References
- Hidalgo M . Pancreatic cancer . N. Engl. J. Med.362 , 1605 – 1617 ( 2010 ).
- Stathis A , MooreMJ . Advanced pancreatic carcinoma: current treatment and future challenges . Nat. Rev. Clin. Oncol.7 , 163 – 172 ( 2010 ).
- Fernandez-del-Castillo C , JimenezRE , SteerML . Surgery in the treatment of exocrine pancreas and prognosis . www.uptodate.com/contents/overview-of-surgery-in-the-treatment-of-exocrine-pancreatic-cancer-and-prognosis?source=search_result&search=Surgery+in+the+treatment+of+exocrine+pancreas+and+prognosis&selectedTitle=1~150 .
- Li Y , KongD , AhmadA , BaoB , SarkarFH . Pancreatic cancer stem cells: emerging target for designing novel therapy . Cancer Lett.338 ( 1 ), 94 – 100 ( 2013 ).
- Kalluri R . EMT: when epithelial cells decide to becomemesenchymallike cells . J. Clin. Invest.119 , 1417 – 1419 ( 2009 ).
- Karamitopoulou E , ZlobecI , PanayiotidesIet al. Systematic analysis of proteins from different signaling pathways in the tumor centre and the invasive front of colorectal cancer . Hum. Pathol.42 , 1888 – 1896 ( 2011 ).
- Krantz SB , ShieldsMA , Dangi-GarimellaS , MunshiHG , BentremDJ . Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression . J. Surg. Res.173 , 105 – 112 ( 2012 ).
- Masugi Y , YamazakiK , HibiT , AiuraK , KitagawaY , SakamotoM . Solitary cell infiltration is a novel indicator of poor prognosis and epithelial–mesenchymal transition in pancreatic cancer . Hum. Pathol.41 , 1061 – 1068 ( 2010 ).
- Toth M , FridmanR . Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography . Methods Mol. Med.57 , 163 – 172 ( 2001 ).
- Pryczynicz A , Guzińska-UstymowiczK , Dymicka-PiekarskaVet al. Expression of matrix metalloproteinase-9 in pancreatic ductal carcinoma is associated with tumor metastasis formation . Folia Histochem. Cytobiol.45 , 37 – 40 ( 2007 ).
- Kleiner DE , Stetler-StevensonWG . Matrix metalloproteinases and metastasis . Cancer Chemother. Pharmacol.43 ( Suppl. ), S42 – S51 ( 1999 ).
- Zhang K , ChenD , JiaoXet al. Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling . Lab. Invest.91 , 426 – 438 ( 2011 ).
- Cornelius LA , NehringLC , HardingE , BolanowskiM , WelgusHG , KobayashiDK . Matrix metalloproteinases generate angiostatin: effects on neovascularization . J. Immunol.161 , 6845 – 6852 ( 1998 ).
- Matsuyama Y , TakaoS , AikouT . Comparison of matrix metalloproteinase expression between primary tumors with orwithout liver metastasis in pancreatic and colorectal carcinomas . J. Surg. Oncol.80 , 105 – 110 ( 2002 ).
- Gress TM , Muller-PillaschF , LerchMM , FriessH , BuchlerMW , AdlerG . Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer . Int. J. Cancer62 , 407 – 413 ( 1995 ).
- Giovannetti E , FunelN , PetersGJet al. MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity . Cancer Res.70 ( 11 ), 4528 – 4538 ( 2010 ).
- Hwang JH , VoortmanJ , GiovannettiEet al. Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer . PLoS ONE14 ( 5 ), e10630 ( 2010 ).
- Giovannetti E , van der VeldeA , FunelNet al. High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer . PLoS ONE7 ( 11 ), e49145 ( 2012 ).
- Maftouh M , AvanA , FunelNet al. miR-211 modulates gemcitabine activity through downregulation of ribonucleotide reductase and inhibits the invasive behavior of pancreatic cancer cells . Nucleosides Nucleotides Nucleic Acids33 ( 4–6 ), 384 – 393 ( 2014 ).