Bibliography
- Isaacs JT : Role of androgens in prostatic cancer.Vitam. Horm.49, 433–502 (1994).
- Trapman J , CleutjensKB: Androgen-regulated gene expression in prostate cancer.Semin. Cancer Biol.8(1), 29–36 (1997).
- Huggins C , HodgesCV: Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate.CA Cancer J. Clin.22(4), 232–240 (1972).
- Hobisch A , CuligZ, RadmayrC, BartschG, KlockerH, HittmairA: Distant metastases from prostatic carcinoma express androgen receptor protein.Cancer Res.55(14), 3068–3072 (1995).
- van der Kwast TH , SchalkenJ, Ruizeveld de WinterJAet al.: Androgen receptors in endocrine-therapy-resistant human prostate cancer.Int. J. Cancer48(2), 189–193 (1991).
- Huggins CMD , HodgesCV: The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate.Cancer Res.19, 293–297 (1941).
- Dehm SM , TindallDJ: Regulation of androgen receptor signaling in prostate cancer.Expert Rev. Anticancer Ther.5(1), 63–74 (2005).
- Feldman BJ , FeldmanD: The development of androgen-independent prostate cancer.Nat. Rev. Cancer1(1), 34–45 (2001).
- Pienta KJ , BradleyD: Mechanisms underlying the development of androgen-independent prostate cancer.Clin. Cancer Res.12(6), 1665–1671 (2006).
- Arnold JT , IsaacsJT: Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell’s fault.Endocr. Relat. Cancer9(1), 61–73 (2002).
- Lee SO , LouW, HouM, OnateSA, GaoAC: Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway.Oncogene22(39), 7981–7988 (2003).
- Lee SO , LouW, HouM, de MiguelF, GerberL, GaoAC: Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells.Clin. Cancer Res.9(1), 370–376 (2003).
- Grossmann ME , HuangH, TindallDJ: Androgen receptor signaling in androgen-refractory prostate cancer.J. Natl Cancer Inst.93(22), 1687–1697 (2001).
- Shi XB , MaAH, TepperCGet al.: Molecular alterations associated with LNCaP cell progression to androgen independence.Prostate60(3), 257–271 (2004).
- Chen Q , WatsonJT, MarengoSRet al.: Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo.Cancer Lett.244(2), 274–288 (2006).
- Akira S , TagaT, KishimotoT: Interleukin-6 in biology and medicine.Adv. Immunol.54, 1–78 (1993).
- Murakami M , HibiM, NakagawaNet al.: IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase.Science260(5115), 1808–1810 (1993).
- Simpson RJ , HammacherA, SmithDK, MatthewsJM, WardLD: Interleukin-6: structure-function relationships.Protein Sci.6(5), 929–955 (1997).
- Siegall CB , SchwabG, NordanRP, FitzGeraldDJ, PastanI: Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.Cancer Res.50(24), 7786–7788 (1990).
- Siegsmund MJ , YamazakiH, PastanI: Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia.J. Urol.151(5), 1396–1399 (1994).
- Hobisch A , RogatschH, HittmairAet al.: Immunohistochemical localization of interleukin-6 and its receptor in benign, premalignant and malignant prostate tissue.J. Pathol.191(3), 239–244 (2000).
- Drachenberg DE , ElgamalAA, RowbothamR, PetersonM, MurphyGP: Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer.Prostate41(2), 127–133 (1999).
- Adler HL , McCurdyMA, KattanMW, TimmeTL, ScardinoPT, ThompsonTC: Elevated levels of circulating interleukin-6 and transforming growth factor-β1 in patients with metastatic prostatic carcinoma.J. Urol.161(1), 182–187 (1999).
- Okamoto M , LeeC, OyasuR: Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro.Cancer Res.57(1), 141–146 (1997).
- Hobisch A , EderIE, PutzTet al.: Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor.Cancer Res.58(20), 4640–4645 (1998).
- Chen T , WangLH, FarrarWL: Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells.Cancer Res.60(8), 2132–2135 (2000).
- Lou W , NiZ, DyerK, TweardyDJ, GaoAC: Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway.Prostate42(3), 239–242 (2000).
- Lee SO , LouW, JohnsonCS, TrumpDL, GaoAC: Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway.Prostate60(3), 178–186 (2004).
- Inoue K , SlatonJW, EveBYet al.: Interleukin 8 expression regulates tumorigenicity and metastases in androgen-independent prostate cancer.Clin. Cancer Res.6(5), 2104–2119 (2000).
- Araki S , OmoriY, LynDet al.: Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer.Cancer Res.67(14), 6854–6862 (2007).
- Yang HP , WoodsonK, TaylorPRet al.: Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial.Eur. J. Cancer Prev.15(3), 249–253 (2006).
- Lee LF , LouieMC, DesaiSJet al.: Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK.Oncogene23(12), 2197–2205 (2004).
- Gujral A , BurtonDW, TerkeltaubR, DeftosLJ: Parathyroid hormone-related protein induces interleukin 8 production by prostate cancer cells via a novel intracrine mechanism not mediated by its classical nuclear localization sequence.Cancer Res.61(5), 2282–2288 (2001).
- Lehrer S , DiamondEJ, MamkineB, StoneNN, StockRG: Serum interleukin-8 is elevated in men with prostate cancer and bone metastases.Technol. Cancer Res. Treat.3(5), 411 (2004).
- Schauer IG , ResslerSJ, TuxhornJA, DangTD, RowleyDR: Elevated epithelial expression of interleukin-8 correlates with myofibroblast reactive stroma in benign prostatic hyperplasia.Urology72(1), 205–213 (2008).
- Qiu Y , RobinsonD, PretlowTG, KungHJ: Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3‘-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.Proc. Natl Acad. Sci. USA95(7), 3644–3649 (1998).
- Lee SO , ChunJY, NadimintyN, LouW, GaoAC: Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression.Prostate67(7), 764–773 (2007).
- Yuan TC , VeeramaniS, LinFFet al.: Androgen deprivation induces human prostate epithelial neuroendocrine differentiation of androgen-sensitive LNCaP cells.Endocr. Relat. Cancer13(1), 151–167 (2006).
- Spiotto MT , ChungTD: STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells.Prostate42(3), 186–195 (2000).
- Deeble PD , MurphyDJ, ParsonsSJ, CoxME: Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells.Mol. Cell. Biol.21(24), 8471–8482 (2001).
- Lee LF , GuanJ, QiuY, KungHJ: Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase.Mol. Cell. Biol.21(24), 8385–8397 (2001).
- Desai SJ , MaAH, TepperCG, ChenHW, KungHJ: Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implications.Cancer Res.66(21), 10449–10459 (2006).
- Jin RJ , WangY, MasumoriNet al.: NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice.Cancer Res.64(15), 5489–5495 (2004).
- Akakura K , BruchovskyN, GoldenbergSL, RenniePS, BuckleyAR, SullivanLD: Effects of intermittent androgen suppression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigen.Cancer71(9), 2782–2790 (1993).
- Ayala G , TuxhornJA, WheelerTMet al.: Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer.Clin. Cancer Res.9(13), 4792–4801 (2003).
- Rowley DR : What might a stromal response mean to prostate cancer progression?Cancer Metastasis Rev.17, 411–419 (1999).
- Tuxhorn JA , AyalaGE, RowleyDR: Reactive stroma in prostate cancer progression.J. Urol.166(6), 2472–2483 (2001).
- Hendriksen PJ , DitsNF, KokameKet al.: Evolution of the androgen receptor pathway during progression of prostate cancer.Cancer Res.66(10), 5012–5020 (2006).
- Mohler JL , GregoryCW, FordOH3rdet al.: The androgen axis in recurrent prostate cancer.Clin. Cancer Res.10(2), 440–448 (2004).
- Stanbrough M , BubleyGJ, RossKet al.: Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.Cancer Res.66(5), 2815–2825 (2006).
- Montgomery RB , MostaghelEA, VessellaRet al.: Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth.Cancer Res.68(11), 4447–4454 (2008).
- Marks LS , MostaghelEA, NelsonPS: Prostate tissue androgens: history and current clinical relevance.Urology72(2), 247–254 (2008).
- Mostaghel EA , NelsonPS: Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications.Best Pract. Res. Clin. Endocrinol. Metab.22(2), 243–258 (2008).
- Mostaghel EA , PageST, LinDWet al.: Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer.Cancer Res.67(10), 5033–5041 (2007).
- Page ST , LinDW, MostaghelEAet al.: Persistent intraprostatic androgen concentrations after medical castration in healthy men.J. Clin. Endocrinol. Metab.91(10), 3850–3856 (2006).
- Belanger B , BelangerA, LabrieF, DupontA, CusanL, MonfetteG: Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men.J. Steroid Biochem.32(5), 695–698 (1989).
- Mizokami A , KohE, FujitaHet al.: The adrenal androgen androstenediol is present in prostate cancer tissue after androgen deprivation therapy and activates mutated androgen receptor.Cancer Res.64(2), 765–771 (2004).
- Chun JY , NadimintyN, DuttSet al.: Interleukin-6 regulates androgen synthesis in prostate cancer cells.Clin. Cancer Res.15(15), 4815–4822 (2009).
- Arnold JT , GrayNE, JacobowitzKet al.: Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells.J. Steroid Biochem. Mol. Biol.111(3–5), 240–246 (2008).
- Linja MJ , SavinainenKJ, SaramakiOR, TammelaTL, VessellaRL, VisakorpiT: Amplification and overexpression of androgen receptor gene in hormone- refractory prostate cancer.Cancer Res.61(9), 3550–3555 (2001).
- Dehm SM , SchmidtLJ, HeemersHV, VessellaRL, TindallDJ: Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance.Cancer Res.68(13), 5469–5477 (2008).
- Tepper CG , BoucherDL, RyanPEet al.: Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line.Cancer Res.62(22), 6606–6614 (2002).
- Guo Z , YangX, SunFet al.: A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.Cancer Res.69(6), 2305–2313 (2009).
- Hu R , DunnTA, WeiSet al.: Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer.Cancer Res.69(1), 16–22 (2009).
- Jagla M , FeveM, KesslerPet al.: A splicing variant of the androgen receptor detected in a metastatic prostate cancer exhibits exclusively cytoplasmic actions.Endocrinology148(9), 4334–4343 (2007).