Ragweed Sublingual Tablet Immunotherapy: Part II – Practical Considerations and Pertinent Issues

References

• Bousquet J , LockeyR , MallingHJ . Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper . J. Allergy Clin. Immunol.102 ( 4 Pt 1 ), 558 – 562 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Muraro A , RobertsG . Immunotherapy Guidelines Part 1: Systematic Reviews . European Academy of Allergy and Clinical Immunology , Zurich, Switzerland ( 2017 ).
   Google Scholar
• Lin SY , ErekosimaN , Suarez-CuervoCet al. Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma: Comparative Effectiveness Review . Johns Hopkins University Evidence-based Practice Center , Rockville, MD, USA ( 2013 ).
   Google Scholar
• Radulovic S , WilsonD , CalderonM , DurhamS . Systematic reviews of sublingual immunotherapy (SLIT) . Allergy66 ( 6 ), 740 – 752 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Normansell R , KewKM , BridgmanAL . Sublingual immunotherapy for asthma . Cochrane Database Syst. Rev. ( 8 ), CD011293 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Dhami S , KakourouA , AsamoahFet al. Allergen immunotherapy for allergic asthma: a systematic review and meta-analysis . Allergy72 ( 12 ), 1825 – 1848 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Dhami S , NurmatovU , ArasiSet al. Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic review and meta-analysis . Allergy72 ( 11 ), 1597 – 1631 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Canonica GW , CoxL , PawankarRet al. Sublingual immunotherapy: world allergy organization position paper 2013 update . World Allergy Organ. J.7 ( 1 ), 6 ( 2014 ).
   PubMedGoogle Scholar
• Roberts G , PfaarO , AkdisCAet al. EAACI guidelines on allergen immunotherapy: allergic rhinoconjunctivitis . Allergy73 ( 4 ), 765 – 798 ( 2018 ).
   PubMed Web of Science ®Google Scholar
• Cox L , NelsonH , LockeyRet al. Allergen immunotherapy: a practice parameter third update . J. Allergy Clin. Immunol.127 ( 1 Suppl. ), S1 – S55 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Creticos PS . Sublingual immunotherapy for allergic rhinoconjunctivitis and asthma . In : UpToDate . FeldwegAM ( Ed ). UpToDate , Waltham, MA, USA ( 2017 ). ( Accessed on 17February2018) © 2018 UpToDate www.uptodate.com/contents/sublingual-immunotherapy-for-allergic-rhinoconjunctivitis-and-asthma .
   Google Scholar
• Pfaar O , BoniniS , CardonaVet al. Perspectives in allergen immunotherapy: 2017 and beyond . Allergy73 ( Suppl. 104 ), 5 – 23 ( 2018 ).
   Google Scholar
• Hoffmann HJ , ValovirtaE , PfaarOet al. Novel approaches and perspectives in allergen immunotherapy . Allergy72 ( 7 ), 1022 – 1034 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Li JT , BernsteinDI , CalderonMAet al. Sublingual grass and ragweed immunotherapy: clinical considerations – a PRACTALL consensus report . J. Allergy Clin. Immunol.137 ( 2 ), 369 – 376 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Creticos PS , PfaarO . Ragweed sublingual tablet immunotherapy: Part I – evidence-based clinical efficacy and safety . Immunotherapy10 ( 1 ), 55 ( 2018 ).
   Google Scholar
• Food and Drug Administration (FDA) . RAGWITEK® (short ragweed pollen allergen extract) tablet for sublingual use initial U.S. approval, 2014 (internet) ( 2014 ). www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM393600.pdf .
   Google Scholar
• Canonica GW , Baena-CagnaniCE , BousquetJet al. Recommendations for standardization of clinical trials with allergen specific immunotherapy for respiratory allergy. A statement of a world allergy organization (WAO) taskforce . Allergy62 ( 3 ), 317 – 324 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Pfaar O , BachertC , BufeAet al. Guideline on allergen-speci ficc immunotherapy in IgE mediated allergic diseases – S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD) . Allergo J. Int.23 ( 8 ), 282 – 319 ( 2014 ).
   PubMedGoogle Scholar
• German Society for Allergology and Clinical Immunology (DGAKI): online-register on AIT products . www.dgaki.de/leitlinien/s2k-leitlinie-sit/ .
   Google Scholar
• Durham SR , CreticosPS , NelsonHSet al. Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: pooled analyses . J. Allergy Clin. Immunol.138 ( 4 ), 1081 – 1088 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Halken S , Larenas-LinnemannD , RobertsGet al. EAACI guidelines on allergen immunotherapy: prevention of allergy . Pediatr. Allergy Immunol.28 ( 8 ), 728 – 745 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Zielen S , DevillierP , HeinrichJ , RichterH , WahnU . Sublingual immunotherapy provides long-term relief in allergic rhinitis and reduces the risk of asthma: a retrospective, real-world database analysis . Allergy73 ( 1 ), 165 – 177 ( 2018 ).
   PubMed Web of Science ®Google Scholar
• Valovirta E , PetersenTH , PiotrowskaTet al. Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy . J. Allergy Clin. Immunol.141 ( 2 ), 529 – 538 ( 2018 ).
   PubMed Web of Science ®Google Scholar
• Jacobsen L , NiggemannB , DreborgSet al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study . Allergy62 ( 8 ), 943 – 948 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Creticos PS , BernsteinDI , CasaleTB , LockeyRF , MaloneyJ , NolteH . Coseasonal initiation of allergen immunotherapy: a systematic review . J. Allergy Clin. Immunol. Pract.4 ( 6 ), 1194 – 1204 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Cox LS , Larenas LinnemannD , NolteH , WeldonD , FinegoldI , NelsonHS . Sublingual immunotherapy: a comprehensive review . J. Allergy Clin. Immunol.117 ( 5 ), 1021 – 1035 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Bernstein DI , BardelasJAJr , Svanholm FoghB , KaurA , LiZ , NolteH . A practical guide to the sublingual immunotherapy tablet adverse event profile: implications for clinical practice . Postgrad. Med.129 ( 6 ), 590 – 597 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Calderon MA , SimonsFE , MallingHJ , LockeyRF , MoingeonP , DemolyP . Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile . Allergy67 ( 3 ), 302 – 311 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Bachert C , LarcheM , BoniniSet al. Allergen immunotherapy on the way to product-based evaluation-a WAO statement . World Allergy Organ. J.8 ( 1 ), 29 ( 2015 ).
   PubMedGoogle Scholar
• Kiel MA , RöderE , Gerth Van WijkR , AlMJ , HopWC , Rutten-Van MölkenMP . Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy . J. Allergy Clin. Immunol.132 ( 2 ), 353 – 360 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Hsu NM , ReisacherWR . A comparison of attrition rates in patients undergoing sublingual immunotherapy vs subcutaneous immunotherapy . Int. Forum Allergy Rhinol.2 ( 4 ), 280 – 284 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Bender BG , OppenheimerJ . The special challenge of nonadherence with sublingual immunotherapy . J. Allergy Clin. Immunol. Pract.2 ( 2 ), 152 – 155 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Sondermann N , Shah-HosseiniK , HenkelK , SchwalfenbergA , MösgesR . Erfolgsfaktoren der Adherence bei Hyposensibilisierung . Allergologie34 , 441 – 446 ( 2011 ).
   Web of Science ®Google Scholar
• Nolte H , AmarN , BernsteinDIet al. Safety and tolerability of a short ragweed sublingual immunotherapy tablet . Ann. Allergy. Asthma. Immunol.113 ( 1 ), 93 – 100 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Blaiss M , MaloneyJ , NolteH , GawchikS , YaoR , SkonerDP . Efficacy and safety of timothy grass allergy immunotherapy tablets in North American children and adolescents . J. Allergy Clin. Immunol.127 ( 1 ), 64 – 71 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Bufe A , EberleP , Franke-BeckmannEet al. Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy . J. Allergy Clin. Immunol.123 ( 1 ), 167 – 173 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Kaur A , SkonerD , IbrahimJet al. Effect of grass sublingual tablet immunotherapy is similar in children and adults: a Bayesian approach to design pediatric sublingual immunotherapy trials . J. Allergy Clin. Immunol.141 ( 5 ), 1744 – 1749 ( 2018 ).
   PubMed Web of Science ®Google Scholar
• Wahn U , TabarA , KunaPet al. Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis . J. Allergy Clin. Immunol.123 ( 1 ), 160 – 166 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Maloney J , BernsteinDI , NelsonHet al. Efficacy and safety of grass sublingual immunotherapy tablet, MK-7243: a large randomized controlled trial . Ann. Allergy Asthma. Immunol.112 ( 2 ), 146 – 153 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Durham SR , EmmingerW , KappAet al. SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial . J. Allergy Clin. Immunol.129 ( 3 ), 717 – 725 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Didier A , MallingHJ , WormM , HorakF , SussmanGL . Prolonged efficacy of the 300IR 5-grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score . Clin. Transl. Allergy5 , 12 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• US Food and Drug Administration . Vaccines, blood & biologics . www.fda.gov/BiologicsBloodVaccines/Allergenics/ucm393572.htm .
   Google Scholar
• Demoly P , PassalacquaG , PfaarO , SastreJ , WahnU . Management of the polyallergic patient with allergy immunotherapy: a practice-based approach . Allergy Asthma Clin. Immunol.12 , 2 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Bousquet PJ , CastelliC , DauresJPet al. Assessment of allergen sensitization in a general population-based survey (European Community Respiratory Health Survey I) . Ann. Epidemiol.20 ( 11 ), 797 – 803 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Arbes SJ , Jr. , GergenPJ , ElliottL , ZeldinDC . Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey . J. Allergy Clin. Immunol.116 ( 2 ), 377 – 383 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Creticos PS , MaloneyJ , BernsteinDIet al. Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults . J. Allergy Clin. Immunol.131 ( 5 ), 1342 – 1349 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Nolte H , HébertJ , BermanGet al. Randomized controlled trial of ragweed allergy immunotherapy tablet efficacy and safety in North American adults . Ann. Allergy Asthma. Immunol.110 ( 6 ), 450 – 456 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Pepper AN , CalderonMA , CasaleTB . Sublingual immunotherapy for the polyallergic patient . J. Allergy Clin. Immunol. Pract.5 ( 1 ), 41 – 45 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Nelson H , BlaissM , NolteH , WürtzSØ , AndersenJS , DurhamSR . Efficacy and safety of the SQ-standardized grass allergy immunotherapy tablet in mono- and polysensitized subjects . Allergy68 ( 2 ), 252 – 255 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Maloney J , BermanG , GagnonRet al. Sequential treatment initiation with timothy grass and ragweed sublingual immunotherapy tablets followed by simultaneous treatment is well tolerated . J. Allergy Clin. Immunol. Pract.4 ( 2 ), 301 – 309 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Pitsios C , DemolyP , BiloMBet al. Clinical contraindications to allergen immunotherapy: an EAACI position paper . Allergy70 ( 8 ), 897 – 909 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Epstein TG , CreticosPS . Virtual patient: rhinitis and asthma in a pregnant patient (making IT count) . American Academy of Allergy, Asthma and Immunology website ( 2016 ). https://education.aaaai.org/ARAsthmaPregnantPt .
   Google Scholar