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Review

Histone methylations in heart development, congenital and adult heart diseases

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Pages 321-330 | Published online: 05 May 2015

References

  • Alabert C , GrothA . Chromatin replication and epigenome maintenance . Nat. Rev. Mol. Cell Biol.13 ( 3 ), 153 – 167 ( 2012 ).
  • Mummaneni P , ShordSS . Epigenetics and oncology . Pharmacotherapy34 ( 5 ), 495 – 505 ( 2014 ).
  • Zhang G , PradhanS . Mammalian epigenetic mechanisms . IUBMB Life66 ( 4 ), 240 – 256 ( 2014 ).
  • Rozek LS , DolinoyDC , SartorMA , OmennGS . Epigenetics: relevance and implications for public health . Annu. Rev. Public Health35 , 105 – 222 ( 2014 ).
  • Kimura H . Histone modifications for human epigenome analysis . J. Hum. Genet.58 ( 7 ), 439 – 445 ( 2013 ).
  • Tingare A , ThienpontB , RoderickHL . Epigenetics in the heart: the role of histone modifications in cardiac remodeling . Biochem. Soc. Trans.41 ( 3 ), 789 – 796 ( 2013 ).
  • Rea S , EisenhaberF , O’CarrollDet al. Regulation of chromatin structure by site-specific histone H3 methyltransferases . Nature406 ( 6796 ), 593 – 599 ( 2000 ).
  • Shi Y , LanF , MatsonCet al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 . Cell119 , 941 – 953 ( 2004 ).
  • Shi YG , TsukadaY . The discovery of histone demethylases . Cold Spring Harb. Perspect. Biol.5 ( 9 ), a017947 ( 2013 ).
  • Rothbart SB , StrahlBD . Interpreting the language of histone and DNA modifications . Biochim. Biophys. Acta1839 ( 8 ), 627 – 643 ( 2014 ).
  • Black JC , WhetstineJR . Tipping the lysine methylation balance in disease . Biopolymers99 ( 2 ), 127 – 135 ( 2013 ).
  • Yang M , GockeCB , LuoXet al. Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase . Mol. Cell23 , 377 – 387 ( 2006 ).
  • Metzger E , WissmannM , YinNet al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription . Nature437 , 436 – 439 ( 2005 ).
  • Klose RJ , KallinEM , ZhangY . JmjC-domain-containing proteins and histone demethylation . Nat. Rev. Genet.7 ( 9 ), 715 – 727 ( 2006 ).
  • Olson EN . Gene regulatory networks in the evolution and development of the heart . Science313 ( 5795 ), 1922 – 1927 ( 2006 ).
  • Vincent SD , BuckinghamME . How to make a heart: the origin and regulation of cardiac progenitor cells . Curr. Top. Dev. Biol.90 , 1 – 41 ( 2010 ).
  • McCulley DJ , BlackBL . Transcription factor pathways and congenital heart disease . Curr. Top. Dev. Biol.100 , 253 – 277 ( 2012 ).
  • Bruneau BG . Signaling and transcriptional networks in heart development and regeneration . Cold Spring Harb. Perspect. Biol.5 ( 3 ), a008292 ( 2013 ).
  • Chan SS , ShiX , ToyamaAet al. Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner . Cell Stem Cell12 , 587 – 601 ( 2013 ).
  • Fahed AC , GelbBD , SeidmanJG , SeidmanCE . Genetics of congenital heart disease: the glass half empty . Circ. Res.112 , 707 – 720 ( 2013 ).
  • Yuan S , ZaidiS , BruecknerM . Congenital heart disease: emerging themes linking genetics and development . Curr. Opin. Genet. Dev.23 ( 3 ), 352 – 359 ( 2013 ).
  • Hill JA , OlsonEN . Cardiac plasticity . N. Engl. J. Med.358 ( 13 ), 1370 – 1380 ( 2008 ).
  • Song HK , HongSE , KimT , Kim doH . Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophy . PLoS ONE7 ( 4 ), e35552 ( 2012 ).
  • Young LC , HendzelMJ . The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression . Biochem. Cell Biol.91 ( 6 ), 369 – 377 ( 2013 ).
  • Wamstad JA , AlexanderJM , TrutyRMet al. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage . Cell151 ( 1 ), 206 – 220 ( 2012 ).
  • He A , MaQ , CaoJet al. Polycomb repressive complex 2 regulates normal development of the mouse heart . Circ. Res.110 ( 3 ), 406 – 415 ( 2012 ).
  • Delgado-Olguín P , HuangY , LiXet al. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis . Nat. Genet.44 ( 3 ), 343 – 347 ( 2012 ).
  • Zhang QJ , ChenHZ , WangLet al. The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice . J. Clin. Invest.121 , 2447 – 2456 ( 2011 ).
  • Stein AB , JonesTA , HerronTJet al. Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes . J. Clin. Invest.121 ( 7 ), 2641 – 2650 ( 2011 ).
  • Kaneda R , TakadaS , YamashitaYet al. Genome-wide histone methylation profile for heart failure . Genes Cells14 ( 1 ), 69 – 77 ( 2009 ).
  • Vermeulen M , MulderKW , DenissovSet al. Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4 . Cell131 ( 1 ), 58 – 69 ( 2007 ).
  • Voigt P , TeeWW , ReinbergD . A double take on bivalent promoters . Genes Dev.27 ( 12 ), 1318 – 1338 ( 2013 ).
  • Bernstein BE , MikkelsenTS , XieXet al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells . Cell125 ( 2 ), 315 – 326 ( 2006 ).
  • Ruthenburg AJ , AllisCD , WysockaJ . Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark . Mol. Cell25 ( 1 ), 15 – 30 ( 2007 ).
  • Shilatifard A . The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis . Annu. Rev. Biochem.81 , 65 – 95 ( 2012 ).
  • Zaidi S , ChoiM , WakimotoH . De novo mutations in histone-modifying genes in congenital heart disease . Nature498 ( 7453 ), 220 – 223 ( 2013 ).
  • Ng SB , BighamAW , BuckinghamKJet al. Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome . Nat. Genet.42 ( 9 ), 790 – 793 ( 2010 ).
  • Bokinni Y . Kabuki syndrome revisited . J. Hum. Genet.57 ( 4 ), 223 – 227 ( 2012 ).
  • Glaser S , SchaftJ , LubitzSet al. Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development . Development133 ( 8 ), 1423 – 1432 ( 2006 ).
  • Glaser S , LubitzS , LovelandKLet al. The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis . Epigenetics Chromatin2 ( 1 ), 5 ( 2009 ).
  • Goldsworthy M , AbsalomNL , SchröterDet al. Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice . PLoS ONE8 ( 6 ), e61870 ( 2013 ).
  • Aramaki M , UdakaT , KosakiRet al. Phenotypic spectrum of CHARGE syndrome with CHD7 mutations . J. Pediatr.148 ( 3 ), 410 – 414 ( 2006 ).
  • Randall V , McCueK , RobertsCet al. Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice . J. Clin. Invest.119 ( 11 ), 3301 – 3310 ( 2009 ).
  • Patel SR , KimD , LevitanI , DresslerGR . The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex . Dev. Cell13 ( 4 ), 580 – 592 ( 2007 ).
  • Kim D , PatelSR , XiaoH , DresslerGR . The role of PTIP in maintaining embryonic stem cell pluripotency . Stem Cells27 ( 7 ), 1516 – 1523 ( 2009 ).
  • Brown MA , SimsRJ3rd , GottliebPDet al. Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex . Mol. Cancer5 , 26 ( 2006 ).
  • Abu-Farha M , LambertJP , Al-MadhounASet al. The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase . Mol. Cell. Proteomics7 ( 3 ), 560 – 572 ( 2008 ).
  • Hamamoto R , FurukawaY , MoritaMet al. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells . Nat. Cell Biol.6 ( 8 ), 731 – 740 ( 2004 ).
  • Gottlieb PD , PierceSA , SimsRJet al. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis . Nat. Genet.31 ( 1 ), 25 – 32 ( 2002 ).
  • Park CY , PierceSA , von DrehleMet al. skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration . Proc. Natl Acad. Sci. USA107 ( 48 ), 20750 – 20755 ( 2010 ).
  • Just S , MederB , BergerIMet al. The myosin-interacting protein SMYD1 is essential for sarcomere organization . J. Cell Sci.124 ( Pt 18 ), 3127 – 3136 ( 2011 ).
  • Voelkel T , AndresenC , UngerAet al. Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function . Biochim. Biophys. Acta1833 ( 4 ), 812 – 822 ( 2013 ).
  • Diehl F , BrownMA , van AmerongenMJet al. Cardiac deletion of Smyd2 is dispensable for mouse heart development . PLoS ONE5 ( 3 ), e9748 ( 2010 ).
  • Fujii T , TsunesumiS , YamaguchiKet al. Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish . PLoS ONE6 ( 8 ), e23491 ( 2011 ).
  • Pojoga LH , WilliamsJS , YaoTMet al. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension . Am. J. Physiol. Heart Circ. Physiol.301 ( 5 ), H1862 – H1871 ( 2011 ).
  • Nestorov P , TardatM , PetersAH . H3K9/HP1 and Polycomb: two key epigenetic silencing pathways for gene regulation and embryo development . Curr. Top. Dev. Biol.104 , 243 – 291 ( 2013 ).
  • Stock JK , GiadrossiS , CasanovaMet al. Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells . Nat. Cell Biol.9 ( 12 ), 1428 – 1435 ( 2007 ).
  • Lee S , LeeJW , LeeSK . UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program . Dev. Cell22 ( 1 ), 25 – 37 ( 2012 ).
  • Han P , HangCT , YangJ , ChangCP . Chromatin remodeling in cardiovascular development and physiology . Circ. Res.108 ( 3 ), 378 – 396 ( 2011 ).
  • Krauss V . Glimpses of evolution: heterochromatic histone H3K9 methyltransferases left its marks behind . Genetica133 ( 1 ), 93 – 106 ( 2008 ).
  • Bannister AJ , ZegermanP , PartridgeJFet al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain . Nature410 ( 6824 ), 120 – 124 ( 2001 ).
  • Lachner M , O’CarrollD , ReaSet al. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins . Nature410 ( 6824 ), 116 – 120 ( 2001 ).
  • Bilodeau S , KageyMH , FramptonGMet al. SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state . Genes Dev.23 , 2484 – 2489 ( 2009 ).
  • Magklara A , YenA , ColquittBMet al. An epigenetic signature for monoallelic olfactory receptor expression . Cell145 , 555 – 570 ( 2011 ).
  • Sheikh F , RaskinA , ChuPHet al. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice . J. Clin. Invest.118 ( 12 ), 3870 – 3880 ( 2008 ).
  • Strobl-Mazzulla PH , Sauka-SpenglerT , Bronner-FraserM . Histone demethylase JmjD2A regulates neural crest specification . Dev. Cell.19 ( 3 ), 460 – 468 ( 2010 ).
  • Raj A , RifkinSA , AndersenE , van OudenaardenA . Variability in gene expression underlies incomplete penetrance . Nature463 , 913 – 918 ( 2010 ).
  • Marango J , ShimoyamaM , NishioHet al. The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor . Blood111 , 3145 – 3154 ( 2008 ).
  • Wagner EJ , CarpenterPB . Understanding the language of Lys36 methylation at histone H3 . Nat. Rev. Mol. Cell Biol.13 ( 2 ), 115 – 126 ( 2012 ).
  • Nimura K , UraK , ShiratoriHet al. A histone H3 lysine 36 trimethyltransferase links Nkx2–5 to Wolf-Hirschhorn syndrome . Nature460 ( 7252 ), 287 – 291 ( 2009 ).
  • Nguyen AT , XiaoB , NepplRLet al. DOT1L regulates dystrophin expression and is critical for cardiac function . Genes Dev.25 ( 3 ), 263 – 274 ( 2011 ).
  • Wolff GL , KodellRL , MooreSR , CooneyCA . Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice . FASEB J.12 ( 11 ), 949 – 957 ( 1998 ).
  • Dolinoy DC , HuangD , JirtleRL . Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development . Proc. Natl Acad. Sci. USA104 ( 32 ), 13056 – 13061 ( 2007 ).
  • Dominguez-Salas P , CoxSE , PrenticeAMet al. Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects . Proc. Nutr. Soc.71 ( 1 ), 154 – 165 ( 2012 ).
  • Kaelin WG Jr , McKnightSL . Influence of metabolism on epigenetics and disease . Cell153 ( 1 ), 56 – 69 ( 2013 ).

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