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Perspective

Characterization and Risk of Blood-Borne Virus Transmission in Organ Transplantation: What are the Priorities?

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Pages 1049-1060 | Published online: 23 Dec 2014

References

  • Smith JM , McdonaldRA . Emerging viral infections in transplantation . Pediatr. Transplant.10 ( 7 ), 838 – 843 ( 2006 ).
  • Palacios G , DruceJ , DULet al. A new arenavirus in a cluster of fatal transplant-associated diseases . N. Engl. J. Med.358 ( 10 ), 991 – 998 ( 2008 ).
  • Tugwell BD , PatelPR , WilliamsITet al. Transmission of hepatitis C virus to several organ and tissue recipients from an antibody-negative donor . Ann. Intern. Med.143 ( 9 ), 648 – 654 ( 2005 ).
  • CDC . West Nile virus transmission via organ transplantation and blood transfusion - Louisiana, 2008 . MMWR Morb. Mortal. Wkly. Rep.58 ( 45 ), 1263 – 1267 ( 2009 ).
  • Su WJ , HoMC , NiYHet al. Clinical course of de novo hepatitis B infection after pediatric liver transplantation . Liver Transpl.16 ( 2 ), 215 – 221 ( 2010 ).
  • CDC . Brief report: Lymphocytic choriomeningitis virus transmitted through solid organ transplantation – Massachusetts, 2008 . MMWR Morb. Mortal. Wkly. Rep.57 ( 29 ), 799 – 801 ( 2008 ).
  • Kotton CN . Zoonoses in solid-organ and hematopoietic stem cell transplant recipients . Clin. Infect. Dis.44 ( 6 ), 857 – 866 ( 2007 ).
  • Serap A , FundaO , BenguKet al. Sustained seroconversion of chronic hepatitis B infection after stem cell transplantation . Pediatr. Transplant.15 ( 5 ), E92 – E95 ( 2011 ).
  • Ison MG , LlataE , ConoverCSet al. Transmission of human immunodeficiency virus and hepatitis C virus from an organ donor to four transplant recipients . Am. J. Transplant.11 ( 6 ), 1218 – 1225 ( 2011 ).
  • Ison MG , NalesnikMA . An update on donor-derived disease transmission in organ transplantation . Am. J. Transplant.11 , 1123 – 1130 ( 2011 ).
  • Grossi PA , FishmanJA . AST infectious disease community of practice. Donor-derived infections in solid organ transplant recipients . Am. J. Transplant.9 ( Suppl. 4 ), S19 – S26 ( 2009 ).
  • Ison MG , LlataE , ConoverCSet al. Transmission of human immunodeficiency virus and hepatitis C virus from an organ donor to four transplant recipients . Am. J. Transplant.11 ( 6 ), 1218 – 1225 ( 2011 ).
  • Research Nchecr . HIV/AIDS, viral hepatitis and sexually transmissible infections in Australia. Annual Surveillance Report 2009 ( 2009 ). www.nchecr.unsw.edu.au
  • Watzinger F , SudaA , PreunerSet al. Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients . J. Clin. Microbiol.42 ( 11 ), 5189 – 5198 ( 2004 ).
  • Druce J , CattonM , ChiboDet al. Utility of a multiplex PCR assay for detecting herpesvirus DNA in clinical samples . J. Clin. Microbiol.40 ( 5 ), 1728 – 1732 ( 2002 ).
  • Baginski I , CheminI , HantzOet al. Transmission of serologically silent hepatitis B virus along with hepatitis C virus in two cases of posttransfusion hepatitis . Transfusion32 ( 3 ), 215 – 220 ( 1992 ).
  • Quiroga JA , BartolomeJ , PorresJCet al. Identification of different degrees of hepatitis B virus (HBV) replication by serological (HBV-DNAp, HBcAg and HBV-DNA) and histological (HBcAg) methods . Liver7 ( 3 ), 169 – 175 ( 1987 ).
  • Michalak TI , PasquinelliC , GuilhotS , ChisariFV . Hepatitis-B virus persistence after recovery from acute viral-hepatitis . J. Clin. Invest.93 ( 1 ), 230 – 239 ( 1994 ).
  • Weinberger KM , BauerT , BohmS , JilgW . High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum . J. Gen. Virol.81 , 1165 – 1174 ( 2000 ).
  • Carreño V , BartolomeJ , CastilloI , QuirogaJA . Occult hepatitis B virus and hepatitis C virus infections . Rev. Med. Virol.18 ( 3 ), 139 – 157 ( 2008 ).
  • Raimondo G , AllainJ , BrunettoMRet al. Statements from the Taormina expert meeting on occult hepatitis B virus infection . J. Hepatol.49 ( 4 ), 652 – 657 ( 2008 ).
  • Levrero M , PollicinoT , PetersenJ , BelloniL , RaimondoG , DandriM . Control of cccDNA function in hepatitis B virus infection . J. Hepatol.51 ( 3 ), 581 – 592 ( 2009 ).
  • Zoulim F . New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA . J. Hepatol.42 ( 3 ), 302 – 308 ( 2005 ).
  • Rehermann BFC , PasquinelliC , ChisariFV . The hepatitis B virus persists for decades after patients’ recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response . Nat. Med.2 ( 10 ), 1104 – 1108 ( 1996 ).
  • Yotsuyanagi H , YasudaK , LinoSet al. Persistent viraemia after recovery from self-limited acute hepatitis B . Hepatology27 ( 5 ), 1377 – 1382 ( 1998 ).
  • The Transplantation Society of Australia and New Zealand (TSANZ) . Organ transplantation from deceased donors: consensus statement on eligibility criteria and allocation protocols, version 1.1 ( 2011 ). www.donatelife.gov.au
  • Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) . Guidance on the microbiological safety of human organs, tissues and cells used in transplantation ( 2011 ). www.gov.uk
  • Fischer SA , AveryRK . AST infectious disease community of practice: screening of donor and recipient prior to solid organ transplantation . Am. J. Transplant.9 , S7 – S18 ( 2009 ).
  • Ramia S , MokhbatJ , RamlawiF , El-ZaatariM . Occult hepatitis B virus infection in HIV-infected Lebanese patients with isolated antibodies to hepatitis B core antigen . Int. J. STD AIDS19 ( 3 ), 197 – 199 ( 2008 ).
  • Tseliou P , SpiliotakaraA , DimitracopoulosGO , ChristofidouM . Detection of hepatitis B virus DNA in blood units with anti-HBc as the only positive serological marker . Haematologia (Budap.)30 ( 3 ), 159 – 165 ( 2000 ).
  • Behzad-Behbahani A , Mafi-NejadA , TabeiSZet al. Anti-HBc & HBV-DNA detection in blood donors negative for hepatitis B virus surface antigen in reducing risk of transfusion associated HBV infection . Indian J. Med. Res.123 ( 1 ), 37 – 42 ( 2006 ).
  • Mei SD , YatsuhashiH , ParquetMCet al. Detection of HBV RNA in peripheral blood mononuclear cells in patients with and without HBsAg by reverse transcription polymerase chain reaction . Hepatol. Res.18 ( 1 ), 19 – 28 ( 2000 ).
  • Zaghloul H , El-SherbinyW . Detection of occult hepatitis C and hepatitis B virus infections from peripheral blood mononuclear cells . Immunol. Invest.39 ( 3 ), 284 – 291 ( 2010 ).
  • Allain JP . Occult hepatitis B virus infection: implications in transfusion . Vox Sang.86 , 83 – 91 ( 2004 ).
  • Fang Y , ShangQL , LiuJY , AlE . Prevalence of occult hepatitis B virus infection among hepatopathy patients and healthy people in China . J. Infect. Dis.58 , 383 – 388 ( 2009 ).
  • Kim SM , LeeKS , ParkCJet al. Prevalence of occult HBV infection among subjects with normal serum ALT levels in Korea . J. Infect.54 , 185 – 191 ( 2007 ).
  • Raimondo G , CaccamoG , FilomiaR , PollicinoT . Occult HBV infection . Semin. Immunopathol.35 , 39 – 52 ( 2013 ).
  • Cheung CK , LoCM , ManK , LauGK . Occult hepatitis B virus infection of donor and recipient origin after liver transplantation despite nucleoside analogue prophylaxis . Liver Transplant.16 , 1314 – 1323 ( 2010 ).
  • Toniutto P , MinisiniR , FabrisCet al. Occult hepatitis B virus infection in liver transplant recipients with recurrent hepatitis C: relationship with donor age and fibrosis progression . Clin. Transplant.23 , 184 – 190 ( 2009 ).
  • Angelico M , NardiA , MarianelliTet al. Hepatitis B-core antibody positive donors in liver transplantation and their impact on graft survival: evidence from the Liver Match cohort study . J. Hepatol.58 , 715 – 723 ( 2013 ).
  • Busch M . 10 years of NAT testing – what has been achieved and what needs to be done? Workshop on Surveillance and Screening of Blood Borne Pathogens ( 2010 ). www.ipfa.nl
  • Humar A , MorrisM , BlumbergEet al. Nucleic acid testing (NAT) of organ donors: is the ‘best’ test the right test? A consensus conference report . Am. J. Transplant.10 ( 4 ), 889 – 899 ( 2010 ).
  • Challine D , PellegrinB , Bouvier-AliasM , RigotP , LapercheL , PawlotskyJM . HIV and hepatitis C virus RNA in seronegative organ and tissue donors . Lancet364 ( 9445 ), 1611 – 1612 ( 2004 ).
  • Delmonico FL . Cadaver donor screening for infectious agents in solid organ transplantation . Clin. Infect. Dis.31 ( 3 ), 781 – 786 ( 2000 ).
  • Aswad S , KhanNS , ComanorLet al. Role of nucleic acid testing in cadaver organ donor screening: detection of hepatitis C virus RNA in seropositive and seronegative donors . J. Viral Hepat.12 ( 6 ), 627 – 634 ( 2005 ).
  • Pereira BJG , LeveyAS . Hepatitis C infection in cadaver organ donors: strategies to reduce transmission of infection and prevent organ waste . Pediatr. Nephrol.9 ( 0 ), S23 – S28 ( 1995 ).
  • Pruss A , CaspariG , KrügerDHet al. Tissue donation and virus safety: more nucleic acid amplification testing is needed . Transpl. Infect. Dis.12 ( 5 ), 375 – 386 ( 2010 ).
  • Rawlinson WD . Preventing donor derived infections through virology screening - reducing risk and increasing organ availability. Presented at : The Transplant Society Meeting, Transplant Infectious Diseases Symposium.Vancouver, BC, Canada , 15–19 August 2010 .
  • Baleriola C , TuE , JohalHet al. Organ donor screening using parallel nucleic acid testing allows assessment of transmission risk and assay results in real time . Transpl. Infect. Dis.14 ( 3 ), 278 – 287 ( 2012 ).
  • Baleriola C , RayS , KokCC , DavisR , RawlinsonWD . Real-time confirmation of initially reactive NAT results for HIV-1, HBV and HCV using parallel NAT testing in increased-risk organ donors . Presented at : TSANZ Annual Meeting.Canberra, Australia , 31 March–April 2012 .
  • Blumberg EA , IsonMG , PruettTl , SegevDl . Optimal testing of the live organ donor for blood-borne viral pathogens: the report of a consensus conference . Am. J. Transplant.13 ( 6 ), 1405 – 1415 ( 2013 ).
  • Baleriola C , JohalH , JackaBet al. Stability of hepatitis C virus, HIV, and hepatitis B virus nucleic acids in plasma samples after long-term storage at -20°C and -70°C . J. Clin. Virol.49 ( 9 ), 3163 – 3167 ( 2011 ).
  • Baleriola C , JohalH , RobertsonPet al. Infectious disease screening of blood specimens collected post-mortem provides comparable results to pre-mortem specimens . Cell Tissue Bank.13 ( 2 ), 251 – 258 ( 2012 ).
  • Eastlund T . Hemodilution due to blood loss and transfusion and reliability of cadaveric tissue donor infectious disease testing . Cell Tissue Bank.1 ( 2 ), 121 – 127 ( 2000 ).
  • Eastlund T , SchullerR . The effect of hemodilution on detectability of anti-HIV, anti-HCV and HBsAg: an in vitro study . Presented at : 18th Annual Meeting, American Association of Tissue Banks.San Francisco, CA, USA , 20–22 August 1994 .
  • Fishman J , StrongD , KuehnertM . Organ and tissue safefty workshop 2007: advances and challenges . Cell Tissue Bank.10 ( 3 ), 271 – 280 ( 2009 ).
  • Fishman JA . Infection in solid-organ transplant recipients . N. Engl. J. Med.357 ( 25 ), 2601 – 2614 ( 2007 ).
  • Reesink HW , EngelfrietCP , HylandCAet al. Biobanks of blood from donors and recipients of blood products . Vox Sang.94 ( 3 ), 242 – 260 ( 2008 ).
  • Eid AJ , RazonableRR . Cytomegalovirus disease in solid organ transplant recipients: advances lead to new challenges and opportunities . Curr. Opin. Organ Transplant.12 ( 6 ), 610 – 617 ( 2007 ).
  • Budino BS , MartulEV , DiazSP , BarreiroAV , ReyEC , ReboredoJM . Autopsy-determined causes of death in solid organ transplant recipients . Transplant. Proc.36 ( 3 ), 787 – 789 ( 2004 ).
  • Shirali GS , NiJ , ChinnockREet al. Association of viral genome with graft loss in children after cardiac transplantation . N. Engl. J. Med.344 ( 20 ), 1498 – 1503 ( 2001 ).
  • Jiménez-Pérez M , Sáez-GómezAB , Mongil PoceL , Lozano-ReyJM , De La Cruz-LombardoJ , Rodrigo-LópezJM . Efficacy and safety of entecavir and/or tenofovir for prophylaxis and treatment of hepatitis B recurrence post-liver transplant . Transplant. Proc.42 ( 8 ), 3167 – 3168 ( 2010 ).
  • Angus PW , PattersonSJ , StrasserSI , MccaughanGW , GaneE . A randomized study of adefovir dipivoxil in place of HBIG in combination with lamivudine as post–liver transplantation hepatitis B prophylaxis . Hepatology48 ( 5 ), 1460 – 1466 ( 2008 ).
  • Kasprzyk T , KwiatkowskiA , WszolaMet al. Long-term results of kidney transplantation from HCV-Positive donors . Transplant. Proc.39 ( 9 ), 2701 – 2703 ( 2007 ).
  • Fabrizi F , MessaP , MartinP . Current status of renal transplantation from HCV-positive donors . Int. J. Artif. Organs32 ( 5 ), 251 – 261 ( 2009 ).
  • Kallinowski B , BenzC , BuchholzL , StremmelW . Accelerated schedule of Hepatitis B vaccination in liver transplant candidates . Transplant. Proc.30 ( 3 ), 797 – 799 ( 1998 ).
  • Candotti D , AllainJP . Transfusion-transmitted hepatitis B virus infection . J. Hepatol.51 ( 4 ), 798 – 809 ( 2009 ).
  • Jacobson IM , McHutchisonJG , DusheikoGet al. ADVANCE Study Team. Telaprevir for previously untreated chronic hepatitis C virus infection . N. Engl. J. Med.364 , 2405 – 2416 ( 2011 ).
  • Poordad F , McconeJJ , BaconBRet al. SPRINT-2 Investigators. Boceprevir for untreated chronic HCV genotype 1 infection . N. Engl. J. Med.364 , 1195 – 1206 ( 2011 ).
  • Prieto M , BerenguerM , RayonJMet al. High incidence of allograft cirrhosis in hepatitis C virus genotype 1b infection following transplantation: relationship with rejection episodes . Hepatology29 ( 1 ), 250 – 256 ( 1999 ).
  • Saab S , GhobrialRM , IbrahimABet al. Hepatitis C positive grafts may be used in orthotopic liver transplantation: a matched analysis . Am. J. Transplant.3 ( 9 ), 1167 – 1172 ( 2003 ).
  • Sugo H , BaldersonGA , CrawfordDHGet al. The influence of viral genotypes and rejection episodes on the recurrence of hepatitis C after liver transplantation . Surg. Today33 ( 6 ), 421 – 425 ( 2003 ).
  • Velidedeoglu E , DesaiNM , CamposLet al. The outcome of liver grafts procured from hepatitis C-positive donors . Transplantation73 ( 4 ), 582 – 587 ( 2002 ).
  • Vargas HE , LaskusT , WangLFet al. Outcome of liver transplantation in hepatitis C virus-infected patients who received hepatitis C virus-infected grafts . Gastroenterology117 ( 1 ), 149 – 153 ( 1999 ).
  • Khapra AP , AgarwalK , FielMIet al. Impact of donor age on survival and fibrosis progression in patients with hepatitis C undergoing liver transplantation using HCV plus allografts . Liver Transplant.12 ( 10 ), 1496 – 1503 ( 2006 ).
  • Northup PG , McbrideMA , SchrnittTM , ArgoCK , PruettTl . Hepatitis C positive liver transplant recipients who recieve grafts from donors with hepatitis C antibodies have similar outcomes to hepatitis C negative donors . Hepatology48 ( 4 ), 524 ( 2008 ).
  • Lang L . Hepatitis C virus-infected donors in liver transplantation . Gastroenterology133 ( 2 ), 381 – 382 ( 2007 ).
  • Duhart BT , HonakerMR , Shokouh-AmiriMHet al. Retrospective evaluation of the risk of hepatitis B virus reactivation after transplantation . Transpl. Infect. Dis.5 ( 3 ), 126 – 131 ( 2003 ).
  • Brind A , BennettM , BassendineM . Nucleoside analogue therapy in fibrosing cholestatic hepatitis – a case report in an HBsAg positive renal transplant recipient . Liver18 ( 2 ), 134 – 139 ( 1998 ).
  • Whiting JF , KiberdB , KaloZ , KeownP , RoelsL , KjerulfM . Cost–effectiveness of organ donation: evaluating investment into donor action and other donor initiatives . Am. J. Transplant.4 ( 4 ), 569 – 573 ( 2004 ).
  • Webster A , ChapmanJ , CraigJC , SupramaniamR , O’ConnellD . Validity of registry data: agreement between cancer records in an end stage kidney disease registry (voluntary reporting) and a cancer register (statutory reporting) . Nephrology15 ( 4 ), 491 – 501 ( 2010 ).
  • Webster AC , CraigJC , SimpsonJM , JonesMP , ChapmanJR . Identifying high risk groups and quantifying absolute risk of cancer after kidney transplantation: a cohort study of 15,183 recipients . Am. J. Transplant.7 ( 9 ), 2140 – 2151 ( 2007 ).
  • Europe Co . European Union Standards and Training in the Inspection of Tissue Establishments ( 2010 ).
  • Notify . www.notifylibrary.org
  • Ison MG , HagerJ , BlumbergEet al. Donor-derived disease transmission events in the united states: data reviewed by the OPTN/UNOS disease transmission advisory committee . Am. J. Transplant.9 ( 8 ), 1929 – 1935 ( 2009 ).
  • Participants in the international summit on transplant tourism: the declaration of Instanbul on organ trafficking and transplant tourism . Clin. J. Am. Soc. Nephrol.3 , 1227 – 1231 ( 2008 ).
  • Kotton CN . Transplant tourism and donor-derived parasitic infections . Transplant. Proc.43 ( 6 ), 2448 – 2449 ( 2011 ).
  • Reese PP , HalpernSD , AschDAet al. Longer-term outcomes after kidney transplantation from seronegative deceased donors at increased risk for blood-borne viral infection . Transplantation91 ( 11 ), 1211 – 1217 ( 2011 ).
  • ANZDATA and ANZOD . www.anzdata.org.au

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