192
Views
0
CrossRef citations to date
0
Altmetric
Preliminary Communication

Etomidate Inhibits the Growth of MRSA and Exhibits Synergism with Oxacillin

ORCID Icon, , , , , , , , , , & show all
Pages 1611-1619 | Received 11 Apr 2020, Accepted 05 Nov 2020, Published online: 20 Nov 2020

References

  • Liu C , BayerA , CosgroveSEet al. Clinical Practice Guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin. Infect. Dis.52(3), 18–55 (2011).
  • World Health Organization . WHO publishes list of bacteria for which new antibiotics are urgently needed. http://www.who.int/news-room/detail/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed
  • Centers for Disease Control and Prevention . Staph infections can kill (2019). http://www.cdc.gov/vitalsigns/staph/index.html
  • Figueiredo AMS , FerreiraFA , BeltrameCO , CortesMF. The role of biofilms in persistent infections and factors involved in ica-independent biofilm development and gene regulation in Staphylococcus aureus. Crit. Rev. Microbiol.43, 602–620 (2017).
  • Magill SS , EdwardsJR , BambergWet al. Multistate point-prevalence survey of health care–associated infections. N. Eng. J. Med.370(13), 1198–1208 (2014).
  • Qureshi SI , ChaudhariHK. Design, synthesis, in silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA. Bioorg. Med. Chem.27(12), 2676–2688 (2019).
  • Siles SA , SrinivasanA , PierceCG , Lopez-RibotJL , RamasubramanianAK. High-throughput screening of a collection of known pharmacologically active small compounds for identification of Candida albicans biofilm inhibitors. Antimicrob. Agents Chemother.57(8), 3681–3687 (2013).
  • Andrade-Neto VV , CunhaJunior EF , FaioesVDSet al. Leishmaniasis treatment update of possibilities for drug repurposing. Front. Biosci.23(3), 967–996 (2018).
  • Keleş GT , KurutepeS , TokD , GaziH , DinçG. Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam. Eur. J. Anaesthesiol.23(12), 1037–1040 (2006).
  • Begec Z , YucelA , YakupogullarıYet al. The antimicrobial effects of ketamine combined with propofol: an in vitro study. Braz. J. Anesthesiol.63(6), 461–465 (2013).
  • Tulgar S , AlasehirEA , SelviO. The antimicrobial activity of ephedrine and admixture of ephedrine and propofol: an in vitro study. Braz. J. Anesthesiol.68(1), 69–74 (2018).
  • Sá LGDA , SilvaCRD , CamposRDSet al. Synergistic anticandidal activity of etomidate and azoles against clinical fluconazole-resistant Candida isolates. Future Microbiol.14(17), 1477–1488 (2019).
  • Neto JBDA , SilvaCRD , BarrosoFDet al. Synergistic effects of ketamine and azole derivatives on Candida spp. resistance to fluconazole. Future Microbiol.15(3), 177–188 (2020).
  • Clinical and Laboratory Standards Institute . Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Ninth Edition. Approved Standard M7-A9 (2012).
  • Clinical and Laboratory Standards Institute . Performance Standards for Antimicrobial Susceptibility Testing Twenty-seventh Edition Informational Supplement: Approved standard M100-S23 (2013).
  • Odds FC . Synergy, antagonism and what the chequerboard puts between them. J. Antimicrob. Chemother.52(1), 1–1 (2003).
  • Neto JBDA , JosinoMAA , SilvaCRDet al. A mechanistic approach to the in vitro resistance modulating effects of fluoxetine against meticillin resistant Staphylococcus aureus strains. Microb. Pathog.127, 335–340 (2019).
  • Das B , MandalD , DashSKet al. Eugenol provokes ROS-mediated membrane damage-associated antibacterial activity against clinically isolated multidrug-resistant Staphylococcus aureus strains. Infect. Dis.9, 11–19 (2016).
  • Neto JBDA , SilvaCRD , NascimentoFBet al. Screening of antimicrobial metabolite yeast isolates derived biome Ceará against pathogenic bacteria, including MRSA: antibacterial activity and mode of action evaluated by flow cytometry. Int. J. Curr. Microbiol. App. Sci.4(5), 459–472 (2015).
  • Shi L , GüntherS , HübschmannT , WickLY , HarmsH , MüllerS. Limits of propidium iodide as a cell viability indicator for environmental bacteria. Cytometry Part A.71A(8), 592–598 (2007).
  • Williams S , HongY , DanavallDet al. Distinguishing between living and non living bacteria: evaluation of the vital stain propidium iodide and its combined use with molecular probes in aquatic samples. J. Microbiol. Methods.32(3), 225–236 (1998).
  • Neto JBDA , SilvaCRD , NetaMASet al. Antifungal activity of naphthoquinoidal compounds in vitro against fluconazole-resistant strains of different Candida species: a special emphasis on mechanisms of action on Candida tropicalis. PLoS ONE9(5), e93698 (2014).
  • Dwyer DJ , CamachoDM , KohanskiMA , CalluraJM , CollinsJJ. Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis. Mol. Cell.46(5), 561–572 (2012).
  • Brambilla LZ , EndoEH , CortezDA , FilhoBPD. Anti-biofilm activity against Staphylococcus aureus MRSA and MSSA of neolignans and extract of Piper regnellii. Revista Brasileira de Farmacognosia27(1), 112–117 (2017).
  • Schillaci D , ArizzaV , DaytonT , CamardaL , StefanoV. In vitro anti-biofilm activity of Boswellia spp. oleo gum resin essential oils. Lett. Appl. Microbiol.47(5), 433–438 (2008).
  • Venter H . Reversing resistance to counter antimicrobial resistance in the World Health Organisation's critical priority of most dangerous pathogens. Biosci. Rep.39(4), (2019).
  • Cock I , CheesmanM , IlankoA , BlonkB. Developing new antimicrobial therapies: are synergistic combinations of plant extracts/compounds with conventional antibiotics the solution?Pharmacogn. Rev.11(22), 57 (2017).
  • Sosis MB , BravermanB. Growth of Staphylococcus aureus in four intravenous anesthetics. Anesth. Analg.77(4), 766–8 (1993).
  • Pelz K , Wiedmann-Al-AhmadM , BogdanC , OttenJ-E. Analysis of the antimicrobial activity of local anaesthetics used for dental analgesia. J. Med. Microbiol.57(1), 88–94 (2008).
  • Kaewjiaranai T , SrisatjalukRL , SakdajeyontW , PairuchvejV , WongsirichatN. The efficiency of topical anesthetics as antimicrobial agents: a review of use in dentistry. J. Dent. Anesth. Pain Med.18(4), 223 (2018).
  • Liu X , PaiP-J , ZhangWet al. Proteomic response of methicillin-resistant S. aureus to a synergistic antibacterial drug combination: a novel erythromycin derivative and oxacillin. Sci. Rep.6(1), 19841 (2016).
  • Gil D , GrindyS , MuratogluO , BedairH , OralE. Antimicrobial effect of anesthetic-eluting ultra-high molecular weight polyethylene for post-arthroplasty antibacterial prophylaxis. J. Orthop. Res.37(4), 981–990 (2019).
  • Oyama T , MiyazakiM , YoshimuraM , TakataT , OhjimiH , JimiS. Biofilm-forming methicillin-resistant Staphylococcus aureus survive in Kupffer cells and exhibit high virulence in mice. Toxins8(7), 198 (2016).
  • Dupieux C , Trouillet-AssantS , CamusCet al. Intraosteoblastic activity of daptomycin in combination with oxacillin and ceftaroline against MSSA and MRSA. J. Antimicrob. Chemother.72(12), 3353–3356 (2017).
  • Bessa LJ , PalmeiraA , GomesASet al. Synergistic effects between thioxanthones and oxacillin against methicillin-resistant Staphylococcus aureus. Microb. Drug Resist.21(4), 404–415 (2015).
  • Dilworth TJ , SliwinskiJ , RyanK , DoddM , MercierR-C. Evaluation of vancomycin in combination with piperacillin-tazobactam or oxacillin against clinical methicillin-resistant Staphylococcus aureus Isolates and vancomycin-intermediate S. aureus isolates in vitro. Antimicrob. Agents Chemother.58(2), 1028–1033 (2013).
  • Silva MT , SousaJC , PolóniaJJ , MacedoPM. Effects of local anesthetics on bacterial cells. J. Bacteriol.137(1), 461–468 (1979).
  • Pina-Vaz CL , RodriguesACGA , SansonettyF , Martinez-De-OliveiraJ , FonsecaANF , MårdhP-A. Antifungal activity of local anesthetics against Candida species. Infect. Dis. Obstet. Gynecol.8(3–4), 124–137 (2000).
  • Chu C-N , WuK-C , ChungW-Set al. Etomidate suppresses invasion and migration of human A549 lung adenocarcinoma cells. Anticancer Res.39(1), 215–223 (2018).
  • Chen HT , ZhouJ , FanYLet al. Anesthetic agent etiomidate induces apoptosis in N2a brain tumor cell line. Mol. Med. Rep.18(3), 3137–3142 (2018).
  • Tanouchi Y , LeeAJ , MeredithH , YouL. Programmed cell death in bacteria and implications for antibiotic therapy. Trends Microbiol.21(6), 265–270 (2013).
  • Engelberg-Kulka H , SatB , RechesM , AmitaiS , HazanR. Bacterial programmed cell death systems as targets for antibiotics. Trends Microbiol.12(2), 66–71 (2004).
  • Williams JJ , HergenrotherPJ. Artificial activation of toxin–antitoxin systems as an antibacterial strategy. Trends Microbiol.20(6), 291–298 (2012).
  • Fesik SW . Promoting apoptosis as a strategy for cancer drug discovery. Nat. Rev. Cancer5(11), 876–885 (2005).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.