Esophageal stenosis as an independent factor of poor prognosis in patients with ESCC treated with definitive chemoradiotherapy

References

• Sung H , FerlayJ, SiegelRL. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J. Clin.71(3), 209–249 (2021).
   PubMed Web of Science ®Google Scholar
• Huang FL , YuSJ. Esophageal cancer: risk factors, genetic association, and treatment.Asian J. Surg.41(3), 210–215 (2018).
   PubMed Web of Science ®Google Scholar
• Uhlenhopp DJ , ThenEO, SunkaraTet al. Epidemiology of esophageal cancer: update in global trends, etiology and risk factors. Clin. J. Gastroenterol. 13(6), 1010–1021 (2020).
   PubMed Web of Science ®Google Scholar
• Fatehi Hassanabad A , ChehadeR, BreadnerDet al. Esophageal carcinoma: towards targeted therapies. Cell Oncol. (Dordr.) 43(2), 195–209 (2020).
   PubMed Web of Science ®Google Scholar
• Murphy G , McCormackV, Abedi-ArdekaniBet al. International cancer seminars: a focus on esophageal squamous cell carcinoma. Ann. Oncol. 28(9), 2086–2093 (2017).
   PubMed Web of Science ®Google Scholar
• He Y , LiangD, DuLet al. Clinical characteristics and survival of 5283 esophageal cancer patients: a multicenter study from eighteen hospitals across six regions in China. Cancer Commun. (Lond.) 40(10), 531–544 (2020).
   PubMed Web of Science ®Google Scholar
• Slooter MD , de BruinDM, EshuisWJet al. Quantitative fluorescence-guided perfusion assessment of the gastric conduit to predict anastomotic complications after esophagectomy. Dis. Esophagus 34(5), doaa100 (2021).
   PubMed Web of Science ®Google Scholar
• Deng W , LinSH. Advances in radiotherapy for esophageal cancer.Ann. Transl. Med.6(4), 79 (2018).
   PubMed Web of Science ®Google Scholar
• Hoeben A , PolakJ, VanDe Voorde Let al. Cervical esophageal cancer: a gap in cancer knowledge. Ann. Oncol. 27(9), 1664–1674 (2016).
   PubMed Web of Science ®Google Scholar
• Jeene PM , van LaarhovenHWM, HulshofM. The role of definitive chemoradiation in patients with non-metastatic oesophageal cancer.Best Pract. Res. Clin. Gastroenterol.36–37, 53–59 (2018).
   PubMed Web of Science ®Google Scholar
• Zhang B , QiL, WangXet al. Phase II clinical trial using camrelizumab combined with apatinib and chemotherapy as the first-line treatment of advanced esophageal squamous cell carcinoma. Cancer Commun. (Lond.) 40(12), 711–720 (2020).
   PubMed Web of Science ®Google Scholar
• Rice TW , LerutTE, OrringerMBet al. Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data. Dis. Esophagus 29(7), 715–723 (2016).
   PubMed Web of Science ®Google Scholar
• Cai P , YangY, LiDJ. Efficacy and prognostic analysis of 315 stage I–IVa esophageal cancer patients treated with simultaneous integrated boost-intensity-modulated radiation therapy.Cancer Manag. Res.13, 6969–6975 (2021).
   PubMed Web of Science ®Google Scholar
• Koh HK , ParkY, KooTet al. Neutrophil-to-lymphocyte ratio after definitive concurrent chemoradiotherapy predicts survival in patients with esophageal squamous cell carcinoma. In Vivo 35(2), 1133–1139 (2021).
   PubMed Web of Science ®Google Scholar
• Tullie LG , SohnHM, ZylstraJet al. A role for tumor volume assessment in resectable esophageal cancer. Ann. Surg. Oncol. 23(9), 3063–3070 (2016).
   PubMed Web of Science ®Google Scholar
• Zhang M , CuiM, ZuoQet al. Construction and evaluation of prognostic models for esophageal cancer patients with distant and non-distant metastases: providing a reference process for clinical diagnosis and treatment. J. Gastrointest. Oncol. 12(4), 1241–1254 (2021).
   PubMed Web of Science ®Google Scholar
• Xu L , ChenXK, XieHNet al. Treatment and prognosis of resectable cervical esophageal cancer: a population-based study. Ann. Thorac. Surg. 113(6), 1873–1881 (2022).
   PubMed Web of Science ®Google Scholar
• Liao G , ZhaoZ, YangHet al. Can prognostic nutritional index be a prediction factor in esophageal cancer?: A meta-analysis. Nutr. Cancer 72(2), 187–193 (2020).
   PubMed Web of Science ®Google Scholar
• Kawazoe K , IsomotoH, YamaguchiNet al. Effects of photodynamic therapy for superficial esophageal squamous cell carcinoma in vivo and in vitro . Oncol. Lett. 1(5), 877–882 (2010).
   PubMed Web of Science ®Google Scholar
• Créhange G , BossetM, LorchelFet al. Tumor volume as outcome determinant in patients treated with chemoradiation for locally advanced esophageal cancer. Am. J. Clin. Oncol. 29(6), 583–587 (2006).
   PubMed Web of Science ®Google Scholar
• Chen Y , ZhangZ, JiangGet al. Gross tumor volume is the prognostic factor for squamous cell esophageal cancer patients treated with definitive radiotherapy. J. Thorac. Dis. 8(6), 1155–1161 (2016).
   PubMed Web of Science ®Google Scholar
• Boggs DH , HannaA, BurrowsWet al. Primary gross tumor volume is an important prognostic factor in locally advanced esophageal cancer patients treated with trimodality therapy. J. Gastrointest. Cancer 46(2), 131–137 (2015).
   PubMedGoogle Scholar
• Lv J , GanH, ZhangWet al. Relative tumor volume is a better independent prognostic factor in esophageal squamous cell carcinoma: results of a retrospective study. Medicine (Baltimore) 98(14), e14963 (2019).
   PubMed Web of Science ®Google Scholar
• Camp RL , Dolled-FilhartM, RimmDL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization.Clin. Cancer Res.10(21), 7252–7259 (2004).
   PubMed Web of Science ®Google Scholar
• Chen H , WuS, HuJet al. Prognostic models for nonmetastatic triple-negative breast cancer based on the pretreatment serum tumor markers with machine learning. J. Oncol. 2021, 6641421 (2021).
   PubMed Web of Science ®Google Scholar
• Huang AC , PostowMA, OrlowskiRJet al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature 545(7652), 60–65 (2017).
   PubMed Web of Science ®Google Scholar
• Popat V , LuR, AhmedMet al. Lack of association between radiographic tumor burden and efficacy of immune checkpoint inhibitors in advanced lung cancer. Oncologist 25(6), 515–522 (2020).
   PubMed Web of Science ®Google Scholar
• Xu H , WuS, LuoHet al. Prognostic value of tumor length and diameter for esophageal squamous cell cancer patients treated with definitive (chemo)radiotherapy: potential indicators for nonsurgical T staging. Cancer Med. 8(14), 6326–6334 (2019).
   PubMed Web of Science ®Google Scholar
• Mirinezhad SK , JangjooAG, SeyednejadFet al. Impact of tumor length on survival for patients with resected esophageal cancer. Asian Pac. J. Cancer Prev. 15(2), 691–694 (2014).
   PubMedGoogle Scholar
• Lee YH , HsiaCY, HsuCYet al. Total tumor volume is a better marker of tumor burden in hepatocellular carcinoma defined by the Milan criteria. World J. Surg. 37(6), 1348–1355 (2013).
   PubMed Web of Science ®Google Scholar
• Cho CJ , SongHJ, LeeGHet al. Clinical implications of endoscopic ultrasonography non-traversability in patients with locoregional esophageal cancer receiving multimodality therapy. Korean J. Intern. Med. 32(3), 443–451 (2017).
   PubMed Web of Science ®Google Scholar
• Dong J , ZhangW, ZhangTet al. Baseline nutritional status could be a predictor for radiation esophagitis in esophageal cancer patients undergoing radiotherapy. Ann. Transl. Med. 8(18), 1148 (2020).
   PubMed Web of Science ®Google Scholar
• Morgan MA , TwineCP, LewisWGet al. Prognostic significance of failure to cross esophageal tumors by endoluminal ultrasound. Dis. Esophagus 21(6), 508–513 (2008).
   PubMed Web of Science ®Google Scholar
• Mariette C , BalonJM, MaunouryVet al. Value of endoscopic ultrasonography as a predictor of long-term survival in oesophageal carcinoma. Br. J. Surg. 90(11), 1367–1372 (2003).
   PubMed Web of Science ®Google Scholar
• Hiele M , DeLeyn P, SchurmansPet al. Relation between endoscopic ultrasound findings and outcome of patients with tumors of the esophagus or esophagogastric junction. Gastrointest. Endosc. 45(5), 381–386 (1997).
   PubMed Web of Science ®Google Scholar
• Okuno T , WakabayashiM, KatoKet al. Esophageal stenosis and the Glasgow Prognostic Score as independent factors of poor prognosis for patients with locally advanced unresectable esophageal cancer treated with chemoradiotherapy (exploratory analysis of JCOG0303). Int. J. Clin. Oncol. 22(6), 1042–1049 (2017).
   PubMed Web of Science ®Google Scholar
• Javle M , AilawadhiS, YangGYet al. Palliation of malignant dysphagia in esophageal cancer: a literature-based review. J. Support. Oncol. 4(8), 365–373, 379 (2006).
   PubMedGoogle Scholar
• Kim JW , KimTH, KimJHet al. Predictors of post-treatment stenosis in cervical esophageal cancer undergoing high-dose radiotherapy. World J. Gastroenterol. 24(7), 862–869 (2018).
   PubMed Web of Science ®Google Scholar
• Atsumi K , ShioyamaY, ArimuraHet al. Esophageal stenosis associated with tumor regression in radiotherapy for esophageal cancer: frequency and prediction. Int. J. Radiat. Oncol. Biol. Phys. 82(5), 1973–1980 (2012).
   PubMed Web of Science ®Google Scholar
• Remy J , WegrowskiJ, CrechetFet al. Long-term overproduction of collagen in radiation-induced fibrosis. Radiat. Res. 125(1), 14–19 (1991).
   PubMed Web of Science ®Google Scholar
• King SN , DunlapNE, TennantPAet al. Pathophysiology of radiation-induced dysphagia in head and neck cancer. Dysphagia 31(3), 339–351 (2016).
   PubMed Web of Science ®Google Scholar
• Wegrowski J , LefaixJL, LafumaC. Accumulation of glycosaminoglycans in radiation-induced muscular fibrosis.Int. J. Radiat. Biol.61(5), 685–693 (1992).
   PubMed Web of Science ®Google Scholar
• Guthrie GJ , CharlesKA, RoxburghCSet al. The systemic inflammation-based neutrophil–lymphocyte ratio: experience in patients with cancer. Crit. Rev. Oncol. Hematol. 88(1), 218–230 (2013).
   PubMed Web of Science ®Google Scholar
• Takata T , HiraiH, ShigemotoTet al. The release of glutamate and accumulation of intracellular calcium in the guinea pig hippocampal slices during glucose deprivation. Neurosci. Lett. 189(1), 21–24 (1995).
   PubMed Web of Science ®Google Scholar
• Colloca G , VenturinoA. Peripheral blood cell variables related to systemic inflammation in patients with unresectable or metastatic pancreatic cancer: a systematic review and meta-analysis.Pancreas50(8), 1131–1136 (2021).
   PubMed Web of Science ®Google Scholar
• Kawashita Y , KitamuraM, SoutomeSet al. Association of neutrophil-to-lymphocyte ratio with severe radiation-induced mucositis in pharyngeal or laryngeal cancer patients: a retrospective study. BMC Cancer 21(1), 1064 (2021).
   PubMed Web of Science ®Google Scholar
• Coia LR , MyersonRJ, TepperJE. Late effects of radiation therapy on the gastrointestinal tract.Int. J. Radiat. Oncol. Biol. Phys.31(5), 1213–1236 (1995).
   PubMed Web of Science ®Google Scholar
• Murro D , JakateS. Radiation esophagitis.Arch. Pathol. Lab. Med.139(6), 827–830 (2015).
   PubMed Web of Science ®Google Scholar
• Giese MA , HindLE, HuttenlocherA. Neutrophil plasticity in the tumor microenvironment.Blood133(20), 2159–2167 (2019).
   PubMed Web of Science ®Google Scholar
• Damera G , JesterWF, JiangMet al. Inhibition of myristoylated alanine-rich C kinase substrate (MARCKS) protein inhibits ozone-induced airway neutrophilia and inflammation. Exp. Lung Res. 36(2), 75–84 (2010).
   PubMed Web of Science ®Google Scholar
• Bronze-da-Rocha E , Santos-SilvaA. Neutrophil elastase inhibitors and chronic kidney disease.Int. J. Biol. Sci.14(10), 1343–1360 (2018).
   PubMed Web of Science ®Google Scholar
• Kuo C , HsuehWT, WuYHet al. The role of pretreatment serum neutrophil-to-lymphocyte ratio in hypopharyngeal cancer treated with definitive chemoradiotherapy: a pilot study. Sci. Rep. 9(1), 1618 (2019).
   PubMedGoogle Scholar
• Suppiah A , MaldeD, ArabTet al. The prognostic value of the neutrophil-lymphocyte ratio (NLR) in acute pancreatitis: identification of an optimal NLR. J. Gastrointest. Surg. 17(4), 675–681 (2013).
   PubMed Web of Science ®Google Scholar
• Herzberg H , LifshitzK. Association between early change in neutrophil-to-lymphocyte ratio after radical cystectomy and treatment outcomes.BJU Int.130(4), 470–477 (2022).
   PubMed Web of Science ®Google Scholar
• Tanrikulu Y , SenTanrikulu C, SabuncuogluMZet al. Is the neutrophil-to-lymphocyte ratio a potential diagnostic marker for peptic ulcer perforation? A retrospective cohort study. Am. J. Emerg. Med. 34(3), 403–406 (2016).
   PubMed Web of Science ®Google Scholar
• De Larco JE , WuertzBR, FurchtLT. The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8.Clin. Cancer Res.10(15), 4895–4900 (2004).
   PubMed Web of Science ®Google Scholar
• Davis JL , LanganRC, PanageasKSet al. Elevated blood neutrophil-to-lymphocyte ratio: a readily available biomarker associated with death due to disease in high risk nonmetastatic melanoma. Ann. Surg. Oncol. 24(7), 1989–1996 (2017).
   PubMed Web of Science ®Google Scholar
• Mitamura A , KanetaT, MiyataGet al. Positive correlations between tumor uptake on FDG PET and energy expenditure of patients with esophageal cancer. Ann. Nucl. Med. 25(4), 241–246 (2011).
   PubMed Web of Science ®Google Scholar
• Peng J , CaiJ, NiuZXet al. Early enteral nutrition compared with parenteral nutrition for esophageal cancer patients after esophagectomy: a meta-analysis. Dis. Esophagus 29(4), 333–341 (2016).
   PubMed Web of Science ®Google Scholar
• Lyu J , LiT, XieCet al. Enteral nutrition in esophageal cancer patients treated with radiotherapy: a Chinese expert consensus 2018. Future Oncol. 15(5), 517–531 (2019).
   PubMed Web of Science ®Google Scholar
• Furuta M , YokotaT, TsushimaTet al. Comparison of enteral nutrition with total parenteral nutrition for patients with locally advanced unresectable esophageal cancer harboring dysphagia in definitive chemoradiotherapy. Jpn J. Clin. Oncol. 49(10), 910–918 (2019).
   PubMed Web of Science ®Google Scholar
• Kita R , MiyataH, SugimuraKet al. Clinical effect of enteral nutrition support during neoadjuvant chemotherapy on the preservation of skeletal muscle mass in patients with esophageal cancer. Clin. Nutr. 40(6), 4380–4385 (2021).
   PubMed Web of Science ®Google Scholar
• de la Mora Levy JG , Manzano-RobledaMDC. Nutrition before chemoradiotherapy or surgery: temporary esophageal stents or tube feeding? Is the evidence hard to swallow?Gastrointest. Endosc.88(1), 32–34 (2018).
   PubMed Web of Science ®Google Scholar
• Yu FJ , ShihHY, WuCYet al. Enteral nutrition and quality of life in patients undergoing chemoradiotherapy for esophageal carcinoma: a comparison of nasogastric tube, esophageal stent, and ostomy tube feeding. Gastrointest. Endosc. 88(1), 21–31; e24 (2018).
   PubMed Web of Science ®Google Scholar
• Wiggenraad RG , FliermanL, GoossensAet al. Prophylactic gastrostomy placement and early tube feeding may limit loss of weight during chemoradiotherapy for advanced head and neck cancer, a preliminary study. Clin. Otolaryngol. 32(5), 384–390 (2007).
   PubMed Web of Science ®Google Scholar
• Caudell JJ , SchanerPE, MeredithRFet al. Factors associated with long-term dysphagia after definitive radiotherapy for locally advanced head-and-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 73(2), 410–415 (2009).
   PubMed Web of Science ®Google Scholar
• Mazurek M , MlakR. Polymorphism of the regulatory region of the ITGAM gene (-323G>A) as a novel predictor of a poor nutritional status in head and neck cancer patients subjected to intensity-modulated radiation therapy.J. Clin. Med.9(12), 4041 (2020).
   PubMed Web of Science ®Google Scholar
• Tsitkanou S , MurachKA, WashingtonTA. Exercise counteracts the deleterious effects of cancer cachexia.Cancers (Basel)14(10), 2512 (2022).
   PubMed Web of Science ®Google Scholar
• Santarpia L , ContaldoF, PasanisiF. Nutritional screening and early treatment of malnutrition in cancer patients.J. Cachexia Sarcopenia Muscle2(1), 27–35 (2011).
   PubMed Web of Science ®Google Scholar