Structure and Functions of the Ebola Virus Matrix Protein VP40

References

• Feldmann H , KlenkHD . Marburg and Ebola viruses . Adv. Virus Res.47, 1 – 52 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Burk R , BollingerL, JohnsonJCet al. Neglected filoviruses . FEMS Microbiol. Rev.40 ( 4 ), 494 – 519 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Bausch DG , RojekA . West Africa 2013: re-examining Ebola . Microbiol. Spectr.4 ( 3 ), EI10 – E0022 ( 2016 ).
   Web of Science ®Google Scholar
• Beniac DR , MelitoPL, DevarennesSLet al. The organisation of Ebola virus reveals a capacity for extensive, modular polyploidy . PLoS ONE7 ( 1 ), e29608 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Sanchez A , KileyMP, HollowayBP, AuperinDD . Sequence analysis of the Ebola virus genome: organization, genetic elements, and comparison with the genome of Marburg virus . Virus Res.29 ( 3 ), 215 – 240 ( 1993 ).
   PubMed Web of Science ®Google Scholar
• Banadyga L , HoenenT, AmbroggioX, DunhamE, GrosethA, EbiharaH . Ebola virus VP24 interacts with NP to facilitate nucleocapsid assembly and genome packaging . Sci. Rep.7 ( 1 ), 7698 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Watt A , MoukambiF, BanadygaLet al. A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity . J. Virol.88 ( 18 ), 10511 – 10524 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Timmins J , ScianimanicoS, SchoehnG, WeissenhornW . Vesicular release of ebola virus matrix protein VP40 . Virology283 ( 1 ), 1 – 6 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Jasenosky LD , NeumannG, LukashevichI, KawaokaY . Ebola virus VP40-induced particle formation and association with the lipid bilayer . J. Virol.75 ( 11 ), 5205 – 5214 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Bornholdt ZA , NodaT, AbelsonDMet al. Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle . Cell154 ( 4 ), 763 – 774 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Dessen A , VolchkovV, DolnikO, KlenkHD, WeissenhornW . Crystal structure of the matrix protein VP40 from Ebola virus . EMBO J.19 ( 16 ), 4228 – 4236 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Clifton MC , BruhnJF, AtkinsKet al. High-resolution crystal structure of dimeric VP40 from Sudan ebolavirus . J. Infect. Dis.212 ( Suppl. 2 ), S167 – S171 ( 2015 ).
   PubMedGoogle Scholar
• Oda S , NodaT, WijesingheKJet al. Crystal structure of marburg virus VP40 reveals a broad, basic patch for matrix assembly and a requirement of the N-terminal domain for immunosuppression . J. Virol.90 ( 4 ), 1839 – 1848 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Timmins J , SchoehnG, KohlhaasC, KlenkHD, RuigrokRW, WeissenhornW . Oligomerization and polymerization of the filovirus matrix protein VP40 . Virology312 ( 2 ), 359 – 368 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Hoenen T , BiedenkopfN, ZieleckiFet al. Oligomerization of Ebola virus VP40 is essential for particle morphogenesis and regulation of viral transcription . J. Virol.84 ( 14 ), 7053 – 7063 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Gc JB , JohnsonKA, HusbyMLet al. Interdomain salt-bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization . Protein Sci.25 ( 9 ), 1648 – 1658 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Silva LP , VanzileM, BavariS, AmanJM, SchriemerDC . Assembly of Ebola virus matrix protein VP40 is regulated by latch-like properties of N and C terminal tails . PLoS ONE7 ( 7 ), e39978 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Scianimanico S , SchoehnG, TimminsJ, RuigrokRH, KlenkHD, WeissenhornW . Membrane association induces a conformational change in the Ebola virus matrix protein . EMBO J.19 ( 24 ), 6732 – 6741 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Hoenen T , VolchkovV, KolesnikovaLet al. VP40 octamers are essential for Ebola virus replication . J. Virol.79 ( 3 ), 1898 – 1905 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Adu-Gyamfi E , DigmanMA, GrattonE, StahelinRV . Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis . Biophys. J.102 ( 11 ), 2517 – 2525 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Adu-Gyamfi E , SoniSP, XueY, DigmanMA, GrattonE, StahelinRV . The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress . J. Biol. Chem.288 ( 8 ), 5779 – 5789 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Soni SP , Adu-GyamfiE, YongSS, JeeCS, StahelinRV . The Ebola virus matrix protein deeply penetrates the plasma membrane: an important step in viral egress . Biophys. J.104 ( 9 ), 1940 – 1949 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Gomis-Ruth FX , DessenA, TimminsJet al. The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties . Structure11 ( 4 ), 423 – 433 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Radzimanowski J , EffantinG, WeissenhornW . Conformational plasticity of the Ebola virus matrix protein . Protein Sci.23 ( 11 ), 1519 – 1527 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Adu-Gyamfi E , DigmanMA, GrattonE, StahelinRV . Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein . Biophys. J.103 ( 9 ), L41 – L43 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Votteler J , SundquistWI . Virus budding and the ESCRT pathway . Cell Host Microbe14 ( 3 ), 232 – 241 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Henne WM , BuchkovichNJ, EmrSD . The ESCRT pathway . Dev. Cell21 ( 1 ), 77 – 91 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Raposo G , StoorvogelW . Extracellular vesicles: exosomes, microvesicles, and friends . J. Cell Biol.200 ( 4 ), 373 – 383 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Carlton JG , Martin-SerranoJ . Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery . Science316 ( 5833 ), 1908 – 1912 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Nabhan JF , HuR, OhRS, CohenSN, LuQ . Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein . Proc. Natl Acad. Sci. USA109 ( 11 ), 4146 – 4151 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Harty RN , BrownME, WangG, HuibregtseJ, HayesFP . A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding . Proc. Natl Acad. Sci. USA97 ( 25 ), 13871 – 13876 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Licata JM , Simpson-HolleyM, WrightNT, HanZ, ParagasJ, HartyRN . Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG101 and VPS-4 . J. Virol.77 ( 3 ), 1812 – 1819 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Martin-Serrano J , ZangT, BieniaszPD . HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress . Nat. Med.7 ( 12 ), 1313 – 1319 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Han Z , SagumCA, BedfordMT, SidhuSS, SudolM, HartyRN . ITCH E3 ubiquitin ligase interacts with Ebola virus VP40 to regulate budding . J. Virol.90 ( 20 ), 9163 – 9171 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Han Z , SagumCA, TakizawaFet al. Ubiquitin ligase WWP1 interacts with Ebola virus VP40 to regulate egress . J. Virol.91 ( 20 ), e00812 – 17 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Timmins J , SchoehnG, Ricard-BlumSet al. Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4 . J. Mol. Biol.326 ( 2 ), 493 – 502 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Yasuda J , NakaoM, KawaokaY, ShidaH . Nedd4 regulates egress of Ebola virus-like particles from host cells . J. Virol.77 ( 18 ), 9987 – 9992 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Neumann G , EbiharaH, TakadaAet al. Ebola virus VP40 late domains are not essential for viral replication in cell culture . J. Virol.79 ( 16 ), 10300 – 10307 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Han Z , MadaraJJ, LiuYet al. ALIX rescues budding of a double PTAP/PPEY L-domain deletion mutant of Ebola VP40: a role for ALIX in Ebola virus egress . J. Infect. Dis.212 ( Suppl. 2 ), S138 – S145 ( 2015 ).
   PubMedGoogle Scholar
• Wendt L , KamperL, SchmidtML, MettenleiterTC, HoenenT . Analysis of a putative late domain using an Ebola virus transcription and replication-competent virus-like particle system . J. Infect. Dis.218 ( Suppl. 5 ), S355 – S359 ( 2018 ).
   PubMedGoogle Scholar
• Spiegelberg L , Wahl-JensenV, KolesnikovaL, FeldmannH, BeckerS, HoenenT . Genus-specific recruitment of filovirus ribonucleoprotein complexes into budding particles . J. Gen. Virol.92 ( Pt 12 ), 2900 – 2905 ( 2011 ).
   PubMedGoogle Scholar
• Noda T , SagaraH, SuzukiE, TakadaA, KidaH, KawaokaY . Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP . J. Virol.76 ( 10 ), 4855 – 4865 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Ruigrok RW , SchoehnG, DessenAet al. Structural characterization and membrane binding properties of the matrix protein VP40 of Ebola virus . J. Mol. Biol.300 ( 1 ), 103 – 112 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Del Vecchio K , FrickCT, GcJBet al. A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine . J. Biol. Chem.293 ( 9 ), 3335 – 3349 ( 2018 ).
   PubMed Web of Science ®Google Scholar
• Johnson KA , TaghonGJ, ScottJL, StahelinRV . The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress . Sci. Rep.6, 19125 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Soni SP , StahelinRV . The Ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes . J. Biol. Chem.289 ( 48 ), 33590 – 33597 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Nanbo A , MaruyamaJ, ImaiMet al. Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles . PLoS Pathogens14 ( 1 ), e1006848 ( 2018 ).
   PubMed Web of Science ®Google Scholar
• Moller-Tank S , KondratowiczAS, DaveyRA, RennertPD, MauryW . Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry . J. Virol.87 ( 15 ), 8327 – 8341 ( 2013 ).
   PubMed Web of Science ®Google Scholar