LncRNA SNHG16 Induces the SREBP2 to Promote Lipogenesis and Enhance the Progression of Pancreatic Cancer

References

• Siegel RL , MillerKD, JemalA. Cancer Statistics, 2017. CA Cancer J. Clin.67(1), 7–30 (2017).
   PubMed Web of Science ®Google Scholar
• Rahib L , SmithBD, AizenbergR, RosenzweigAB, FleshmanJM, MatrisianLM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res.74(11), 2913–2921 (2014).
   PubMed Web of Science ®Google Scholar
• Poplin E , WasanH, RolfeLet al. Randomized, multicenter, Phase II study of CO-101 versus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma: including a prospective evaluation of the role of hENT1 in gemcitabine or CO-101 sensitivity. J. Clin. Oncol.31(35), 4453–4461 (2013).
   PubMed Web of Science ®Google Scholar
• Salem AA , MackenzieGG. Pancreatic cancer: a critical review of dietary risk. Nutr. Res.52, 1–13 (2018).
   PubMed Web of Science ®Google Scholar
• Hidalgo M . Pancreatic cancer. N. Engl. J. Med.362(17), 1605–1617 (2010).
   PubMed Web of Science ®Google Scholar
• Maitra A , HrubanRH. Pancreatic cancer. Annu. Rev. Pathol.3, 157–188 (2008).
   PubMed Web of Science ®Google Scholar
• Rossi ML , RehmanAA, GondiCS. Therapeutic options for the management of pancreatic cancer. World J. Gastroenterol.20(32), 11142–11159 (2014).
   PubMed Web of Science ®Google Scholar
• Ward PS , ThompsonCB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell21(3), 297–308 (2012).
   PubMed Web of Science ®Google Scholar
• Swinnen JV , BrusselmansK, VerhoevenG. Increased lipogenesis in cancer cells: new players, novel targets. Curr. Opin. Clin. Nutr. Metab. Care9(4), 358–365 (2006).
   PubMed Web of Science ®Google Scholar
• Mounier C , BouraouiL, RassartE. Lipogenesis in cancer progression (review). Int. J. Oncol.45(2), 485–492 (2014).
   PubMed Web of Science ®Google Scholar
• Swierczynski J , HebanowskaA, SledzinskiT. Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. World J. Gastroenterol.20(9), 2279–2303 (2014).
   PubMed Web of Science ®Google Scholar
• Suburu J , ChenYQ. Lipids and prostate cancer. Prostaglandins Other Lipid Mediat.98(1–2), 1–10 (2012).
   PubMed Web of Science ®Google Scholar
• Nieva C , MarroM, Santana-CodinaN, RaoS, PetrovD, SierraA. The lipid phenotype of breast cancer cells characterized by Raman microspectroscopy: towards a stratification of malignancy. PLoS ONE7(10), e46456 (2012).
   PubMed Web of Science ®Google Scholar
• Ma J , DuanW, HanSet al. Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis. Oncotarget6(25), 20993–21003 (2015).
   PubMedGoogle Scholar
• Bonasio R , ShiekhattarR. Regulation of transcription by long noncoding RNAs. Annu. Rev. Genet.48, 433–455 (2014).
   PubMed Web of Science ®Google Scholar
• Kung JT , ColognoriD, LeeJT. Long noncoding RNAs: past, present, and future. Genetics193(3), 651–669 (2013).
   PubMed Web of Science ®Google Scholar
• Xu F , ZhaG, WuY, CaiW, AoJ. Overexpressing lncRNA SNHG16 inhibited HCC proliferation and chemoresistance by functionally sponging hsa-miR-93. Onco. Targets Ther.11, 8855–8863 (2018).
   PubMed Web of Science ®Google Scholar
• Yang XS , WangGX, LuoL. Long non-coding RNA SNHG16 promotes cell growth and metastasis in ovarian cancer. Eur. Rev. Med. Pharmacol. Sci.22(3), 616–622 (2018).
   PubMed Web of Science ®Google Scholar
• Christensen LL , TrueK, HamiltonMPet al. SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism. Mol. Oncol.10(8), 1266–1282 (2016).
   PubMed Web of Science ®Google Scholar
• Kong Q , QiuM. Long noncoding RNA SNHG15 promotes human breast cancer proliferation, migration and invasion by sponging miR-211-3p. Biochem. Biophys. Res. Commun.495(2), 1594–1600 (2018).
   PubMed Web of Science ®Google Scholar
• Liu S , ZhangW, LiuK, LiuY. LncRNA SNHG16 promotes tumor growth of pancreatic cancer by targeting miR-218-5p. Biomed. Pharmacother.114, 108862 (2019).
   PubMed Web of Science ®Google Scholar
• Wahid F , ShehzadA, KhanT, KimYY. MicroRNAs: synthesis, mechanism, function, and recent clinical trials. Biochim. Biophys. Acta1803(11), 1231–1243 (2010).
   PubMed Web of Science ®Google Scholar
• Peng Y , CroceCM. The role of microRNAs in human cancer. Signal Transduct. Targeted Ther.1, 15004 (2016).
   PubMed Web of Science ®Google Scholar
• Negoi I , HostiucS, SartelliM, NegoiRI, BeuranM. MicroRNA-21 as a prognostic biomarker in patients with pancreatic cancer – a systematic review and meta-analysis. Am. J. Surg.214(3), 515–524 (2017).
   PubMed Web of Science ®Google Scholar
• Wu J , JiA, WangXet al. MicroRNA-195-5p, a new regulator of Fra-1, suppresses the migration and invasion of prostate cancer cells. J. Transl. Med.13, 289 (2015).
   PubMed Web of Science ®Google Scholar
• Luo Q , WeiC, LiXet al. MicroRNA-195-5p is a potential diagnostic and therapeutic target for breast cancer. Oncol. Rep.31(3), 1096–1102 (2014).
   PubMed Web of Science ®Google Scholar
• Xu Z , LiC, QuH, LiH, GuQ, XuJ. MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells by targeting the fatty acid synthase/Wnt signaling pathway. Tumour Biol.39(6), 1–11 (2017).
   Google Scholar
• Singh R , YadavV, KumarS, SainiN. MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1. Sci. Rep.5, 17454 (2015).
   PubMed Web of Science ®Google Scholar
• Eberle D , HegartyB, BossardP, FerreP, FoufelleF. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie86(11), 839–848 (2004).
   PubMed Web of Science ®Google Scholar
• Horton JD , GoldsteinJL, BrownMS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest.109(9), 1125–1131 (2002).
   PubMed Web of Science ®Google Scholar
• Zeng L , LuM, MoriKet al. ATF6 modulates SREBP2-mediated lipogenesis. EMBO J.23(4), 950–958 (2004).
   PubMed Web of Science ®Google Scholar
• Wu W , YangJ, FengXet al. MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells. Mol. Cancer12, 30 (2013).
   PubMed Web of Science ®Google Scholar
• Zhao J , LiP, FengHet al. Cadherin-12 contributes to tumorigenicity in colorectal cancer by promoting migration, invasion, adhersion and angiogenesis. J. Transl. Med.11, 288 (2013).
   PubMed Web of Science ®Google Scholar
• Yao HR , LiuJ, PlumeriDet al. Lipotoxicity in HepG2 cells triggered by free fatty acids. Am. J. Translational Res.3(3), 284–291 (2011).
   PubMed Web of Science ®Google Scholar
• Liu ZQ , MahmoodT, YangPC. Western blot: technique, theory and trouble shooting. N. Am. J. Med. Sci.6(3), 160 (2014).
   PubMedGoogle Scholar
• Lian D , AminB, DuD, YanW. Enhanced expression of the long non-coding RNA SNHG16 contributes to gastric cancer progression and metastasis. Cancer Biomark.21(1), 151–160 (2017).
   PubMed Web of Science ®Google Scholar
• Han GH , LuKJ, WangP, YeJ, YeYY, HuangJX. LncRNA SNHG16 predicts poor prognosis in ESCC and promotes cell proliferation and invasion by regulating Wnt/beta-catenin signaling pathway. Eur. Rev. Med. Pharmacol. Sci.22(12), 3795–3803 (2018).
   PubMed Web of Science ®Google Scholar
• Okuno Y , FukuharaA, HashimotoEet al. Oxidative stress inhibits healthy adipose expansion through suppression of SREBF1-mediated lipogenic pathway. Diabetes67(6), 1113–1127 (2018).
   PubMed Web of Science ®Google Scholar
• Wen YA , XiongX, ZaytsevaYYet al. Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer. Cell Death Dis.9(3), 265 (2018).
   PubMed Web of Science ®Google Scholar
• Deer EL , Gonzalez-HernandezJ, CoursenJDet al. Phenotype and genotype of pancreatic cancer cell lines. Pancreas39(4), 425–435 (2010).
   PubMed Web of Science ®Google Scholar
• Kyriazis AP , McCombsWB 3rd, SandbergAA, KyriazisAA, SloaneNH, LeperaR. Establishment and characterization of human pancreatic adenocarcinoma cell line SW-1990 in tissue culture and the nude mouse. Cancer Res.43(9), 4393–4401 (1983).
   PubMed Web of Science ®Google Scholar
• Jia S , ZhouL, ShenT, ZhouS, DingG, CaoL. Down-expression of CD36 in pancreatic adenocarcinoma and its correlation with clinicopathological features and prognosis. J. Cancer9(3), 578–583 (2018).
   PubMed Web of Science ®Google Scholar
• Liu B , WuS, MaJet al. lncRNA GAS5 reverses EMT and tumor stem cell-mediated gemcitabine resistance and metastasis by targeting miR-221/SOCS3 in pancreatic cancer. Mol. Ther. Nucleic Acids13, 472–482 (2018).
   PubMedGoogle Scholar
• Hodul PJ , DongY, HusainKet al. Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. PLoS ONE8(2), e52526 (2013).
   PubMed Web of Science ®Google Scholar
• Al-Wadei MH , Al-WadeiHA, SchullerHM. Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7. Mol. Cancer Res.10(2), 239–249 (2012).
   PubMed Web of Science ®Google Scholar
• Zhou B , SunC, HuXet al. MicroRNA-195 suppresses the progression of pancreatic cancer by targeting DCLK1. Cell. Physiol. Biochem.44(5), 1867–1881 (2017).
   PubMedGoogle Scholar
• Huang WC , LiX, LiuJ, LinJ, ChungLW. Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells. Mol. Cancer Res.10(1), 133–142 (2012).
   PubMed Web of Science ®Google Scholar
• Zaidi N , LupienL, KuemmerleNB, KinlawWB, SwinnenJV, SmansK. Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Prog. Lipid Res.52(4), 585–589 (2013).
   PubMed Web of Science ®Google Scholar
• Zhou C , QianW, MaJet al. Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1. Cell Prolif.52(1), e12514 (2019).
   PubMed Web of Science ®Google Scholar
• Wu W , SunY, ZhaoCet al. Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPARγ signaling pathway. Acta Biochim. Biophys. Sinica48(6), 509–519 (2016).
   PubMed Web of Science ®Google Scholar
• Bose SK , KimH, MeyerK, WolinsN, DavidsonNO, RayR. Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus. J. Virol.88(8), 4195–4203 (2014).
   PubMed Web of Science ®Google Scholar
• Shen CJ , ChengYM, WangCL. LncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells. J. Drug Target.25(7), 637–644 (2017).
   PubMed Web of Science ®Google Scholar
• Soon PS , TaconLJ, GillAJet al. miR-195 and miR-483-5p identified as predictors of poor prognosis in adrenocortical cancer. Clin. Cancer Res.15(24), 7684–7692 (2009).
   PubMed Web of Science ®Google Scholar
• Guo H , LiW, ZhengT, LiuZ. MiR-195 targets HDGF to inhibit proliferation and invasion of NSCLC cells. Tumour Biol.35(9), 8861–8866 (2014).
   PubMedGoogle Scholar
• Nie H , MuJ, WangJ, LiY. miR1955p regulates multidrug resistance of gastric cancer cells via targeting ZNF139. Oncol. Rep.40(3), 1370–1378 (2018).
   PubMed Web of Science ®Google Scholar