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Review

Etiologic Factors in Testicular Germ-Cell Tumors

Katherine A McGlynna Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Suite 550, 6120 Executive Boulevard, Rockville, MD20852-7234, USA. [email protected]Correspondence[email protected]
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Michael B Cookb National Cancer Institute, MD, USAView further author information
Pages 1389-1402 | Published online: 10 Nov 2009

Bibliography

  • Skakkebaek NE : Possible carcinoma-in-situ of the testis.Lancet2, 516–517 (1972).
  • Oosterhuis JW , LooijengaLH: Testicular germ-cell tumours in a broader perspective.Nat. Rev. Cancer5, 210–222 (2005).
  • Rajpert-De Meyts E , JorgensenN, Brondum-NielsenK, MullerJ, SkakkebaekNE: Developmental arrest of germ cells in the pathogenesis of germ cell neoplasia.APMIS106, 198–204; discussion 204–206 (1998).
  • Honecker F , StoopH, de KrijgerRR, Chris LauYF, BokemeyerC, LooijengaLH: Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells.J. Pathol.203, 849–857 (2004).
  • Sonne SB , AlmstrupK, DalgaardMet al.: Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte.Cancer Res.69, 5241–5250 (2009).
  • Almstrup K , SonneSB, Hoei-HansenCEet al.: From embryonic stem cells to testicular germ cell cancer – should we be concerned?Int. J. Androl.29, 211–218 (2006).
  • Stoop H , van GurpR, de KrijgerRet al.: Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications.Lab. Invest.81, 919–928 (2001).
  • Rajpert-De Meyts E , JacobsenGK, BartkovaJet al.: The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma.Histopathology42, 217–226 (2003).
  • Carriere P , BaadeP, FritschiL: Population based incidence and age distribution of spermatocytic seminoma.J. Urol.178(1), 125–128 (2007).
  • Ferlay J , BrayF, PisaniP, ParkinDM: GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide. IARC CancerBase No. 5. version 2.0 ed., IARC Press, Lyon, France (2004).
  • Parkin DM , WhelanSL, FerlayJ, TeppoL, ThomasDB (Eds): Cancer Incidence in Five Continents Volume VIII. IARC Scientific Publication No 155., IARC Press, Lyon, France (2002).
  • Shah MN , DevesaSS, ZhuK, McGlynnKA: Trends in testicular germ cell tumours by ethnic group in the United States.Int. J. Androl.30, 206–213; discussion 213–214 (2007).
  • Weir HK , MarrettLD, MoravanV: Trends in the incidence of testicular germ cell cancer in Ontario by histologic subgroup, 1964–1996.CMAJ160, 201–205 (1999).
  • Wanderas EH , TretliS, FossaSD: Trends in incidence of testicular cancer in Norway 1955–1992.Eur. J. Cancer31A, 2044–2048 (1995).
  • Bergstrom R , AdamiHO, MohnerMet al.: Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon.J. Natl Cancer Inst.88, 727–733 (1996).
  • Stone JM , CruickshankDG, SandemanTF, MatthewsJP: Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia.Br. J. Cancer64, 132–138 (1991).
  • Ekbom A , AkreO: Increasing incidence of testicular cancer – birth cohort effects.APMIS106, 225–229; discussion 229–231 (1998).
  • McGlynn KA , DevesaSS, SigurdsonAJ, BrownLM, TsaoL, TaroneRE: Trends in the incidence of testicular germ cell tumors in the United States.Cancer97, 63–70 (2003).
  • Moller H : Decreased testicular cancer risk in men born in wartime.J. Natl Cancer Inst.81, 1668–1669 (1989).
  • Fossa SD , ChromoJ, SchonfeldSJet al.: Risk of contralateral testicular cancer: a population-based study of 29,515 US men.J. Natl Cancer Inst.97, 1056–1066 (2005).
  • Coupland CA , ChilversCE, DaveyG, PikeMC, OliverRT, FormanD: Risk factors for testicular germ cell tumours by histological tumour type. United Kingdom Testicular Cancer Study Group.Br. J. Cancer80, 1859–1863 (1999).
  • Dieckmann KP , PichlmeierU: Clinical epidemiology of testicular germ cell tumors.World J. Urol.22, 2–14 (2004).
  • Coupland CA , FormanD, ChilversCE, DaveyG, PikeMC, OliverRT: Maternal risk factors for testicular cancer: a population-based case–control study (UK).Cancer Causes Control15, 277–283 (2004).
  • Gallagher RP , HuchcroftS, PhillipsNet al.: Physical activity, medical history, and risk of testicular cancer (Alberta and British Columbia, Canada).Cancer Causes Control6, 398–406 (1995).
  • Moller H , PrenerA, SkakkebaekNE: Testicular cancer, cryptorchidism, inguinal hernia, testicular atrophy, and genital malformations: case–control studies in Denmark.Cancer Causes Control7, 264–274 (1996).
  • Swerdlow AJ , HigginsCD, PikeMC: Risk of testicular cancer in cohort of boys with cryptorchidism.BMJ314, 1507–1511 (1997).
  • Moller H , CortesD, EngholmG, ThorupJ: Risk of testicular cancer with cryptorchidism and with testicular biopsy: cohort study.BMJ317, 729 (1998).
  • Swerdlow AJ , HuttlySR, SmithPG: Testicular cancer and antecedent diseases.Br. J. Cancer55, 97–103 (1987).
  • Haughey BP , GrahamS, BrasureJ, ZieleznyM, SufrinG, BurnettWS: The epidemiology of testicular cancer in upstate New York.Am. J. Epidemiol.130, 25–36 (1989).
  • Oliver RT : Atrophy, hormones, genes and viruses in aetiology germ cell tumours.Cancer Surv.9, 263–286 (1990).
  • Skakkebaek NE , Rajpert-De MeytsE, MainKM: Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects.Hum. Reprod.16, 972–978 (2001).
  • Wohlfahrt-Veje C , MainKM, SkakkebaekNE: Testicular dysgenesis syndrome; fetal origin of adult reproductive problems.Clin. Endocrinol. (Oxf)71(4), 459–465 (2009).
  • Sharpe RM , SkakkebaekNE: Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects.Fertil. Steril.89, E33–E38 (2008).
  • Batata MA , ChuFC, HilarisBS, WhitmoreWF, GolbeyRB: Testicular cancer in cryptorchids.Cancer49, 1023–1030 (1982).
  • Moller H , SkakkebaekNE: Risks of testicular cancer and cryptorchidism in relation to socio-economic status and related factors: case–control studies in Denmark.Int. J. Cancer66, 287–293 (1996).
  • Berkowitz GS , LapinskiRH, GodboldJH, DolginSE, HolzmanIR: Maternal and neonatal risk factors for cryptorchidism.Epidemiology6, 127–131 (1995).
  • McGlynn KA , DevesaSS, GraubardBI, CastlePE: Increasing incidence of testicular germ cell tumors among black men in the United States.J. Clin. Oncol.23, 5757–5761 (2005).
  • Ginsburg J : Unanswered questions in carcinoma of the testis.Lancet349, 1785–1786 (1997).
  • United Kingdom Testicular Cancer Study Group : Aetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exercise.BMJ308, 1393–1399 (1994).
  • Pettersson A , RichiardiL, NordenskjoldA, KaijserM, AkreO: Age at surgery for undescended testis and risk of testicular cancer.N. Engl. J. Med.356, 1835–1841 (2007).
  • Tuazon E , BanksK, KohCJet al.: Re: prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer.J. Urol.180, 783–784; author reply 784–785 (2008).
  • Dusek L , AbrahamovaJ, LakomyRet al.: Multivariate analysis of risk factors for testicular cancer: a hospital-based case–control study in the Czech Republic.Neoplasma55, 356–368 (2008).
  • Chilvers CED , PikeMC: Epidemiology of undescended testis. In: Urological and Genital Cancer. Oliver RTD, Blandy JP, Hope-Stone HF (Eds). Blackwell Scientific Publications, Oxford, UK, 306–321 (1989).
  • Raman JD , NobertCF, GoldsteinM: Increased incidence of testicular cancer in men presenting with infertility and abnormal semen analysis.J. Urol.174, 1819–1822; discussion 1822 (2005).
  • Jacobsen R , BostofteE, EngholmGet al.: Risk of testicular cancer in men with abnormal semen characteristics: cohort study.BMJ321, 789–792 (2000).
  • Petersen PM , SkakkebaekNE, VistisenK, RorthM, GiwercmanA: Semen quality and reproductive hormones before orchiectomy in men with testicular cancer.J. Clin. Oncol.17, 941–947 (1999).
  • Lass A , AkagbosuF, AbusheikhaNet al.: A programme of semen cryopreservation for patients with malignant disease in a tertiary infertility centre: lessons from 8 years’ experience.Hum. Reprod.13, 3256–3261 (1998).
  • Carlsen E , GiwercmanA, KeidingN, SkakkebaekNE: Evidence for decreasing quality of semen during past 50 years.BMJ305, 609–613 (1992).
  • Olsen GW , BodnerKM, RamlowJM, RossCE, LipshultzLI: Have sperm counts been reduced 50 percent in 50 years? A statistical model revisited.Fertil. Steril.63, 887–893 (1995).
  • Fisch H , GoluboffET: Geographic variations in sperm counts: a potential cause of bias in studies of semen quality.Fertil. Steril.65, 1044–1046 (1996).
  • Fisch H , GoluboffET, OlsonJH, FeldshuhJ, BroderSJ, BaradDH: Semen analyses in 1283 men from the United States over a 25-year period: no decline in quality.Fertil. Steril.65, 1009–1014 (1996).
  • Becker S , BerhaneK: A meta-analysis of 61 sperm count studies revisited.Fertil. Steril.67, 1103–1108 (1997).
  • Lerchl A , NieschlagE: Decreasing sperm counts? A critical (re)view.Exp. Clin. Endocrinol. Diabetes104, 301–307 (1996).
  • Swan SH , ElkinEP, FensterL: Have sperm densities declined? A reanalysis of global trend data.Environ. Health Perspect.105, 1228–1232 (1997).
  • Safe SH : Endocrine disruptors and human health – is there a problem? An update.Environ. Health Perspect.108, 487–493 (2000).
  • Hughes IA , HoukC, AhmedSF, LeePA: Consensus statement on management of intersex disorders.J. Pediatr. Urol.2, 148–162 (2006).
  • Cools M , DropSL, WolffenbuttelKP, OosterhuisJW, LooijengaLH: Germ cell tumors in the intersex gonad: old paths, new directions, moving frontiers.Endocr. Rev.27, 468–484 (2006).
  • Ahlgren M , WohlfahrtJ, OlsenLW, SorensenTI, MelbyeM: Birth weight and risk of cancer.Cancer (2007).
  • Akre O , EkbomA, HsiehCC, TrichopoulosD, AdamiHO: Testicular nonseminoma and seminoma in relation to perinatal characteristics.J. Natl Cancer Inst.88, 883–889 (1996)
  • Brown LM , PotternLM, HooverRN: Prenatal and perinatal risk factors for testicular cancer.Cancer Res.46, 4812–4816 (1986).
  • Depue RH , PikeMC, HendersonBE: Estrogen exposure during gestation and risk of testicular cancer.J. Natl Cancer Inst.71, 1151–1155 (1983).
  • Moller H , SkakkebaekNE: Testicular cancer and cryptorchidism in relation to prenatal factors: case–control studies in Denmark.Cancer Causes Control8, 904–912 (1997).
  • Richiardi L , PetterssonA, AkreO: Genetic and environmental risk factors for testicular cancer.Int. J. Androl. (2007).
  • Richiardi L , AkreO, BelloccoR, EkbomA: Perinatal determinants of germ-cell testicular cancer in relation to histological subtypes.Br. J. Cancer87, 545–550 (2002).
  • Gershman ST , StolleyPD: A case–control study of testicular cancer using Connecticut tumour registry data.Int. J. Epidemiol.17, 738–742 (1988).
  • Klebanoff MA : Gestational age: not always what it seems.Obstet. Gynecol.109, 798–799 (2007).
  • Dieckmann KP , EndsinG, PichlmeierU: How valid is the prenatal estrogen excess hypothesis of testicular germ cell cancer? A case–control study on hormone-related factors.Eur. Urol.40, 677–683; discussion 684 (2001).
  • Aschim EL , HaugenTB, TretliS, DaltveitAK, GrotmolT: Risk factors for testicular cancer – differences between pure non-seminoma and mixed seminoma/non-seminoma?Int. J. Androl.29, 458–467 (2006).
  • Cook MB , GraubardBI, RubertoneMV, EricksonRL, McGlynnKA: Perinatal factors and the risk of testicular germ cell tumors.Int. J. Cancer122, 2600–2606 (2008).
  • Sabroe S , OlsenJ: Perinatal correlates of specific histological types of testicular cancer in patients below 35 years of age: a case-cohort study based on midwives’ records in Denmark.Int. J. Cancer78, 140–143 (1998).
  • English PB , GoldbergDE, WolffC, SmithD: Parental and birth characteristics in relation to testicular cancer risk among males born between 1960 and 1995 in California (United States).Cancer Causes Control14, 815–825 (2003).
  • Wanderas EH , GrotmolT, FossaSD, TretliS: Maternal health and pre- and perinatal characteristics in the etiology of testicular cancer: a prospective population- and register-based study on Norwegian males born between 1967 and 1995.Cancer Causes Control9, 475–486 (1998).
  • Swerdlow AJ , StillerCA, WilsonLM: Prenatal factors in the aetiology of testicular cancer: an epidemiological study of childhood testicular cancer deaths in Great Britain, 1953–1973.J. Epidemiol. Community Health36, 96–101 (1982).
  • Weir HK , MarrettLD, KreigerN, DarlingtonGA, SugarL: Pre-natal and peri-natal exposures and risk of testicular germ-cell cancer.Int. J. Cancer87, 438–443 (2000).
  • Sonke GS , ChangS, StromSS, SweeneyAM, AnnegersJF, SigurdsonAJ: Prenatal and perinatal risk factors and testicular cancer: a hospital-based case–control study.Oncol. Res.16, 383–387 (2007).
  • Swerdlow AJ , HuttlySR, SmithPG: Prenatal and familial associations of testicular cancer.Br. J. Cancer55, 571–577 (1987).
  • Prener A , HsiehCC, EngholmG, TrichopoulosD, JensenOM: Birth order and risk of testicular cancer.Cancer Causes Control3, 265–272 (1992).
  • Westergaard T , AndersenPK, PedersenJB, FrischM, OlsenJH, MelbyeM: Testicular cancer risk and maternal parity: a population-based cohort study.Br. J. Cancer77, 1180–1185 (1998).
  • Richiardi L , AkreO, LambeM, GranathF, MontgomerySM, EkbomA: Birth order, sibship size, and risk for germ-cell testicular cancer.Epidemiology15, 323–329 (2004).
  • Sharpe RM : The ‘oestrogen hypothesis’ – where do we stand now?Int. J. Androl.26, 2–15 (2003).
  • Altieri A , HemminkiK: Number of siblings and the risk of solid tumours: a nation-wide study.Br. J. Cancer96, 1755–1759 (2007).
  • Morrison AS : Some social and medical characteristics of Army men with testicular cancer.Am. J. Epidemiol.104, 511–516 (1976).
  • Clemmesen J : Is pregnancy smoking causal to testis cancer in sons? A hypothesis.Acta Oncol.36, 59–63 (1997).
  • Pettersson A , KaijserM, RichiardiL, AsklingJ, EkbomA, AkreO: Women smoking and testicular cancer: one epidemic causing another?Int. J. Cancer109, 941–944 (2004).
  • Henderson BE , BentonB, JingJ, YuMC, PikeMC: Risk factors for cancer of the testis in young men.Int. J. Cancer23, 598–602 (1979).
  • Moller MB : Association of testicular non-Hodgkin’s lymphomas with elevated serum levels of human chorionic gonadotropin-like material.Oncology53, 94–98 (1996).
  • McGlynn KA , ZhangY, SakodaLC, RubertoneMV, EricksonRL, GraubardBI: Maternal smoking and testicular germ cell tumors.Cancer Epidemiol. Biomarkers Prev.15, 1820–1824 (2006).
  • Pettersson A , AkreO, RichiardiL, EkbomA, KaijserM: Maternal smoking and the epidemic of testicular cancer – a nested case–control study.Int. J. Cancer120, 2044–2046 (2007).
  • Tuomisto J , HollK, RantakokkoPet al.: Maternal smoking during pregnancy and testicular cancer in the sons: a nested case–control study and a meta-analysis.Eur. J. Cancer45, 1640–1648 (2009).
  • Aschim EL , GrotmolT, TretliS, HaugenTB: Is there an association between maternal weight and the risk of testicular cancer? An epidemiologic study of Norwegian data with emphasis on World War II.Int. J. Cancer116, 327–330 (2005).
  • Hemminki K , LiX: Cancer risks in twins: results from the Swedish family-cancer database.Int. J. Cancer99, 873–878 (2002).
  • Patja K , PukkalaE, SundR, IivanainenM, KaskiM: Cancer incidence of persons with Down syndrome in Finland: a population-based study.Int. J. Cancer118, 1769–1772 (2006).
  • Petridou E , RoukasKI, DessyprisNet al.: Baldness and other correlates of sex hormones in relation to testicular cancer.Int. J. Cancer71, 982–985 (1997).
  • Bernstein L , DepueRH, RossRK, JuddHL, PikeMC, HendersonBE: Higher maternal levels of free estradiol in first compared with second pregnancy: early gestational differences.J. Natl Cancer Inst.76, 1035–1039 (1986).
  • Henderson BE , RossR, BernsteinL: Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture.Cancer Res.48, 246–253 (1988).
  • Sharpe RM , SkakkebaekNE: Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?Lancet341, 1392–1395 (1993).
  • Henderson BE , BernsteinL, RossRK, DepueRH, JuddHL: The early in utero oestrogen and testosterone environment of blacks and whites: potential effects on male offspring.Br. J. Cancer57, 216–218 (1988).
  • Burton MH , DaviesTW, RaggattPR: Undescended testis and hormone levels in early pregnancy.J. Epidemiol. Community Health41, 127–129 (1987).
  • Key TJ , BullD, AnsellPet al.: A case–control study of cryptorchidism and maternal hormone concentrations in early pregnancy.Br. J. Cancer73, 698–701 (1996).
  • Bernstein L , PikeMC, DepueRH, RossRK, MooreJW, HendersonBE: Maternal hormone levels in early gestation of cryptorchid males: a case–control study.Br. J. Cancer58, 379–381 (1988).
  • McGlynn KA , GraubardBI, NamJM, StanczykFZ, LongneckerMP, KlebanoffMA: Maternal hormone levels and risk of cryptorchism among populations at high and low risk of testicular germ cell tumors.Cancer Epidemiol. Biomarkers Prev.14, 1732–1737 (2005).
  • Loughlin JE , RobboySJ, MorrisonAS: Risk factors for cancer of the testis.N. Engl. J. Med.303, 112–113 (1980).
  • Strohsnitter WC , NollerKL, HooverRNet al.: Cancer risk in men exposed in utero to diethylstilbestrol.J. Natl Cancer Inst.93, 545–551 (2001).
  • Moss AR , OsmondD, BacchettiP, TortiFM, GurginV: Hormonal risk factors in testicular cancer. A case–control study.Am. J. Epidemiol.124, 39–52 (1986).
  • Newbold RR : Lessons learned from perinatal exposure to diethylstilbestrol.Toxicol. Appl. Pharmacol.199, 142–150 (2004).
  • Golden RJ , NollerKL, Titus-ErnstoffLet al.: Environmental endocrine modulators and human health: an assessment of the biological evidence.Crit. Rev. Toxicol.28, 109–227 (1998).
  • Kavlock RJ , DastonGP, DeRosaCet al.: Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the US EPA-sponsored workshop.Environ. Health Perspect.104(Suppl. 4), 715–740 (1996).
  • Pflieger-Bruss S , SchuppeHC, SchillWB: The male reproductive system and its susceptibility to endocrine disrupting chemicals.Andrologia36, 337–345 (2004).
  • Hardell L , van BavelB, LindstromGet al.: Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.Environ. Health Perspect.111, 930–934 (2003).
  • McGlynn KA , QuraishiSM, GraubardBI, WeberJP, RubertoneMV, EricksonRL: Persistent organochlorine pesticides and risk of testicular germ cell tumors.J. Natl Cancer Inst.100, 663–671 (2008).
  • McGlynn KA , QuraishiSM, GraubardBI, WeberJP, RubertoneMV, EricksonRL: Polychlorinated biphenyls and risk of testicular germ cell tumors.Cancer Res.69, 1901–1909 (2009).
  • Biggs ML , DavisMD, EatonDLet al.: Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case–control study.Cancer Epidemiol. Biomarkers Prev.17, 2012–2018 (2008).
  • Akre O , EkbomA, SparenP, TretliS: Body size and testicular cancer.J. Natl Cancer Inst.92, 1093–1096 (2000).
  • Garner MJ , BirkettNJ, JohnsonKC, ShatensteinB, GhadirianP, KrewskiD: Dietary risk factors for testicular carcinoma.Int. J. Cancer106, 934–941 (2003).
  • Dieckmann KP , HartmannJT, ClassenJ, DiederichsM, PichlmeierU: Is increased body mass index associated with the incidence of testicular germ cell cancer?J. Cancer Res. Clin. Oncol.135, 731–738 (2009).
  • Davies TW , PrenerA, EngholmG: Body size and cancer of the testis.Acta Oncol.29, 287–290 (1990).
  • Dieckmann KP , PichlmeierU: Is risk of testicular cancer related to body size?Eur. Urol.42, 564–569 (2002).
  • Rasmussen F , GunnellD, EkbomA, HallqvistJ, TyneliusP: Birth weight, adult height, and testicular cancer: cohort study of 337,249 Swedish young men.Cancer Causes Control14, 595–598 (2003).
  • Richiardi L , AsklingJ, GranathF, AkreO: Body size at birth and adulthood and the risk for germ-cell testicular cancer.Cancer Epidemiol. Biomarkers Prev.12, 669–673 (2003).
  • Srivastava A , KreigerN: Relation of physical activity to risk of testicular cancer.Am. J. Epidemiol.151, 78–87 (2000).
  • Thune I , LundE: Physical activity and the risk of prostate and testicular cancer: a cohort study of 53,000 Norwegian men.Cancer Causes Control5, 549–556 (1994).
  • Whittemore AS , PaffenbargerRSJr, AndersonK, LeeJE: Early precursors of urogenital cancers in former college men.J. Urol.132, 1256–1261 (1984).
  • Bjorge T , TretliS, LieAK, EngelandA: The impact of height and body mass index on the risk of testicular cancer in 600,000 Norwegian men.Cancer Causes Control17, 983–987 (2006).
  • McGlynn KA , SakodaLC, RubertoneMVet al.: Body size, dairy consumption, puberty, and risk of testicular germ cell tumors.Am. J. Epidemiol.165, 355–363 (2007).
  • Dieckmann KP , HartmannJT, ClassenJ, LuddeR, DiederichsM, PichlmeierU: Tallness is associated with risk of testicular cancer: evidence for the nutrition hypothesis.Br. J. Cancer99, 1517–1521 (2008).
  • Swerdlow AJ , HuttlySR, SmithPG: Testis cancer: post-natal hormonal factors, sexual behaviour and fertility.Int. J. Cancer43, 549–553 (1989).
  • Zavos C , AndreadisC, DiamantopoulosN, MouratidouD: A hypothesis on the role of insulin-like growth factor I in testicular germ cell tumours.Med. Hypotheses63, 511–514 (2004).
  • Weir HK , KreigerN, MarrettLD: Age at puberty and risk of testicular germ cell cancer (Ontario, Canada).Cancer Causes Control9, 253–258 (1998).
  • Armstrong B , DollR: Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices.Int. J. Cancer15, 617–631 (1975).
  • Sigurdson AJ , ChangS, AnnegersJFet al.: A case–control study of diet and testicular carcinoma.Nutr. Cancer34, 20–26 (1999).
  • Decarli A , La VecchiaC: Environmental factors and cancer mortality in Italy: correlational exercise.Oncology43, 116–126 (1986).
  • Davies TW , PalmerCR, RujaE, LipscombeJM: Adolescent milk, dairy product and fruit consumption and testicular cancer.Br. J. Cancer74, 657–660 (1996).
  • Ganmaa D , LiXM, WangJ, QinLQ, WangPY, SatoA: Incidence and mortality of testicular and prostatic cancers in relation to world dietary practices.Int. J. Cancer98, 262–267 (2002).
  • Stang A , AhrensW, Baumgardt-ElmsCet al.: Adolescent milk fat and galactose consumption and testicular germ cell cancer.Cancer Epidemiol. Biomarkers Prev.15, 2189–2195 (2006).
  • Walcott FL , HauptmannM, DuphorneCM, PillowPC, StromSS, SigurdsonAJ: A case–control study of dietary phytoestrogens and testicular cancer risk.Nutr. Cancer44, 44–51 (2002).
  • Lee PA , BellingerMF, CoughlinMT: Correlations among hormone levels, sperm parameters and paternity in formerly unilaterally cryptorchid men.J. Urol.160, 1155–1157; discussion 1178 (1998).
  • United Kingdom Testicular Cancer Study Group : Social, behavioural and medical factors in the aetiology of testicular cancer: results from the UK study.Br. J. Cancer70, 513–520 (1994).
  • Cook MB , ZhangY, GraubardBI, RubertoneMV, EricksonRL, McGlynnKA: Risk of testicular germ-cell tumours in relation to childhood physical activity.Br. J. Cancer98, 174–178 (2008).
  • Dosemeci M , HayesRB, VetterRet al.: Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey.Cancer Causes Control4, 313–321 (1993).
  • Paffenbarger RS Jr , HydeRT, WingAL: Physical activity and incidence of cancer in diverse populations: a preliminary report.Am. J. Clin. Nutr.45, 312–317 (1987).
  • Bates MN : Registry-based case–control study of cancer in California firefighters.Am. J. Ind. Med.50, 339–344 (2007).
  • Stang A , JockelKH, Baumgardt-ElmsC, AhrensW: Firefighting and risk of testicular cancer: results from a German population-based case–control study.Am. J. Ind. Med.43, 291–294 (2003).
  • Pollan M , GustavssonP, CanoMI: Incidence of testicular cancer and occupation among Swedish men gainfully employed in 1970.Ann. Epidemiol.11, 554–562 (2001).
  • Rhomberg W , SchmollHJ, SchneiderB: High frequency of metalworkers among patients with seminomatous tumors of the testis: a case–control study.Am. J. Ind. Med.28, 79–87 (1995).
  • Marshall EG , MeliusJM, LondonMA, NascaPC, BurnettWS: Investigation of a testicular cancer cluster using a case–control approach.Int. J. Epidemiol.19, 269–273 (1990).
  • Ryder SJ , CrawfordPI, PethybridgeRJ: Is testicular cancer an occupational disease? A case–control study of Royal Naval personnel.J. R. Nav. Med. Serv.83, 130–146 (1997).
  • Foley S , MiddletonS, StitsonD, MahoneyM: The incidence of testicular cancer in Royal Air Force personnel.Br J. Urol.76, 495–496 (1995).
  • Hardell L , NasmanA, OhlsonCG, FredriksonM: case–control study on risk factors for testicular cancer.Int. J. Oncol.13, 1299–1303 (1998).
  • Moller H : Work in agriculture, childhood residence, nitrate exposure, and testicular cancer risk: a case–control study in Denmark.Cancer Epidemiol. Biomarkers Prev.6, 141–144 (1997).
  • Dement J , PompeiiL, LipkusIM, SamsaGP: Cancer incidence among union carpenters in New Jersey.J. Occup. Environ. Med.45, 1059–1067 (2003).
  • Andersson E , NilssonR, TorenK: Testicular cancer among Swedish pulp and paper workers.Am. J. Ind. Med.43, 642–646 (2003).
  • Knight JA , MarrettLD, WeirHK: Occupation and risk of germ cell testicular cancer by histologic type in Ontario.J. Occup. Environ. Med.38, 884–890 (1996).
  • Van den Eeden SK , WeissNS, StraderCH, DalingJR: Occupation and the occurrence of testicular cancer.Am. J. Ind. Med.19, 327–337 (1991).
  • Office of Population Censuses and Surveys (OPCS): Cancer statistics – registrations, 1987, England and Wales. HMSO, London, UK, Series MB1, No. 20 (1993).
  • Ross RK , McCurtisJW, HendersonBE, MenckHR, MackTM, MartinSP: Descriptive epidemiology of testicular and prostatic cancer in Los Angeles.Br. J. Cancer39, 284–292 (1979).
  • Pukkala E , WeiderpassE: Socio–economic differences in incidence rates of cancers of the male genital organs in Finland, 1971–1995.Int. J. Cancer102, 643–648 (2002).
  • Newell GR , MillsPK, JohnsonDE: Epidemiologic comparison of cancer of the testis and Hodgkin’s disease among young males.Cancer54, 1117–1123 (1984).
  • Logothetis CJ , NewellGR, SamuelsML: Testicular cancer in homosexual men with cellular immune deficiency: report of 2 cases.J. Urol.133, 484–486 (1985).
  • Goedert JJ , CoteTR, VirgoPet al.: Spectrum of AIDS-associated malignant disorders.Lancet351, 1833–1839 (1998).
  • Frisch M , BiggarRJ, EngelsEA, GoedertJJ: Association of cancer with AIDS-related immunosuppression in adults.JAMA285, 1736–1745 (2001).
  • Lyter DW , BryantJ, ThackerayR, RinaldoCR, KingsleyLA: Incidence of human immunodeficiency virus-related and nonrelated malignancies in a large cohort of homosexual men.J. Clin. Oncol.13, 2540–2546 (1995).
  • Gabutti G , VercelliM, De RosaMGet al.: AIDS related neoplasms in Genoa, Italy.Eur. J. Epidemiol.11, 609–614 (1995).
  • Algood CB , NewellGR, JohnsonDE: Viral etiology of testicular tumors.J. Urol.139, 308–310 (1988).
  • Mueller N , HinkulaJ, WahrenB: Elevated antibody titers against cytomegalovirus among patients with testicular cancer.Int. J. Cancer41, 399–403 (1988).
  • Akre O , LipworthL, TretliSet al.: Epstein–Barr virus and cytomegalovirus in relation to testicular-cancer risk: a nested case–control study.Int. J. Cancer82, 1–5 (1999).
  • Holl K , SurcelHM, KoskelaPet al.: Maternal Epstein–Barr virus and cytomegalovirus infections and risk of testicular cancer in the offspring: a nested case–control study.APMIS116, 816–822 (2008).
  • Muganda P , MendozaO, HernandezJ, QianQ: Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts.J. Virol.68, 8028–8034 (1994).
  • Morris JD , EddlestonAL, CrookT: Viral infection and cancer.Lancet346, 754–758 (1995).
  • Brown LM , PotternLM, HooverRN: Testicular cancer in young men: the search for causes of the epidemic increase in the United States.J. Epidemiol. Community Health41, 349–354 (1987).
  • Karagas MR , WeissNS, StraderCH, DalingJR: Elevated intrascrotal temperature and the incidence of testicular cancer in noncryptorchid men.Am. J. Epidemiol.129, 1104–1109 (1989).
  • Chilvers CE , PikeMC, PeckhamMJ: Torsion of the testis: a new risk factor for testicular cancer.Br. J. Cancer55, 105–106 (1987).
  • Moller H , SkakkebaekNE: Risk of testicular cancer in subfertile men: case–control study.BMJ318, 559–562 (1999).
  • Husson G , HerrintonLJ: Regarding ‘a case–control study of sexually transmitted disease and risk of testicular cancer’.Ann. Epidemiol.13, 541–542 (2003).
  • Moller H : Clues to the aetiology of testicular germ cell tumours from descriptive epidemiology.Eur. Urol.23, 8–13; discussion 14–15 (1993).
  • Pike MC , ChilversCE, BobrowLG: Classification of testicular cancer in incidence and mortality statistics.Br. J. Cancer56, 83–85 (1987).
  • Prener A , EngholmG, JensenOM: Genital anomalies and risk for testicular cancer in Danish men.Epidemiology7, 14–19 (1996).
  • Morrison AS : Cryptorchidism, hernia, and cancer of the testis.J. Natl Cancer Inst.56, 731–733 (1976).
  • Hemminki K , ChromoB: Familial risks in testicular cancer as aetiological clues.Int. J. Androl.29, 205–210 (2006).
  • Hemminki K , LiX: Familial risk in testicular cancer as a clue to a heritable and environmental aetiology.Br. J. Cancer90, 1765–1770 (2004).
  • Dieckmann KP , PichlmeierU: The prevalence of familial testicular cancer: an analysis of two patient populations and a review of the literature.Cancer80, 1954–1960 (1997).
  • Khoury MJ , BeatyTH, LiangKY: Can familial aggregation of disease be explained by familial aggregation of environmental risk factors?Am. J. Epidemiol.127, 674–683 (1988).
  • Heimdal K , OlssonH, TretliS, FossaSD, BorresenAL, BishopDT: A segregation analysis of testicular cancer based on Norwegian and Swedish families.Br. J. Cancer75, 1084–1087 (1997).
  • Nicholson PW , HarlandSJ: Inheritance and testicular cancer.Br. J. Cancer71, 421–426 (1995).
  • Einhorn LH , DonohueJ: Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer.Ann. Intern. Med.87, 293–298 (1977).
  • Hopper JL , CarlinJB: Familial aggregation of a disease consequent upon correlation between relatives in a risk factor measured on a continuous scale.Am. J. Epidemiol.136, 1138–1147 (1992).
  • Nathanson KL , KanetskyPA, HawesRet al.: The Y deletion gr/gr and susceptibility to testicular germ cell tumor.Am. J. Hum. Genet.77, 1034–1043 (2005).
  • Horvath A , KordeL, GreeneMHet al.: Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors.Cancer Res.69(13), 5301–5306 (2009).
  • Rapley EA , TurnbullC, Al OlamaAAet al.: A genome-wide association study of testicular germ cell tumor.Nat. Genet.41, 807–810 (2009).
  • Kanetsky PA , MitraN, VardhanabhutiSet al.: Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.Nat. Genet.41, 811–815 (2009).
  • Runyan C , SchaibleK, MolyneauxK, WangZ, LevinL, WylieC: Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration.Development133, 4861–4869 (2006).
  • Swerdlow AJ , De StavolaBL, SwanwickMA, MaconochieNE: Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology.Lancet350, 1723–1728 (1997).
  • Braun MM , AhlbomA, FloderusB, BrintonLA, HooverRN: Effect of twinship on incidence of cancer of the testis, breast, and other sites (Sweden).Cancer Causes Control6, 519–524 (1995).
  • Hemminki K , ChromoB: Are twins at risk of cancer: results from the Swedish family-cancer database.Twin Res. Hum. Genet.8, 509–514 (2005).
  • Lambalk CB , BoomsmaDI: Genetic risk factors in tumours of the testis: lessons from twin studies.Twin Res.1, 154–155 (1998).
  • Satge D , SascoAJ, CureH, LeducB, SommeletD, VekemansMJ: An excess of testicular germ cell tumors in Down’s syndrome: three case reports and a review of the literature.Cancer80, 929–935 (1997).
  • van Montfrans JM , DorlandM, OosterhuisGJ, van VugtJM, Rekers-MombargLT, LambalkCB: Increased concentrations of follicle-stimulating hormone in mothers of children with Down’s syndrome.Lancet353, 1853–1854 (1999).
  • Heimdal K , OlssonH, TretliS, FlodgrenP, BorresenAL, FossaSD: Familial testicular cancer in Norway and southern Sweden.Br. J. Cancer73, 964–969 (1996).
  • Westergaard T , OlsenJH, FrischM, KromanN, NielsenJW, MelbyeM: Cancer risk in fathers and brothers of testicular cancer patients in Denmark. A population-based study.Int. J. Cancer66, 627–631 (1996).
  • Hemminki K , CzeneK: Attributable risks of familial cancer from the Family-Cancer Database.Cancer Epidemiol. Biomarkers Prev.11, 1638–1644 (2002).
  • Czene K , LichtensteinP, HemminkiK: Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database.Int. J. Cancer99, 260–266 (2002).

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