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Review

CNS Germ Cell Tumors: A Clinical Review and Future Directions

Pages 47-62 | Received 08 Nov 2015, Accepted 15 Jan 2016, Published online: 08 Feb 2016

References

  • Hoffman HJ , OtsuboH, HendrickEBet al. Intracranial germ-cell tumors in children. J. Neurosurg.74, 545–551 (1991).
  • Fuller BG , KappDS, CoxR. Radiation therapy of pineal region tumors: 25 new cases and a review of 208 previously reported cases. Int. J. Radiat. Oncol. Biol. Phy.28, 229–245 (1994).
  • McCarthy BJ , ShibuiS, KayamaTet al. Primary CNS germ cell tumors in Japan and the United States: an analysis of 4 tumor registries. Neuro. Oncol.14, 1194–1200 (2012).
  • Packer RJ , CohenBH, CooneyK. Intracranial germ cell tumors. Oncologist5, 312–320 (2000).
  • Jennings MT , GelmanR, HochbergF. Intracranial germ-cell tumors: natural history and pathogenesis. J. Neurosurg.63, 155–167 (1985).
  • Matsutani M , TakakuraK, SanoK. Primary intracranial germ cell tumors: pathology and treatment. Prog. Exp.Tumor Res.30, 307–312 (1987).
  • Heideman R , PackerRJ, AlbrightLA, FreemanCR, RorkeLB. Tumors of the central nervous system. In: Principles and Practice of Pediatric Oncology, 2nd edition. PizzoPA, PoplackDG ( Eds). Lippincott Williams & Wilkins, PA, USA, 633–681 (1993).
  • Matsutani M , SanoK, TakakuraKet al. Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J. Neurosurg.86, 446–455 (1987).
  • Aoyama H , ShiratoH, YoshidaHet al. Retrospective multi-institutional study of radiotherapy for intracranial nongerminomatous germ cell tumors. Radiother. Oncol.9, 55–59 (1998).
  • DiGiovanni LM , SheikhZ. Prenatal diagnosis, clinical significance and management of fetal intracranial teratoma: a case report and literature review. Am. J. Perinatol.11, 420–422 (1994).
  • Allen JC . Controversies in the management of intrcranial germ cell tumors. Neurol. Clin.9, 441–452 (1991).
  • Janmohamed S , GrossmanAB, MetcalfeKet al. Suprasellar germ cell tumours: specific problems and the evolution of optimal management with a combined chemoradiotherapy regimen. Clin. Endocrinol. (Oxf.)57(4), 487–500 (2002).
  • Taylor M , Couto-SilvaAC, AdanLet al. Hypothalamic–pituitary lesions in pediatric patients: endocrine symptoms often precede neuro-ophthalmic presenting symptoms. J. Pediatr.161, 855–863 (2012).
  • Rivarola MA , MendilaharzuH, WarmanMet al. Endocrine disorders in 66 suprasellar and pineal tumors of patients with prepubertal and pubertal ages. Horm. Res.37, 1–6 (1992).
  • Sethi RV , MarinoR, NiemierkoA, TarbellNJ, YockTI, MacdonaldSM. Delayed diagnosis in children with intracranial germ cell tumors. J. Pediatr.163, 1448–53 (2013).
  • Allen JC , BoslG, WalkerR. Chemotherapy trials in recurrent primary intracranial germ cell tumors. J. Neurooncol.3, 147–152 (1985).
  • Edwards MS , HudginsRJ, WilsonCBet al. Pineal regions tumors in children. J. Neurosurg.68, 689–697 (1988).
  • Smirniotopoulos JG , RushingEJ, MenaH. Pineal region masses: differential diagnosis. Radiographics12, 577–596 (1992).
  • Allen JC , NisselbaumJ, EpsteinFet al. Alpha fetoprotein and human chorionic gonadotropin determination in cerebrospinal fluid: an aid to the diagnosis and management of intracranial germ-cell tumors. J. Neurosurg.1, 368–374 (1979).
  • Bruce JN , SteinBM. Surgical management of pineal region tumors. Acta Neurochir. (Wein)134, 130–135 (1995).
  • Bruce DA , AllenJC. Tumor staging for pineal region tumors of childhood. Cancer56, 1792–1794 (1985).
  • Aoyama H , ShiratoH, IkedaJet al. Induction chemotherapy followed by low-dose involved-field radiotherapy for intracranial germ cell tumors. J. Clin. Oncol.20, 857–865 (2002).
  • Finlay J , da SilvaNS, LaveyRet al. The management of patients with primary central nervous system germinoma: current controversies requiring resolution. Pediatr. Blood Cancer51, 313–316 (2008).
  • Fujimaki T , MatsutaniM. The Japanese Pediatric Brain Tumor Study Group. HCG-producing germinoma: analysis of Japanese Pediatric Brain Tumor Study Group results. Neuro. Oncol.7, Abstract 518 (2005).
  • Legault G , AllenJC. Potential role of ventricular tumor markers in CNS germ cell tumors. Pediatr. Blood Cancer60, 1647–1650 (2013).
  • Sung DI . Suprasellar tumors in children: a review of clinical manifestations and managements. Cancer50, 1420–1425 (1982).
  • Nakagawa K , AokiY, AkanumaAet al. Radiation therapy of intracranial germ cell tumors with radiosensitivity assessment. Radiat. Med.10, 55–61 (1992).
  • Oi S , MatsumotoS. Controversy pertaining to therapeutic modalities for tumors of the pineal region: a worldwide survey of different patient populations. Childs Nerv. Syst.8, 332–336 (1992).
  • Souweidane MM , SandbergDI, BilskyMH, GutinPH. Endoscopic biopsy for tumors of the third ventricle. Pediatr. Neurosurg.33, 132–137 (2000).
  • Pople IK , AthanasiouTC, SandemanDR, CoakhamHB. The role of endoscopic biopsy and third ventriculostomy in the management of pineal region tumours. Br. J. Neurosurg.15, 305–311 (2001).
  • Dearnaley D . A’HearnPWhittakerSet al. Pineal and CNS germ cell tumors: Royal Marsden Hospital experience 1962–1987. Int. J. Radiat. Oncol. Biol. Phys.18, 773–781 (1990).
  • Baumgartner JE , EdwardsMS. Pineal tumors. Neurosurg. Clin. N. Am.3(4), 853–862 (1992).
  • Peltier J , VinchonM, BaronciniM, KerdraonO, DhellemmesP. Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases; case report. J. Neuro. Oncol.90, 111–115 (2008).
  • Cuccia V , AldereteD. Suprasellar/pineal bifocal germ cell tumors. Childs Nerv. Syst.26, 1043–1049 (2010).
  • Aizer AA , SethiRV, Hedley-WhyteTet al. Bifocal intracranial tumors of nongerminomatous germ cell etiology: diagnostic and therapeutic implications. Neuro. Oncol.15, 955–960 (2013).
  • Keene D , JohnstonD, StrotherDet al. Epidemiological survey of central nervous system germ cell tumors in Canadian children. J. Neurooncol.82, 289–295 (2007).
  • Schild SE , ScheithauerBW, HaddockMGet al. Histologically confirmed pineal tumors and other germ cell tumors of brain. Cancer78, 2564–2571 (1996).
  • Shinoda J , SakaiN, HirohitoYet al. Prognostic factors and therapeutic problems of primary intracranial choriocarcinoma/germ-cell tumors with high levels of HCG. J. Neurooncol.66, 225–240 (2004).
  • Calaminus G , BambergM, HarmsDet al. AFP/B-HCG secreting CNS germ cell tumors: long-term outcome with respect to initial symptoms and primary tumor resection. Results of the cooperative trial MAKEI 89. Neuropediatrics36, 71–77 (2005).
  • Nicholson JC , PuntJ, HaleJ, SaranF, CalaminusG. Neurosurgical management of paediatric germ cell tumours of the central nervous system-a multi-disciplinary team approach for the new millennium. Br. Neurosurg.16, 93–95 (2002).
  • Kochi M , ItoyamaY, ShiraishiSet al. Successful treatment of intracranial nongerminomatous malignant germ cell tumors by administering neoadjuvant chemotherapy and radiotherapy before excision of residual tumor. J. Neurosurg.99(1), 106–114 (2003).
  • Souweidane MM , KriegerMD, WeinerHL, FinlayJL. Surgical management of primary central nervous system germ cell tumors: proceedings from the Second International Symposium on Central Nervous System Germ Cell Tumors. J. Neurosurg. Ped.6(2), 125–130 (2010).
  • Ogiwara H , KiyotaniC, TerashimaK, MorotaN. Second-look surgery for intracranial germ cell tumors. Neurosurg.76, 658–662 (2015).
  • Echevarria ME , FangusaroJ, GoldmanS. Pediatric central nervous system germ cell tumors: a review. Oncologist13, 690–699 (2008).
  • Kim CY , ChoiJW, LeeJYet al. Intracranial growing teratoma syndrome: clinical characteristics and treatment strategy. J. Neurooncol.10, 109–115 (2011).
  • Bi WL , BannykhSI, BaehringJ. The growing teratoma syndrome after subtotal resection of an intracranial nongerminomatous germ cell tumor in an adult; case report. Neurosurgery56, E191–E194 (2005).
  • Sawamura Y , IkedaJ, ShiratoH, TadaM, AbeH. Germ cell tumours of the central nervous system: treatment consideration based on 111 cases and their long-term clinical outcomes. Eur. J. Cancer34, 104–110 (1998).
  • Ogawa K , ShikamaN, ToitaTet al. Long-term results of radiotherapy for intracranial germinoma: a multiinstitutional retrospective review of 126 patients. Int. J.Radiat. Oncol.Biol. Phys.58, 705–713 (2004).
  • Haas-Kogan DA , MissettBT, WaraWMet al. Radiation therapy for intracranial germ cell tumors. Int. J. Rad. Oncol. Biol. Phys.56, 511–518 (2003).
  • Alapetite C , BrisseH, PatteCet al. Pattern of relapse and outcome of nonmetastatic germinoma patients treated with chemotherapy and limited field radiation: the SFOP experience. Neuro. Oncol.12, 1318–1325 (2010).
  • Baranzelli MC , PatteC, BouffetEet al. Nonmetastatic intracranial germinoma: the experience of the French Society of Pediatric Oncology. Cancer80, 1792–1797 (1997).
  • Calaminus G , BambergM, BaranzelliMCet al. Intracranial germ cell tumors: a comprehensive update of the European data. Neuropediatrics25, 26–31 (1994).
  • Calaminus G , KortmannR, WorchJet al. SIOP CNS GCT final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease. Neuro. Oncol.15, 788–796 (2013).
  • Allen JC , Da RossoRC, DonahueB, NirenbergA. A Phase II trial of pre-irradiation carboplatin in newly diagnosed germinoma of the central nervous system. Cancer74, 940–944 (1994).
  • Buckner JC , PeethambaramPP, SmithsonWAet al. Phase II trial of primary chemotherapy followed by reduced-dose radiation for CNS germ cell tumors. J. Clin. Oncol.17, 933–940 (1999).
  • Balmaceda C , HellerG, RosenblumMet al. Chemotherapy without irradiation – a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. J. Clin. Oncol.14, 2908–2915 (1996).
  • da Silva NS , CappellanoAM, DiezBet al. Primary chemotherapy for intracranial germ cell tumors: results of the third international CNS germ cell tumor study. Pediatr. Blood Cancer54, 377–383 (2010).
  • Bamberg M , KortmannRD, CalaminusGet al. Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J. Clin. Oncol.17, 2585–2592 (1999).
  • Chao CK , LeeST, LinFJet al. A multivariate analysis of prognostic factors in management of pineal tumor. Int. J. Radiat. Oncol. Biol. Phys.27, 1185–1191 (1993).
  • Wolden SL , WaraWM, LarsonDA, PradosMD, EdwardsMS, SneedPK. Radiation therapy for primary intracranial germ-cell tumors. Int. J. Rad. Oncol. Biol. Phys.32, 943–949 [1995].
  • Calaminus G , AndreussiL, GarreML, KortmannRD, SchoberR, GobelU. Secreting germ cell tumors of the central nervous system (CNS): first results of the cooperative German/Italian study (CNS germ cell tumor). Klin. Pediatr.209, 222–227 (1997).
  • Robertson PL , DaRossoR, AllenJC. Improved prognosis of nongerminoma germ cell tumor with multimodality therapy. J. Neurooncol.32, 71–80 (1997).
  • Baranzelli MF , PatteC, BouffetEet al. Carboplatin-based chemotherapy (CT) and focal irradiation (RT) in primary cerebral germ cell tumors (GCT): a study of the French Society of Pediatric Oncology (SFOP). Proc. Annu. Meet. Am. Soc. Clinic. Oncol.18, S538 (1999).
  • Kretschmar C , KleinbergL, GreenbergM, BurgerP, HolmesE, WharamM. Pre-radiation chemotherapy with response-based radiation therapy in children with central nervous system germ cell tumors: a report from the Children’s Oncology Group. Pediatr. Blood Cancer48, 285–291 (2007).
  • Goldman S , BouffetE, FisherP, AllenJ, RobertsonP, ChubaP. A Phase II trial to assess the ability of neoadjuvant chemotherapy ± second-look surgery to eliminate measurable disease for NGGCT: a Children's Oncology Group study. J. Clin. Oncol.33, 2464–2471 (2015).
  • Robertson PL , SiffertJ, JakackiR, HukinJ, VelasquezL, AllenJ. Neoadjuvant chemotherapy and radiation therapy for newly diagnosed primary intracranial non-germinoma germ cell tumors (NGGCT), with dose-intensified chemotherapy and peripheral blood stem cell support for initially refractory disease: results of a multi-institutional Phase II pilot. J. Neurooncol.118, 93–100 (2014).
  • Yoshida J , SugitaK, KobayashiTet al. Prognosis of intracranial germ cell tumors: effectiveness of chemotherapy with cisplatin and etoposide CDDP and VP-16. Acta Neurochir. (Wien)120(3–4), 111–117 (1993).
  • Calaminus G , NicholsonJ, FrappazDet al. Localised and metastatic non-germinoma (NGGCT) treated according to the SIOP CNS 96. Protocol. Neurooncol.12, GCT.05 ii28 (2010).
  • Einhorn LH . Clinical trials in testicular cancer. Cancer71, 3182–3184 (1993).
  • Rustin GJ , NewlandsES, BagshaweKDet al. Successful management of metastatic and primary germ cell tumors in the brain. Cancer57, 2108–2113 (1986).
  • Kobayashi T , YoshidaJ, IshiyamaJ, NodaS, KitoA, KidaY. Combination chemotherapy with cisplatin and etoposide for malignant intracranial germ cell tumors: an experimental and clinical study. J. Neurosurg.70, 676–681 (1989).
  • Jereb B , ZupancicN, PetricJ. Intracranial germinoma: report of seven cases. Pediatr. Hematol. Oncol.7, 183–188 (1990).
  • Itoyama Y , KochiM, KuratsuJet al. Treatment of intracranial nongerminomatous malignant germ cell tumors producing alpha fetoprotein. Neurosurg.36, 459–464 (1995).
  • Patel SR , BucknerJC, SmithsonWA, ScheithauerBW, GrooverRV. Cisplatin-based chemotherapy in primary central nervous system germ cell tumors. J. Neurooncol.12, 47–52 (1992).
  • Elyan SA , TraishD, AshlelySet al. The management of cranial germ cell tumours with primary chemotherapy. Presented at: Proc. Royal Marsdsen Third International Neuro-Oncology Conference, April1993.
  • Matsukado Y , AbeH, TanakaRet al. Cisplatin, vinblastine, and bleomycin (PVB) combination chemotherapy in the treatment of intracranial malignant germ cell tumors: a preliminary report of Phase II study. The Japanese Intracranial Germ Cell Study Group. Gan No Rhinsho32, 1387–1393 (1986).
  • Baranzelli MC , PatteC, BouffetEet al. An attempt to treat pediatric intracranial alphaFP and betaHCG secreting germ cell tumors with chemotherapy alone: SFOP experience with 18 cases. Societe Francaise d'Oncologie Pediatrique. J. Neurooncol.37, 229–239 (1998).
  • Calaminus G , PatteC. Experience within the SIOP CNS GCT 96 trial/SFOP studies with HDC/SCR in patients with CNS germ cell tumours and further implications for high risk patients. Bone Marrow Trans.30, S34 abstract 54 (2002).
  • Modak S , GardnerS, DunkelIJet al. Thiotepa-based high-dose chemotherapy with autologous stem-cell rescue in patients with recurrent or progressive CNS germ cell tumors. J. Clin. Oncol.22(10), 1934–1943 (2004).
  • De Giorgi U , RostiG, SlavinSet al. Salvage high-dose chemotherapy for children with extragonadal germ-cell tumours. Br. J. Cancer93(4), 412–417 (2005).
  • Beyer J , KingreenD, KrauseMet al. Long-term survival of patients with recurrent or refractory germ cell tumors after high dose chemotherapy. Cancer79(1), 161–168 (1997).
  • Bouffet E . The role of myeloablative chemotherapy with autologous hematopoietic cell rescue in central nervous system germ cell tumors. Pediatr. Blood Cancer54(4), 644–666 (2010).
  • Herrmann HD , WestphalM, LaasRet al. Treatment of nongerminomatous germ-cell tumours of the pineal region. Neurosurgery34, 524–529 (1994).
  • Packer RJ , SuttonLN, RosenstockJGet al. Pineal region tumors of childhood. Pediatrics74, 97–102 (1984).
  • Danoff BF , CowchockFS, MarquetteC, MulgrewL, KramerS. Assessment of the long-term effects of primary radiation therapy for brain tumors in children. Cancer49, 1580–1586 (1982).
  • Duffner PK , CohenME. The long-term effects of central nervous system therapy on children with brain tumors. Neurol. Clin.9, 479–495 (1991).
  • Sakai N , YamadaH, AndohT, HirataT, ShimizuK, ShinodaJ. Primary intracranial germ-cell tumors: a retrospective analysis with special reference to long-term results of treatment and the behavior of rare types of tumors. Acta Oncol.27, 43–50 (1988).
  • Kiltie AE , GattamaneniHR. Survival and quality of life of pediatric intracranial germ cell tumour patients treated at the Christie Hospital, 1972–1993. Med. Pediatr. Oncol.25, 450–456 (1995).
  • Shirato H , NishioM, SawamuraYet al. Analysis of long-term treatment of intracranial germinoma. Int. J. Radiat. Oncol. Biol. Phys.37, 511–515 (1997).
  • Wilkening GN , MaddenJR, BartonVN, RobertsA, ForemanNK. Memory deficits in patients with pediatric CNS germ cell tumors. Pediatr. Blood Cancer57, 486–491 (2011).
  • Mabbott DJ , MonsalvesE, SpieglerBJet al. Longitudinal evaluation of neurocognitive function after treatment for central nervous system germ cell tumors in childhood. Cancer117, 5402–5411 (2011).
  • Liang SY , YangTF, ChenYQet al. Neuropsychological functions and quality of life in survived patients with intracranial germ cell tumors after treatment. Neuro. Oncol.15, 1543–1551 (2013).
  • Benesch M , LacknerH, SchagerlS, GallistlS, FreyEM, UrbanC. Tumor-and treatment-related side effects after multimodal therapy of childhood intracranial germ cell tumors. Acta Paediatr.90, 264–270 (2001).
  • Nichols CR , BreedenES, LoehrerPJ, WilliamsSD, EinhornLH. Secondary leukemia associated with a conventional dose of etoposide: review of serial germ cell tumor protocols. J. Natl Cancer Inst.85, 36–40 (1993).
  • McKay D , HertigA, AdamsE, DanzigerA. Histochemical observations on the germ cell of human embryos. Anat. Rec.117, 201–220 (1953).
  • Hoei-Hansen CE , SehestedA, JuhlerMet al. New Evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of plluripotency and cell differentiation markers. J. Pathol.209, 25–33 (2006).
  • Gomperts M , Garcia-CastroM, WylieC, HeasmanJ. Interactions between primordial germ cells play a role in their migration in mouse embryos. Development120, 135–141 (1994).
  • Meyer D . The migration of primordial germ cells in the chick embryo. Dev. Biol.10, 154–90 (1964).
  • Fujimoto T , UkeshimaA, MiyayamaY, KuwanaT, YoshinagaK, NakamuraM. The primordial germ cells in amniotes: their migration in vivo and behaviors in vitro. Prog. Clin. Biol. Res.296, 13–21 (1989).
  • Sandberg AA , MeloniAM, SuijkerbuijkRF. Reviews of chromosome studies in urological tumors III: cytogenetics and genes in testicular tumors. J. Urol.155, 1531–1556 (1996).
  • Bosl GJ , DmitrovskyE, ReuterVEet al. Isochromosome of the short arm of chromosome 12: clinically useful markers for male germ cell tumors. J. Natl Cancer Inst.81, 1874–1878 (1989).
  • Biegel JA . Cytogenetics and moledular genetics of childhood brain tumors. Neuro. Oncol.1, 139–151 (1999).
  • Schneider DT , ZahnS, SieversSet al. Molecular genetic analysis of central nervous system germ cell tumors with comparative genomic hybridization. Mod. Path.19, 864–873 (2006).
  • Terashima K , YuA, ChowWTet al. Genome-wide analysis of DNA copy number alterations and loss of heterozygosity in intracranial germ cell tumors. Pediatr. Blood Cancer61, 593–600 (2014).
  • Vaughn DJ , HwangW, LalP, RosenMA, GallagherM, O’DwyerPJ. Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors. Cancer121, 1463–1468 (2015).
  • Kim KD , ChoBK, HongSJet al. The detection of p53 gene mutation using a microdissection technique in primary intracranial germ cell tumors. Int. J. Oncol.18, 111–116 (2001).
  • Iwato M , TachibanaO, TohmaY, NittaH, HayashiY, YamashitaJ. Molecular analysis for p53 and MDM2 in intracranial germ cell tumors. Acta Neuropathol.99, 21–25 (2000).
  • Iwato M , TachibanaO, TohmaYet al. Alterations of the INK4a/ARF locus in human intracranial germ cell tumors. Cancer Res.60, 2113–2115 (2000).
  • Wang L , YamaguchiS, BursteinMDet al. Novel somatic and germline mutations in intracranial germ cell tumours. Nature511, 241–245 (2014).
  • Janne PA , ShawAT, PereiraJRet al. Selumetinib plus doxetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomized multicentre, placebo-controlled, Phase 2 study. Lancet Oncol.13, 38–47 (2013).
  • Hatzivassiliou G , LiuB, O'BrienCet al. ERK inhibition overcomes acquired resistance to MEK inhibitors. Mol. Cancer Ther.11, 1143–1154 (2012).
  • Makishima H , SugimotoY, SzpurkaHet al. CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors. Leukemia26, 1547–1554 (2012).

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