Advanced search
Publication Cover
Epigenomics Volume 7, 2015 - Issue 1
Submit an article Journal homepage
1,298
Views
0
CrossRef citations to date
0
Altmetric
Editorial

How Might Epigenetic Dysregulation in Early Embryonic Life Contribute to Autism Spectrum Disorder?

Esther R Berkoa Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA;b Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY10032, USA
&
John M Greallya Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USACorrespondence[email protected]
Pages 1-4 | Published online: 17 Feb 2015

References

  • Sharif J , MutoM , TakebayashiSet al. The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA . Nature450 ( 7171 ), 908 – 912 ( 2007 ).
  • Hansen KH , BrackenAP , PasiniDet al. A model for transmission of the H3K27me3 epigenetic mark . Nat. Cell Biol.10 ( 11 ), 1291 – 1300 ( 2008 ).
  • Grabrucker AM . Environmental factors in autism . Front. Psychiatry3 , 118 ( 2012 ).
  • Shulha HP , CheungI , WhittleCet al. Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons . Arch. Gen. Psychiatry69 ( 3 ), 314 – 324 ( 2012 ).
  • Wong CC , MeaburnEL , RonaldAet al. Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits . Mol. Psychiatry19 ( 4 ), 495 – 503 ( 2014 ).
  • Ladd-Acosta C , HansenKD , BriemE , FallinMD , KaufmannWE , FeinbergAP . Common DNA methylation alterations in multiple brain regions in autism . Mol. Psychiatry19 ( 8 ), 862 – 871 ( 2014 ).
  • Nardone S , SamsDS , ReuveniEet al. DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways . Transl. Psychiatry4 , e433 ( 2014 ).
  • Berko ER , SuzukiM , BerenFet al. Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder . PLoS Genet.10 ( 5 ), e1004402 ( 2014 ).
  • Sandin S , HultmanCM , KolevzonA , GrossR , MaccabeJH , ReichenbergA . Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis . J. Am. Acad. Child Adolesc. Psychiatry51 ( 5 ), 477 – 486e471 ( 2012 ).
  • Ben-David E , ShifmanS . Combined analysis of exome sequencing points toward a major role for transcription regulation during brain development in autism . Mol. Psychiatry18 ( 10 ), 1054 – 1056 ( 2012 ).
  • Lasalle JM . Autism genes keep turning up chromatin . OA Autism1 ( 2 ), 14 ( 2013 ).
  • De Rubeis S , HeX , GoldbergAPet al. Synaptic, transcriptional and chromatin genes disrupted in autism . Nature515 ( 7526 ), 209 – 215 ( 2014 ).
  • Houseman EA , AccomandoWP , KoestlerDCet al. DNA methylation arrays as surrogate measures of cell mixture distribution . BMC Bioinformatics13 , 86 ( 2012 ).
  • Jaffe AE , IrizarryRA . Accounting for cellular heterogeneity is critical in epigenome-wide association studies . Genome Biol.15 ( 2 ), R31 ( 2014 ).
  • Zilberman D , GehringM , TranRK , BallingerT , HenikoffS . Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription . Nat. Genet.39 ( 1 ), 61 – 69 ( 2007 ).
  • Ball MP , LiJB , GaoYet al. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells . Nat. Biotechnol.27 ( 4 ), 361 – 368 ( 2009 ).
  • Suzuki M , OdaM , RamosMPet al. Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome . Genome Res.21 ( 11 ), 1833 – 1840 ( 2011 ).
  • Bell JT , PaiAA , PickrellJKet al. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines . Genome Biol.12 ( 1 ), R10 ( 2011 ).
  • Gertz J , VarleyKE , ReddyTEet al. Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation . PLoS Genet.7 ( 8 ), e1002228 ( 2011 ).
  • Grundberg E , MeduriE , SandlingJKet al. Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements . Am. J. Hum. Genet.93 ( 5 ), 876 – 890 ( 2013 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.