3869 – 3880 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Kottakis F , PolytarchouC , FoltopoulouP , SanidasI , KampranisSC , TsichlisPN . FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway . Mol. Cell43 ( 2 ), 285 – 298 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Tzatsos A , PaskalevaP , FerrariFet al. KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs . J. Clin. Invest.123 ( 2 ), 727 – 739 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Chen H , GiriNC , ZhangRet al. Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers . J. Biol. Chem.285 ( 10 ), 7374 – 7383 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Hickok JR , VasudevanD , AntholineWE , ThomasDD . Nitric oxide modifies global histone methylation by Inhibiting Jumonji C domain-containing demethylases . J. Biol. Chem.288 ( 22 ), 16004 – 16015 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Yang F , StenoienDL , StrittmatterEFet al. Phosphoproteome profiling of human skin fibroblast cells in response to low- and high-dose irradiation . J. Proteome Res.5 ( 5 ), 1252 – 1260 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Liu Z , ZhouS , LiaoL , ChenX , MeistrichM , XuJ . Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis . J. Biol. Chem.285 ( 4 ), 2758 – 2770 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Okada Y , ScottG , RayMK , MishinaY , ZhangY . Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis . Nature450 ( 7166 ), 119 – 123 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Inagaki T , TachibanaM , MagooriKet al. Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice . Genes Cells14 ( 8 ), 991 – 1001 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Tateishi K , OkadaY , KallinEm , ZhangY . Role of Jhdm2a in regulating metabolic gene expression and obesity resistance . Nature458 ( 7239 ), 757 – 761 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Wellmann S , BettkoberM , ZelmerAet al. Hypoxia upregulates the histone demethylase JMJD1A via HIF-1 . Biochem. Biophys. Res. Commun.372 ( 4 ), 892 – 897 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Osawa T , TsuchidaR , MuramatsuMet al. Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages . Cancer Res.73 ( 10 ), 3019 – 3028 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Yamada D , KobayashiS , YamamotoHet al. Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: clinical impact on recurrence after hepatic resection . Ann. Surg. Oncol.19 ( Suppl. 3 ), S355 – 364 ( 2012 ).
   Google Scholar
• Qi J , NakayamaK , CardiffRdet al. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors . Cancer Cell18 ( 1 ), 23 – 38 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Uemura M , YamamotoH , TakemasaIet al. Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells . Clin. Cancer Res.16 ( 18 ), 4636 – 4646 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Guo X , ShiM , SunLet al. The expression of histone demethylase JMJD1A in renal cell carcinoma . Neoplasma58 ( 2 ), 153 – 157 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Mackinnon RN , KannourakisG , WallM , CampbellLJ . A cryptic deletion in 5q31.2 provides further evidence for a minimally deleted region in myelodysplastic syndromes . Cancer Genet.204 ( 4 ), 187 – 194 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Tang MH , VaradanV , KamalakaranS , ZhangMG , DimitrovaN , HicksJ . Major chromosomal breakpoint intervals in breast cancer co-localize with differentially methylated regions . Front. Oncol.2 , 197 ( 2012 ).
   PubMedGoogle Scholar
• Hu Z , GomesI , HorriganSKet al. A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31 . Oncogene20 ( 47 ), 6946 – 6954 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Kim JY , KimKB , EomGHet al. KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia . Mol. Cell Biol.32 ( 14 ), 2917 – 2933 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Lee JW , ChoiHS , GyurisJ , BrentR , MooreDD . Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor . Mol. Endocrinol.9 ( 2 ), 243 – 254 ( 1995 ).
   PubMedGoogle Scholar
• Katoh M . Identification and characterization of TRIP8 gene in silico . Int. J. Mol. Med.12 ( 5 ), 817 – 821 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Katoh M . Comparative integromics on JMJD1C gene encoding histone demethylase: conserved POU5F1 binding site elucidating mechanism of JMJD1C expression in undifferentiated ES cells and diffuse-type gastric cancer . Int. J. Oncol.31 ( 1 ), 219 – 223 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Wolf SS , PatchevVK , ObendorfM . A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR . Arch. Biochem. Biophys.460 ( 1 ), 56 – 66 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Kim SM , KimJY , ChoeNWet al. Regulation of mouse steroidogenesis by WHISTLE and JMJD1C through histone methylation balance . Nucleic Acids Res.38 ( 19 ), 6389 – 6403 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Cachon-Gonzalez MB , FennerS , CoffinJM , MoranC , BestS , StoyeJP . Structure and expression of the hairless gene of mice . Proc. Natl Acad. Sci. USA91 ( 16 ), 7717 – 7721 ( 1994 ).
   PubMed Web of Science ®Google Scholar
• Thompson CC . Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog . J. Neurosci.16 ( 24 ), 7832 – 7840 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Hsieh JC , SiskJM , JurutkaPWet al. Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling . J. Biol. Chem.278 ( 40 ), 38665 – 38674 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Moraitis AN , GiguereV , ThompsonCC . Novel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants . Mol. Cell Biol.22 ( 19 ), 6831 – 6841 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Potter GB , BeaudoinGM3rd , DerenzoCL , ZarachJM , ChenSH , ThompsonCC . The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor . Genes Dev.15 ( 20 ), 2687 – 2701 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Mi Y , ZhangY , ShenYf . Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function . Biochim. Biophys. Acta1812 ( 12 ), 1675 – 1680 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Potter GB , ZarachJM , SiskJM , ThompsonCC . The thyroid hormone-regulated corepressor hairless associates with histone deacetylases in neonatal rat brain . Mol. Endocrinol.16 ( 11 ), 2547 – 2560 ( 2002 ).
   PubMedGoogle Scholar
• Ahmad W , Faiyaz UL , Haque M , BrancoliniVet al. Alopecia universalis associated with a mutation in the human hairless gene . Science279 ( 5351 ), 720 – 724 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Katoh Y , KatohM . Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells . Int. J. Mol. Med.20 ( 2 ), 269 – 273 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Berry WL , JanknechtR . KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells . Cancer Res.73 ( 10 ), 2936 – 2942 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Crea F , SunL , MaiAet al. The emerging role of histone lysine demethylases in prostate cancer . Mol. Cancer11 , 52 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Cloos PA , ChristensenJ , AggerKet al. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 . Nature442 ( 7100 ), 307 – 311 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Shin S , JanknechtR . Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D . Biochem. Biophys. Res. Commun.359 ( 3 ), 742 – 746 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Wissmann M , YinN , MullerJmet al. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression . Nat. Cell. Biol.9 ( 3 ), 347 – 353 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Suikki He , KujalaPm , TammelaTl , VanWeerden Wm , VessellaRl , VisakorpiT . Genetic alterations and changes in expression of histone demethylases in prostate cancer . Prostate70 ( 8 ), 889 – 898 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Coffey K , RogersonL , Ryan-MundenCet al. The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover . Nucleic Acids Res.41 ( 8 ), 4433 – 4446 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Gaughan L , StockleyJ , CoffeyKet al. KDM4B is a master regulator of the estrogen receptor signalling cascade . Nucleic Acids Res.41 ( 14 ), 6892 – 6904 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Liu G , Bollig-FischerA , KreikeBet al. Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer . Oncogene28 ( 50 ), 4491 – 4500 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Li BX , ZhangMC , LuoCLet al. Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro . J. Exp. Clin. Cancer Res.30 , 90 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Berry WL , ShinS , LightfootSA , JanknechtR . Oncogenic features of the JMJD2A histone demethylase in breast cancer . Int. J. Oncol.41 ( 5 ), 1701 – 1706 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Yang J , JubbAM , PikeLet al. The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth . Cancer Res.70 ( 16 ), 6456 – 6466 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Kawazu M , SasoK , TongKiet al. Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development . PLoS ONE6 ( 3 ), e17830 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Shi L , SunL , LiQet al. Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis . Proc. Natl Acad. Sci. USA108 ( 18 ), 7541 – 7546 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Pollard PJ , LoenarzC , MoleDRet al. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha . Biochem. J.416 ( 3 ), 387 – 394 ( 2008 ).
   PubMedGoogle Scholar
• Zhu Y , Van EssenD , SaccaniS . Cell-type-specific control of enhancer activity by H3K9 trimethylation . Mol. Cell.46 ( 4 ), 408 – 423 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Strobl-Mazzulla PH , Sauka-SpenglerT , Bronner-FraserM . Histone demethylase JmjD2A regulates neural crest specification . Dev. Cell19 ( 3 ), 460 – 468
   PubMed Web of Science ®Google Scholar
• Zhang QJ , ChenHZ , WangL , LiuDP , HillJA , LiuZP . The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice . J. Clin. Invest.121 ( 6 ), 2447 – 2456 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Ye L , FanZ , YuBet al. Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs . Cell Stem Cell11 ( 1 ), 50 – 61 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Guo L , LiX , HuangJXet al. Histone demethylase Kdm4b functions as a co-factor of C/EBPbeta to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes . Cell Death Differ.19 ( 12 ), 1917 – 1927 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Chen Wd , FuX , DongBet al. Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver . Hepatology56 ( 4 ), 1499 – 1509 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Kim TD , OhS , ShinS , JanknechtR . Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D . PLoS ONE7 ( 4 ), e34618 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Wilsker D , ProbstL , WainHM , MaltaisL , TuckerPW , MoranE . Nomenclature of the ARID family of DNA-binding proteins . Genomics86 ( 2 ), 242 – 251 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Wysocka J , SwigutT , XiaoHet al. A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling . Nature442 ( 7098 ), 86 – 90 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Tahiliani M , MeiP , FangRet al. The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation . Nature447 ( 7144 ), 601 – 605 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Defeo-Jones D , HuangPS , JonesREet al. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product . Nature352 ( 6332 ), 251 – 254 ( 1991 ).
   PubMed Web of Science ®Google Scholar
• Benevolenskaya EV , MurrayHL , BrantonP , YoungRA , KaelinW G Jr. Binding of pRB to the PHD protein RBP2 promotes cellular differentiation . Mol. Cell18 ( 6 ), 623 – 635 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Chicas A , KapoorA , WangXet al. H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence . Proc. Natl Acad. Sci. USA109 ( 23 ), 8971 – 8976 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Ditacchio L , LeHD , VollmersCet al. Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock . Science333 ( 6051 ), 1881 – 1885 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• De Rooij JD , HollinkIH , Arentsen-PetersSTet al. NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern . Leukemia27 ( 12 ), 2280 – 2288 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Pointon JJ , HarveyD , KaraderiT , AppletonLH , FarrarC , WordsworthBP . The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis . Genes Immun.12 ( 5 ), 395 – 398 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Sharma SV , LeeDY , LiBet al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations . Cell141 ( 1 ), 69 – 80 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Cellot S , HopeKJ , ChagraouiJet al. RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity . Blood122 ( 9 ), 1545 – 1555 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Dey BK , StalkerL , SchnerchA , BhatiaM , Taylor-PapidimitriouJ , WynderC . The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation . Mol. Cell Biol28 ( 17 ), 5312 – 5327 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Schmitz Su , AlbertM , MalatestaMet al. Jarid1b targets genes regulating development and is involved in neural differentiation . EMBO J.30 ( 22 ), 4586 – 4600 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Li Q , ShiL , GuiBet al. Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14 . Cancer Res.71 ( 21 ), 6899 – 6908 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Kuzbicki L , LangeD , Straczynska-NiemiecA , ChwirotBW . JARID1B expression in human melanoma and benign melanocytic skin lesions . Melanoma Res.23 ( 1 ), 8 – 12 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Lu Pj , SundquistK , BaeckstromDet al. A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer . J. Biol. Chem.274 ( 22 ), 15633 – 15645 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Roesch A , Fukunaga-KalabisM , SchmidtECet al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth . Cell141 ( 4 ), 583 – 594 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Wouters J , StasM , GremeauxLet al. The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis . PLoS ONE8 ( 10 ), e76550 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Jensen LR , AmendeM , GurokUet al. Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation . Am. J. Hum. Genet.76 ( 2 ), 227 – 236 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Agulnik Ai , MitchellMj , MatteiMget al. A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human . Hum. Mol. Genet.3 ( 6 ), 879 – 884 ( 1994 ).
   PubMed Web of Science ®Google Scholar
• Adegbola A , GaoH , SommerS , BrowningM . A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD) . Am. J. Med. Genet. Part A146A ( 4 ), 505 – 511 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Niu X , ZhangT , LiaoLet al. The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C . Oncogene31 ( 6 ), 776 – 786 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Agulnik Ai , MitchellMj , LernerJl , WoodsDr , BishopCe . A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens . Hum. Mol. Genet.3 ( 6 ), 873 – 878 ( 1994 ).
   PubMed Web of Science ®Google Scholar
• Scott DM , EhrmannIE , EllisPSet al. Identification of a mouse male-specific transplantation antigen, H-Y . Nature376 ( 6542 ), 695 – 698 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Wang W , MeadowsLR , DenHaan JMet al. Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein . Science269 ( 5230 ), 1588 – 1590 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Akimoto C , KitagawaH , MatsumotoT , KatoS . Spermatogenesis-specific association of SMCY and MSH5 . Genes Cells13 ( 6 ), 623 – 633 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Perinchery G , SasakiM , AnganA , KumarV , CarrollP , DahiyaR . Deletion of Y-chromosome specific genes in human prostate cancer . J. Urol.163 ( 4 ), 1339 – 1342 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Kruidenier L , ChungCW , ChengZet al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response . Nature488 ( 7411 ), 404 – 408 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Sola S , XavierJM , SantosDMet al. p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation . PLoS ONE6 ( 3 ), e18421 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Miller SA , MohnSE , WeinmannAS . Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression . Mol. Cell40 ( 4 ), 594 – 605 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Miller SA , WeinmannAS . Molecular mechanisms by which T-bet regulates T-helper cell commitment . Immunol. Rev.238 ( 1 ), 233 – 246 ( 2010 ).
   PubMedGoogle Scholar
• Bernstein BE , MikkelsenTS , XieXet al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells . Cell125 ( 2 ), 315 – 326 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Awe JP , ByrneJA . Identifying candidate oocyte reprogramming factors using cross-species global transcriptional analysis . Cell Reprogram.15 ( 2 ), 126 – 133 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Canovas S , CibelliJB , RossPJ . Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development . Proc. Natl Acad. Sci. USA109 ( 7 ), 2400 – 2405 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Jiang W , WangJ , ZhangY . Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway . Cell Res.23 ( 1 ), 122 – 130 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Kim SW , YoonSJ , ChuongEet al. Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs . Dev. Biol.357 ( 2 ), 492 – 504 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Agger K , CloosPA , ChristensenJet al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development . Nature449 ( 7163 ), 731 – 734 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Shahhoseini M , TaghizadehZ , HatamiM , BaharvandH . Retinoic acid dependent histone 3 demethylation of the clustered HOX genes during neural differentiation of human embryonic stem cells . Biochem. Cell Biol.91 ( 2 ), 116 – 122 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Zhao W , LiQ , AyersSet al. Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination . Cell152 ( 5 ), 1037 – 1050 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Yasui T , HiroseJ , TsutsumiS , NakamuraK , AburataniH , TanakaS . Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1 . J. Bone Miner. Res.26 ( 11 ), 2665 – 2671 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Burgold T , VoituronN , CaganovaMet al. The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival . Cell Rep.2 ( 5 ), 1244 – 1258 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Jepsen K , SolumD , ZhouTet al. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron . Nature450 ( 7168 ), 415 – 419 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Estaras C , AkizuN , GarciaA , BeltranS , De La CruzX , Martinez-BalbasMA . Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program . Development139 ( 15 ), 2681 – 2691 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Fei T , XiaK , LiZet al. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination . Genome Res.20 ( 1 ), 36 – 44 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Dai JP , LuJY , ZhangY , ShenYF . Jmjd3 activates Mash1 gene in RA-induced neuronal differentiation of P19 cells . J. Cell Biochem.110 ( 6 ), 1457 – 1463 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Giovarelli M , BucciG , PaseroM , GherziR , BriataP . KSRP silencing favors neural differentiation of P19 teratocarcinoma cells . Biochim. Biophys. Acta1829 ( 5 ), 469 – 479 ( 2013 ).
   Google Scholar
• Lederer D , GrisartB , DigilioMCet al. Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome . Am. J. Human Genet.90 ( 1 ), 119 – 124 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Priolo M , MicaleL , AugelloBet al. Absence of deletion and duplication of MLL2 and KDM6A genes in a large cohort of patients with Kabuki syndrome . Mol. Genet. Metab.107 ( 3 ), 627 – 629 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Das ND , JungKH , ChoiMR , YoonHS , KimSH , ChaiYG . Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell line . Cell Biochem. Funct.30 ( 3 ), 224 – 232 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Wei Y , ChenR , DimicoliSet al. Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells . Leukemia27 ( 11 ), 2177 – 2186 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• De Santa F , NarangV , YapZHet al. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages . EMBO J.28 ( 21 ), 3341 – 3352 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Ishii M , WenH , CorsaCAet al. Epigenetic regulation of the alternatively activated macrophage phenotype . Blood114 ( 15 ), 3244 – 3254 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Satoh T , TakeuchiO , VandenbonAet al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection . Nat. Immunol.11 ( 10 ), 936 – 944 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Zhang Q , LongH , LiaoJet al. Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus . J. Autoimmun.37 ( 3 ), 180 – 189 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Sen Gl , WebsterDE , BarraganDI , ChangHY , KhavariPA . Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3 . Genes Dev.22 ( 14 ), 1865 – 1870 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Shaw T , MartinP . Epigenetic reprogramming during wound healing. loss of polycomb-mediated silencing may enable upregulation of repair genes . EMBO Rep.10 ( 8 ), 881 – 886 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Ciavatta DJ , YangJ , PrestonGAet al. Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis . J. Clin. Invest.120 ( 9 ), 3209 – 3219 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Dumon S , WaltonDS , VolpeGet al. Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation . PLoS ONE7 ( 8 ), e43300 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Anderton JA , BoseS , VockerodtMet al. The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin’s Lymphoma . Oncogene30 ( 17 ), 2037 – 2043 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Mclaughlin-Drubin ME , CrumCP , MungerK . Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming . Proc. Natl Acad. Sci. USA108 ( 5 ), 2130 – 2135 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Shen Y , GuoX , WangYet al. Expression and significance of histone H3K27 demethylases in renal cell carcinoma . BMC Cancer12 , 470 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Svotelis A , BiancoS , MadoreJet al. H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERalpha ligand dependency . EMBO J.30 ( 19 ), 3947 – 3961 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Bunt J , HasseltNA , ZwijnenburgDA , KosterJ , VersteegR , KoolM . OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels . Acta Neuropathol.125 ( 3 ), 385 – 394 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Dubuc Am , RemkeM , KorshunovAet al. Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma . Acta Neuropathol.125 ( 3 ), 373 – 384 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Agger K , CloosPA , RudkjaerLet al. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence . Genes Dev.23 ( 10 ), 1171 – 1176 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Agherbi H , Gaussmann-WengerA , VerthuyC , ChassonL , SerranoM , DjabaliM . Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence . PLoS ONE4 ( 5 ), e5622 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Barradas M , AndertonE , AcostaJCet al. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS . Genes Dev.23 ( 10 ), 1177 – 1182 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Ramadoss S , ChenX , WangCy . Histone demethylase KDM6B promotes epithelial-mesenchymal transition . J. Biol. Chem.287 ( 53 ), 44508 – 44517 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Pereira F , BarbachanoA , SilvaJet al. KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells . Hum. Mol. Genet.20 ( 23 ), 4655 – 4665 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Pereira F , BarbachanoA , SinghPK , CampbellMJ , MunozA , LarribaMJ . Vitamin D has wide regulatory effects on histone demethylase genes . Cell Cycle11 ( 6 ), 1081 – 1089 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Chen C , BartenhagenC , GombertMet al. Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia . Genes Chromosomes Cancer52 ( 6 ), 564 – 579 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Van Haaften G , DalglieshGL , DaviesHet al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer . Nat. Genet.41 ( 5 ), 521 – 523 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Laaser I , TheisFJ , DeAngelis MH , KolbHJ , AdamskiJ . Huge splicing frequency in human Y chromosomal UTY gene . OMICS15 ( 3 ), 141 – 154 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Warren EH , GavinMA , SimpsonEet al. The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen . J. Immunol.164 ( 5 ), 2807 – 2814 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Bloomer LD , NelsonCP , EalesJet al. Male-specific region of the Y chromosome and cardiovascular risk: phylogenetic analysis and gene expression studies . Arterioscler. Thromb. Vasc. Biol.33 ( 7 ), 1722 – 1727 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Fortschegger K , ShiekhattarR . Plant homeodomain fingers form a helping hand for transcription . Epigenetics6 ( 1 ), 4 – 8 ( 2010 ).
   Web of Science ®Google Scholar
• Dai J , SultanS , TaylorSS , HigginsJM . The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment . Genes Dev.19 ( 4 ), 472 – 488 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Fortschegger K , DeGraaf P , OutchkourovNs , Van SchaikFM , TimmersHT , ShiekhattarR . PHF8 targets histone methylation and RNA polymerase II to activate transcription . Mol. Cell Biol.30 ( 13 ), 3286 – 3298 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Liu W , TanasaB , TyurinaOVet al. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression . Nature466 ( 7305 ), 508 – 512 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Kleine-Kohlbrecher D , ChristensenJ , VandammeJet al. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation . Mol. Cell38 ( 2 ), 165 – 178 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Feng W , YonezawaM , YeJ , JenuweinT , GrummtI . PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation . Nat. Struct. Mol. Biol.17 ( 4 ), 445 – 450 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Arteaga MF , MikeschJH , QiuJet al. The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia . Cancer Cell23 ( 3 ), 376 – 389 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Stender Jd , PascualG , LiuWet al. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20 . Mol. Cell48 ( 1 ), 28 – 38 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Huang C , XiangY , WangYet al. Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4 . Cell Res.20 ( 2 ), 154 – 165 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Sinha S , SinghRK , AlamN , RoyA , RoychoudhuryS , PandaCK . Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region. pathological significance in early- and late-onset breast carcinoma . Mol. Cancer7 , 84 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Abidi F , MianoM , MurrayJ , SchwartzC . A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate . Clin. Genet.72 ( 1 ), 19 – 22 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Koivisto AM , Ala-MelloS , LemmelaS , KomuHA , RautioJ , JarvelaI . Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate . Clin. Genet.72 ( 2 ), 145 – 149 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Laumonnier F , HolbertS , RonceNet al. Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate . J. Med. Genet.42 ( 10 ), 780 – 786 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Siderius LE , HamelBC , Van BokhovenHet al. X-linked mental retardation associated with cleft lip/palate maps to Xp11.3-q21.3 . Am. J. Med. Genet.85 ( 3 ), 216 – 220 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Qiao Y , LiuX , HarvardCet al. Autism-associated familial microdeletion of Xp11.22 . Clin. Genet.74 ( 2 ), 134 – 144 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Nava C , LamariF , HeronDet al. Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE . Transl Psychiatry2 , e179 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Aragones J , FraislP , BaesM , CarmelietP . Oxygen sensors at the crossroad of metabolism . Cell Metab.9 ( 1 ), 11 – 22 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Schofield CJ , RatcliffePJ . Oxygen sensing by HIF hydroxylases . Nat. Rev. Mol. Cell Biol.5 ( 5 ), 343 – 354 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Melvin A , MudieS , RochaS . The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH . Mol. Biol. 22 ( 21 ), 4171 – 4181 ( 2011 ).
   Web of Science ®Google Scholar
• Zhang N , FuZ , LinkeSet al. The asparaginyl hydroxylase factor inhibiting HIF-1α is an essential regulator of metabolism . Cell Metabolism11 ( 5 ), 364 – 378 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Liu C-J , TsaiM-M , HungP-Set al. miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma . Cancer Research70 ( 4 ), 1635 – 1644 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Kroeze SGC , VermaatJS , Van BrusselAet al. Expression of nuclear FIH independently predicts overall survival of clear cell renal cell carcinoma patients . Eur. J. Cancer46 ( 18 ), 3375 – 3382 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Khan MN , BhattacharyyaT , AndrikopoulosPet al. Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1[alpha]-mediated apoptosis . Br. J. Cancer104 ( 7 ), 1151 – 1159 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Andersen S , DonnemT , StenvoldHet al. Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival . PLoS ONE6 ( 8 ), e23847 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Hyseni A , GroepP , WallE , DiestP . Subcellular FIH-1 expression patterns in invasive breast cancer in relation to HIF-1α expression . Cell Oncol.34 ( 6 ), 565 – 570 ( 2011 ).
   Web of Science ®Google Scholar
• Liu Y , HigashitsujiH , HigashitsujiHet al. Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1 . Biochem. Biophys. Res. Comm.432 ( 1 ), 22 – 27 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Tsuneoka M , KodaY , SoejimaM , TeyeK , KimuraH . A novel myc target gene, mina53, that is involved in cell proliferation . J. Biol. Chem.277 ( 38 ), 35450 – 35459 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Hoffman B , LiebermannDA . Apoptotic signaling by c-MYC . Oncogene27 ( 50 ), 6462 – 6472 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Lu Y , ChangQ , ZhangYet al. Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3 . Cell Cycle8 ( 13 ), 2101 – 2109 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Fukahori S , YanoH , TsuneokaMet al. Immunohistochemical expressions of Cap43 and Mina53 proteins in neuroblastoma . J. Pediatric Surg.42 ( 11 ), 1831 – 1840 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Ishizaki H , YanoH , TsuneokaMet al. Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma . Pathol. Int.57 ( 10 ), 672 – 680 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Komiya K , Sueoka-AraganeN , SatoAet al. Expression of Mina53, a novel c-Myc target gene, is a favorable prognostic marker in early stage lung cancer . Lung Cancer69 ( 2 ), 232 – 238 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Tan XP , ZhangQ , DongWG , LeiXW , YangZR . Upregulated expression of Mina53 in cholangiocarcinoma and its clinical significance . Oncol. Lett.3 ( 5 ), 1037 – 1041 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Teye K , TsuneokaM , ArimaNet al. Increased expression of a Myc target gene Mina53 in human colon cancer . Am. J. Pathol.164 ( 1 ), 205 – 216 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Tsuneoka M , FujitaH , ArimaNet al. Mina53 as a Potential Prognostic Factor for Esophageal Squamous Cell Carcinoma . Clin. Cancer Res.10 ( 21 ), 7347 – 7356 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Tsuneoka M , NishimuneY , OhtaKet al. Expression of Mina53, a product of a Myc target gene in mouse testis . Int. J. Androl.29 ( 2 ), 323 – 330 ( 2006 ).
   PubMedGoogle Scholar
• Zhang Y , LuY , YuanBZet al. The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer . Oncogene24 ( 31 ), 4873 – 4882 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Mori T , OkamotoK , TanakaYet al. Ablation of mina53 in mice reduces allergic response in the airways . Cell Struct. Funct.38 ( 2 ), 155 – 167 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Yosef N , ShalekAk , GaublommeJTet al. Dynamic regulatory network controlling TH17 cell differentiation . Nature496 ( 7446 ), 461 – 468 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Eilbracht J , ReichenzellerM , HergtMet al. NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin . Mol Biol Cell15 ( 4 ), 1816 – 1832 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Brien GL , GamberoG , O’ConnellDJet al. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation . Nat. Struct. Mol. Biol.19 ( 12 ), 1273 – 1281 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Tao Y , WuM , ZhouXet al. Structural Insights into histone demethylase NO66 in interaction with osteoblast-specific transcription factor Osterix and gene repression . J. Biol. Chem.288 ( 23 ), 16430 – 16437 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Suzuki C , TakahashiK , HayamaSet al. Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer . Mol. Cancer Ther.6 ( 2 ), 542 – 551 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Jones MA , CovingtonMF , DitacchioL , VollmersC , PandaS , HarmerSl . Jumonji domain protein JMJD5 functions in both the plant and human circadian systems . Proc. Natl Acad. Sci. USA107 ( 50 ), 21623 – 21628 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Oh S , JanknechtR . Histone demethylase JMJD5 is essential for embryonic development . Biochem. Biophys. Res. Comm.420 ( 1 ), 61 – 65 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Ishimura A , MinehataK-I , TerashimaM , KondohG , HaraT , SuzukiT . Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression . Development139 ( 4 ), 749 – 759 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Cikala M , AlexandrovaO , DavidCNet al. The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity . BMC Cell Biol.5 , 26 ( 2004 ).
   PubMedGoogle Scholar
• Mantri M , KrojerT , BaggEAet al. Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6 . J. Mol. Biol.401 ( 2 ), 211 – 222 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Hong X , ZangJ , WhiteJet al. Interaction of JMJD6 with single-stranded RNA . Proc. Natl Acad. Sci. USA107 ( 33 ), 14568 – 14572 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Bose J , GruberAD , HelmingLet al. The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal . J. Biol.3 ( 4 ), 15 ( 2004 ).
   PubMedGoogle Scholar
• Kunisaki Y , MasukoS , NodaMet al. Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor . Blood103 ( 9 ), 3362 – 3364 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Schneider JE , BoseJ , BamforthSDet al. Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique . BMC Dev. Biol.4 , 16 ( 2004 ).
   PubMedGoogle Scholar
• Hahn P , WegenerI , BurrellsAet al. Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation . PLoS ONE5 ( 10 ), e13769 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Lee Y , MillerL , ChanXet al. JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer . Breast Cancer Res.14 ( 3 ), R85 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Ghosh M , LoperR , GelbMh , LeslieCc . Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes . J Biol Chem281 ( 24 ), 16615 – 16624 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Ding X , PanH , LiJet al. Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis . Sci. Signal.6 ( 273 ), ra28 21–13, S20–S15 ( 2013 ).
   Web of Science ®Google Scholar
• Liu C , GilmontRr , BenndorfR , WelshMJ . Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27 . J. Biol. Chem.275 ( 25 ), 18724 – 18731 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Jiang M , MaY , ChengHet al. Molecular cloning and characterization of a novel human gene (HSPBAP1) from human fetal brain . Cytogenet. Cell Genet.95 ( 1–2 ), 48 – 51 ( 2001 ).
   PubMedGoogle Scholar
• Srivastava AK , RenuschSR , NaimanNEet al. Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice . Neurobiol. Dis.47 ( 2 ), 163 – 173 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Xi ZQ , SunJJ , WangXFet al. HSPBAP1 is found extensively in the anterior temporal neocortex of patients with intractable epilepsy . Synapse61 ( 9 ), 741 – 747 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Xi ZQ , XiaoF , YuanJet al. Gene expression analysis on anterior temporal neocortex of patients with intractable epilepsy . Synapse63 ( 11 ), 1017 – 1028 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Aas PA , OtterleiM , FalnesPOet al. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA . Nature421 ( 6925 ), 859 – 863 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Dango S , MosammaparastN , SowaMEet al. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation . Mol. Cell44 ( 3 ), 373 – 384 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Fu D , SamsonLD . Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase . DNA Repair (Amst.)11 ( 1 ), 46 – 52 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Lee DH , JinSG , CaiS , ChenY , PfeiferGP , O’connorTR . Repair of methylation damage in DNA and RNA by mammalian AlkB homologues . J. Biol. Chem.280 ( 47 ), 39448 – 39459 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Muller TA , MeekK , HausingerRP . Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites . DNA Repair (Amst.)9 ( 1 ), 58 – 65 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Westbye MP , FeyziE , AasPAet al. Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA . J. Biol. Chem.283 ( 36 ), 25046 – 25056 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Bethke L , MurrayA , WebbEet al. Comprehensive analysis of DNA repair gene variants and risk of meningioma . J. Natl Cancer Inst.100 ( 4 ), 270 – 276 ( 2008 ).
   PubMedGoogle Scholar
• Fujii T , ShimadaK , AnaiS , FujimotoK , KonishiN . ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression . Cancer Sci.104 ( 3 ), 321 – 327 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Hu L , WuC , ZhaoXet al. Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy . Clin. Cancer Res.18 ( 19 ), 5507 – 5514 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Johannessen TC , PrestegardenL , GrudicA , HegiME , TysnesBB , BjerkvigR . The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells . Neuro Oncol.15 ( 3 ), 269 – 278 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Koike K , UedaY , HaseHet al. anti-tumor effect of AlkB homolog 3 knockdown in hormone- independent prostate cancer cells . Curr. Cancer Drug Targets12 ( 7 ), 847 – 856 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Shimada K , FujiiT , TsujikawaK , AnaiS , FujimotoK , KonishiN . ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and tweak/Fn14/VEGF signals . Clin. Cancer Res.18 ( 19 ), 5247 – 5255 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Tasaki M , ShimadaK , KimuraH , TsujikawaK , KonishiN . ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer . Br. J. Cancer104 ( 4 ), 700 – 706 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Yamato I , ShoM , ShimadaKet al. PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis . Cancer Res.72 ( 18 ), 4829 – 4839 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Bjornstad LG , MezaTJ , OtterleiM , OlafsrudSM , Meza-ZepedaLA , FalnesPO . Human ALKBH4 interacts with proteins associated with transcription . PLoS ONE7 ( 11 ), e49045 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Fu Y , HeC . Nucleic acid modifications with epigenetic significance . Curr. Opin. Chem. Biol.16 ( 5–6 ), 516 – 524 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Jia G , FuY , HeC . Reversible RNA adenosine methylation in biological regulation . Trends Genet.29 ( 2 ), 108 – 115 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Jia G , FuY , ZhaoXet al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO . Nat. Chem. Biol.7 ( 12 ), 885 – 887 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Frayling TM , TimpsonNJ , WeedonMNet al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity . Science316 ( 5826 ), 889 – 894 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Gao X , ShinYH , LiM , WangF , TongQ , ZhangP . The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice . PLoS ONE5 ( 11 ), e14005 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Do R , BaileySD , DesbiensKet al. Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study . Diabetes57 ( 4 ), 1147 – 1150 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Jacobsson JA , KlovinsJ , KapaIet al. Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents . Int. J. Obes. (Lond.)32 ( 11 ), 1730 – 1735 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Keller L , XuW , WangHx , WinbladB , FratiglioniL , GraffC . The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer’s disease risk: a prospective cohort study . J. Alzheimers Dis.23 ( 3 ), 461 – 469 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Lappalainen T , KolehmainenM , SchwabUSet al. Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism–the Finnish Diabetes Prevention Study . Nutr Metab Cardiovasc Dis21 ( 9 ), 691 – 698 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Hubacek JA , ViklickyO , DlouhaDet al. The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population . Nephrol. Dial. Transplant27 ( 3 ), 1030 – 1035 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Kaklamani V , YiN , SadimMet al. The role of the fat mass and obesity associated gene (FTO) in breast cancer risk . BMC Med. Genet.12 , 52 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Tarabra E , ActisGC , FaddaMet al. The obesity gene and colorectal cancer risk: a population study in Northern Italy . Eur. J. Intern. Med.23 ( 1 ), 65 – 69 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Boissel S , ReishO , ProulxKet al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations . Am. J. Hum. Genet.85 ( 1 ), 106 – 111 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Shimada K , NakamuraM , AnaiSet al. A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression . Cancer Res.69 ( 7 ), 3157 – 3164 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Lorsbach RB , MooreJ , MathewS , RaimondiSC , MukatiraST , DowningJR . TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23) . Leukemia17 ( 3 ), 637 – 641 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Ono R , TakiT , TaketaniT , TaniwakiM , KobayashiH , HayashiY . LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23) . Cancer Res.62 ( 14 ), 4075 – 4080 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Pastor Wa , AravindL , RaoA . TETonic shift: biological roles of TET proteins in DNA demethylation and transcription . Nat. Rev. Mol. Cell Biol.14 ( 6 ), 341 – 356 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Abdel-Wahab O , MullallyA , HedvatCet al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies . Blood114 ( 1 ), 144 – 147 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Comuzzie Ag , ColeSa , LastonSlet al. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population . PLoS ONE7 ( 12 ), e51954 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Cao XJ , ArnaudoAM , GarciaBA . Large-scale global identification of protein lysine methylation in vivo . Epigenetics8 ( 5 ), 477 – 485 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Chowdhury R , YeohKK , TianYMet al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases . EMBO Rep.12 ( 5 ), 463 – 469 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Watson JA , WatsonCJ , MccannA , BaughJ . Epigenetics, the epicenter of the hypoxic response . Epigenetics5 ( 4 ), 293 – 296 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Edwards AM , IsserlinR , BaderGD , FryeSV , WillsonTM , YuFH . Too many roads not taken . Nature470 ( 7333 ), 163 – 165 ( 2011 ).
   PubMed Web of Science ®Google Scholar