Elucidating the Role of T cells in Protection Against and Pathogenesis of Dengue Virus Infections

References

• Sahaphong S , RiengrojpitakS , BhamarapravatiN , ChirachariyavejT . Electron microscopic study of the vascular endothelial cell in dengue hemorrhagic fever . Southeast Asian J. Trop. Med. Public Health11 , 194 – 204 ( 1980 ).
   PubMedGoogle Scholar
• Kurane I , EnnisFA . Immunity and immunopathology in dengue virus infections . Sem. Immunol.4 , 121 – 127 ( 1992 ).
   PubMedGoogle Scholar
• Rothman AL . Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms . Nat. Rev. Immunol.11 , 532 – 543 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Sun P , KochelTJ.  The battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis The battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis . ScientificWorldJournal2013 , 843469 ( 2013 ).
   PubMedGoogle Scholar
• Balsitis SJ , ColomaJ , CastroGet al. Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining . Am. J. Trop. Med. Hyg.80 , 416 – 424 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• King AD , NisalakA , KalayanroojSet al. B cells are the principal circulating mononuclear cells infected by dengue virus . Southeast Asian J. Trop. Med. Public Health30 , 718 – 728 ( 1999 ).
   PubMedGoogle Scholar
• Lin YW , WangKJ , LeiHYet al. Virus replication and cytokine production in dengue virus-infected human B lymphocytes . J. Virol.76 , 12242 – 12249 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Kou Z , QuinnM , ChenHet al. Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells . J. Med. Virol.80 , 134 – 146 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Murphy BR , WhiteheadSS . Immune response to dengue virus and prospects for a vaccine . Annu. Rev. Immunol.29 , 587 – 619 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Dowd KA , PiersonTC . Antibody-mediated neutralization of flaviviruses: a reductionist view . Virology411 , 306 – 315 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Burton DR , PoignardP , StanfieldRL , WilsonIA . Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses . Science337 , 183 – 186 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Flipse J , WilschutJ , SmitJM . Molecular mechanisms involved in antibody-dependent enhancement of dengue virus infection in humans . Traffic14 , 25 – 35 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Garcia G , ArangoM , PerezABet al. Antibodies from patients with dengue viral infection mediate cellular cytotoxicity . J. Clin. Virol.37 , 53 – 57 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Laoprasopwattana K , LibratyDH , EndyTPet al. Antibody dependent cellular cytotoxicity in pre-secondary dengue virus serotype 3 (DV3) but not in DV2 infection plasma samples inversely correlated with viremia levels . J. Infect. Dis.195 , 1108 – 1116 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Green S , RothmanA . Immunopathological mechanisms in dengue and dengue hemorrhagic fever . Curr. Opin. Infect. Dis.19 , 429 – 436 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Kurane I , MatsutaniT , SuzukiRet al. T-cell responses to dengue virus in humans . Trop. Med. Health39 , 45 – 51 ( 2011 ).
   PubMedGoogle Scholar
• Rothman AL . Dengue: defining protective versus pathologic immunity . J. Clin. Invest.113 , 946 – 951 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Mathew A , RothmanAL . Understanding the contribution of cellular immunity to dengue disease pathogenesis . Immunol. Rev.225 , 300 – 313 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Gagnon SJ , ZengW , KuraneI , EnnisFA . Identification of two epitopes on the dengue 4 virus capsid protein recognized by a serotype-specific and a panel of serotype-cross-reactive human CD4+ cytotoxic T-lymphocyte clones . J. Virol.70 , 141 – 147 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Green S , KuraneI , PincusS , PaolettiE , EnnisFA . Recognition of dengue virus NS1-NS2a proteins by human CD4+ cytotoxic T lymphocyte clones . Virology234 , 383 – 386 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Kurane I , DaiLC , LivingstonPG , ReedE , EnnisFA . Definition of an HLADPw2-restricted epitope on NS3, recognized by a dengue virus serotype-cross-reactive human CD4+ CD8- cytotoxic T-cell clone . J. Virol.67 , 6285 – 6288 ( 1993 ).
   PubMed Web of Science ®Google Scholar
• Kurane I , OkamotoY , DaiLCet al. Flavivirus-cross-reactive, HLADR15-restricted epitope on NS3 recognized by human CD4+ CD8- cytotoxic T lymphocyte clones . J. Gen. Virol.76 , 2243 – 2249 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Livingston PG , KuraneI , DaiLCet al. Dengue virus-specific, HLAB35-restricted, human CD8+ cytotoxic T lymphocyte (CTL) clones. Recognition of NS3 amino acids 500 to 508 by CTL clones of two different serotype specificities . J. Immunol.154 , 1287 – 1295 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Mathew A , KuraneI , GreenSet al. Predominance of HLArestricted cytotoxic T-lymphocyte responses to serotype-cross-reactive epitopes on nonstructural proteins following natural secondary dengue virus infection . J. Virol.72 , 3999 – 4004 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Mongkolsapaya J , DejnirattisaiW , XuXet al. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever . Nat. Med.921 – 927 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Rivino L , KumaranEA , JovanovicVet al. Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection . J. Virol.87 , 2693 – 2706 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Weiskopf D , AngeloMA , de AzeredoELet al. Comprehensive analysis of dengue virus-specific responses supports an HLAlinked protective role for CD8+ T cells . Proc. Natl Acad. Sci. USA110 , E2046 – E2053 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Simmons CP , DongT , ChauNVet al. Early T-cell responses to dengue virus epitopes in Vietnamese adults with secondary dengue virus infections . J. Virol.79 , 5665 – 5675 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Duangchinda T , DejnirattisaiW , VasanawathanaSet al. Immunodominant T-cell responses to dengue virus NS3 are associated with DHF . Proc. Natl Acad. Sci. USA107 , 16922 – 16927 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Testa JS , ShettyV , SinnathambyGet al. Conserved MHC class I-presented dengue virus epitopes identified by immunoproteomics analysis are targets for cross-serotype reactive T-cell response . J. Infect. Dis.205 , 647 – 655 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Appanna R , HuatTL , SeeLLet al. Cross-reactive T-cell responses to the nonstructural regions of dengue viruses among dengue fever and dengue hemorrhagic fever patients in Malaysia . Clin. Vaccine Immunol.14 , 969 – 977 ( 2007 ).
   PubMedGoogle Scholar
• Imrie A , MeeksJ , GuraryAet al. Differential functional avidity of dengue virus-specific T-cell clones for variant peptides representing heterologous and previously encountered serotypes . J. Virol.81 , 10081 – 10091 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Malavige GN , McGowanS , AtukoraleVet al. Identification of serotype-specific T cell responses to highly conserved regions of the dengue viruses . Clin. Exp. Immunol.168 , 215 – 223 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Okamoto Y , KuraneI , LeporatiAM , EnnisFA . Definition of the region on NS3 which contains multiple epitopes recognized by dengue virus serotype-cross-reactive and flavivirus-cross-reactive, HLADPw2-restricted CD4+ T cell clones . J. Gen. Virol.79 , 697 – 704 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Wen J , DuanZ , JiangL . Identification of a dengue virus-specific HLAA*0201-restricted CD8+ T cell epitope . J. Med. Virol.82 , 642 – 648 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Zeng L , KuraneI , OkamotoY , EnnisFA , BrintonMA . Identification of amino acids involved in recognition by dengue virus NS3-specific, HLADR15-restricted cytotoxic CD4+ T-cell clones . J. Virol.70 , 3108 – 3117 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Zivny J , DeFronzoM , JarryWet al. Partial agonist effect influences the CTL response to a heterologous dengue virus serotype . J. Immunol.163 , 2754 – 2760 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Mangada MM , RothmanAL . Altered cytokine responses of dengue-specific CD4+ T cells to heterologous serotypes . J. Immunol.175 , 2676 – 2683 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Kurane I , BrintonMA , SamsonAL , EnnisFA . Dengue virus-specific, human CD4+ CD8- cytotoxic T-cell clones: multiple patterns of virus cross-reactivity recognized by NS3-specific T-cell clones . J. Virol.65 , 1823 – 1828 ( 1991 ).
   PubMed Web of Science ®Google Scholar
• Kurane I , MeagerA , EnnisFA . Dengue virus-specific human T cell clones. Serotype crossreactive proliferation, interferon gamma production, and cytotoxic activity . J. Exp. Med.170 , 763 – 775 ( 1989 ).
   PubMed Web of Science ®Google Scholar
• Kurane I , ZengL , BrintonMA , EnnisFA . Definition of an epitope on NS3 recognized by human CD4+ cytotoxic T lymphocyte clones cross-reactive for dengue virus types 2, 3, and 4 . Virology240 , 169 – 174 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Mathew A , KuraneI , RothmanAL , Dominant recognition by human CD8+ cytotoxic T lymphocytes of dengue virus nonstructural proteins NS3 and NS1.2a . J. Clin. Invest.98 , 1684 – 1694 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Zivny J , KuraneI , LeporatiAMet al. A single nine-amino acid peptide induces virus-specific, CD8+ human cytotoxic T lymphocyte clones of heterogeneous serotype specificities . J. Exp. Med.182 , 853 – 863 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Co MD , TerajimaM , CruzJ , EnnisFA , RothmanAL . Human cytotoxic T lymphocyte responses to live attenuated 17D Yellow fever vaccine: identification of HLAB35-restricted CTL epitopes on nonstructural proteins NS1, NS2b, NS3, and the structural protein E . Virology293 , 151 – 163 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Rothman AL , KuraneI , LaiCJet al. Dengue virus protein recognition by virus-specific murine CD8+ cytotoxic T lymphocytes . J. Virol.67 , 801 – 806 ( 1993 ).
   PubMed Web of Science ®Google Scholar
• Hill AB , MullbacherA , ParrishCet al. Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses . J. Gen. Virol.73 , 1115 – 1123 ( 1992 ).
   PubMed Web of Science ®Google Scholar
• Lobigs M , ArthurCE , MullbacherA , BlandenRV . The flavivirus nonstructural protein NS3 is a dominant source of cytotoxic T cell peptide determinants . Virology202 , 195 – 201 ( 1994 ).
   PubMed Web of Science ®Google Scholar
• Parrish CR , CoiaG , HillAet al. Preliminary analysis of murine cytotoxic T cell responses to the proteins of the flavivirus Kunjin using vaccinia virus expression . J. Gen. Virol.72 , 1645 – 1653 ( 1991 ).
   PubMed Web of Science ®Google Scholar
• Khan AM , MiottoO , NascimentoEJet al. Conservation and variability of dengue virus proteins: implications for vaccine design . PLoS Negl. Trop. Dis.2 , e272 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Zhang L , MohanPM , PadmanabhanR . Processing and localization of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 . J. Virol.66 , 7549 – 7554 ( 1992 ).
   PubMed Web of Science ®Google Scholar
• Zhang L , PadmanabhanR . Role of protein conformation in the processing of dengue virus type 2 nonstructural polyprotein precursor . Gene129 , 197 – 205 ( 1993 ).
   PubMed Web of Science ®Google Scholar
• Stephens HA , KlaythongR , SirikongMet al. HLAA and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais . Tissue Antigens60 , 309 – 318 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Stephens HA . HLA and other gene associations with dengue disease severity . Curr. Top. Microbiol. Immunol.338 , 99 – 114 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Malavige GN , RostronT , RohanachandraLTet al. HLA class I and class II associations in dengue viral infections in a Sri Lankan population . PLoS ONE6 , e20581 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Fernandez-Mestre MT , GendzekhadzeK , Rivas-VetencourtP , LayrisseZ . TNF-alpha-308A allele, a possible severity risk factor of hemorrhagic manifestation in dengue fever patients . Tissue Antigens64 , 469 – 472 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Perez AB , SierraB , GarciaGet al. Tumor necrosis factor-alpha, transforming growth factor-beta1, and interleukin-10 gene polymorphisms: implication in protection or susceptibility to dengue hemorrhagic fever . Hum. Immunol.71 , 1135 – 1140 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Gagnon SJ , MoriM , KuraneIet al. Cytokine gene expression and protein production in peripheral blood mononuclear cells of children with acute dengue virus infections . J. Med. Virol.67 , 41 – 46 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Vejbaesya S , LuangtrakoolP , LuangtrakoolKet al. TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais . J. Infect. Dis.199 , 1442 – 1448 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Rothman AL . Cellular immunology of sequential dengue virus infection and its role in disease pathogenesis . Curr. Top. Microbiol. Immunol.338 , 83 – 98 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Friberg H , BashyamH , Toyosaki-MaedaTet al. Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans . Sci. Rep.1 , 51 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Townsley E , WodaM , ThomasSJet al. Distinct activation phenotype of a highly conserved novel HLAb57-restricted epitope during dengue virus infection . Immunology141 , 27 – 38 ( 2013 ).
   Web of Science ®Google Scholar
• Green S , PichyangkulS , VaughnDWet al. Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever . J. Inf. Dis.180 , 1429 – 1435 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Green S , VaughnDW , KalayanaroojSet al. Early immune activation in acute dengue is related to development of plasma leakage and disease severity . J. Inf. Dis.179 , 755 – 762 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Hober D , DelannoyAS , BenyoucefS , DeGroote D , WattreP . High levels of sTNFR p75 and TNF alpha in dengue-infected patients . Microbiol. Immunol.40 , 569 – 573 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Hober D , PoliL , RoblinBet al. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in dengue-infected patients . Am. J. Trop. Med. Hyg.48 , 324 – 331 ( 1993 ).
   PubMed Web of Science ®Google Scholar
• Mustafa AS , ElbishbishiEA , AgarwalR , ChaturvediUC . Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever . FEMS Immunol. Med. Microbiol.30 , 229 – 233 ( 2001 ).
   PubMedGoogle Scholar
• Srikiatkhachorn A , AjariyakhajornC , EndyTPet al. Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic fever . J. Virol.81 , 1592 – 1600 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Friberg H , BurnsL , WodaMet al. Memory CD8(+) T cells from naturally acquired primary dengue virus infection are highly cross-reactive . Immunol Cell Biol . 89 ( 1 ), 122 – 129 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Dung NT , DuyenHT , ThuyNTet al. Timing of CD8+ T cell responses in relation to commencement of capillary leakage in children with dengue . J. Immunol.184 , 7281 – 7287 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Chau TN , QuyenNT , ThuyTTet al. Dengue in Vietnamese infants – results of infection-enhancement assays correlate with age-related disease epidemiology, and cellular immune responses correlate with disease severity . J. Infect. Dis.198 , 516 – 524 ( 2008 ).
   PubMedGoogle Scholar
• Mongkolsapaya J , DuangchindaT , DejnirattisaiWet al. T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal? J. Immunol. 176 , 3821 – 3829 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Zivna I , GreenS , VaughnDWet al. T cell responses to an HLA B*07-restricted epitope on the dengue NS3 protein correlate with disease severity . J. Immunol.168 , 5959 – 5965 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Bashyam HS , GreenS , RothmanAL . Dengue virus-reactive CD8+ T cells display quantitative and qualitative differences in their response to variant epitopes of heterologous viral serotypes . J. Immunol.176 , 2817 – 2824 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Akondy RS , MonsonND , MillerJDet al. The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response . J. Immunol.183 , 7919 – 7930 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Miller JD , vander Most RG , AkondyRSet al. Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines . Immunity28 , 710 – 722 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Mangada MM , EndyTP , NisalakAet al. Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren . J. Inf. Dis.185 , 1697 – 1703 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Hatch S , EndyTP , ThomasSet al. Intracellular cytokine production by dengue virus-specific T cells correlates with subclinical secondary infection . J. Infect. Dis.203 , 1282 – 1291 ( 2010 ).
   Web of Science ®Google Scholar
• Gunther VJ , PutnakR , EckelsKHet al. A human challenge model for dengue infection reveals a possible protective role for sustained interferon gamma levels during the acute phase of illness . Vaccine29 , 3895 – 3904 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Lindow JC , Borochoff-PorteN , DurbinAPet al. Primary vaccination with low dose live dengue 1 virus generates a proinflammatory, multifunctional T cell response in humans . PLoS Negl. Trop. Dis.6 , e1742 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Johnson AJ , RoehrigJT . New mouse model for dengue virus vaccine testing . J. Virol.73 , 783 – 786 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Weiskopf D , YauchLE , AngeloMAet al. Insights into HLArestricted T cell responses in a novel mouse model of dengue virus infection point toward new implications for vaccine design . J. Immunol.187 , 4268 – 4279 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Shresta S , ShararKL , PrigozhinDM , BeattyPR , HarrisE . Murine model for dengue virus-induced lethal disease with increased vascular permeability . J. Virol.80 , 10208 – 10217 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Yauch LE , ZellwegerRM , KotturiMFet al. A protective role for dengue virus-specific CD8+ T cells . J. Immunol.182 , 4865 – 4873 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Yauch LE , PrestwoodTR , MayMMet al. CD4+ T cells are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses but contribute to protection after vaccination . J. Immunol.185 , 5405 – 5416 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Gil L , LopezC , LazoLet al. Recombinant nucleocapsid-like particles from dengue-2 virus induce protective CD4+ and CD8+ cells against viral encephalitis in mice . Int. Immunol.21 , 1175 – 1183 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Gil L , LopezC , BlancoAet al. The cellular immune response plays an important role in protecting against dengue virus in the mouse encephalitis model . Viral Immunol.22 , 23 – 30 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• An J , ZhouDS , ZhangJLet al. Dengue-specific CD8+ T cells have both protective and pathogenic roles in dengue virus infection . Immunol. Lett.95 , 167 – 174 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Kyle JL , BalsitisSJ , ZhangL , BeattyPR , HarrisE . Antibodies play a greater role than immune cells in heterologous protection against secondary dengue virus infection in a mouse model . Virology380 , 296 – 303 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Yauch LE , ShrestaS . Mouse models of dengue virus infection and disease . Antiviral Res.80 , 87 – 93 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Zompi S , HarrisE . Animal models of dengue virus infection . Viruses4 , 62 – 82 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Shultz LD , BrehmMA , Garcia-MartinezJV , GreinerDL . Humanized mice for immune system investigation: progress, promise and challenges . Nat. Rev. Immunol.12 , 786 – 798 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Jaiswal S , PazolesP , WodaMet al. Enhanced humoral and HLAA2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice . Immunology136 , 334 – 343 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Jaiswal S , PearsonT , FribergHet al. Dengue virus infection and virus-specific HLAA2 restricted immune responses in humanized NOD-SCID IL2rgammanull mice . PLoS ONE4 , e7251 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Koraka P , BentonS , van AmerongenG , StittelaarKJ , OsterhausAD . Characterization of humoral and cellular immune responses in cynomolgus macaques upon primary and subsequent heterologous infections with dengue viruses . Microbes Infect.9 , 940 – 946 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Mladinich KM , PiaskowskiSM , RudersdorfRet al. Dengue virus-specific CD4+ and CD8+ T lymphocytes target NS1, NS3 and NS5 in infected Indian rhesus macaques . Immunogenetics64 , 111 – 121 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Raviprakash K , KochelTJ , EwingDet al. Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein . Vaccine18 , 2426 – 2434 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Seder RA , DarrahPA , RoedererM . T-cell quality in memory and protection: implications for vaccine design . Nat. Rev. Immunol.8 , 247 – 258 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• McArthur MA , SzteinMB , EdelmanR . Dengue vaccines: recent developments, ongoing challenges and current candidates . Expert Rev. Vaccines12 , 933 – 953 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Thomas SJ , EndyTP . Critical issues in dengue vaccine development . Curr. Opin. Infect. Dis.24 , 442 – 450 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Guy B , NougaredeN , BegueSet al. Cell-mediated immunity induced by chimeric tetravalent dengue vaccine in naive or flavivirus-primed subjects . Vaccine26 , 5712 – 5721 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Harenberg A , BegueS , MamessierAet al. Persistence of Th1/Tc1 responses one year after tetravalent dengue vaccination in adults and adolescents in Singapore . Hum. Vaccin. Immunother. doi:10.4161/hv.25562 ( 2013 ) (Epub ahead of print).
   PubMed Web of Science ®Google Scholar
• Sabchareon A , WallaceD , SirivichayakulCet al. Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled Phase 2b trial . Lancet380 , 1559 – 1567 ( 2012 ).
   PubMed Web of Science ®Google Scholar