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Editorial

Liver Hepatokines and Peroxisomes As Therapeutic Targets for Cardiovascular Diseases

ORCID Icon & ORCID Icon
Pages 535-538 | Received 30 Sep 2020, Accepted 05 Oct 2020, Published online: 22 Oct 2020

References

  • El Hadi H , DiVincenzo A, VettorR, RossatoM. Relationship between heart disease and liver disease: a two-way street. Cells, 9(3), 567 (2020).
  • Wiese S , HoveJD, BendtsenF, MollerS. Cirrhotic cardiomyopathy: pathogenesis and clinical relevance. Nat. Rev. Gastroenterol. Hepatol., 11(3), 177–186 (2014).
  • Vanwagner LB , LapinB, LevitskyJet al. High early cardiovascular mortality after liver transplantation. Liver Transpl., 20(11), 1306–1316 (2014).
  • Bezinover D , KadryZ, McculloughPet al. Release of cytokines and hemodynamic instability during the reperfusion of a liver graft. Liver Transpl., 17(3), 324–330 (2011).
  • Targher G , DayCP, BonoraE. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N. Engl. J. Med., 363(14), 1341–1350 (2010).
  • Targher G , ByrneCD, LonardoA, ZoppiniG, BarbuiC. Nonalcoholic fatty liver disease and risk of incident cardiovascular disease: a meta-analysis. J. Hepatol., 65(3), 589–600 (2016).
  • Motamed N , RabieeB, PoustchiHet al. Nonalcoholic fatty liver disease (NAFLD) and 10-year risk of cardiovascular diseases. Clin. Res. Hepatol. Gastroenterol., 41(1), 31–38 (2017).
  • Premoli A , PaschettaE, HvalrygM, SpandreM, BoS, DurazzoM. Characteristics of liver diseases in the elderly: a review. Minerva Gastroenterol. Dietol., 55(1), 71–78 (2009).
  • Huang K , MiaoT, ChangKet al. Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine. Nature Communications, 11(1), 2943 (2020).
  • Dunn W , XuR, WingardDLet al. Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study. Am. J. Gastroenterol., 103(9), 2263–2271 (2008).
  • Akahoshi M , AmasakiY, SodaMet al. Correlation between fatty liver and coronary risk factors: a population study of elderly men and women in Nagasaki, Japan. Hypertens. Res., 24(4), 337–343 (2001).
  • Meex RCR , WattMJ. Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance. Nat. Rev. Endocrinol., 13(9), 509–520 (2017).
  • Yoo HJ , ChoiKM. Hepatokines as a link between obesity and cardiovascular diseases. Diabetes Metab. J., 39(1), 10–15 (2015).
  • Fontes JA , RoseNR, CihakovaD. The varying faces of IL-6: from cardiac protection to cardiac failure. Cytokine, 74(1), 62–68 (2015).
  • Wieckowska A , PapouchadoBG, LiZ, LopezR, ZeinNN, FeldsteinAE. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am. J. Gastroenterol., 103(6), 1372–1379 (2008).
  • Pal D , DasguptaS, KunduRet al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat. Med., 18(8), 1279–1285 (2012).
  • Jung TW , YooHJ, ChoiKM. Implication of hepatokines in metabolic disorders and cardiovascular diseases. BBA Clin., 5, 108–113 (2016).
  • Haukeland JW , DahlTB, YndestadAet al. Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies. Eur. J. Endocrinol., 166(3), 503–510 (2012).
  • Waterham HR , FerdinandusseS, WandersRJ. Human disorders of peroxisome metabolism and biogenesis. Biochim. Biophys. Acta, 1863(5), 922–933 (2016).
  • Baes M , GressensP, BaumgartEet al. A mouse model for Zellweger syndrome. Nat. Genet., 17(1), 49–57 (1997).

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