Diagnostic and Prognostic Value of HOXC Family Members in Gastric Cancer

References

• Smyth EC , NilssonM, GrabschHI, Van GriekenNCT, LordickF. Gastric cancer. Lancet396(10251), 635–648 (2020).
   PubMed Web of Science ®Google Scholar
• Bray F , FerlayJ, SoerjomataramI, SiegelRL, TorreLA, JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.68(6), 394–424 (2018).
   PubMed Web of Science ®Google Scholar
• Oliveira C , PinheiroH, FigueiredoJ, SerucaR, CarneiroF. Familial gastric cancer: genetic susceptibility, pathology, and implications for management. Lancet Oncol.16(2), e60–e70 (2015).
   PubMed Web of Science ®Google Scholar
• Lewis EB . A gene complex controlling segmentation in Drosophila. Nature276(5688), 565–70 (1978).
   PubMed Web of Science ®Google Scholar
• Shah N , SukumarS. The HOX genes and their roles in oncogenesis. Nat. Rev. Cancer10(5), 361–371 (2010).
   PubMed Web of Science ®Google Scholar
• Paco A , AparecidaDe Bessa Garcia S, LeitaoCastro J, Costa-PintoAR, FreitasR. Roles of the HOX proteins in cancer invasion and metastasis. Cancers (Basel)13(1), 10 (2020).
   PubMed Web of Science ®Google Scholar
• De Bessa Garcia SA , AraujoM, PereiraT, MoutaJ, FreitasR. HOX genes function in breast cancer development. Biochim. Biophys. Acta Rev. Cancer1873(2), 188358 (2020).
   PubMed Web of Science ®Google Scholar
• Bhatlekar S , FieldsJZ, BomanBM. HOX genes and their role in the development of human cancers. J. Mol. Med. (Berl)92(8), 811–823 (2014).
   PubMed Web of Science ®Google Scholar
• Javed S , LangleySEM. Importance of HOX genes in normal prostate gland formation, prostate cancer development and its early detection. BJU International113(4), 535–540 (2014).
   PubMed Web of Science ®Google Scholar
• Kachgal S , MaceKA, BoudreauNJ. The dual roles of homeobox genes in vascularization and wound healing. Cell Adh. Migr.6(6), 457–470 (2012).
   PubMed Web of Science ®Google Scholar
• Tan Z , ChenK, WuWet al. Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression. Theranostics8(18), 5143–5158 (2018).
   PubMed Web of Science ®Google Scholar
• Jung J , JeongS, JeongHet al. Increased HOXC6 mRNA expression is a novel biomarker of gastric cancer. PLoS One15(8), e0236811 (2020).
   PubMed Web of Science ®Google Scholar
• Liu H , ZhangM, XuSet al. HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFbeta1 in non-small cell lung cancer. Oncogenesis7(2), 1 (2018).
   PubMedGoogle Scholar
• Hur H , LeeJY, YangS, KimJM, ParkAE, KimMH. HOXC9 induces phenotypic switching between proliferation and invasion in breast cancer cells. J. Cancer7(7), 768–773 (2016).
   PubMed Web of Science ®Google Scholar
• Cui Y , ZhangC, WangY, MaS, CaoW, GuanF. HOXC11 functions as a novel oncogene in human colon adenocarcinoma and kidney renal clear cell carcinoma. Life Sci.243, 117230 (2020).
   PubMed Web of Science ®Google Scholar
• Sharma S , KellyTK, JonesPA. Epigenetics in cancer. Carcinogenesis31(1), 27–36 (2009).
   PubMed Web of Science ®Google Scholar
• Qu Y , DangS, HouP. Gene methylation in gastric cancer. Clin. Chim. Acta424, 53–65 (2013).
   PubMed Web of Science ®Google Scholar
• Jones PA . Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet.13(7), 484–492 (2012).
   PubMed Web of Science ®Google Scholar
• Wang L , ChenS, XueMet al. Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis. Mol. Med.18, 389–400 (2012).
   PubMed Web of Science ®Google Scholar
• Park JH , ParkJ, ChoiJKet al. Identification of DNA methylation changes associated with human gastric cancer. BMC Med. Genomics4, 82 (2011).
   PubMed Web of Science ®Google Scholar
• Tomczak K , CzerwinskaP, WiznerowiczM. The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge. Contemp. Oncol. (Pozn)19(1A), A68–77 (2015).
   PubMedGoogle Scholar
• Cancer Genome Atlas Research N . Comprehensive molecular characterization of gastric adenocarcinoma. Nature513(7517), 202–209 (2014).
   PubMed Web of Science ®Google Scholar
• Barrett T , WilhiteSE, LedouxPet al. NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res.41(Database issue), D991–995 (2013).
   PubMed Web of Science ®Google Scholar
• Cristescu R , LeeJ, NebozhynMet al. Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. Nat. Med.21(5), 449–456 (2015).
   PubMed Web of Science ®Google Scholar
• Rhodes DR , YuJ, ShankerKet al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia6(1), 1–6 (2004).
   PubMed Web of Science ®Google Scholar
• Chandrashekar DS , BashelB, BalasubramanyaSAHet al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia19(8), 649–658 (2017).
   PubMed Web of Science ®Google Scholar
• Gyorffy B , LanczkyA, EklundACet al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat.123(3), 725–731 (2010).
   PubMed Web of Science ®Google Scholar
• Cerami E , GaoJ, DogrusozUet al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov.2(5), 401–404 (2012).
   PubMed Web of Science ®Google Scholar
• Szklarczyk D , GableAL, LyonDet al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res.47(D1), D607–D613 (2019).
   PubMed Web of Science ®Google Scholar
• Huang Da W , ShermanBT, LempickiRA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc.4(1), 44–57 (2009).
   PubMed Web of Science ®Google Scholar
• Aravind Subramanianl PT , MoothalVK, MukherjeeSet al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA102(43), 15545–15550 (2005).
   PubMed Web of Science ®Google Scholar
• Zweig MH 1 , CampbellG. Receiver-operating characteristic (ROC) plots a fundamental evaluation tool in clinical medicine. Clin. Chem.39(4), 561–577 (1993).
   PubMed Web of Science ®Google Scholar
• Cho JY , LimJY, CheongJHet al. Gene expression signature-based prognostic risk score in gastric cancer. Clin. Cancer Res.17(7), 1850–1857 (2011).
   PubMed Web of Science ®Google Scholar
• D’errico M , DeRinaldis E, BlasiMFet al. Genome-wide expression profile of sporadic gastric cancers with microsatellite instability. Eur. J. Cancer45(3), 461–469 (2009).
   PubMed Web of Science ®Google Scholar
• Wang Q , WenYG, LiDPet al. Upregulated INHBA expression is associated with poor survival in gastric cancer. Med. Oncol.29(1), 77–83 (2012).
   PubMed Web of Science ®Google Scholar
• Cui J , ChenY, ChouWCet al. An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer. Nucleic Acids Res.39(4), 1197–1207 (2011).
   PubMed Web of Science ®Google Scholar
• Pai P , SukumarS. HOX genes and the NF-kappaB pathway: a convergence of developmental biology, inflammation and cancer biology. Biochim. Biophys. Acta Rev. Cancer1874(2), 188450 (2020).
   PubMed Web of Science ®Google Scholar
• Northcott JM , NortheyJJ, BarnesJM, WeaverVM. Fighting the force: potential of homeobox genes for tumor microenvironment regulation. Biochim. Biophys. Acta1855(2), 248–253 (2015).
   PubMed Web of Science ®Google Scholar
• Wu Y , ZhouT, TangQ, XiaoJ. HOXA5 inhibits tumor growth of gastric cancer under the regulation of microRNA-196a. Gene681, 62–68 (2019).
   PubMed Web of Science ®Google Scholar
• Wang Y , WangC, LiuN, HouJ, XiaoW, WangH. HOXC6 promotes cervical cancer progression via regulation of Bcl-2. FASEB J.33(3), 3901–3911 (2019).
   PubMed Web of Science ®Google Scholar
• Huang Y , ChenL, GuoA. Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer. Oncol. Lett.15(5), 7291–7296 (2018).
   PubMed Web of Science ®Google Scholar
• Xu P , ZhangX, NiWet al. Upregulated HOXC8 expression is associated with poor prognosis and oxaliplatin resistance in hepatocellular carcinoma. Dig. Dis. Sci.60(11), 3351–3363 (2015).
   PubMed Web of Science ®Google Scholar
• Liu YJ , ZhuY, YuanHX, ZhangJP, GuoJM, LinZM. Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis. Tumour Biol.36(4), 2821–2829 (2015).
   PubMedGoogle Scholar
• Lai JF , XuWN, NohSH, LuWQ. Effect of World Health Organization (WHO) histological classification on predicting lymph node metastasis and recurrence in early gastric cancer. Med. Sci. Monit.22, 3147–3153 (2016).
   PubMed Web of Science ®Google Scholar
• Feinberg AP , TyckoB. The history of cancer epigenetics. Nat. Rev. Cancer4(2), 143–153 (2004).
   PubMed Web of Science ®Google Scholar
• Ibanez De Caceres I , CairnsP. Methylated DNA sequences for early cancer detection, molecular classification and chemotherapy response prediction. Clin. Transl. Oncol.9(7), 429–437 (2007).
   PubMed Web of Science ®Google Scholar
• Miwa T , KandaM, UmedaSet al. Homeobox C10 influences on the malignant phenotype of gastric cancer cell lines and its elevated expression positively correlates with recurrence and poor survival. Ann. Surg. Oncol.26(5), 1535–1543 (2019).
   PubMed Web of Science ®Google Scholar
• Su J , HuangYH, CuiXet al. Homeobox oncogene activation by pan-cancer DNA hypermethylation. Genome Biol.19(1), 108 (2018).
   PubMed Web of Science ®Google Scholar
• Okuda H , ToyotaM, IshidaWet al. Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma. Oncogene25(12), 1733–1742 (2006).
   PubMed Web of Science ®Google Scholar
• Wu Q , LotheRA, AhlquistTet al. DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. Mol. Cancer6, 45 (2007).
   PubMed Web of Science ®Google Scholar
• Paco A , FreitasR. HOX genes as transcriptional and epigenetic regulators during tumorigenesis and their value as therapeutic targets. Epigenomics11(13), 1539–1155 (2019).
   PubMed Web of Science ®Google Scholar
• Kim J , BaeDH, KimJH, SongKS, KimYS, KimSY. HOXC10 overexpression promotes cell proliferation and migration in gastric cancer. Oncol. Rep.42(1), 202–212 (2019).
   PubMed Web of Science ®Google Scholar
• Palakurthy RK , WajapeyeeN, SantraMKet al. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. Mol. Cell36(2), 219–230 (2009).
   PubMed Web of Science ®Google Scholar
• Hu W , LiuQ, PanJ, SuiZ. MiR-373-3p enhances the chemosensitivity of gemcitabine through cell cycle pathway by targeting CCND2 in pancreatic carcinoma cells. Biomed. Pharmacother.105, 887–898 (2018).
   PubMed Web of Science ®Google Scholar
• Owen DH , WilliamsTM, BertinoEMet al. Homologous recombination and DNA repair mutations in patients treated with carboplatin and nab-paclitaxel for metastatic non-small cell lung cancer. Lung Cancer134, 167–173 (2019).
   PubMed Web of Science ®Google Scholar
• Chen SW , ZhangQ, XuZFet al. HOXC6 promotes gastric cancer cell invasion by upregulating the expression of MMP9. Mol. Med. Rep.14(4), 3261–3268 (2016).
   PubMed Web of Science ®Google Scholar
• Ayuk SM , AbrahamseH. mTOR signaling pathway in cancer targets photodynamic therapy In Vitro. Cells8(5), 431 (2019).
   PubMed Web of Science ®Google Scholar