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Research Article

Nanoemulsion is an Effective Antimicrobial for Methicillin-Resistant Staphylococcus Aureus in Infected Wounds

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Pages 1177-1185 | Received 17 Jan 2017, Accepted 10 Mar 2017, Published online: 27 Apr 2017

References

  • Finland M . Emergence of antibiotic-resistant bacteria. N. Engl. J. Med.253 (21), 909 – 922 (1955).
  • Jevons MP . Celbenin-resistant staphylocci [letter]. Br. Med. J.1 (5219), 124 – 125 (1961).
  • Stryjewski ME Corey GR . Methicillin-resistant Staphylococcus aureus: an evolving pathogen. Clin. Infect. Dis.58 (Suppl. 1), S10 – S19 (2014).
  • Pottinger PS . Methicillin-resistant Staphylococcus aureus infections. Med. Clin. North Am.97 (4), 601 – 619 (2013).
  • Kawamura H Matsumoto K Shigemi A et al. A bundle that includes active surveillance, contact precaution for carriers, and cefazolin-based antimicrobial prophylaxis prevents methicillin-resistant Staphylococcus aureus infections in clean orthopedic surgery. Am. J. Infect. Control.44 (2), 210 – 214 (2016).
  • Lee YJ Chen JZ Lin HC et al. Impact of active screening for methicillin-resistant Staphylococcus aureus (MRSA) and decolonization on MRSA infections, mortality and medical cost: a quasi-experimental study in surgical intensive care unit. Crit. Care19, 143 (2015).
  • Allareddy V Das A Lee MK et al. Prevalence, predictors, and outcomes of methicillin-resistant Staphylococcus aureus infections in patients undergoing major surgical procedures in the United States: a population-based study. Am. J. Surg.210 (1), 59 – 67 (2015).
  • Rodvold KA McConeghy KW . Methicillin-resistant Staphylococcus aureus therapy: past, present, and future. Clin. Infect. Dis.58 (Suppl. 1), S20 – S27 (2014).
  • Long SW Olsen RJ Mehta SC et al. PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates. Antimicrob. Agents Chemother.58 (11), 6668 – 6674 (2014).
  • Kaewpoowat Q Ostrosky-Zeichner L . Tigecycline: a critical safety review. Expert Opin. Drug Saf.14 (2), 335 – 342 (2015).
  • Barriere SL . The ATTAIN trials: efficacy and safety of telavancin compared with vancomycin for the treatment of hospital-acquired and ventilator-associated bacterial pneumonia. Future Microbiol.9 (3), 281 – 289 (2014).
  • Vingsbo Lundberg C Frimodt-Moller N . Efficacy of topical and systemic antibiotic treatment of meticillin-resistant Staphylococcus aureus in a murine superficial skin wound infection model. Int. J. Antimicrob. Agents42 (3), 272 – 275 (2013).
  • Hemmila MR Mattar A Taddonio MA et al. Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury. Surgery148 (3), 499 – 509 (2010).
  • Fan Y Ciotti SM Cao Z Eisma R Baker JR Jr Wang SH . Screening of nanoemulsion formulations and identification of NB-201 as an effective topical antimicrobial for Staphylococcus aureus in a mouse model of infected wounds. Mil. Med.181 (Suppl. 5), 259 – 264 (2016).
  • LiPuma JJ Rathinavelu S Foster BK et al. In vitro activities of a novel nanoemulsion against Burkholderia and other multidrug-resistant cystic fibrosis-associated bacterial species. Antimicrob. Agents Chemother.53 (1), 249 – 255 (2009).
  • Greenhalgh DG Sprugel KH Murray MJ Ross R . PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am. J. Pathol.136 (6), 1235 – 1246 (1990).
  • Halin C Fahrngruber H Meingassner JG et al. Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am. J. Pathol.173 (1), 265 – 277 (2008).
  • Grellner W . Time-dependent immunohistochemical detection of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in human skin wounds. Forensic Sci. Int.130 (2–3), 90 – 96 (2002).
  • Montgomery CP Daniels MD Zhao F Spellberg B Chong AS Daum RS . Local inflammation exacerbates the severity of Staphylococcus aureus skin infection. PLoS ONE8 (7), e69508 (2013).
  • Dolgachev VA Ciotti SM Eisma R et al. Nanoemulsion therapy for burn wounds is effective as a topical antimicrobial against gram-negative and gram-positive bacteria. J. Burn Care Res.37 (2), e104 – e114 (2016).
  • Berglund C Mölling P Sjöberg L Söderguist B . Predominance of staphylococcal cassette chromosome mec (SCCmec) type IV among methicillin-resistant Staphylococcus aureus (MRSA) in a Swedish county and presence of unknown SCCmec types with Panton-Valentine leukocidin genes. Clin. Microbiol. Infect.11 (6), 447 – 456 (2005).
  • Buntaran L Hatta M Sultan AR Dwiyanti R Sabir M . Sccmec type II gene is common among clinical isolates of methicillin-resistant Staphylococcus aureus in Jakarta, Indonesia. BMC Res. Notes.6, 100 (2013).
  • Johnson J Khoie T Shurland S Kreisel K Stine O Roghmann M . Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus USA 300 clone. Emerg. Infect. Dis.13 (8), 1195 – 1200 (2007).
  • Kaneko J Kamio Y . Bacterial two-component and hetero-heptameric pore-forming cytolytic toxins: structures, pore-forming mechanism, and organization of the genes. Biosci. Biotechnol. Biochem.68 (5), 981 – 1003 (2004).
  • Sullivan TP Eaglstein WH Davis SC Mertz P . The pig as a model for human wound healing. Wound Repair. Regen.9 (2), 66 – 76 (2001).
  • Ambrosch A Lobmann R Pott A Preissler J . Interleukin-6 concentrations in wound fluids rather than serological markers are useful in assessing bacterial triggers of ulcer inflammation. Int. Wound J.5 (1), 99 – 106 (2008).
  • Tambuyzer T De Waele T Chiers K Berckmans D Goddeeris BM Aerts JM . Interleukin-6 dynamics as a basis for an early-warning monitor for sepsis and inflammation in individual pigs. Res. Vet. Sci.96 (3), 460 – 463 (2014).
  • Zhang M Zhou J Wang L et al. Caffeic acid reduces cutaneous tumor necrosis factor alpha (TNF-alpha), IL-6 and IL-1 beta levels and ameliorates skin edema in acute and chronic model of cutaneous inflammation in mice. Biol. Pharm. Bull.37 (3), 347 – 354 (2014).
  • Washburn NR Prata JE Friedrich EE Ramadan MH Elder AN Sun LT . Polymer-conjugated inhibitors of tumor necrosis factor-alpha for local control of inflammation. Biomatter3 (3), e25597 (2013).
  • Lee DC Lau AS . Effects of Panax ginseng on tumor necrosis factor-alpha-mediated inflammation: a mini-review. Molecules16 (4), 2802 – 2816 (2011).
  • Franks Z Campbell RA Vieira de Abreu A et al. Methicillin-resistant Staphylococcus aureus-induced thrombo-inflammatory response is reduced with timely antibiotic administration. Thromb. Haemost.109 (4), 684 – 695 (2013).
  • Gu J Zuo J Lei L et al. LysGH15 reduces the inflammation caused by lethal methicillin-resistant Staphylococcus aureus infection in mice. Bioeng. Bugs.2 (2), 96 – 99 (2011).
  • Coffey RP Rice TL Thomson PD . Effect of blood and serum on in vitro antibacterial activity of nitrofurazone. Am. J. Hosp. Pharm.48 (7), 1496 – 1499 (1991).
  • Hamouda T Baker JR Jr . Antimicrobial mechanism of action of surfactant lipid preparations in enteric Gram-negative bacilli. J. Appl. Microbiol.89 (3), 397 – 403 (2000).
  • Hamouda T Hayes M Cao ZZ et al. A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against Bacillus species. J. Infect. Dis.180 (6), 1939 – 1949 (1999).
  • Hamouda T Myc A Donovan B Shih AY Reuter JD Baker JR Jr . A novel surfactant nanoemulsion with a unique non-irritant topical antimicrobial activity against bacteria, enveloped viruses and fungi. Microbiol. Res.156 (1), 1 – 7 (2001).

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