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Case Report

Lipid Inclusions in Cardiac Myocytes – a Rare Case of Cardiolipotoxicity

ORCID Icon, , ORCID Icon, , , & show all
Pages 293-299 | Received 20 May 2020, Accepted 15 Jul 2020, Published online: 25 Aug 2020

References

  • Gupta R , RanchalP, PattarkineRet al. Lipid inclusions in cardiac myocytes – a rare case of cardiolipotoxicity. J. Cardiac Failure, 25(8), Supplement S116 (2019).
  • Lopaschuk GD , BelkeDD, GambleJ, ItoiT, SchonekessBO. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim. Biophys. Acta, 1213(3), 263–276 (1994).
  • Cheng L , DingG, QinQet al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat. Med., 10(11), 1245–1250 (2004).
  • Wende AR , AbelED. Lipotoxicity in the heart. Biochim. Biophys. Acta, 1801(3), 311–319 (2010).
  • Rajabi M , KassiotisC, RazeghiP, TaegtmeyerH. Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail. Rev., 12(3-4), 331–343 (2007).
  • Schulze PC . Myocardial lipid accumulation and lipotoxicity in heart failure. J. Lipid Res., 50(11), 2137–2138 (2009).
  • Alpert MA . Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome. Am. J. Med. Sci., 321(4), 225–236 (2001).
  • Boudina S , AbelED. Diabetic cardiomyopathy revisited. Circulation, 115(25), 3213–3223 (2007).
  • Herrero P , PetersonLR, McgillJBet al. Increased myocardial fatty acid metabolism in patients with Type 1 diabetes mellitus. J. Am. Coll. Cardiol., 47(3), 598–604 (2006).
  • Hemnes AR , BrittainEL, TrammellAWet al. Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med., 189(3), 325–334 (2014).
  • Wang W , JamesCA, CalkinsH. Diagnostic and therapeutic strategies for arrhythmogenic right ventricular dysplasia/cardiomyopathy patient. Europace, 21(1), 9–21 (2019).
  • Pieroni M , ChimentiC, DeCobelli Fet al. Fabry’s disease cardiomyopathy: echocardiographic detection of endomyocardial glycosphingolipid compartmentalization. J. Am. Coll. Cardiol., 47(8), 1663–1671 (2006).
  • Lingvay I , RaskinP, SzczepaniakLS. The fatty hearts of patients with diabetes. Nat. Rev. Cardiol., 6(4), 268–269 (2009).
  • Rijzewijk LJ , VanDer Meer RW, LambHJet al. Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging. J. Am. Coll. Cardiol., 54(16), 1524–1532 (2009).
  • Quarta G , SadoDM, MoonJC. Cardiomyopathies: focus on cardiovascular magnetic resonance. Br. J. Radiol., 84(Spec. No 3), S296–S305 (2011).
  • Tuunanen H , EngblomE, NaumAet al. Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy. Circulation, 118(12), 1250–1258 (2008).

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