260
Views
0
CrossRef citations to date
0
Altmetric
Systematic Review

Adherence to Subcutaneous Biological Therapies in Patients with Inflammatory Rheumatic Diseases and Inflammatory Bowel Disease: A Systematic Review

ORCID Icon, ORCID Icon, ORCID Icon, &
Pages 433-458 | Received 15 Dec 2020, Accepted 22 Jan 2021, Published online: 09 Feb 2021

References

  • Maniadakis N , TothE , SchiffMet al. A targeted literature review examining biologic therapy compliance and persistence in chronic inflammatory diseases to identify the associated unmet needs, driving factors, and consequences. Adv. Ther.35(9), 1333–1355 (2018).
  • Baumgart DC , MiseryL , NaeyaertS , TaylorPC. Biological therapies in immune-mediated inflammatory diseases: can biosimilars reduce access inequities?Front. Pharmacol.10, 279 (2019).
  • World Heath Organization . Adherence to long-term therapies: evidence for action. www.who.int/chp/knowledge/publications/adherence_report/en/
  • Bluett J , MorganC , ThurstonLet al. Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Rheumatology (Oxford)54(3), 494–499 (2015).
  • Brown MT , BussellJK. Medication adherence: WHO cares?Mayo Clin. Proc.86(4), 304–314 (2011).
  • López-González R , LeónL , LozaE , RedondoM , GarciaDe Yébenes MJ , CarmonaL. Adherence to biologic therapies and associated factors in rheumatoid arthritis, spondyloarthritis and psoriatic arthritis: a systematic literature review. Clin. Exp. Rheumatol.33(4), 559–569 (2015).
  • Michetti P , WeinmanJ , MrowietzUet al. Impact of treatment-related beliefs on medication adherence in immune-mediated inflammatory diseases: results of the global ALIGN study. Adv. Ther.34(1), 91–108 (2017).
  • Cea-Calvo L , CarmonaL , Calvo-AlenJ. The challenge of assessing adherence to subcutaneous biological drugs in immune-mediated inflammatory diseases. Letter to the editor regarding Michetti P, Weinman J, Mrowietz U et al. Adv. Ther.34(9), 2173–2176 (2017).
  • Cramer JA , RoyA , BurrellAet al. Medication compliance and persistence: terminology and definitions. Value Health11(1), 44–47 (2008).
  • Vrijens B , DeGeest S , HughesDAet al. A new taxonomy for describing and defining adherence to medications. Br. J. Clin. Pharmacol.73(5), 691–705 (2012).
  • Hoy D , BrooksP , WoolfAet al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J. Clin. Epidemiol.65(9), 934–939 (2012).
  • Ottawa Hospital Research Institute . WellsGA , SheaB , O’ConnellDet al.The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. www.ohri.ca/programs/clinical_epidemiology/oxford.asp
  • Liberati A , AltmanDG , TetzlaffJet al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ339, b2700 (2009).
  • Bhoi P , BessetteL , BellMJ , TkaczykC , NantelF , MaslovaK. Adherence and dosing interval of subcutaneous antitumour necrosis factor biologics among patients with inflammatory arthritis: analysis from a Canadian administrative database. BMJ Open7(9), e015872 (2017).
  • Borah BJ , HuangX , ZarotskyV , GlobeD. Trends in RA patients’ adherence to subcutaneous anti-TNF therapies and costs. Curr. Med. Res. Opin.25(6), 1365–1377 (2009).
  • Calip GS , AdimadhyamS , XingS , RinconJC , LeeWJ , AnguianoRH. Medication adherence and persistence over time with self-administered TNF-alpha inhibitors among young adult, middle-aged, and older patients with rheumatologic conditions. Semin. Arthritis Rheum.47(2), 157–164 (2017).
  • Calvo-Alen J , VelaP , BustabadS , MaceirasF , CarmonaL , Cea-CalvoL. Satisfaction, fulfillment of expectations and adherence to subcutaneous biological drugs in patients with rheumatoid arthritis: ARCO study. Reumatol. Clin.16(2 Pt 1), 116–119 (2020).
  • Cea-Calvo L , RayaE , MarrasCet al. The beliefs of rheumatoid arthritis patients in their subcutaneous biological drug: strengths and areas of concern. Rheumatol. Int.38(9), 1735–1740 (2018).
  • Gendelman O , WeitzmanD , RosenbergV , ShalevV , ChodickG , AmitalH. Characterization of adherence and persistence profile in a real-life population of patients treated with adalimumab. Br. J. Clin. Pharmacol.84(4), 786–795 (2018).
  • Govani SM , NoureldinM , HigginsPDRet al. Defining an optimal adherence threshold for patients taking subcutaneous anti-TNFs for inflammatory bowel diseases. Am. J. Gastroenterol.113(2), 276–282 (2018).
  • Harley CR , FrytakJR , TandonN. Treatment compliance and dosage administration among rheumatoid arthritis patients receiving infliximab, etanercept, or methotrexate. Am. J. Manag. Care9(Suppl. 6), S136–S143 (2003).
  • Haydek J , ShahN , SlaughterJC , AlE. Non-adherence to self-injectable biologic medication in patients with moderate to severe inflammatory bowel disease is associated with increased healthcare resource utilization. Gastroenterology156(6), S–414 (2019).
  • Khilfeh I , GuyetteE , WatkinsJ , DanielsonD , GrossD , YeungK. Adherence, persistence, and expenditures for high-cost anti-inflammatory drugs in rheumatoid arthritis: an exploratory study. J. Manag. Care Spec. Pharm.25(4), 461–467 (2019).
  • Mena-Vazquez N , Manrique-ArijaS , Yunquera-RomeroLet al. Adherence of rheumatoid arthritis patients to biologic disease-modifying antirheumatic drugs: a cross-sectional study. Rheumatol. Int.37(10), 1709–1718 (2017).
  • Oton T , CarmonaL , Urruticoechea-AranaA , Calvo-AlenJ , ArteagaMJ , Cea-CalvoL. Discordance between doctor and patient assessments and non-adherence to subcutaneous biological drugs. Rheumatol. Int.39(6), 1077–1082 (2019).
  • Srulovici E , GargV , GhilaiAet al. Is patient support program participation associated with longer persistence and improved adherence among new users of adalimumab? A retrospective cohort study. Adv. Ther.35(5), 655–665 (2018).
  • Wang L , LeongR. IDDF2018-ABS-0026 Persistence and adherence of anti-tumour necrosis factor (TNF) biologics for inflammatory bowel disease (IBD) in Australia. Gut67, A298 (2018).
  • Wentworth BJ , BuerleinRCD , TuskeyAG , OverbyMA , SmolkinME , BehmBW. Nonadherence to biologic therapies in inflammatory bowel disease. Inflamm. Bowel Dis.24(9), 2053–2061 (2018).
  • Tkacz J , EllisL , BolgeSC , MeyerR , BradyBL , RuetschC. Utilization and adherence patterns of subcutaneously administered anti-tumor necrosis factor treatment among rheumatoid arthritis patients. Clin. Ther.36(5), 737–747 (2014).
  • Wolf DC , JaganathanS , BurudpakdeeCet al. Adherence rates and health care costs in Crohn’s disease patients receiving certolizumab pegol with and without home health nurse assistance: results from a retrospective analysis of patient claims and home health nurse data. Patient Prefer. Adherence12, 869–878 (2018).
  • Vogelzang EH , HebingRCF , NurmohamedMTet al. Adherence to etanercept therapy in rheumatoid arthritis patients during 3 years of follow-up. PLoS ONE13(10), e0205125 (2018).
  • Kiltz U , PeterlikD , WinkelmannV , TonyH-P. AB0705 Aquila study in Germany – real world adherence and persistence of secukinumab treatment in ankylosing spondylitis and psoriatic arthritis patients – an interim analysis. Ann. Rheum. Dis.78(Suppl. 2), 1814–1815 (2019).
  • Santoleri F , SoriceP , LasalaR , RizzoRC , CostantiniA. Medication adherence and persistence in the treatment of rheumatoid arthritis with adalimumab and etanercept. Six years of analysis. J. Med. Econ.17(5), 320–325 (2014).
  • Hilliquin P , BarnetcheT , BaudensG , NiarraR , IdierI , SarauxA. Subcutaneous tocilizumab in monotherapy or in combination with DMARD in patients with moderate to severe active rheumatoid arthritis: observational study to describe real-world drug retention rate at 12 months, interim analysis. Arthritis Rheumatol.70(Suppl. 9), 621–622 (2018).
  • Morgan C , McbethJ , CordingleyLet al. The influence of behavioural and psychological factors on medication adherence over time in rheumatoid arthritis patients: a study in the biologics era. Rheumatology (Oxford)54(10), 1780–1791 (2015).
  • Salaffi F , CarottiM , DiCarlo M , FarahS , GutierrezM. Adherence to anti-tumor necrosis factor therapy administered subcutaneously and associated factors in patients with rheumatoid arthritis. J. Clin. Rheumatol.21(8), 419–425 (2015).
  • Horne R , AlbertA , BooneC. Relationship between beliefs about medicines, adherence to treatment, and disease activity in patients with rheumatoid arthritis under subcutaneous anti-TNF alpha therapy. Patient Prefer. Adherence12, 1099–1111 (2018).
  • Nisar MK , MirzaW , RafiqA , EisenhutM. Adherence to biologic therapy: does it vary with ethnicity?Biologicals54, 28–32 (2018).
  • Alañón Pardo M , DelÁguila VA , DíazJCet al. CP-104 Adherence to disease modifying antirheumatic drugs in patients with rheumatoid arthritis. Eur. J. Hosp. Pharm.23(Suppl. 1), A45–A46 (2016).
  • Bruna-Barranco I , AlarconP , LuéAet al. P524 Active smoking and personal concerns about treatment can impair adherence to adalimumab in inflammatory bowel diseases: a prospective evaluation. J. Crohns Colitis12(Suppl. 1), S371–S371 (2018).
  • van der Have M , OldenburgB , KapteinAAet al. Non-adherence to anti-TNF therapy is associated with illness perceptions and clinical outcomes in outpatients with inflammatory bowel disease: results from a prospective multicentre study. J. Crohns Colitis10(5), 549–555 (2016).
  • Saez Bello M , LlopisSalvia P , AlegreSancho JJ , ParedesArquiola JM , AsencioMunoz MDC , ClimenteMarti M. Clinical utility of serum concentrations of adalimumab as predictor of treatment adherence. Reumatol. Clin.16(1), 32–37 (2020).
  • Calvo-Alen J , MonteagudoI , SalvadorGet al. Non-adherence to subcutaneous biological medication in patients with rheumatoid arthritis: a multicentre, non-interventional study. Clin. Exp. Rheumatol.35(3), 423–430 (2017).
  • Feldman CH , LiiJ , GopalakrishnanC , FranklinJM , KimSC. THU0664 Treatment adherence to conventional and biologic disease modifying antirheumatic drugs in patients with rheumatoid arthritis. Ann. Rheum. Dis.77(Suppl. 2), 526–526 (2018).
  • Smith T , HarnettJ , GrubenD , ChenC , AgarwalE , WoolcottJ. Real-world experience with tofacitinib versus adalimumab and etanercept in biologic-naive patients with RA previously treated with methotrexate: data from a US administrative healthcare insurance claims database. Arthritis Rheumatol.69(Suppl. 10), (2017). https://acrabstracts.org/abstract/real-world-experience-with-tofacitinib-versus-adalimumab-and-etanercept-in-biologic-naive-patients-with-ra-previously-treated-with-methotrexate-data-from-a-us-administrative-healthcare-insurance-clai/
  • Levy RA , TeichV , FernandesRet al. Patient support program for adalimumab-treated patients in Brazil: impact on patients’adherence and persistence. Arthritis Rheumatol.68(Suppl. 10), (2016). https://acrabstracts.org/abstract/patient-support-program-for-adalimumab-treated-patients-in-brazil-impact-on-patients-adherence-and-persistence/
  • Oelke KR , ChambenoitO , MajjhooAQ , GrayS , HigginsK , HurP. Persistence and adherence of biologics in US patients with psoriatic arthritis: analyses from a claims database. J. Comp. Eff. Res.8(8), 607–621 (2019).
  • Brixner D , RubinDT , MeasePet al. Patient support program increased medication adherence with lower total health care costs despite increased drug spending. J. Manag. Care. Spec. Pharm.25(7), 770–779 (2019).
  • Stolshek BS , WadeS , MutebiA , DeAP , WadeRL , YeawJ. Two-year adherence and costs for biologic therapy for rheumatoid arthritis. Am. J. Manag. Care24(8 Spec No.), SP315–SP321 (2018).
  • Bonafede M , JohnsonBH , TangDH , HarrisonDJ , StolshekBS. Compliance and cost of biologic therapies for rheumatoid arthritis. Am. J. Pharm. Benefits9(5), 84–90 (2017).
  • Accortt NA , SchenfeldJ , ChangE , PapoyanE , BroderMS. Changes in healthcare utilization after etanercept initiation in patients with rheumatoid arthritis: a retrospective claims analysis. Adv. Ther.34(9), 2093–2103 (2017).
  • Chu LH , KawatkarAA , GabrielSE. Medication adherence and attrition to biologic treatment in rheumatoid arthritis patients. Clin. Ther.37(3), 660–666e668 (2015).
  • Degli Esposti L , SangiorgiD , PerroneVet al. Adherence and resource use among patients treated with biologic drugs: findings from BEETLE study. Clinicoecon. Outcomes Res.6, 401–407 (2014).
  • Li P , BlumMA , Von FeldtJ , HennessyS , DoshiJA. Adherence, discontinuation, and switching of biologic therapies in medicaid enrollees with rheumatoid arthritis. Value Health13(6), 805–812 (2010).
  • Li L , CuiY , YinRet al. Medication adherence has an impact on disease activity in rheumatoid arthritis: a systematic review and meta-analysis. Patient Prefer. Adherence11, 1343–1356 (2017).
  • Khan S , RupniewskaE , NeighborsM , SingerD , ChiarappaJ , ObandoC. Real-world evidence on adherence, persistence, switching and dose escalation with biologics in adult inflammatory bowel disease in the United States: a systematic review. J. Clin. Pharm. Ther.44(4), 495–507 (2019).
  • Kane S , HuoD , AikensJ , HanauerS. Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. Am. J. Med.114(1), 39–43 (2003).
  • Perry J , ChenA , KariyawasamVet al. Medication non-adherence in inflammatory bowel diseases is associated with disability. Intest. Res.16(4), 571–578 (2018).
  • Simpson SH , EurichDT , MajumdarSRet al. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ333(7557), 15 (2006).
  • Karlsson SA , EliassonB , FranzenS , MiftarajM , SvenssonAM , AnderssonSundell K. Risk of cardiovascular event and mortality in relation to refill and guideline adherence to lipid-lowering medications among patients with Type 2 diabetes mellitus in Sweden. BMJ Open Diabetes Res. Care7(1), e000639 (2019).
  • Pasma A , SchenkC , TimmanRet al. Does non-adherence to DMARDs influence hospital-related healthcare costs for early arthritis in the first year of treatment? PLoS ONE 12(2), e0171070 (2017).
  • Chan W , ChenA , TiaoD , SelingerC , LeongR. Medication adherence in inflammatory bowel disease. Intest. Res.15(4), 434–445 (2017).
  • Doyle C , LennoxL , BellD. A systematic review of evidence on the links between patient experience and clinical safety and effectiveness. BMJ Open3(1), e001570 (2013).
  • Foot H , LaCaze A , GujralG , CottrellN. The necessity-concerns framework predicts adherence to medication in multiple illness conditions: a meta-analysis. Patient Educ. Couns.99(5), 706–717 (2016).
  • Vangeli E , BakhshiS , BakerAet al. A systematic review of factors associated with non-adherence to treatment for immune-mediated inflammatory diseases. Adv. Ther.32(11), 983–1028 (2015).
  • Coleman CI , LimoneB , SobierajDMet al. Dosing frequency and medication adherence in chronic disease. J. Manag. Care Pharm.18(7), 527–539 (2012).
  • Shah NB , HaydekJ , SlaughterJet al. Risk factors for medication nonadherence to self-injectable biologic therapy in adult patients with inflammatory bowel disease. Inflamm. Bowel Dis.26(2), 314–320 (2020).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.