Simultaneous In Situ Visualization and Quantitation of Dual Antigens Adsorbed on Adjuvants Using High Content Analysis

References

• Schiller JT , CastellsaguéX , GarlandS. A review of clinical trials of human papillomavirus prophylactic vaccines. Vaccine30(Suppl. 5), F123–F128 (2012).
   PubMed Web of Science ®Google Scholar
• Nascimento IP , LeiteLC. Recombinant vaccines and the development of new vaccine strategies. Braz. J. Med. Biol. Res.45(12), 1102–1111 (2012).
   PubMed Web of Science ®Google Scholar
• Schmidt MR , McGinnesLW , KenwardSA , WillemsKN , WoodlandRT , MorrisonTG. Long-term and memory immune responses in mice against Newcastle disease virus-like particles containing respiratory syncytial virus glycoprotein ectodomains. J. Virol.86(21), 11654–11662 (2014).
   Web of Science ®Google Scholar
• McKee AS , MarrackP. Old and new adjuvants. Curr. Opin. Immunol.47, 44–51 (2017).
   PubMed Web of Science ®Google Scholar
• Hem SL , HogeneschH. Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. Expert Rev. Vaccines6(5), 685–698 (2007).
   PubMed Web of Science ®Google Scholar
• Li H , LiY , JiaoJ , HuHM. Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response. Nat. Nanotechnol.6(10), 645–650 (2011).
   PubMed Web of Science ®Google Scholar
• Li N , PengLH , ChenX , ZhangTY , ShaoGF , LiangWQ. Antigen-loaded nanocarriers enhance the migration of stimulated Langerhans cells to draining lymph nodes and induce effective transcutaneous immunization. Nanomedicine10(1), 215–223 (2014).
   PubMed Web of Science ®Google Scholar
• Zhao Q , AllenMJ , WangYet al. Disassembly and reassembly improves morphology and thermal stability of human papillomavirus type 16 virus-like particles. Nanomedicine8(7), 1182–1189 (2012).
   PubMed Web of Science ®Google Scholar
• Zhao Q , ModisY , HighKet al. Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity. J. Virol.9, 52 (2012).
   Web of Science ®Google Scholar
• Jones LS , PeekLJ , PowerJ , MarkhamA , YazzieB , MiddaughCR. Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. J. Biol. Chem.280(14), 13406–13414 (2005).
   PubMed Web of Science ®Google Scholar
• Agnolon V , BrunoC , GallettiBet al. Multiplex immunoassay for in vitro characterization of acellular pertussis antigens in combination vaccines. Vaccine34(8), 1040–1046 (2016).
   PubMed Web of Science ®Google Scholar
• Lai X , ZhengY , JacobsenSet al. Determination of adsorbed protein concentration in aluminum hydroxide suspensions by near-infrared transmittance spectroscopy. Appl. Spectrosc.62(7), 784–790 (2008).
   PubMed Web of Science ®Google Scholar
• Zhu D , SaulA , HuangS , MartinLB , MillerLH , RauschKM. Use of o-phthalaldehyde assay to determine protein contents of Alhydrogel-based vaccines. Vaccine27(43), 6054–6059 (2009).
   PubMed Web of Science ®Google Scholar
• Ugozzoli M , LaeraD , NutiSet al. Flow cytometry: an alternative method for direct quantification of antigens adsorbed to aluminum hydroxide adjuvant. Anal. Biochem.418(2), 224–230 (2011).
   PubMed Web of Science ®Google Scholar
• Mattiazzi UM , StylesEB , VersterAJ , FriesenH , BooneC , AndrewsBJ. High-content screening for quantitative cell biology. Trends Cell Biol.26(8), 598–611 (2016).
   PubMed Web of Science ®Google Scholar
• Kriston-Vizi J , FlotowH. Getting the whole picture: high content screening using three-dimensional cellular model systems and whole animal assays. Cytometry A91(2), 152–159 (2017).
   PubMedGoogle Scholar
• Kartoglu U , MilstienJ. Tools and approaches to ensure quality of vaccines throughout the cold chain. Expert Rev. Vaccines13(7), 843–854 (2014).
   PubMed Web of Science ®Google Scholar
• Kristensen DD , LorensonT , BartholomewK , VilladiegoS. Can thermostable vaccines help address cold-chain challenges? Results from stakeholder interviews in six low- and middle-income countries. Vaccine34(7), 899–904 (2016).
   PubMed Web of Science ®Google Scholar
• Zaffran M , VandelaerJ , KristensenDet al. The imperative for stronger vaccine supply and logistics systems. Vaccine31(Suppl. 2), B73–B70 (2013).
   PubMed Web of Science ®Google Scholar
• Gu Y , WeiM , WangDet al. Characterization of an Escherichia coli-derived human papillomavirus type 16 and 18 bivalent vaccine. Vaccine35(35), 4637–4645 (2017).
   PubMed Web of Science ®Google Scholar
• Massey AJ . Multiparametric cell cycle analysis using the operetta high-content imager and harmony software with PhenoLOGIC. PLoS ONE10(7), e0134306 (2015).
   PubMed Web of Science ®Google Scholar
• Jully V , MathotF , MoniotteN , PréatV , LemoineD. Mechanisms of antigen adsorption onto an aluminum-hydroxide adjuvant evaluated by high-throughput screening. J. Pharm. Sci.105(6), 1829–1836 (2016).
   PubMed Web of Science ®Google Scholar
• Duellman T , BurnettJ , YangJ. Quantitation of secreted proteins using mCherry fusion constructs and a fluorescent microplate reader. Anal. Biochem.473, 34–40 (2015).
   PubMed Web of Science ®Google Scholar
• Ludwig DB , TrotterJT , GabrielsonJP , CarpenterJF , RandolphTW. Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulations. Anal. Biochem.410(2), 191–199 (2011).
   PubMed Web of Science ®Google Scholar
• Hng KI , DormannD. Confocal Check-a software tool for the automated monitoring of confocal microscope performance. PLoS ONE8(11), e79879 (2013).
   PubMed Web of Science ®Google Scholar
• Ranhei T , MozierN , EganW , NunnallyBK , TurulaVE , SitrinRD. Vaccine Potency Assay. In: Vaccine Analysis: Strategies, Principles and Control. Springer-Verlag, Berlin, Heidelberg, 521–541 (2015).
   Google Scholar
• Shank-Retzlaff M , WangF , MorleyTet al. Correlation between mouse potency and in vitro relative potency for human papillomavirus type 16 virus-like particles and Gardasil vaccine samples. Hum. Vaccin.1(5), 191–197 (2005).
   PubMed Web of Science ®Google Scholar
• Schiller J , LowyD. Explanations for the high potency of HPV prophylactic vaccines. Vaccine36(32 Pt A), 4768–4773 (2018).
   PubMed Web of Science ®Google Scholar
• Sankaranarayanan R , JoshiS , MuwongeRet al. Can a single dose of human papillomavirus (HPV) vaccine prevent cervical cancer? Early findings from an Indian study. Vaccine36(32 Pt A), 4783–4791 (2018).
   PubMed Web of Science ®Google Scholar
• Al-Barwani F , DonaldsonB , PelhamSJ , YoungSL , WardVK. Antigen delivery by virus-like particles for immunotherapeutic vaccination. Ther. Deliv.5(11), 1223–1240 (2014).
   PubMedGoogle Scholar
• Hong S , ZhangZ , LiuHet al. B cells are the dominant antigen-presenting cells that activate naive CD4+ T cells upon immunization with a virus-derived nanoparticle antigen. Immunity49(4), 695–708 (2018).
   PubMed Web of Science ®Google Scholar
• Morefield GL , HogenEschH , RobinsonJP , HemSL. Distribution of adsorbed antigen in mono-valent and combination vaccines. Vaccine22(15-16), 1973–1984 (2004).
   PubMed Web of Science ®Google Scholar