An Update On Primary Findings and New Designs in Biotherapy Studies for Acute Myocardial Infarction

References

• Cohn JN , FerrariR, SharpeN . Cardiac remodeling – concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling . J. Am. Coll. Cardiol.35 ( 3 ), 569 – 582 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Jugdutt BI . Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?Circulation108 ( 11 ), 1395 – 1403 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Roncalli J , BrunelleF, GalinierMet al. Pre-hospital fibrinolysis followed by angioplasty or primary angioplasty in acute myocardial infarction: the long-term clinical outcome . J. Thromb. Thrombolysis15 ( 3 ), 181 – 188 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Bonnefoy E , StegPG, BoutitieFet al. Comparison of primary angioplasty and pre-hospital fibrinolysis in acute myocardial infarction (CAPTIM) trial: a 5-year follow-up . Eur. Heart J.30 ( 13 ), 1598 – 1606 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Steg PG , JamesSK, AtarDTask Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation . Eur. Heart J.33 ( 20 ), 2569 – 2619 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Braunwald E , KlonerRA . Myocardial reperfusion: a double-edged sword?J. Clin. Invest.76 ( 5 ), 1713 – 1719 ( 1985 ).
   PubMed Web of Science ®Google Scholar
• Moens AL , ClaeysMJ, TimmermansJP, VrintsCJ . Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process . Int. J. Cardiol.100 ( 2 ), 179 – 190 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Di Lisa F , CantonM, MenaboR, DodoniG, BernardiP . Mitochondria and reperfusion injury. The role of permeability transition . Basic Res. Cardiol.98 ( 4 ), 235 – 241 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Javadov S , KarmazynM . Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection . Cell. Physiol. Biochem.20 ( 1–4 ), 1 – 22 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Prunier F , AngoulvantD, Saint EtienneCet al. The RIPOST-MI study, assessing remote ischemic perconditioning alone or in combination with local ischemic postconditioning in ST-segment elevation myocardial infarction . Basic Res. Cardiol.109 ( 2 ), 400 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Roubille F , MewtonN, ElbazMet al. No post-conditioning in the human heart with thrombolysis in myocardial infarction flow 2–3 on admission . Eur. Heart J.35 ( 25 ), 1675 – 1682 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Oka N , WangL, MiW, ZhuW, HonjoO, CaldaroneCA . Cyclosporine a prevents apoptosis-related mitochondrial dysfunction after neonatal cardioplegic arrest . J. Thorac. Cardiovasc. Surg.135 ( 1 ), 123 – 130, 130.e1 – 2 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Piot C , CroisilleP, StaatPet al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction . N. Engl. J. Med.359 ( 5 ), 473 – 481 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• ClinicalTrials.gov . clinicaltrials.gov#NCT01502774 .
   Google Scholar
• Bolognese L , NeskovicAN, ParodiGet al. Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications . Circulation106 ( 18 ), 2351 – 2357 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Savoye C , EquineO, TricotOet al. Left ventricular remodeling after anterior wall acute myocardial infarction in modern clinical practice (from the REmodelage VEntriculaire [REVE] study group) . Am. J. Cardiol.98 ( 9 ), 1144 – 1149 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Verma A , MerisA, SkaliHet al. Prognostic implications of left ventricular mass and geometry following myocardial infarction: the VALIANT (VALsartan In Acute myocardial iNfarcTion) Echocardiographic Study . JACC Cardiovasc. Imaging1 ( 5 ), 582 – 591 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Christman KL , LeeRJ . Biomaterials for the treatment of myocardial infarction . J. Am. Coll. Cardiol.48 ( 5 ), 907 – 913 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Davis ME , MotionJP, NarmonevaDAet al. Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells . Circulation111 ( 4 ), 442 – 450 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Tsur-Gang O , RuvinovE, LandaNet al. The effects of peptide-based modification of alginate on left ventricular remodeling and function after myocardial infarction . Biomaterials30 ( 2 ), 189 – 195 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Landa N , MillerL, FeinbergMSet al. Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat . Circulation117 ( 11 ), 1388 – 1396 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Leor J , TuviaS, GuettaVet al. Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine . J. Am. Coll. Cardiol.54 ( 11 ), 1014 – 1023 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• ClinicalTrials.gov . clinicaltrials.gov#NCT01226563 .
   Google Scholar
• Strauer BE , BrehmM, ZeusTet al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans . Circulation106 ( 15 ), 1913 – 1918 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Kawamoto A , IwasakiH, KusanoKet al. CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells . Circulation114 ( 20 ), 2163 – 2169 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Schachinger V , ErbsS, ElsasserAet al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction . N. Engl. J. Med.355 ( 12 ), 1210 – 1221 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Schachinger V , AssmusB, BrittenMBet al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial . J. Am. Coll. Cardiol.44 ( 8 ), 1690 – 1699 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Wollert KC , MeyerGP, LotzJet al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial . Lancet364 ( 9429 ), 141 – 148 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Meyer GP , WollertKC, LotzJet al. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months’ follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial . Circulation113 ( 10 ), 1287 – 1294 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Janssens S , DuboisC, BogaertJet al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial . Lancet367 ( 9505 ), 113 – 121 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Lunde K , SolheimS, AakhusSet al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction . N. Engl. J. Med.355 ( 12 ), 1199 – 1209 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Abdel-Latif A , BolliR, TleyjehIMet al. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis . Arch. Intern. Med.167 ( 10 ), 989 – 997 ( 2007 ).
   PubMedGoogle Scholar
• Seeger FH , TonnT, KrzossokN, ZeiherAM, DimmelerS . Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction . Eur. Heart J.28 ( 6 ), 766 – 772 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Martin-Rendon E , BrunskillSJ, HydeCJ, StanworthSJ, MathurA, WattSM . Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review . Eur. Heart J.29 ( 15 ), 1807 – 1818 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Lipinski MJ , Biondi-ZoccaiGG, AbbateAet al. Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials . J. Am. Coll. Cardiol.50 ( 18 ), 1761 – 1767 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Jeevanantham V , ButlerM, SaadA, Abdel-LatifA, Zuba-SurmaEK, DawnB . Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis . Circulation126 ( 5 ), 551 – 568 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Delewi R , HirschA, TijssenJGet al. Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of ST-segment elevation myocardial infarction: a collaborative meta-analysis . Eur. Heart J.35 ( 15 ), 989 – 998 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Vasa M , FichtlschererS, AicherAet al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease . Circ. Res.89 ( 1 ), E1 – E7 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Senior R , KaulS, LahiriA . Myocardial viability on echocardiography predicts long-term survival after revascularization in patients with ischemic congestive heart failure . J. Am. Coll. Cardiol.33 ( 7 ), 1848 – 1854 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Roncalli J , MouquetF, PiotCet al. Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI trial . Eur. Heart J.32 ( 14 ), 1748 – 1757 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Lamirault G , SusenS, ForestVet al. Difference in mobilization of progenitor cells after myocardial infarction in smoking versus non-smoking patients: insights from the BONAMI trial . Stem Cell Res. Ther.4 ( 6 ), 152 ( 2013 ).
   PubMedGoogle Scholar
• Nieda M , NicolA, Denning-KendallP, SweetenhamJ, BradleyB, HowsJ . Endothelial cell precursors are normal components of human umbilical cord blood . Br. J. Haematol.98 ( 3 ), 775 – 777 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Shintani S , MuroharaT, IkedaHet al. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction . Circulation103 ( 23 ), 2776 – 2779 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Asahara T , MuroharaT, SullivanAet al. Isolation of putative progenitor endothelial cells for angiogenesis . Science275 ( 5302 ), 964 – 967 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Peichev M , NaiyerAJ, PereiraDet al. Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors . Blood95 ( 3 ), 952 – 958 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Kalka C , TehraniH, LaudenbergBet al. Mobilization of endothelial progenitor cells following gene therapy with VEGF165 in patients with inoperable coronary disease . Ann. Thorac. Surg.70, 829 – 834 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Roncalli JG , TongersJ, RenaultMA, LosordoDW . Endothelial progenitor cells in regenerative medicine and cancer: a decade of research . Trends Biotechnol.26 ( 5 ), 276 – 283 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Kawamoto A , GwonHC, IwaguroHet al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia . Circulation103 ( 5 ), 634 – 637 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Kamihata H , MatsubaraH, NishiueTet al. Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines . Circulation104 ( 9 ), 1046 – 1052 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Kocher AA , SchusterMD, SzabolcsMJet al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function . Nat. Med.7 ( 4 ), 430 – 436 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Schatteman GC , HanlonHD, JiaoC, DoddsSG, ChristyBA . Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice . J. Clin. Invest.106, 571 – 578 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Assmus B , HonoldJ, SchachingerVet al. Transcoronary transplantation of progenitor cells after myocardial infarction . N. Engl. J. Med.355 ( 12 ), 1222 – 1232 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Losordo DW , SchatzRA, WhiteCJet al. Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a Phase I/IIa double-blind, randomized controlled trial . Circulation115 ( 25 ), 3165 – 3172 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Pasquet S , SovalatH, HenonPet al. Long-term benefit of intracardiac delivery of autologous granulocyte-colony-stimulating factor-mobilized blood CD34+ cells containing cardiac progenitors on regional heart structure and function after myocardial infarct . Cytotherapy11 ( 8 ), 1002 – 1015 ( 2009 ).
   PubMed Web of Science ®Google Scholar