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Short Communication

Phase I/Ib dose-escalation study of avelumab in Chinese patients with advanced solid tumors

ORCID Icon, , , ORCID Icon, ORCID Icon, , , , , , , , , , & show all
Pages 2053-2062 | Received 17 Oct 2021, Accepted 09 Mar 2022, Published online: 31 Mar 2022

References

  • D'Angelo SP , BhatiaS, BrohlASet al. Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase II JAVELIN Merkel 200 trial. J. Immunother. Cancer8(1), e000674 (2020).
  • Powles T , ParkSH, VoogEet al. Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma. N. Engl. J. Med.383(13), 1218–1230 (2020).
  • Apolo AB , EllertonJA, InfanteJRet al. Avelumab as second-line therapy for metastatic, platinum-treated urothelial carcinoma in the phase Ib JAVELIN solid tumor study: 2-year updated efficacy and safety analysis. J. Immunother. Cancer8(2), e001246 (2020).
  • Barlesi F , VansteenkisteJ, SpigelDet al. Avelumab versus docetaxel in patients with platinum-treated advanced non-small-cell lung cancer (JAVELIN Lung 200): an open-label, randomised, phase III study. Lancet Oncol.19(11), 1468–1479 (2018).
  • Keilholz U , MehnertJM, BauerSet al. Avelumab in patients with previously treated metastatic melanoma: phase 1b results from the JAVELIN Solid Tumor trial. J. Immunother. Cancer7(1), 12 (2019).
  • Hassan R , ThomasA, NemunaitisJJet al. Efficacy and safety of avelumab treatment in patients with advanced unresectable mesothelioma: phase 1b results from the JAVELIN Solid Tumor trial. JAMA Oncol.5(3), 351–357 (2019).
  • Kelly K , InfanteJR, TaylorMHet al. Safety profile of avelumab in patients with advanced solid tumors: a pooled analysis of data from the phase I JAVELIN Solid Tumor and phase II JAVELIN Merkel 200 clinical trials. Cancer124(9), 2010–2017 (2018).
  • D'Angelo SP , RussellJ, LebbeCet al. Efficacy and safety of first-line avelumab treatment in patients with stage IV metastatic Merkel cell carcinoma: a preplanned interim analysis of a clinical trial. JAMA Oncol.4(9), e180077 (2018).
  • Choueiri TK , MotzerRJ, RiniBIet al. Updated efficacy results from the JAVELIN Renal 101 trial: first-line avelumab plus axitinib versus sunitinib in patients with advanced renal cell carcinoma. Ann. Oncol.31(8), 1030–1039 (2020).
  • Bavencio (avelumab) . Prescribing information. EMD Serono (2020). www.bavencio.com/content/dam/web/health-care/biopharma/web/Bavencio/us/redesign/hcp/bavencio-hcp-home/bavencio-pi.pdf
  • Bavencio (avelumab) . Summary of product characteristics. Merck KGaA, Darmstadt, Germany (2020). www.ema.europa.eu/documents/product-information/bavencio-epar-product-information_en.pdf
  • Rajman I , HiranoM, HonmaW, ZhaoS. New paradigm for expediting drug development in Asia. Drug Discov. Today25(3), 491–496 (2020).
  • Peng L , QinBD, XiaoKet al. A meta-analysis comparing responses of Asian versus non-Asian cancer patients to PD-1 and PD-L1 inhibitor-based therapy. Oncoimmunology9(1), 1781333 (2020).
  • Ma Y , LinQ, YangYet al. Clinical pharmacokinetics and drug exposure-toxicity correlation study of docetaxel based chemotherapy in Chinese head and neck cancer patients. Ann. Transl. Med.8(5), 236 (2020).
  • Doi T , IwasaS, MuroKet al. Phase 1 trial of avelumab (anti-PD-L1) in Japanese patients with advanced solid tumors, including dose expansion in patients with gastric or gastroesophageal junction cancer: the JAVELIN Solid Tumor JPN trial. Gastric Cancer22(4), 817–827 (2019).
  • Heery CR , O'Sullivan-CoyneG, MadanRAet al. Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial. Lancet Oncol.18(5), 587–598 (2017).
  • Enrico D , PaciA, ChaputN, KaramouzaE, BesseB. Antidrug antibodies against immune checkpoint blockers: impairment of drug efficacy or indication of immune activation?Clin. Cancer Res.26(4), 787–792 (2020).